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Found 21 of ic50 for UniProtKB: P22756
TargetGlutamate receptor ionotropic, kainate 1(RAT)
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50399430(CHEMBL2178920)
Affinity DataIC50:  0.190nMAssay Description:Antagonist activity at rat GluK1 receptor expressed in Xenopus oocytes by two-electrode voltage-clamp at membrane potential -60 to -80 mV electrophys...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, kainate 1(RAT)
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50399431(CHEMBL2178919)
Affinity DataIC50:  0.280nMAssay Description:Antagonist activity at rat GluK1 receptor expressed in Xenopus oocytes by two-electrode voltage-clamp at membrane potential -60 to -80 mV electrophys...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, kainate 1(RAT)
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50399430(CHEMBL2178920)
Affinity DataIC50:  0.330nMAssay Description:Antagonist activity at rat GluK1 receptor expressed in Xenopus oocytes at membrane potential -60 mV by two-electrode voltage-clamp electrophysiology ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, kainate 1(RAT)
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50399431(CHEMBL2178919)
Affinity DataIC50:  0.820nMAssay Description:Antagonist activity at rat GluK1 receptor expressed in Xenopus oocytes at membrane potential -60 mV by two-electrode voltage-clamp electrophysiology ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, kainate 1(RAT)
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50252920((S)-1-[2'-Amino-2'-carboxyethyl]-5,7-dihydrothieno...)
Affinity DataIC50:  5.20nMAssay Description:Displacement of [3H]SYM2081 from rat recombinant iGluR5(Q)1b expressed in Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, kainate 1(RAT)
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50252922((S)-1-(2'-Amino-2'-carboxyethyl)thieno[3,2-d]pyrim...)
Affinity DataIC50:  5.30nMAssay Description:Displacement of [3H]SYM2081 from rat recombinant iGluR5(Q)1b expressed in Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, kainate 1(RAT)
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50105843(2-Amino-N-{3-[4-(3-amino-propylamino)-butylamino]-...)
Affinity DataIC50:  19nMAssay Description:Antagonist activity at rat GluK1 receptor expressed in Xenopus oocytes at membrane potential -60 mV by two-electrode voltage-clamp electrophysiology ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, kainate 1(RAT)
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50002369((2S-(2alpha,3beta,4beta))-2-carboxy-4-(1-methyleth...)
Affinity DataIC50:  77nMAssay Description:Inhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECAMore data for this Ligand-Target Pair
TargetGlutamate receptor ionotropic, kainate 1(RAT)
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50399433(CHEMBL2178917)
Affinity DataIC50:  164nMAssay Description:Antagonist activity at rat GluK1 receptor expressed in Xenopus oocytes at membrane potential -60 mV by two-electrode voltage-clamp electrophysiology ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, kainate 1(RAT)
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50399432(CHEMBL2178918)
Affinity DataIC50:  2.58E+3nMAssay Description:Antagonist activity at rat GluK1 receptor expressed in Xenopus oocytes at membrane potential -60 mV by two-electrode voltage-clamp electrophysiology ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, kainate 1(RAT)
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50234094(CHEMBL4089715)
Affinity DataIC50:  5.70E+3nMAssay Description:Antagonist activity at recombinant rat full length GluK1 receptor expressed in HEK293T cells assessed as inhibition of glutamate induced increase in ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, kainate 1(RAT)
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50175229(6-(4-amino-phenyl)-2,3,8,10-tetrahydro-1,4-dioxa-7...)
Affinity DataIC50: >1.00E+4nMAssay Description:Ability to inhibit domoic acid-induced increase of calcium in rat HEK293 cells expressing GluR5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, kainate 1(RAT)
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50109653(2-Amino-3-[3-hydroxy-4-(4-hydroxy-phenyl)-isoxazol...)
Affinity DataIC50: >1.00E+5nMAssay Description:Concentration of the compound which causes 50% reduction in receptor binding affinity against Ionotropic glutamate receptor ionotropic kainate using ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, kainate 1(RAT)
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50109654(2-Amino-3-(3-hydroxy-4-pyridin-2-yl-isoxazol-5-yl)...)
Affinity DataIC50: >1.00E+5nMAssay Description:Concentration of the compound which causes 50% reduction in receptor binding affinity against Ionotropic glutamate receptor ionotropic kainate using ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, kainate 1(RAT)
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50109658(2-Amino-3-(3-hydroxy-4-phenethyl-isoxazol-5-yl)-pr...)
Affinity DataIC50: >1.00E+5nMAssay Description:Concentration of the compound which causes 50% reduction in receptor binding affinity against Ionotropic glutamate receptor ionotropic kainate using ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, kainate 1(RAT)
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50089901(2-Amino-3-(3-hydroxy-isoxazol-5-yl)-propionic acid...)
Affinity DataIC50: >1.00E+5nMAssay Description:Concentration of the compound which causes 50% reduction in receptor binding affinity against Ionotropic glutamate receptor ionotropic kainate using ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, kainate 1(RAT)
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50109652(2-Amino-3-[3-hydroxy-4-(3-hydroxy-phenyl)-isoxazol...)
Affinity DataIC50: >1.00E+5nMAssay Description:Concentration of the compound which causes 50% reduction in receptor binding affinity against Ionotropic glutamate receptor ionotropic kainate using ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, kainate 1(RAT)
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50109656(2-Amino-3-(3-hydroxy-4-naphthalen-2-yl-isoxazol-5-...)
Affinity DataIC50: >1.00E+5nMAssay Description:Concentration of the compound which causes 50% reduction in receptor binding affinity against Ionotropic glutamate receptor ionotropic kainate using ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, kainate 1(RAT)
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50109657(2-Amino-3-[3-hydroxy-4-(2-hydroxy-phenyl)-isoxazol...)
Affinity DataIC50: >1.00E+5nMAssay Description:Concentration of the compound which causes 50% reduction in receptor binding affinity against Ionotropic glutamate receptor ionotropic kainate using ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, kainate 1(RAT)
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50109655(2-Amino-3-(3-hydroxy-4-naphthalen-1-yl-isoxazol-5-...)
Affinity DataIC50: >1.00E+5nMAssay Description:Concentration of the compound which causes 50% reduction in receptor binding affinity against Ionotropic glutamate receptor ionotropic kainate using ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, kainate 1(RAT)
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50098248(2-Amino-3-(3-hydroxy-4-phenyl-isoxazol-5-yl)-propi...)
Affinity DataIC50: >1.00E+5nMAssay Description:Concentration of the compound which causes 50% reduction in receptor binding affinity against Ionotropic glutamate receptor ionotropic kainate using ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed