Compile Data Set for Download or QSAR
maximum 50k data
Found 51 of ic50 for UniProtKB: P31390
TargetHistamine H1 receptor(RAT)
Universidad De Valencia

Curated by ChEMBL
LigandPNGBDBM50079527((3E)-3-dibenzo[b,e]oxepin-11(6H)-ylidene-N,N-dimet...)
Affinity DataIC50:  0.00300nMAssay Description:Compound tested for its inhibitory activity against Histamine H1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(RAT)
Universidad De Valencia

Curated by ChEMBL
LigandPNGBDBM31005(2-methyl-1,2,3,4,10,14b-hexahydrodibenzo[c,f]pyraz...)
Affinity DataIC50:  0.00600nMAssay Description:Compound tested for its inhibitory activity against Histamine H1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(RAT)
Universidad De Valencia

Curated by ChEMBL
LigandPNGBDBM50020712(10,11-dihydro-5-(gamma-dimethylaminopropylidene)-5...)
Affinity DataIC50:  0.0200nMAssay Description:Compound tested for its inhibitory activity against Histamine H1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(RAT)
Universidad De Valencia

Curated by ChEMBL
LigandPNGBDBM112777(NORTRIPTYLINE | US8629135, SW-02)
Affinity DataIC50:  0.0500nMAssay Description:Compound tested for its inhibitory activity against Histamine H1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(RAT)
Universidad De Valencia

Curated by ChEMBL
LigandPNGBDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)
Affinity DataIC50:  0.0600nMAssay Description:Compound tested for its inhibitory activity against Histamine H1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(RAT)
Universidad De Valencia

Curated by ChEMBL
LigandPNGBDBM77970(3-(2-chloranyl-5,6-dihydrobenzo[b][1]benzazepin-11...)
Affinity DataIC50:  0.200nMAssay Description:Compound tested for its inhibitory activity against Histamine H1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(RAT)
Universidad De Valencia

Curated by ChEMBL
LigandPNGBDBM35229(3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N-met...)
Affinity DataIC50:  0.800nMAssay Description:Compound tested for its inhibitory activity against Histamine H1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(RAT)
Universidad De Valencia

Curated by ChEMBL
LigandPNGBDBM50240514((3Z)-3-(2-chloro-9H-thioxanthen-9-ylidene)-N,N-dim...)
Affinity DataIC50:  1.07nMAssay Description:Displacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(RAT)
Universidad De Valencia

Curated by ChEMBL
LigandPNGBDBM50025124(3-{2-[4-(4-Fluoro-benzoyl)-piperidin-1-yl]-ethyl}-...)
Affinity DataIC50:  2.20nMAssay Description:Compound was evaluated for binding activity against [3H]pyrilamine as radioligand for Histamine H1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(RAT)
Universidad De Valencia

Curated by ChEMBL
LigandPNGBDBM22567(3H]pyrilamine | CHEMBL511 | Dorantamin | Mepyramin...)
Affinity DataIC50:  5.75nMAssay Description:Displacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(RAT)
Universidad De Valencia

Curated by ChEMBL
LigandPNGBDBM50001884(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Affinity DataIC50:  9nMAssay Description:Displacement of [3H]mepyramine from H1R in rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(RAT)
Universidad De Valencia

Curated by ChEMBL
LigandPNGBDBM35254(2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3...)
Affinity DataIC50:  13nMAssay Description:Displacement of [3H]mepyramine from H1R in rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(RAT)
Universidad De Valencia

Curated by ChEMBL
LigandPNGBDBM50001884(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Affinity DataIC50:  23nMAssay Description:Binding affinity towards histamine H1 receptor from rat brain membranes using [3H]-mepyramine as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(RAT)
Universidad De Valencia

Curated by ChEMBL
LigandPNGBDBM50001884(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Affinity DataIC50:  23nMAssay Description:Inhibitory binding of [3H]-mepyramine to histamine H1 receptors in rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(RAT)
Universidad De Valencia

Curated by ChEMBL
LigandPNGBDBM50095890(2-[2-(4-Dibenzo[b,f][1,4]thiazepin-11-yl-1-piperaz...)
Affinity DataIC50:  40nMAssay Description:Displacement of [3H]mepyramine from H1R in rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(RAT)
Universidad De Valencia

Curated by ChEMBL
LigandPNGBDBM50061559(CHEMBL72292 | Trifluoro-methanesulfonic acid 11-(4...)
Affinity DataIC50:  47nMAssay Description:Inhibitory binding of [3H]-mepyramine to histamine H1 receptors in rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(RAT)
Universidad De Valencia

Curated by ChEMBL
LigandPNGBDBM50061559(CHEMBL72292 | Trifluoro-methanesulfonic acid 11-(4...)
Affinity DataIC50:  47nMAssay Description:Binding affinity towards histamine H1 receptor from rat brain membranes using [3H]-mepyramine as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(RAT)
Universidad De Valencia

Curated by ChEMBL
LigandPNGBDBM50001885((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Affinity DataIC50:  80nMAssay Description:Displacement of [3H]mepyramine from H1R in rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(RAT)
Universidad De Valencia

Curated by ChEMBL
LigandPNGBDBM50002338((Thioridazine)10-[2-(1-Methyl-piperidin-2-yl)-ethy...)
Affinity DataIC50:  99nMAssay Description:Binding affinity against Histamine H1 receptor was measured using radioligand ([3H]pyrilamine) binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(RAT)
Universidad De Valencia

Curated by ChEMBL
LigandPNGBDBM50162859(2,3-Dihydro-benzo[1,4]dioxine-5-carboxylic acid {1...)
Affinity DataIC50:  100nMAssay Description:Concentration for 50% inhibition towards central histamine H1 receptor More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(RAT)
Universidad De Valencia

Curated by ChEMBL
LigandPNGBDBM50078062(CHEMBL430798 | Trifluoro-methanesulfonic acid 11-(...)
Affinity DataIC50:  120nMAssay Description:Binding affinity towards histamine H1 receptor from rat brain membranes using [3H]-mepyramine as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(RAT)
Universidad De Valencia

Curated by ChEMBL
LigandPNGBDBM50048803(5-(2-(4-(benzo[d]isothiazol-3-yl)piperazin-1-yl)et...)
Affinity DataIC50:  150nMAssay Description:Displacement of [3H]mepyramine from H1R in rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(RAT)
Universidad De Valencia

Curated by ChEMBL
LigandPNGBDBM50062614(CHEMBL900 | Dimethyl-[2-(phenyl-o-tolyl-methoxy)-e...)
Affinity DataIC50:  162nMAssay Description:Displacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(RAT)
Universidad De Valencia

Curated by ChEMBL
LigandPNGBDBM50061560(CHEMBL310712 | Trifluoro-methanesulfonic acid 11-(...)
Affinity DataIC50:  720nMAssay Description:Inhibitory binding of [3H]-mepyramine to histamine H1 receptors in rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(RAT)
Universidad De Valencia

Curated by ChEMBL
LigandPNGBDBM50061560(CHEMBL310712 | Trifluoro-methanesulfonic acid 11-(...)
Affinity DataIC50:  720nMAssay Description:Binding affinity towards histamine H1 receptor from rat brain membranes using [3H]-mepyramine as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(RAT)
Universidad De Valencia

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataIC50: >1.00E+3nMAssay Description:Binding affinity towards histamine H1 receptor from rat brain membranes using [3H]-mepyramine as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(RAT)
Universidad De Valencia

Curated by ChEMBL
LigandPNGBDBM22871(13-chloro-10-(4-methylpiperazin-1-yl)-2-oxa-9-azat...)
Affinity DataIC50:  1.00E+3nMAssay Description:Binding affinity towards histamine H1 receptor from rat brain membranes using [3H]-mepyramine as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(RAT)
Universidad De Valencia

Curated by ChEMBL
LigandPNGBDBM50202924((+/-)-1-[3-(4'-fluorobiphenyl-2-yl)propyl]-4-[2-(4...)
Affinity DataIC50: >1.00E+3nMAssay Description:Displacement of [3H]pyrilamine from histamine H1 receptor in rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(RAT)
Universidad De Valencia

Curated by ChEMBL
LigandPNGBDBM50202934((+/-)-1-[3-(5-fluorobiphenyl-2-yl)propyl]-4-[2-(4-...)
Affinity DataIC50: >1.00E+3nMAssay Description:Displacement of [3H]pyrilamine from histamine H1 receptor in rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(RAT)
Universidad De Valencia

Curated by ChEMBL
LigandPNGBDBM50202929((+/-)-1-[3-(3-chlorobiphenyl-2-yl)propyl]-4-[2-(4-...)
Affinity DataIC50: >1.00E+3nMAssay Description:Displacement of [3H]pyrilamine from histamine H1 receptor in rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(RAT)
Universidad De Valencia

Curated by ChEMBL
LigandPNGBDBM50202926((+/-)-1-[3-(4-fluorobiphenyl-2-yl)propyl]-4-[2-(4-...)
Affinity DataIC50: >1.00E+3nMAssay Description:Displacement of [3H]pyrilamine from histamine H1 receptor in rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(RAT)
Universidad De Valencia

Curated by ChEMBL
LigandPNGBDBM50202930((+/-)-1-(3-biphenyl-2-ylpropyl)-4-[2-(4-fluorophen...)
Affinity DataIC50: >1.00E+3nMAssay Description:Displacement of [3H]pyrilamine from histamine H1 receptor in rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(RAT)
Universidad De Valencia

Curated by ChEMBL
LigandPNGBDBM50202933((+/-)-1-[2-(4-fluorophenyl)-2-(4-isopropylpiperazi...)
Affinity DataIC50: >1.00E+3nMAssay Description:Displacement of [3H]pyrilamine from histamine H1 receptor in rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(RAT)
Universidad De Valencia

Curated by ChEMBL
LigandPNGBDBM50202938((+/-)-1-[3-(3'-fluorobiphenyl-2-yl)propyl]-4-[2-(4...)
Affinity DataIC50: >1.00E+3nMAssay Description:Displacement of [3H]pyrilamine from histamine H1 receptor in rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(RAT)
Universidad De Valencia

Curated by ChEMBL
LigandPNGBDBM50202941((+/-)-1-[3-(6-fluorobiphenyl-2-yl)propyl]-4-[2-(4-...)
Affinity DataIC50: >1.00E+3nMAssay Description:Displacement of [3H]pyrilamine from histamine H1 receptor in rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(RAT)
Universidad De Valencia

Curated by ChEMBL
LigandPNGBDBM50202947((+/-)-1-[3-(3-fluorobiphenyl-2-yl)propyl]-4-[2-(4-...)
Affinity DataIC50: >1.00E+3nMAssay Description:Displacement of [3H]pyrilamine from histamine H1 receptor in rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(RAT)
Universidad De Valencia

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibitory binding of [3H]-mepyramine to histamine H1 receptors in rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(RAT)
Universidad De Valencia

Curated by ChEMBL
LigandPNGBDBM50203992((+/-)-1-[3-(40-fluorobiphenyl-2-yl)propyl]-4-[2-(4...)
Affinity DataIC50: >1.00E+3nMAssay Description:Displacement of [3H]pyrilamine from from histamine H1 receptor in rat brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(RAT)
Universidad De Valencia

Curated by ChEMBL
LigandPNGBDBM50203991((+/-)-1-(3-biphenyl-2-ylpropyl)-4-[2-(4-fluorophen...)
Affinity DataIC50: >1.00E+3nMAssay Description:Displacement of [3H]pyrilamine from from histamine H1 receptor in rat brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(RAT)
Universidad De Valencia

Curated by ChEMBL
LigandPNGBDBM50203994((+/-)-1-[3-(30-fluorobiphenyl-2-yl)propyl]-4-[2-(4...)
Affinity DataIC50: >1.00E+3nMAssay Description:Displacement of [3H]pyrilamine from from histamine H1 receptor in rat brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(RAT)
Universidad De Valencia

Curated by ChEMBL
LigandPNGBDBM50203995((+/-)-1-[3-(6-fluorobiphenyl-2-yl)propyl]-4-[2-(4-...)
Affinity DataIC50: >1.00E+3nMAssay Description:Displacement of [3H]pyrilamine from from histamine H1 receptor in rat brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(RAT)
Universidad De Valencia

Curated by ChEMBL
LigandPNGBDBM50203996((+/-)-1-[3-(3-fluorobiphenyl-2-yl)propyl]-4-[2-(4-...)
Affinity DataIC50: >1.00E+3nMAssay Description:Displacement of [3H]pyrilamine from from histamine H1 receptor in rat brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(RAT)
Universidad De Valencia

Curated by ChEMBL
LigandPNGBDBM50203993((+/-)-1-[2-(4-fluorophenyl)-2-(1-isopropylpiperidi...)
Affinity DataIC50: >1.00E+3nMAssay Description:Displacement of [3H]pyrilamine from from histamine H1 receptor in rat brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(RAT)
Universidad De Valencia

Curated by ChEMBL
LigandPNGBDBM67545(N,N-dimethyl-3-(10-phenothiazinyl)-1-propanamine;h...)
Affinity DataIC50:  1.26E+3nMAssay Description:Displacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(RAT)
Universidad De Valencia

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataIC50: >2.00E+3nMAssay Description:Displacement of [3H]mepyramine from H1R in rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(RAT)
Universidad De Valencia

Curated by ChEMBL
LigandPNGBDBM50130293(7-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy}...)
Affinity DataIC50: >3.00E+3nMAssay Description:Displacement of [3H]mepyramine from H1R in rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(RAT)
Universidad De Valencia

Curated by ChEMBL
LigandPNGBDBM50062598(1-Cyclohexyl-1-phenyl-3-pyrrolidin-1-yl-propan-1-o...)
Affinity DataIC50:  6.76E+3nMAssay Description:Displacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(RAT)
Universidad De Valencia

Curated by ChEMBL
LigandPNGBDBM50422013(LOBELINE | Lobeline Hydrochloride)
Affinity DataIC50:  1.12E+4nMAssay Description:Displacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(RAT)
Universidad De Valencia

Curated by ChEMBL
LigandPNGBDBM31046(3-[4,5-dihydro-1H-imidazol-2-ylmethyl-(4-methylphe...)
Affinity DataIC50:  1.26E+4nMAssay Description:Displacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(RAT)
Universidad De Valencia

Curated by ChEMBL
LigandPNGBDBM50395519(ADIPHENINE)
Affinity DataIC50:  1.70E+4nMAssay Description:Displacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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