Compile Data Set for Download or QSAR
maximum 50k data
Found 105 of ic50 for UniProtKB: O35435
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Mus musculus)
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50598923(CHEMBL5193821)
Affinity DataIC50:  10nMAssay Description:Inhibition of mouse DHODHMore data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Mus musculus)
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50407985(CHEMBL2111978)
Affinity DataIC50:  22nMAssay Description:Inhibitory concentration tested on enzyme dihydroorotate dehydrogenase in mouseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Mus musculus)
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50054601(5-Methyl-N-(4-(trifluoromethyl)phenyl)-4-isoxazole...)
Affinity DataIC50:  30nMAssay Description:Inhibitory concentration tested on enzyme dihydroorotate dehydrogenase in mouseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Mus musculus)
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50054553((Z)-2-Cyano-N-(4-cyano-3-methyl-phenyl)-3-cyclopro...)
Affinity DataIC50:  36nMAssay Description:Inhibitory concentration tested on enzyme dihydroorotate dehydrogenase in mouseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Mus musculus)
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50054584((Z)-N-(4-Chloro-phenyl)-2-cyano-3-cyclopropyl-3-hy...)
Affinity DataIC50:  36nMAssay Description:Inhibitory concentration tested on enzyme dihydroorotate dehydrogenase in mouseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Mus musculus)
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50054548((Z)-N-(4-Bromo-phenyl)-2-cyano-3-cyclopropyl-3-hyd...)
Affinity DataIC50:  36nMAssay Description:Inhibitory concentration tested on enzyme dihydroorotate dehydrogenase in mouseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Mus musculus)
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50054594((Z)-N-(4-Chloro-3-methyl-phenyl)-2-cyano-3-cyclopr...)
Affinity DataIC50:  40nMAssay Description:Inhibitory concentration tested on enzyme dihydroorotate dehydrogenase in mouseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Mus musculus)
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50054587((Z)-2-Cyano-N-(4-cyano-phenyl)-3-cyclopropyl-3-hyd...)
Affinity DataIC50:  42nMAssay Description:Inhibitory concentration tested on enzyme dihydroorotate dehydrogenase in mouseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Mus musculus)
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM29024(CHEMBL141732 | cyanocyclopropylpropenamide, 4)
Affinity DataIC50:  47nMAssay Description:Inhibitory concentration tested on enzyme dihydroorotate dehydrogenase in mouseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Mus musculus)
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50054557((Z)-2-Cyano-3-cyclopropyl-3-hydroxy-N-(4-nitro-phe...)
Affinity DataIC50:  50nMAssay Description:Inhibitory concentration tested on enzyme dihydroorotate dehydrogenase in mouseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Mus musculus)
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50054560((Z)-2-Cyano-3-cyclopropyl-3-hydroxy-N-(3-methyl-4-...)
Affinity DataIC50:  55nMAssay Description:Inhibitory concentration tested on enzyme dihydroorotate dehydrogenase in mouseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Mus musculus)
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50054565((2Z,4E)-2-Cyano-3-hydroxy-hexa-2,4-dienoic acid (4...)
Affinity DataIC50:  63nMAssay Description:Inhibitory concentration tested on enzyme dihydroorotate dehydrogenase in mouseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Mus musculus)
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50054578((Z)-N-(4-Bromo-3-methyl-phenyl)-2-cyano-3-cyclopro...)
Affinity DataIC50:  63nMAssay Description:Inhibitory concentration tested on enzyme dihydroorotate dehydrogenase in mouseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Mus musculus)
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM14712((2Z)-2-cyano-3-hydroxy-N-[4-(trifluoromethyl)pheny...)
Affinity DataIC50:  69nMAssay Description:Inhibitory concentration tested on enzyme dihydroorotate dehydrogenase in mouseMore data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Mus musculus)
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50054564((Z)-2-Cyano-3-cyclopropyl-N-(3-ethyl-4-trifluorome...)
Affinity DataIC50:  71nMAssay Description:Inhibitory concentration tested on enzyme dihydroorotate dehydrogenase in mouseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Mus musculus)
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50018006(CHEMBL3289672 | US9238653, Table 5, Compound 49)
Affinity DataIC50:  88nMAssay Description:Inhibition of mouse DHODH (amino acid residues 30 to 396) expressed in Escherichia coli BL21 cells assessed as orotic acid production using dihydroor...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Mus musculus)
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50054585((Z)-2-Cyano-3-cyclopropyl-3-hydroxy-N-(4-trifluoro...)
Affinity DataIC50:  89nMAssay Description:Inhibitory concentration tested on enzyme dihydroorotate dehydrogenase in mouseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Mus musculus)
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50054573((Z)-2-Cyano-3-cyclopropyl-3-hydroxy-N-(4-trifluoro...)
Affinity DataIC50:  100nMAssay Description:Inhibitory concentration tested on enzyme dihydroorotate dehydrogenase in mouseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Mus musculus)
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50018011(Aubagio | CHEBI:68540 | HMR-1726 | TERIFLUNOMIDE)
Affinity DataIC50:  110nMAssay Description:Inhibition of C-terminal His6-tagged mouse DHODH expressed in Escherichia coli BL21(DE3) cells using L-DHO as substrate by DCIP dye based assayMore data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Mus musculus)
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50598913(CHEMBL5193591)
Affinity DataIC50:  140nMAssay Description:Inhibition of mouse DHODHMore data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Mus musculus)
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50018011(Aubagio | CHEBI:68540 | HMR-1726 | TERIFLUNOMIDE)
Affinity DataIC50:  150nMAssay Description:Inhibition of mouse DHODH (amino acid residues 30 to 396) expressed in Escherichia coli BL21 cells assessed as orotic acid production using dihydroor...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Mus musculus)
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM14712((2Z)-2-cyano-3-hydroxy-N-[4-(trifluoromethyl)pheny...)
Affinity DataIC50:  156nMAssay Description:Inhibitory activity against mouse dihydroorotate dehydrogenaseMore data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Mus musculus)
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50054597((Z)-2-Cyano-3-cyclopropyl-3-hydroxy-N-(5-trifluoro...)
Affinity DataIC50:  158nMAssay Description:Inhibitory concentration tested on enzyme dihydroorotate dehydrogenase in mouseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Mus musculus)
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50054549((Z)-N-(5-Bromo-pyridin-2-yl)-2-cyano-3-cyclopropyl...)
Affinity DataIC50:  158nMAssay Description:Inhibitory concentration tested on enzyme dihydroorotate dehydrogenase in mouseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Mus musculus)
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50054556((Z)-2-Cyano-3-cyclopropyl-3-hydroxy-N-(4-trifluoro...)
Affinity DataIC50:  173nMAssay Description:Inhibitory concentration tested on enzyme dihydroorotate dehydrogenase in mouseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Mus musculus)
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50054574((Z)-2-Cyano-3-cyclopropyl-3-hydroxy-N-(3-methyl-4-...)
Affinity DataIC50:  178nMAssay Description:Inhibitory concentration tested on enzyme dihydroorotate dehydrogenase in mouseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Mus musculus)
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50054600((Z)-2-Cyano-3-hydroxy-penta-2,4-dienoic acid (4-tr...)
Affinity DataIC50:  178nMAssay Description:Inhibitory concentration tested on enzyme dihydroorotate dehydrogenase in mouseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Mus musculus)
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50054590((Z)-2-Cyano-3-cyclopropyl-3-hydroxy-N-(3-methyl-4-...)
Affinity DataIC50:  178nMAssay Description:Inhibitory concentration tested on enzyme dihydroorotate dehydrogenase in mouseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Mus musculus)
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50018008(CHEMBL3289671 | US9238653, Table 5, Compound 43)
Affinity DataIC50:  180nMAssay Description:Inhibition of mouse DHODH (amino acid residues 30 to 396) expressed in Escherichia coli BL21 cells assessed as orotic acid production using dihydroor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Mus musculus)
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50054543((Z)-2-Cyano-3-hydroxy-4-methyl-penta-2,4-dienoic a...)
Affinity DataIC50:  195nMAssay Description:Inhibitory concentration tested on enzyme dihydroorotate dehydrogenase in mouseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Mus musculus)
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50054555((Z)-N-(5-Chloro-pyridin-2-yl)-2-cyano-3-cyclopropy...)
Affinity DataIC50:  200nMAssay Description:Inhibitory concentration tested on enzyme dihydroorotate dehydrogenase in mouseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Mus musculus)
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50054550((Z)-2-Cyano-3-cyclobutyl-3-hydroxy-N-(4-trifluorom...)
Affinity DataIC50:  209nMAssay Description:Inhibitory concentration tested on enzyme dihydroorotate dehydrogenase in mouseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Mus musculus)
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50054591((Z)-N-(3-Chloro-4-methyl-phenyl)-2-cyano-3-cyclopr...)
Affinity DataIC50:  282nMAssay Description:Inhibitory concentration tested on enzyme dihydroorotate dehydrogenase in mouseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Mus musculus)
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50054541((Z)-2-Cyano-3-cyclopropyl-3-hydroxy-N-(3-methyl-4-...)
Affinity DataIC50:  282nMAssay Description:Inhibitory concentration tested on enzyme dihydroorotate dehydrogenase in mouseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Mus musculus)
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50054547((Z)-2-Cyano-3-cyclopropyl-3-hydroxy-N-p-tolyl-acry...)
Affinity DataIC50:  288nMAssay Description:Inhibitory concentration tested on enzyme dihydroorotate dehydrogenase in mouseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Mus musculus)
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50054581((Z)-2-Cyano-3-cyclopropyl-3-hydroxy-N-(4-trifluoro...)
Affinity DataIC50:  417nMAssay Description:Inhibitory concentration tested on enzyme dihydroorotate dehydrogenase in mouseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Mus musculus)
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM15344(2-({2,3,5,6-tetrafluoro-4-[3-(trifluoromethoxy)phe...)
Affinity DataIC50:  422nMAssay Description:Inhibitory activity against mouse dihydroorotate dehydrogenaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Mus musculus)
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50054552((Z)-2-Cyano-3-cyclopropyl-3-hydroxy-N-(4-methylsul...)
Affinity DataIC50:  445nMAssay Description:Inhibitory concentration tested on enzyme dihydroorotate dehydrogenase in mouseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Mus musculus)
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50054599((Z)-2-Cyano-3-cyclopropyl-3-hydroxy-N-(3-trifluoro...)
Affinity DataIC50:  525nMAssay Description:Inhibitory concentration tested on enzyme dihydroorotate dehydrogenase in mouseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Mus musculus)
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50054554((Z)-N-[4-(4-Chloro-benzoyl)-phenyl]-2-cyano-3-cycl...)
Affinity DataIC50:  562nMAssay Description:Inhibitory concentration tested on enzyme dihydroorotate dehydrogenase in mouseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Mus musculus)
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50054563((Z)-2-Cyano-3-cyclopropyl-3-hydroxy-N-(4-phenoxy-p...)
Affinity DataIC50:  630nMAssay Description:Inhibitory concentration tested on enzyme dihydroorotate dehydrogenase in mouseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Mus musculus)
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50054589((Z)-2-Cyano-3-cyclopropyl-3-hydroxy-N-(4-phenethyl...)
Affinity DataIC50:  630nMAssay Description:Inhibitory concentration tested on enzyme dihydroorotate dehydrogenase in mouseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Mus musculus)
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50054561((Z)-N-[4-(4-Chloro-phenoxy)-phenyl]-2-cyano-3-cycl...)
Affinity DataIC50:  832nMAssay Description:Inhibitory concentration tested on enzyme dihydroorotate dehydrogenase in mouseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Mus musculus)
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50054545(4-((Z)-2-Cyano-3-cyclopropyl-3-hydroxy-acryloylami...)
Affinity DataIC50:  1.12E+3nMAssay Description:Inhibitory concentration tested on enzyme dihydroorotate dehydrogenase in mouseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Mus musculus)
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50054603((Z)-2-Cyano-3-cyclopropyl-3-hydroxy-N-[4-(4-triflu...)
Affinity DataIC50:  1.51E+3nMAssay Description:Inhibitory concentration tested on enzyme dihydroorotate dehydrogenase in mouseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Mus musculus)
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50054569((Z)-2-Cyano-3-cyclopropyl-3-hydroxy-N-phenyl-acryl...)
Affinity DataIC50:  1.58E+3nMAssay Description:Inhibitory concentration tested on enzyme dihydroorotate dehydrogenase in mouseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Mus musculus)
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM29026(CHEMBL142996 | cyanocyclopropylpropenamide, 11)
Affinity DataIC50:  1.58E+3nMAssay Description:Inhibitory concentration tested on enzyme dihydroorotate dehydrogenase in mouseMore data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Mus musculus)
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50018007(CHEMBL3289670 | US9238653, Table 5, Compound 42)
Affinity DataIC50:  1.60E+3nMAssay Description:Inhibition of mouse DHODH (amino acid residues 30 to 396) expressed in Escherichia coli BL21 cells assessed as orotic acid production using dihydroor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Mus musculus)
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50054562((Z)-N-(6-Chloro-pyridin-3-yl)-2-cyano-3-cyclopropy...)
Affinity DataIC50:  1.78E+3nMAssay Description:Inhibitory concentration tested on enzyme dihydroorotate dehydrogenase in mouseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Mus musculus)
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50173144(4-[3-Chloro-4-(2-chloro-6-fluoro-benzyloxy)-phenyl...)
Affinity DataIC50:  1.80E+3nMAssay Description:Inhibitory activity against mouse dihydroorotate dehydrogenaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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