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Found 10 of ec50 for UniProtKB: Q14957
TargetGlutamate receptor ionotropic, NMDA 1/2C(Homo sapiens (Human))
Sage Therapeutics

Curated by ChEMBL
LigandPNGBDBM50597430(DALZANEMDOR | Dalzanemdor)
Affinity DataEC50:  150nMAssay Description:Positive allosteric modulation of recombinant human GluN1/GluN2C receptor stably expressed in HEK293 cells assessed as increase in glycine/L-glutamat...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetGlutamate receptor ionotropic, NMDA 2C(Homo sapiens (Human))TBA
LigandPNGBDBM50611444(CHEMBL5273123)
Affinity DataEC50:  1.90E+3nMAssay Description:Positive allosteric modulator activity at GluN2C NMDA receptor (unknown origin) expressed in CHO cells co-expressing GluN1a in the presence of L-glut...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetGlutamate receptor ionotropic, NMDA 2C(Homo sapiens (Human))TBA
LigandPNGBDBM50436060(CHEMBL2397100 | US10273214, Example 1390)
Affinity DataEC50:  2.70E+3nMAssay Description:Positive allosteric modulation of GluN2C receptor (unknown origin) expressed in xenopus laevis oocytes assessed as increase in glycine-induced channe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1/2C(Homo sapiens (Human))
Sage Therapeutics

Curated by ChEMBL
LigandPNGBDBM50205849(CHEMBL3938522 | US10280165, Example 1)
Affinity DataEC50:  4.70E+3nMAssay Description:Positive allosteric modulation of GluN1/GluN2C receptor (unknown origin) assessed as increase in glutamate-induced calcium flux measured at time inte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2C(Homo sapiens (Human))TBA
LigandPNGBDBM50503147(CHEMBL4435232)
Affinity DataEC50:  6.60E+3nMAssay Description:Positive allosteric modulation of GluN2C receptor (unknown origin) expressed in xenopus laevis oocytes assessed as increase in glycine-induced channe...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1/2C(Homo sapiens (Human))
Sage Therapeutics

Curated by ChEMBL
LigandPNGBDBM50164398(CHEMBL3799213)
Affinity DataEC50:  7.40E+3nMAssay Description:Positive allosteric modulation of GluN1/GluN2C NMDAR (unknown origin) expressed in Dox-inducible cells by BD calcium indicator dye based-fluorescence...More data for this Ligand-Target Pair
TargetGlutamate receptor ionotropic, NMDA 2C(Homo sapiens (Human))TBA
LigandPNGBDBM50007007(CHEMBL3237281)
Affinity DataEC50:  1.30E+4nMAssay Description:Positive allosteric modulation of GluN2C receptor (unknown origin) expressed in xenopus laevis oocytes assessed as increase in glycine-induced channe...More data for this Ligand-Target Pair
TargetGlutamate receptor ionotropic, NMDA 1/2C(Homo sapiens (Human))
Sage Therapeutics

Curated by ChEMBL
LigandPNGBDBM50599751(CHEMBL5092058)
Affinity DataEC50: >3.00E+4nMAssay Description:Positive allosteric modulator activity at GluN1a/GluN2C (unknown origin) expressed in CHO cells in presence of glutamate by Ca2+ influx assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetGlutamate receptor ionotropic, NMDA 2C(Homo sapiens (Human))TBA
LigandPNGBDBM50503152(CHEMBL4452216)
Affinity DataEC50:  3.70E+4nMAssay Description:Positive allosteric modulation of GluN2C receptor (unknown origin) expressed in xenopus laevis oocytes assessed as increase in glycine-induced channe...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2C(Homo sapiens (Human))TBA
LigandPNGBDBM50503144(CHEBI:35420 | CHEMBL1179605)
Affinity DataEC50:  8.30E+4nMAssay Description:Positive allosteric modulation of EGFP-fused human GluN2C receptor expressed in HEK293T cells assessed as increase in glycine-induced channel current...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed