Compile Data Set for Download or QSAR
maximum 50k data
Found 8144 of ic50 for UniProtKB: Q92918
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50569664(CHEMBL4859451)
Affinity DataIC50:  0.00500nMAssay Description:Inhibition of HPK1 (unknown origin) using SLP76 as substrate incubated for 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50598494(CHEMBL5171022)
Affinity DataIC50: <0.0100nMAssay Description:Inhibition of HPK1 (unknown origin) by ADP-Glo kinase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM548828(WO2022098806, Compound 2-89)
Affinity DataIC50:  0.0100nMAssay Description: To each well of black Corning #3820384-well plate, an ECHO was used to dispense 7.5 nL of DMSO or Test compound in DMSO. A 1.5x kinase solution, 5 &...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM529791(US11203591, Example 198)
Affinity DataIC50:  0.0100nMAssay Description:Ten nanoliters of test compounds dissolved in DMSO at various concentrations were dispensed into a 384-well ProxiPlate (PerkinElmer #6008289). Five m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM548859(WO2022098806, Compound 2-120)
Affinity DataIC50:  0.0100nMAssay Description: To each well of black Corning #3820384-well plate, an ECHO was used to dispense 7.5 nL of DMSO or Test compound in DMSO. A 1.5x kinase solution, 5 &...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM548847(WO2022098806, Compound 2-108)
Affinity DataIC50:  0.0100nMAssay Description: To each well of black Corning #3820384-well plate, an ECHO was used to dispense 7.5 nL of DMSO or Test compound in DMSO. A 1.5x kinase solution, 5 &...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM548834(WO2022098806, Compound 2-180 | WO2022098806, Compo...)
Affinity DataIC50:  0.0200nMAssay Description: To each well of black Corning #3820384-well plate, an ECHO was used to dispense 7.5 nL of DMSO or Test compound in DMSO. A 1.5x kinase solution, 5 &...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM548817(WO2022098806, Compound 2-78)
Affinity DataIC50:  0.0200nMAssay Description: To each well of black Corning #3820384-well plate, an ECHO was used to dispense 7.5 nL of DMSO or Test compound in DMSO. A 1.5x kinase solution, 5 &...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM548823(WO2022098806, Compound 2-84)
Affinity DataIC50:  0.0200nMAssay Description: To each well of black Corning #3820384-well plate, an ECHO was used to dispense 7.5 nL of DMSO or Test compound in DMSO. A 1.5x kinase solution, 5 &...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM548829(WO2022098806, Compound 2-179 | WO2022098806, Compo...)
Affinity DataIC50:  0.0200nMAssay Description: To each well of black Corning #3820384-well plate, an ECHO was used to dispense 7.5 nL of DMSO or Test compound in DMSO. A 1.5x kinase solution, 5 &...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM548850(WO2022098806, Compound 2-111)
Affinity DataIC50:  0.0200nMAssay Description: To each well of black Corning #3820384-well plate, an ECHO was used to dispense 7.5 nL of DMSO or Test compound in DMSO. A 1.5x kinase solution, 5 &...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM548860(WO2022098806, Compound 2-121)
Affinity DataIC50:  0.0200nMAssay Description: To each well of black Corning #3820384-well plate, an ECHO was used to dispense 7.5 nL of DMSO or Test compound in DMSO. A 1.5x kinase solution, 5 &...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM548727(WO2022098806, Compound 1-123)
Affinity DataIC50:  0.0200nMAssay Description: To each well of black Corning #3820384-well plate, an ECHO was used to dispense 7.5 nL of DMSO or Test compound in DMSO. A 1.5x kinase solution, 5 &...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM529832(US11203591, Example 238)
Affinity DataIC50:  0.0200nMAssay Description:Ten nanoliters of test compounds dissolved in DMSO at various concentrations were dispensed into a 384-well ProxiPlate (PerkinElmer #6008289). Five m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50569663(CHEMBL4870155)
Affinity DataIC50:  0.0270nMAssay Description:Inhibition of HPK1 (unknown origin) using SLP76 as substrate incubated for 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM548897(WO2022098806, Compound 2-158)
Affinity DataIC50:  0.0300nMAssay Description: To each well of black Corning #3820384-well plate, an ECHO was used to dispense 7.5 nL of DMSO or Test compound in DMSO. A 1.5x kinase solution, 5 &...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM548863(WO2022098806, Compound 2-124 | WO2022098806, Compo...)
Affinity DataIC50:  0.0300nMAssay Description: To each well of black Corning #3820384-well plate, an ECHO was used to dispense 7.5 nL of DMSO or Test compound in DMSO. A 1.5x kinase solution, 5 &...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM548914(WO2022098806, Compound 2-175)
Affinity DataIC50:  0.0300nMAssay Description: To each well of black Corning #3820384-well plate, an ECHO was used to dispense 7.5 nL of DMSO or Test compound in DMSO. A 1.5x kinase solution, 5 &...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM548846(WO2022098806, Compound 2-107 | WO2022098806, Compo...)
Affinity DataIC50:  0.0300nMAssay Description: To each well of black Corning #3820384-well plate, an ECHO was used to dispense 7.5 nL of DMSO or Test compound in DMSO. A 1.5x kinase solution, 5 &...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM548815(WO2022098806, Compound 2-76)
Affinity DataIC50:  0.0300nMAssay Description: To each well of black Corning #3820384-well plate, an ECHO was used to dispense 7.5 nL of DMSO or Test compound in DMSO. A 1.5x kinase solution, 5 &...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM548818(WO2022098806, Compound 2-79)
Affinity DataIC50:  0.0300nMAssay Description: To each well of black Corning #3820384-well plate, an ECHO was used to dispense 7.5 nL of DMSO or Test compound in DMSO. A 1.5x kinase solution, 5 &...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM529862(US11203591, Example 268)
Affinity DataIC50:  0.0300nMAssay Description:Ten nanoliters of test compounds dissolved in DMSO at various concentrations were dispensed into a 384-well ProxiPlate (PerkinElmer #6008289). Five m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM548821(WO2022098806, Compound 2-82)
Affinity DataIC50:  0.0300nMAssay Description: To each well of black Corning #3820384-well plate, an ECHO was used to dispense 7.5 nL of DMSO or Test compound in DMSO. A 1.5x kinase solution, 5 &...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM548824(WO2022098806, Compound 2-85)
Affinity DataIC50:  0.0300nMAssay Description: To each well of black Corning #3820384-well plate, an ECHO was used to dispense 7.5 nL of DMSO or Test compound in DMSO. A 1.5x kinase solution, 5 &...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM548867(WO2022098806, Compound 2-128)
Affinity DataIC50:  0.0300nMAssay Description: To each well of black Corning #3820384-well plate, an ECHO was used to dispense 7.5 nL of DMSO or Test compound in DMSO. A 1.5x kinase solution, 5 &...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50569665(CHEMBL4864568)
Affinity DataIC50:  0.0370nMAssay Description:Inhibition of HPK1 (unknown origin) using SLP76 as substrate incubated for 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50569667(CHEMBL4848845)
Affinity DataIC50:  0.0370nMAssay Description:Inhibition of HPK1 (unknown origin) using SLP76 as substrate incubated for 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM548909(WO2022098806, Compound 2-170)
Affinity DataIC50:  0.0400nMAssay Description: To each well of black Corning #3820384-well plate, an ECHO was used to dispense 7.5 nL of DMSO or Test compound in DMSO. A 1.5x kinase solution, 5 &...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM509018(US11071730, Example 125)
Affinity DataIC50:  0.0400nMAssay Description:Recombinant HPK1 kinase domain produced via baculovirus infection of insect cells was obtained from Proteros (Proteros Biostructures #PR-0322) and wa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM548820(WO2022098806, Compound 2-81)
Affinity DataIC50:  0.0400nMAssay Description: To each well of black Corning #3820384-well plate, an ECHO was used to dispense 7.5 nL of DMSO or Test compound in DMSO. A 1.5x kinase solution, 5 &...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM548822(WO2022098806, Compound 2-83)
Affinity DataIC50:  0.0400nMAssay Description: To each well of black Corning #3820384-well plate, an ECHO was used to dispense 7.5 nL of DMSO or Test compound in DMSO. A 1.5x kinase solution, 5 &...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM548825(WO2022098806, Compound 2-86)
Affinity DataIC50:  0.0400nMAssay Description: To each well of black Corning #3820384-well plate, an ECHO was used to dispense 7.5 nL of DMSO or Test compound in DMSO. A 1.5x kinase solution, 5 &...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM548829(WO2022098806, Compound 2-179 | WO2022098806, Compo...)
Affinity DataIC50:  0.0400nMAssay Description: To each well of black Corning #3820384-well plate, an ECHO was used to dispense 7.5 nL of DMSO or Test compound in DMSO. A 1.5x kinase solution, 5 &...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM548830(WO2022098806, Compound 2-91 | WO2022098806, Compou...)
Affinity DataIC50:  0.0400nMAssay Description: To each well of black Corning #3820384-well plate, an ECHO was used to dispense 7.5 nL of DMSO or Test compound in DMSO. A 1.5x kinase solution, 5 &...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM548835(WO2022098806, Compound 2-102 | WO2022098806, Compo...)
Affinity DataIC50:  0.0400nMAssay Description: To each well of black Corning #3820384-well plate, an ECHO was used to dispense 7.5 nL of DMSO or Test compound in DMSO. A 1.5x kinase solution, 5 &...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM548856(WO2022098806, Compound 2-117)
Affinity DataIC50:  0.0400nMAssay Description: To each well of black Corning #3820384-well plate, an ECHO was used to dispense 7.5 nL of DMSO or Test compound in DMSO. A 1.5x kinase solution, 5 &...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM548858(WO2022098806, Compound 2-119)
Affinity DataIC50:  0.0400nMAssay Description: To each well of black Corning #3820384-well plate, an ECHO was used to dispense 7.5 nL of DMSO or Test compound in DMSO. A 1.5x kinase solution, 5 &...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM548763(WO2022098806, Compound 2-114 | WO2022098806, Compo...)
Affinity DataIC50:  0.0400nMAssay Description: To each well of black Corning #3820384-well plate, an ECHO was used to dispense 7.5 nL of DMSO or Test compound in DMSO. A 1.5x kinase solution, 5 &...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM548878(WO2022098806, Compound 2-139)
Affinity DataIC50:  0.0400nMAssay Description: To each well of black Corning #3820384-well plate, an ECHO was used to dispense 7.5 nL of DMSO or Test compound in DMSO. A 1.5x kinase solution, 5 &...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM548728(WO2022098806, Compound 1-124)
Affinity DataIC50:  0.0400nMAssay Description: To each well of black Corning #3820384-well plate, an ECHO was used to dispense 7.5 nL of DMSO or Test compound in DMSO. A 1.5x kinase solution, 5 &...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM548738(WO2022098806, Compound 1-134)
Affinity DataIC50:  0.0400nMAssay Description: To each well of black Corning #3820384-well plate, an ECHO was used to dispense 7.5 nL of DMSO or Test compound in DMSO. A 1.5x kinase solution, 5 &...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM529840(US11203591, Example 246)
Affinity DataIC50:  0.0400nMAssay Description:Ten nanoliters of test compounds dissolved in DMSO at various concentrations were dispensed into a 384-well ProxiPlate (PerkinElmer #6008289). Five m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM529843(US11203591, Example 249)
Affinity DataIC50:  0.0400nMAssay Description:Ten nanoliters of test compounds dissolved in DMSO at various concentrations were dispensed into a 384-well ProxiPlate (PerkinElmer #6008289). Five m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM529845(US11203591, Example 251)
Affinity DataIC50:  0.0400nMAssay Description:Ten nanoliters of test compounds dissolved in DMSO at various concentrations were dispensed into a 384-well ProxiPlate (PerkinElmer #6008289). Five m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM529868(US11203591, Example 274)
Affinity DataIC50:  0.0400nMAssay Description:Ten nanoliters of test compounds dissolved in DMSO at various concentrations were dispensed into a 384-well ProxiPlate (PerkinElmer #6008289). Five m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM548722(WO2022098806, Compound 1-118)
Affinity DataIC50:  0.0400nMAssay Description: To each well of black Corning #3820384-well plate, an ECHO was used to dispense 7.5 nL of DMSO or Test compound in DMSO. A 1.5x kinase solution, 5 &...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM529833(US11203591, Example 239)
Affinity DataIC50:  0.0400nMAssay Description:Ten nanoliters of test compounds dissolved in DMSO at various concentrations were dispensed into a 384-well ProxiPlate (PerkinElmer #6008289). Five m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM529602(US11203591, Example 17)
Affinity DataIC50:  0.0400nMAssay Description:Ten nanoliters of test compounds dissolved in DMSO at various concentrations were dispensed into a 384-well ProxiPlate (PerkinElmer #6008289). Five m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM548922(WO2022098806, Compound 2-183)
Affinity DataIC50:  0.0400nMAssay Description: To each well of black Corning #3820384-well plate, an ECHO was used to dispense 7.5 nL of DMSO or Test compound in DMSO. A 1.5x kinase solution, 5 &...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50598492(CHEMBL5205694)
Affinity DataIC50:  0.0500nMAssay Description:Inhibition of HPK1 (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
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