Compile Data Set for Download or QSAR
maximum 50k data
Found 26 of ic50 for UniProtKB: P63000
TargetRas-related C3 botulinum toxin substrate 1(Homo sapiens (Human))TBA
LigandPNGBDBM50391237(CHEMBL5290216)
Affinity DataIC50:  100nMAssay Description:In vitro inhibition of angiotensin I converting enzyme in rabbit lung with hippuryl-histidyl-leucine as substrateMore data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50234661(CHEBI:76227 | CHEMBL1619630)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of RAC1/CDC42 in human ovarian cancer cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRas-related C3 botulinum toxin substrate 1(Homo sapiens (Human))TBA
LigandPNGBDBM50007190(CHEMBL3237589)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of Rac1 in human MDA-MB-435 cells after 24 hrs by G-LISA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRas-related C3 botulinum toxin substrate 1(Homo sapiens (Human))TBA
LigandPNGBDBM50007190(CHEMBL3237589)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of Vav2 binding to Rac1 G15A mutant in human MDA-MB-231 cells after 1 hr by pull down assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRas-related C3 botulinum toxin substrate 1(Homo sapiens (Human))TBA
LigandPNGBDBM50007190(CHEMBL3237589)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of Rac1 in human MDA-MB-435 cells assessed as reduction in Rac-GTP level after 24 hrs by ELISA-based pull down assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM85511(CAS_74103-07-4 | KETOROLAC | Ketorolac tris salt |...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of RAC1/CDC42 in human ovarian cancer cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRas-related C3 botulinum toxin substrate 1(Homo sapiens (Human))TBA
LigandPNGBDBM50300554(((2S,3R,4S,5S)-5-(2-amino-6-oxo-1H-purin-9(6H)-yl)...)
Affinity DataIC50:  2.70E+3nMAssay Description:Inhibition of Rac1 GTPase activity assessed as incorporation of BODIPY-GTP after 40 mins by nucleotide binding competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRas-related C3 botulinum toxin substrate 1(Homo sapiens (Human))TBA
LigandPNGBDBM50007190(CHEMBL3237589)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of Rac1 in human MDA-MB-231 cells assessed as reduction in Rac-GTP level after 24 hrs by ELISA-based pull down assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRas-related C3 botulinum toxin substrate 1(Homo sapiens (Human))TBA
LigandPNGBDBM50300547(2,3,9,10-Tetrahydroxy-5,6-dihydro-isoquino[3,2-a]i...)
Affinity DataIC50:  8.00E+3nMAssay Description:Inhibition of Rac1 GTPase activity assessed as incorporation of BODIPY-GTP after 40 mins by nucleotide binding competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRas-related C3 botulinum toxin substrate 1(Homo sapiens (Human))TBA
LigandPNGBDBM50300551(2,3,7,8-Tetrahydroxy-5-methyl-benzo[c]phenanthridi...)
Affinity DataIC50:  9.30E+3nMAssay Description:Inhibition of Rac1 GTPase activity assessed as incorporation of BODIPY-GTP after 40 mins by nucleotide binding competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRas-related C3 botulinum toxin substrate 1(Homo sapiens (Human))TBA
LigandPNGBDBM50391235(CHEMBL3216441)
Affinity DataIC50:  1.00E+4nMAssay Description:In vitro inhibition of angiotensin I converting enzyme in rabbit lung with hippuryl-histidyl-leucine as substrateMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetRas-related C3 botulinum toxin substrate 1(Homo sapiens (Human))TBA
LigandPNGBDBM50293841(3-((3,5-dimethylisoxazol-4-yl)methoxy)-N-(4-methyl...)
Affinity DataIC50:  1.22E+4nMAssay Description:Inhibition of PDGF-BB-stimulated Rac1 activity in human aortic smooth muscle cells assessed as reduction of Rac1GTP level after 4 hrs by G-LISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRas-related C3 botulinum toxin substrate 1(Homo sapiens (Human))TBA
LigandPNGBDBM50468262(CHEMBL4277903)
Affinity DataIC50:  2.10E+4nMAssay Description:In vitro inhibition of angiotensin I converting enzyme in rabbit lung with hippuryl-histidyl-leucine as substrateMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetRas-related C3 botulinum toxin substrate 1(Homo sapiens (Human))TBA
LigandPNGBDBM50293840(CHEMBL562095 | N-(4-methoxy-3-(piperidin-1-ylsulfo...)
Affinity DataIC50:  2.41E+4nMAssay Description:Inhibition of PDGF-BB-stimulated Rac1 activity in human aortic smooth muscle cells assessed as reduction of Rac1GTP level after 4 hrs by G-LISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRas-related C3 botulinum toxin substrate 1(Homo sapiens (Human))TBA
LigandPNGBDBM50293842(1-(4-morpholinophenylamino)-1-oxopropan-2-yl 1-hyd...)
Affinity DataIC50:  2.83E+4nMAssay Description:Inhibition of PDGF-BB-stimulated Rac1 activity in human aortic smooth muscle cells assessed as reduction of Rac1GTP level after 4 hrs by G-LISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRas-related C3 botulinum toxin substrate 1(Homo sapiens (Human))TBA
LigandPNGBDBM50300545(CHEMBL573174 | tetrahydroxycanadine hydrochloride)
Affinity DataIC50:  3.40E+4nMAssay Description:Inhibition of Rac1 GTPase activity assessed as incorporation of BODIPY-GTP after 40 mins by nucleotide binding competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRas-related C3 botulinum toxin substrate 1(Homo sapiens (Human))TBA
LigandPNGBDBM50300548(3,4,10,11-Tetrahydroxy-8-methyl-isoquino[3,2-a]iso...)
Affinity DataIC50:  3.80E+4nMAssay Description:Inhibition of Rac1 GTPase activity assessed as incorporation of BODIPY-GTP after 40 mins by nucleotide binding competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRas-related C3 botulinum toxin substrate 1(Homo sapiens (Human))TBA
LigandPNGBDBM50293843(1,8-diamino-6-methoxy-3-(4-(2-methoxyphenyl)pipera...)
Affinity DataIC50:  4.61E+4nMAssay Description:Inhibition of PDGF-BB-stimulated Rac1 activity in human aortic smooth muscle cells assessed as reduction of Rac1GTP level after 4 hrs by G-LISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRas-related C3 botulinum toxin substrate 1(Homo sapiens (Human))TBA
LigandPNGBDBM50300552(2,3-Dihydroxy-7,8-dimethoxy-5-methyl-benzo[c]phena...)
Affinity DataIC50:  5.40E+4nMAssay Description:Inhibition of Rac1 GTPase activity assessed as incorporation of BODIPY-GTP after 40 mins by nucleotide binding competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRas-related C3 botulinum toxin substrate 1(Homo sapiens (Human))TBA
LigandPNGBDBM50293839(2-(4-fluoro-3-nitrophenylamino)-N-(4-morpholinophe...)
Affinity DataIC50:  5.72E+4nMAssay Description:Inhibition of PDGF-BB-stimulated Rac1 activity in human aortic smooth muscle cells assessed as reduction of Rac1GTP level after 4 hrs by G-LISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRas-related C3 botulinum toxin substrate 1(Homo sapiens (Human))TBA
LigandPNGBDBM25525(24-methyl-5,7,18,20-tetraoxa-24-azahexacyclo[11.11...)
Affinity DataIC50:  5.80E+4nMAssay Description:Inhibition of Rac1 GTPase activity assessed as incorporation of BODIPY-GTP after 40 mins by nucleotide binding competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRas-related C3 botulinum toxin substrate 1(Homo sapiens (Human))TBA
LigandPNGBDBM50300546(6,7-Dimethoxy-1-methyl-3-naphthalen-2-yl-isoquinol...)
Affinity DataIC50:  5.80E+4nMAssay Description:Inhibition of Rac1 GTPase activity assessed as incorporation of BODIPY-GTP after 40 mins by nucleotide binding competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRas-related C3 botulinum toxin substrate 1(Homo sapiens (Human))TBA
LigandPNGBDBM50300549(2,3-Dihydroxy-9,10-dimethoxy-5,6-dihydro-isoquino[...)
Affinity DataIC50:  6.30E+4nMAssay Description:Inhibition of Rac1 GTPase activity assessed as incorporation of BODIPY-GTP after 40 mins by nucleotide binding competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRas-related C3 botulinum toxin substrate 1(Homo sapiens (Human))TBA
LigandPNGBDBM50007189(CHEMBL3237582)
Affinity DataIC50:  9.50E+4nMAssay Description:Inhibition of Rac1 in human MDA-MB-435 cells after 24 hrs by G-LISA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRas-related C3 botulinum toxin substrate 1(Homo sapiens (Human))TBA
LigandPNGBDBM25524(17,18-dimethoxy-21-methyl-5,7-dioxa-21-azapentacyc...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of Rac1 GTPase activity assessed as incorporation of BODIPY-GTP after 40 mins by nucleotide binding competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRas-related C3 botulinum toxin substrate 1(Homo sapiens (Human))TBA
LigandPNGBDBM50300550(3-(3,4-Dihydroxy-phenyl)-6,7-dimethoxy-1-methyl-is...)
Affinity DataIC50:  1.04E+5nMAssay Description:Inhibition of Rac1 GTPase activity assessed as incorporation of BODIPY-GTP after 40 mins by nucleotide binding competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed