Compile Data Set for Download or QSAR
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Found 311 of ic50 for UniProtKB: Q16236
LigandPNGBDBM576177(WO2022056448, Compound 48)
Affinity DataIC50:  0.150nMAssay Description:In a first step, the Keapl /compound complex was prepared by addition of 100 nL of the compound by ECHO 555, followed by 5 pL aliquots of 2x Keapl. T...More data for this Ligand-Target Pair
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LigandPNGBDBM576170(WO2022056448, Compound 41)
Affinity DataIC50:  0.200nMAssay Description:In a first step, the Keapl /compound complex was prepared by addition of 100 nL of the compound by ECHO 555, followed by 5 pL aliquots of 2x Keapl. T...More data for this Ligand-Target Pair
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LigandPNGBDBM576172(WO2022056448, Compound 43)
Affinity DataIC50:  0.200nMAssay Description:In a first step, the Keapl /compound complex was prepared by addition of 100 nL of the compound by ECHO 555, followed by 5 pL aliquots of 2x Keapl. T...More data for this Ligand-Target Pair
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LigandPNGBDBM576179(WO2022056448, Compound 50)
Affinity DataIC50:  0.25nMAssay Description:In a first step, the Keapl /compound complex was prepared by addition of 100 nL of the compound by ECHO 555, followed by 5 pL aliquots of 2x Keapl. T...More data for this Ligand-Target Pair
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LigandPNGBDBM576156(WO2022056448, Compound 27)
Affinity DataIC50:  0.350nMAssay Description:In a first step, the Keapl /compound complex was prepared by addition of 100 nL of the compound by ECHO 555, followed by 5 pL aliquots of 2x Keapl. T...More data for this Ligand-Target Pair
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LigandPNGBDBM576155(WO2022056448, Compound 26)
Affinity DataIC50:  0.350nMAssay Description:In a first step, the Keapl /compound complex was prepared by addition of 100 nL of the compound by ECHO 555, followed by 5 pL aliquots of 2x Keapl. T...More data for this Ligand-Target Pair
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LigandPNGBDBM576162(WO2022056448, Compound 33)
Affinity DataIC50:  0.350nMAssay Description:In a first step, the Keapl /compound complex was prepared by addition of 100 nL of the compound by ECHO 555, followed by 5 pL aliquots of 2x Keapl. T...More data for this Ligand-Target Pair
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LigandPNGBDBM576175(WO2022056448, Compound 46)
Affinity DataIC50:  0.350nMAssay Description:In a first step, the Keapl /compound complex was prepared by addition of 100 nL of the compound by ECHO 555, followed by 5 pL aliquots of 2x Keapl. T...More data for this Ligand-Target Pair
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LigandPNGBDBM576167(WO2022056448, Compound 38)
Affinity DataIC50:  0.350nMAssay Description:In a first step, the Keapl /compound complex was prepared by addition of 100 nL of the compound by ECHO 555, followed by 5 pL aliquots of 2x Keapl. T...More data for this Ligand-Target Pair
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LigandPNGBDBM576157(WO2022056448, Compound 28)
Affinity DataIC50:  0.450nMAssay Description:In a first step, the Keapl /compound complex was prepared by addition of 100 nL of the compound by ECHO 555, followed by 5 pL aliquots of 2x Keapl. T...More data for this Ligand-Target Pair
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LigandPNGBDBM576178(WO2022056448, Compound 49)
Affinity DataIC50:  0.530nMAssay Description:In a first step, the Keapl /compound complex was prepared by addition of 100 nL of the compound by ECHO 555, followed by 5 pL aliquots of 2x Keapl. T...More data for this Ligand-Target Pair
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LigandPNGBDBM576161(WO2022056448, Compound 32)
Affinity DataIC50:  0.550nMAssay Description:In a first step, the Keapl /compound complex was prepared by addition of 100 nL of the compound by ECHO 555, followed by 5 pL aliquots of 2x Keapl. T...More data for this Ligand-Target Pair
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LigandPNGBDBM576166(WO2022056448, Compound 37)
Affinity DataIC50:  0.900nMAssay Description:In a first step, the Keapl /compound complex was prepared by addition of 100 nL of the compound by ECHO 555, followed by 5 pL aliquots of 2x Keapl. T...More data for this Ligand-Target Pair
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LigandPNGBDBM576168(WO2022056448, Compound 39)
Affinity DataIC50:  1.05nMAssay Description:In a first step, the Keapl /compound complex was prepared by addition of 100 nL of the compound by ECHO 555, followed by 5 pL aliquots of 2x Keapl. T...More data for this Ligand-Target Pair
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LigandPNGBDBM576163(WO2022056448, Compound 34)
Affinity DataIC50:  1.10nMAssay Description:In a first step, the Keapl /compound complex was prepared by addition of 100 nL of the compound by ECHO 555, followed by 5 pL aliquots of 2x Keapl. T...More data for this Ligand-Target Pair
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LigandPNGBDBM576171(WO2022056448, Compound 42)
Affinity DataIC50:  1.15nMAssay Description:In a first step, the Keapl /compound complex was prepared by addition of 100 nL of the compound by ECHO 555, followed by 5 pL aliquots of 2x Keapl. T...More data for this Ligand-Target Pair
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LigandPNGBDBM576160(WO2022056448, Compound 31)
Affinity DataIC50:  1.60nMAssay Description:In a first step, the Keapl /compound complex was prepared by addition of 100 nL of the compound by ECHO 555, followed by 5 pL aliquots of 2x Keapl. T...More data for this Ligand-Target Pair
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LigandPNGBDBM576173(WO2022056448, Compound 44)
Affinity DataIC50:  5.90nMAssay Description:In a first step, the Keapl /compound complex was prepared by addition of 100 nL of the compound by ECHO 555, followed by 5 pL aliquots of 2x Keapl. T...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetNuclear factor erythroid 2-related factor 2(Homo sapiens (Human))
The State University Of New Jersey

Curated by ChEMBL
LigandPNGBDBM50568484(CHEMBL4865999)
Affinity DataIC50:  7.20nMAssay Description:Inhibition of recombinant human KEAP1 Kelch domain (321 to 609 residues) expressed in Escherichia coli BL21 (DE3)pLysS cells interaction with FITC-9m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM576165(WO2022056448, Compound 36)
Affinity DataIC50:  7.60nMAssay Description:In a first step, the Keapl /compound complex was prepared by addition of 100 nL of the compound by ECHO 555, followed by 5 pL aliquots of 2x Keapl. T...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetNuclear factor erythroid 2-related factor 2(Homo sapiens (Human))
The State University Of New Jersey

Curated by ChEMBL
LigandPNGBDBM50568478(CHEMBL4860663)
Affinity DataIC50:  8.90nMAssay Description:Inhibition of recombinant human KEAP1 Kelch domain (321 to 609 residues) expressed in Escherichia coli BL21 (DE3)pLysS cells interaction with FITC-9m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNuclear factor erythroid 2-related factor 2(Homo sapiens (Human))
The State University Of New Jersey

Curated by ChEMBL
LigandPNGBDBM50321036(CHEMBL4160447)
Affinity DataIC50: <10nMAssay Description:Inhibition of full length Flag/His-tagged Keap1 kelch domain (unknown origin)/full length Avi-tagged Nrf2 (unknown origin) interaction after 2.25 hrs...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear factor erythroid 2-related factor 2(Homo sapiens (Human))
The State University Of New Jersey

Curated by ChEMBL
LigandPNGBDBM50321036(CHEMBL4160447)
Affinity DataIC50:  10nMAssay Description:Inhibition of Keap1 kelch domain (unknow origin)/Nrf2-ETGE peptide (unknown origin) interaction by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear factor erythroid 2-related factor 2(Homo sapiens (Human))
The State University Of New Jersey

Curated by ChEMBL
LigandPNGBDBM50321027(CHEMBL4175603)
Affinity DataIC50:  10nMAssay Description:Inhibition of full length Flag/His-tagged Keap1 kelch domain (unknown origin)/full length Avi-tagged Nrf2 (unknown origin) interaction after 2.25 hrs...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear factor erythroid 2-related factor 2(Homo sapiens (Human))
The State University Of New Jersey

Curated by ChEMBL
LigandPNGBDBM50568482(CHEMBL4858288)
Affinity DataIC50:  11nMAssay Description:Inhibition of recombinant human KEAP1 Kelch domain (321 to 609 residues) expressed in Escherichia coli BL21 (DE3)pLysS cells interaction with FITC-9m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNuclear factor erythroid 2-related factor 2(Homo sapiens (Human))
The State University Of New Jersey

Curated by ChEMBL
LigandPNGBDBM50568475(CHEMBL4846463)
Affinity DataIC50:  12nMAssay Description:Inhibition of recombinant human KEAP1 Kelch domain (321 to 609 residues) expressed in Escherichia coli BL21 (DE3)pLysS cells interaction with FITC-9m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNuclear factor erythroid 2-related factor 2(Homo sapiens (Human))
The State University Of New Jersey

Curated by ChEMBL
LigandPNGBDBM50109368(CHEMBL3601212)
Affinity DataIC50:  13nMAssay Description:Inhibition of Keap1 Kelch domain/FITC-9mer Nrf2 (unknown origin) interaction after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear factor erythroid 2-related factor 2(Homo sapiens (Human))
The State University Of New Jersey

Curated by ChEMBL
LigandPNGBDBM50109368(CHEMBL3601212)
Affinity DataIC50:  14nMAssay Description:Inhibition of Keap1 Kelch domain-Nrf2 ETGE (unknown origin) protein-protein interaction incubated for 30 mins by fluorescence polarization competitio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear factor erythroid 2-related factor 2(Homo sapiens (Human))
The State University Of New Jersey

Curated by ChEMBL
LigandPNGBDBM50535176(CHEMBL4544116)
Affinity DataIC50:  16nMAssay Description:Inhibition of Keap1 Kelch domain/FITC-9mer Nrf2 (unknown origin) interaction after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNuclear factor erythroid 2-related factor 2(Homo sapiens (Human))
The State University Of New Jersey

Curated by ChEMBL
LigandPNGBDBM50109404(CHEMBL3601208)
Affinity DataIC50:  18nMAssay Description:Inhibition of Keap1 Kelch domain-Nrf2 ETGE (unknown origin) protein-protein interaction incubated for 30 mins by fluorescence polarization competitio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear factor erythroid 2-related factor 2(Homo sapiens (Human))
The State University Of New Jersey

Curated by ChEMBL
LigandPNGBDBM50200461(CHEMBL3946369)
Affinity DataIC50:  22nMAssay Description:Inhibition of Keap1/Nrf2 (unknown origin) interaction assessed as displacement of FITC-betaAla-DEETGEF-OH from Keap1 Kelch domain after 1 hr by FITC-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear factor erythroid 2-related factor 2(Homo sapiens (Human))
The State University Of New Jersey

Curated by ChEMBL
LigandPNGBDBM50006932(CHEMBL3237245)
Affinity DataIC50:  24nMAssay Description:Inhibition of recombinant human KEAP1 Kelch domain (321 to 609 residues) expressed in Escherichia coli BL21 (DE3)pLysS cells interaction with FITC-9m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear factor erythroid 2-related factor 2(Homo sapiens (Human))
The State University Of New Jersey

Curated by ChEMBL
LigandPNGBDBM50006932(CHEMBL3237245)
Affinity DataIC50:  25nMAssay Description:Inhibition of Keap1 Kelch domain (unknown origin) /Nrf2 (unknown origin) interaction using fluorescein-labeled 9-mer peptide containing NRF2 Neh2 dom...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM576176(WO2022056448, Compound 47)
Affinity DataIC50:  26nMAssay Description:In a first step, the Keapl /compound complex was prepared by addition of 100 nL of the compound by ECHO 555, followed by 5 pL aliquots of 2x Keapl. T...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetNuclear factor erythroid 2-related factor 2(Homo sapiens (Human))
The State University Of New Jersey

Curated by ChEMBL
LigandPNGBDBM50006932(CHEMBL3237245)
Affinity DataIC50:  29nMAssay Description:Inhibition of Keap1/Nrf2 complex (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear factor erythroid 2-related factor 2(Homo sapiens (Human))
The State University Of New Jersey

Curated by ChEMBL
LigandPNGBDBM50535743(CHEBI:3197 | CHEMBL459546)
Affinity DataIC50:  29nMAssay Description:Inhibition of NRF2 in human MDA-MB-231 cells harboring ARE-GFP-Luc assessed as reduction in ARE-luciferase activity after 16 hrs by firefly luciferas...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear factor erythroid 2-related factor 2(Homo sapiens (Human))
The State University Of New Jersey

Curated by ChEMBL
LigandPNGBDBM50006932(CHEMBL3237245)
Affinity DataIC50:  31nMAssay Description:Inhibition of Keap1 Kelch domain-Nrf2 ETGE (unknown origin) protein-protein interaction incubated for 30 mins by fluorescence polarization competitio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear factor erythroid 2-related factor 2(Homo sapiens (Human))
The State University Of New Jersey

Curated by ChEMBL
LigandPNGBDBM50568477(CHEMBL4853900)
Affinity DataIC50:  31nMAssay Description:Inhibition of recombinant human KEAP1 Kelch domain (321 to 609 residues) expressed in Escherichia coli BL21 (DE3)pLysS cells interaction with FITC-9m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNuclear factor erythroid 2-related factor 2(Homo sapiens (Human))
The State University Of New Jersey

Curated by ChEMBL
LigandPNGBDBM50109371(CHEMBL3601215)
Affinity DataIC50:  34nMAssay Description:Inhibition of Keap1 Kelch domain-Nrf2 ETGE (unknown origin) protein-protein interaction incubated for 30 mins by fluorescence polarization competitio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear factor erythroid 2-related factor 2(Homo sapiens (Human))
The State University Of New Jersey

Curated by ChEMBL
LigandPNGBDBM50109367(CHEMBL3601211)
Affinity DataIC50:  37nMAssay Description:Inhibition of Keap1 Kelch domain-Nrf2 ETGE (unknown origin) protein-protein interaction incubated for 30 mins by fluorescence polarization competitio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear factor erythroid 2-related factor 2(Homo sapiens (Human))
The State University Of New Jersey

Curated by ChEMBL
LigandPNGBDBM50109366(CHEMBL3601210)
Affinity DataIC50:  42nMAssay Description:Inhibition of Keap1 Kelch domain-Nrf2 ETGE (unknown origin) protein-protein interaction incubated for 30 mins by fluorescence polarization competitio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear factor erythroid 2-related factor 2(Homo sapiens (Human))
The State University Of New Jersey

Curated by ChEMBL
LigandPNGBDBM50109396(CHEMBL3601221)
Affinity DataIC50:  42nMAssay Description:Inhibition of Keap1 Kelch domain-Nrf2 ETGE (unknown origin) protein-protein interaction incubated for 30 mins by fluorescence polarization competitio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear factor erythroid 2-related factor 2(Homo sapiens (Human))
The State University Of New Jersey

Curated by ChEMBL
LigandPNGBDBM50109392(CHEMBL3601217)
Affinity DataIC50:  47nMAssay Description:Inhibition of Keap1 Kelch domain-Nrf2 ETGE (unknown origin) protein-protein interaction incubated for 30 mins by fluorescence polarization competitio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM576169(WO2022056448, Compound 40)
Affinity DataIC50:  50nMAssay Description:In a first step, the Keapl /compound complex was prepared by addition of 100 nL of the compound by ECHO 555, followed by 5 pL aliquots of 2x Keapl. T...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetNuclear factor erythroid 2-related factor 2(Homo sapiens (Human))
The State University Of New Jersey

Curated by ChEMBL
LigandPNGBDBM50109369(CHEMBL3601213)
Affinity DataIC50:  50nMAssay Description:Inhibition of Keap1 Kelch domain-Nrf2 ETGE (unknown origin) protein-protein interaction incubated for 30 mins by fluorescence polarization competitio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear factor erythroid 2-related factor 2(Homo sapiens (Human))
The State University Of New Jersey

Curated by ChEMBL
LigandPNGBDBM50109365(CHEMBL3601209)
Affinity DataIC50:  54nMAssay Description:Inhibition of Keap1 Kelch domain-Nrf2 ETGE (unknown origin) protein-protein interaction incubated for 30 mins by fluorescence polarization competitio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear factor erythroid 2-related factor 2(Homo sapiens (Human))
The State University Of New Jersey

Curated by ChEMBL
LigandPNGBDBM50537622(CHEMBL4634168)
Affinity DataIC50:  55nMAssay Description:Inhibitory potency against isolated epidermal growth factor receptor (EGFR) from human A431 carcinoma cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNuclear factor erythroid 2-related factor 2(Homo sapiens (Human))
The State University Of New Jersey

Curated by ChEMBL
LigandPNGBDBM561983(BDBM50369389 | US11396496, Compound A1)
Affinity DataIC50:  60nMAssay Description:Inhibition of Keap1 Kelch domain (unknown origin) /Nrf2 (unknown origin) interaction using fluorescein-labeled 9-mer peptide containing NRF2 Neh2 dom...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNuclear factor erythroid 2-related factor 2(Homo sapiens (Human))
The State University Of New Jersey

Curated by ChEMBL
LigandPNGBDBM50130549(CHEMBL3632711)
Affinity DataIC50:  63nMAssay Description:Inhibition of Keap1 Kelch domain (unknown origin) /Nrf2 (unknown origin) interaction using fluorescein-labeled 9-mer peptide containing NRF2 Neh2 dom...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear factor erythroid 2-related factor 2(Homo sapiens (Human))
The State University Of New Jersey

Curated by ChEMBL
LigandPNGBDBM561983(BDBM50369389 | US11396496, Compound A1)
Affinity DataIC50:  63nMAssay Description:Concentration required to inhibit the phosphorylation of a 14-residue fragment of phospholipase C gamma 1 by Epidermal growth factor receptor from A4...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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