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TargetNeuronal acetylcholine receptor subunit alpha-4(Human)
University of Bath

Curated by PDSP Ki Database
LigandPNGBDBM50049757((2R,4S)-2-(6-Iodo-pyridin-3-yl)-7-aza-bicyclo[2.2....)
Affinity DataKi:  0.0100nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2012
Entry Details
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Human)
University of Bath

Curated by PDSP Ki Database
LigandPNGBDBM50049757((2R,4S)-2-(6-Iodo-pyridin-3-yl)-7-aza-bicyclo[2.2....)
Affinity DataKi:  0.0100nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2012
Entry Details
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Human)
University of Bath

Curated by PDSP Ki Database
LigandPNGBDBM50049757((2R,4S)-2-(6-Iodo-pyridin-3-yl)-7-aza-bicyclo[2.2....)
Affinity DataKi:  0.0120nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2012
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Human)
University of Bath

Curated by PDSP Ki Database
LigandPNGBDBM50049750(CHEMBL59986 | (S)-3-(azetidin-2-ylmethoxy)pyridine...)
Affinity DataKi:  0.0400nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2012
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Human)
University of Bath

Curated by PDSP Ki Database
LigandPNGBDBM50049757((2R,4S)-2-(6-Iodo-pyridin-3-yl)-7-aza-bicyclo[2.2....)
Affinity DataKi:  0.0500nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2012
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Human)
University of Bath

Curated by PDSP Ki Database
LigandPNGBDBM50049757((2R,4S)-2-(6-Iodo-pyridin-3-yl)-7-aza-bicyclo[2.2....)
Affinity DataKi:  0.0600nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2012
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Human)
University of Bath

Curated by PDSP Ki Database
LigandPNGBDBM50049757((2R,4S)-2-(6-Iodo-pyridin-3-yl)-7-aza-bicyclo[2.2....)
Affinity DataKi:  0.0700nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2012
Entry Details
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Human)
University of Bath

Curated by PDSP Ki Database
LigandPNGBDBM86311(CAS_485-35-8 | NSC_22407 | Cytisine | Cytisine-(-)...)
Affinity DataKi:  0.240nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2012
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Human)
University of Bath

Curated by PDSP Ki Database
LigandPNGBDBM50107863((1S,9R)-7,11-diazatricyclo[7.3.1.0~2,7~]trideca-2,...)
Affinity DataKi:  0.430nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2012
Entry Details
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Human)
University of Bath

Curated by PDSP Ki Database
LigandPNGBDBM50261762((+/-)-exo-2-(3-methylisoxazol-5-yl)-7-aza-bicyclo[...)
Affinity DataKi:  0.460nMAssay Description:Binding affinity to alpha4beta2 nAChRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Human)
University of Bath

Curated by PDSP Ki Database
LigandPNGBDBM50023330(Anatoxin-a | Anatoxin-A,(+) | CHEMBL25619 | 1-(9-a...)
Affinity DataKi:  0.550nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2012
Entry Details
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Human)
University of Bath

Curated by PDSP Ki Database
LigandPNGBDBM50004108((R,S)-nicotine | (RS)-nicotine | nicotine | (+-)-n...)
In Depth
Date in BDB:
2/24/2012
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Human)
University of Bath

Curated by PDSP Ki Database
LigandPNGBDBM50004108((R,S)-nicotine | (RS)-nicotine | nicotine | (+-)-n...)
Affinity DataKi:  1.05nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2012
Entry Details
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Human)
University of Bath

Curated by PDSP Ki Database
LigandPNGBDBM50261762((+/-)-exo-2-(3-methylisoxazol-5-yl)-7-aza-bicyclo[...)
Affinity DataKi:  1.33nMAssay Description:Displacement of [3H]cystisine from alpha4beta2 nAChRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Human)
University of Bath

Curated by PDSP Ki Database
LigandPNGBDBM50397942(CHEMBL2179534)
Affinity DataKi:  1.5nM ΔG°:  -11.9kcal/moleT: 2°CAssay Description:The binding of [3H]MLA was measured using a modification of the methods of Davies et al., Neuropharmacol. 38: 679 (1999). [3H]MLA (Specific Activity=...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2015
Entry Details
US Patent

TargetNeuronal acetylcholine receptor subunit alpha-4(Human)
University of Bath

Curated by PDSP Ki Database
LigandPNGBDBM141885(US8921410, Table 2 Compound 20)
Affinity DataKi:  1.60nM ΔG°:  -11.8kcal/moleT: 2°CAssay Description:The binding of [3H]MLA was measured using a modification of the methods of Davies et al., Neuropharmacol. 38: 679 (1999). [3H]MLA (Specific Activity=...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2015
Entry Details
US Patent

TargetNeuronal acetylcholine receptor subunit alpha-4(Human)
University of Bath

Curated by PDSP Ki Database
LigandPNGBDBM50397929(CHEMBL2179547)
Affinity DataKi:  1.70nM ΔG°:  -11.8kcal/moleT: 2°CAssay Description:The binding of [3H]MLA was measured using a modification of the methods of Davies et al., Neuropharmacol. 38: 679 (1999). [3H]MLA (Specific Activity=...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2015
Entry Details
US Patent

TargetNeuronal acetylcholine receptor subunit alpha-4(Human)
University of Bath

Curated by PDSP Ki Database
LigandPNGBDBM50035398(ABT-418 | (S)-1-Methyl-2-(3-methyl-isoxazol-5-yl)-...)
Affinity DataKi:  1.70nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2012
Entry Details
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Human)
University of Bath

Curated by PDSP Ki Database
LigandPNGBDBM50047021(Lobeline | 2-(6-(2-hydroxy-2-phenylethyl)-1-methyl...)
Affinity DataKi:  1.90nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2012
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Human)
University of Bath

Curated by PDSP Ki Database
LigandPNGBDBM50047021(Lobeline | 2-(6-(2-hydroxy-2-phenylethyl)-1-methyl...)
Affinity DataKi:  1.92nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2012
Entry Details
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Human)
University of Bath

Curated by PDSP Ki Database
LigandPNGBDBM50004108((R,S)-nicotine | (RS)-nicotine | nicotine | (+-)-n...)
In Depth
Date in BDB:
5/29/2012
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Human)
University of Bath

Curated by PDSP Ki Database
LigandPNGBDBM50397888(CHEMBL2179531)
Affinity DataKi:  2.40nM ΔG°:  -11.6kcal/moleT: 2°CAssay Description:The binding of [3H]MLA was measured using a modification of the methods of Davies et al., Neuropharmacol. 38: 679 (1999). [3H]MLA (Specific Activity=...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2015
Entry Details
US Patent

TargetNeuronal acetylcholine receptor subunit alpha-4(Human)
University of Bath

Curated by PDSP Ki Database
LigandPNGBDBM50023330(Anatoxin-a | Anatoxin-A,(+) | CHEMBL25619 | 1-(9-a...)
Affinity DataKi:  2.5nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2012
Entry Details
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Human)
University of Bath

Curated by PDSP Ki Database
LigandPNGBDBM10759(2-acetoxyethyl(trimethyl)ammonium;perchlorate | 2-...)
Affinity DataKi:  2.66nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2012
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetNeuronal acetylcholine receptor subunit alpha-4(Human)
University of Bath

Curated by PDSP Ki Database
LigandPNGBDBM50107863((1S,9R)-7,11-diazatricyclo[7.3.1.0~2,7~]trideca-2,...)
Affinity DataKi:  3.30nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2012
Entry Details
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Human)
University of Bath

Curated by PDSP Ki Database
LigandPNGBDBM85224(SWEP | CAS_1918-18-9 | MCC)
Affinity DataKi:  3.80nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2012
Entry Details
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Human)
University of Bath

Curated by PDSP Ki Database
LigandPNGBDBM50023330(Anatoxin-a | Anatoxin-A,(+) | CHEMBL25619 | 1-(9-a...)
Affinity DataKi:  4.20nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2012
Entry Details
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Human)
University of Bath

Curated by PDSP Ki Database
LigandPNGBDBM50397936(CHEMBL2179540)
Affinity DataKi:  4.60nM ΔG°:  -11.2kcal/moleT: 2°CAssay Description:The binding of [3H]MLA was measured using a modification of the methods of Davies et al., Neuropharmacol. 38: 679 (1999). [3H]MLA (Specific Activity=...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2015
Entry Details
US Patent

TargetNeuronal acetylcholine receptor subunit alpha-4(Human)
University of Bath

Curated by PDSP Ki Database
LigandPNGBDBM50004108((R,S)-nicotine | (RS)-nicotine | nicotine | (+-)-n...)
Affinity DataKi:  4.60nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/25/2012
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Human)
University of Bath

Curated by PDSP Ki Database
LigandPNGBDBM50004108((R,S)-nicotine | (RS)-nicotine | nicotine | (+-)-n...)
Affinity DataKi:  4.90nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2012
Entry Details
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Human)
University of Bath

Curated by PDSP Ki Database
LigandPNGBDBM141867(US8921410, Table 1 Compound 33)
Affinity DataKi:  4.90nM ΔG°:  -11.2kcal/moleT: 2°CAssay Description:The binding of [3H]MLA was measured using a modification of the methods of Davies et al., Neuropharmacol. 38: 679 (1999). [3H]MLA (Specific Activity=...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2015
Entry Details
US Patent

TargetNeuronal acetylcholine receptor subunit alpha-4(Human)
University of Bath

Curated by PDSP Ki Database
LigandPNGBDBM141887(US8921410, Table 2 Compound 25)
Affinity DataKi:  5.20nM ΔG°:  -11.1kcal/moleT: 2°CAssay Description:The binding of [3H]MLA was measured using a modification of the methods of Davies et al., Neuropharmacol. 38: 679 (1999). [3H]MLA (Specific Activity=...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2015
Entry Details
US Patent

TargetNeuronal acetylcholine receptor subunit alpha-4(Human)
University of Bath

Curated by PDSP Ki Database
LigandPNGBDBM50397932(CHEMBL2179544)
Affinity DataKi:  5.20nM ΔG°:  -11.1kcal/moleT: 2°CAssay Description:The binding of [3H]MLA was measured using a modification of the methods of Davies et al., Neuropharmacol. 38: 679 (1999). [3H]MLA (Specific Activity=...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2015
Entry Details
US Patent

TargetNeuronal acetylcholine receptor subunit alpha-4(Human)
University of Bath

Curated by PDSP Ki Database
LigandPNGBDBM10759(2-acetoxyethyl(trimethyl)ammonium;perchlorate | 2-...)
Affinity DataKi:  6.80nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2012
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetNeuronal acetylcholine receptor subunit alpha-4(Human)
University of Bath

Curated by PDSP Ki Database
LigandPNGBDBM50397933(CHEMBL2179543)
Affinity DataKi:  7.30nM ΔG°:  -10.9kcal/moleT: 2°CAssay Description:The binding of [3H]MLA was measured using a modification of the methods of Davies et al., Neuropharmacol. 38: 679 (1999). [3H]MLA (Specific Activity=...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2015
Entry Details
US Patent

TargetNeuronal acetylcholine receptor subunit alpha-4(Human)
University of Bath

Curated by PDSP Ki Database
LigandPNGBDBM50261766((+/-)-exo-(1R,2R,4R)-2-(6-chloropyridin-3-yl)-7-az...)
Affinity DataKi:  7.60nMAssay Description:Binding affinity to alpha4beta2 nAChRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Human)
University of Bath

Curated by PDSP Ki Database
LigandPNGBDBM50004108((R,S)-nicotine | (RS)-nicotine | nicotine | (+-)-n...)
Affinity DataKi:  7.70nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2012
Entry Details
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Human)
University of Bath

Curated by PDSP Ki Database
LigandPNGBDBM141891(US8921410, Table 2 Compound 30)
Affinity DataKi:  8.70nM ΔG°:  -10.8kcal/moleT: 2°CAssay Description:The binding of [3H]MLA was measured using a modification of the methods of Davies et al., Neuropharmacol. 38: 679 (1999). [3H]MLA (Specific Activity=...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2015
Entry Details
US Patent

TargetNeuronal acetylcholine receptor subunit alpha-4(Human)
University of Bath

Curated by PDSP Ki Database
LigandPNGBDBM50397913(CHEMBL2179516)
Affinity DataKi:  9.20nM ΔG°:  -10.8kcal/moleT: 2°CAssay Description:The binding of [3H]MLA was measured using a modification of the methods of Davies et al., Neuropharmacol. 38: 679 (1999). [3H]MLA (Specific Activity=...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2015
Entry Details
US Patent

TargetNeuronal acetylcholine receptor subunit alpha-4(Human)
University of Bath

Curated by PDSP Ki Database
LigandPNGBDBM50397889(CHEMBL2179530)
Affinity DataKi:  9.70nM ΔG°:  -10.8kcal/moleT: 2°CAssay Description:The binding of [3H]MLA was measured using a modification of the methods of Davies et al., Neuropharmacol. 38: 679 (1999). [3H]MLA (Specific Activity=...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2015
Entry Details
US Patent

TargetNeuronal acetylcholine receptor subunit alpha-4(Human)
University of Bath

Curated by PDSP Ki Database
LigandPNGBDBM50397899(CHEMBL2179967)
Affinity DataKi:  9.90nM ΔG°:  -10.8kcal/moleT: 2°CAssay Description:The binding of [3H]MLA was measured using a modification of the methods of Davies et al., Neuropharmacol. 38: 679 (1999). [3H]MLA (Specific Activity=...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2015
Entry Details
US Patent

TargetNeuronal acetylcholine receptor subunit alpha-4(Human)
University of Bath

Curated by PDSP Ki Database
LigandPNGBDBM141886(US8921410, Table 2 Compound 24)
Affinity DataKi:  10nM ΔG°:  -10.8kcal/moleT: 2°CAssay Description:The binding of [3H]MLA was measured using a modification of the methods of Davies et al., Neuropharmacol. 38: 679 (1999). [3H]MLA (Specific Activity=...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2015
Entry Details
US Patent

TargetNeuronal acetylcholine receptor subunit alpha-4(Human)
University of Bath

Curated by PDSP Ki Database
LigandPNGBDBM50061567(DMPP | cid_5911 | CHEMBL134752 | CHEMBL47814 | 1,1...)
Affinity DataKi:  10.7nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2012
Entry Details
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Human)
University of Bath

Curated by PDSP Ki Database
LigandPNGBDBM85207(NSC_123990 | CAS_123990 | Suberyldicholine)
Affinity DataKi:  13nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2012
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Human)
University of Bath

Curated by PDSP Ki Database
LigandPNGBDBM50254538(3-(dimethylamino)butyl methylcarbamate | CHEMBL466...)
Affinity DataKi:  13nMAssay Description:Displacement of [3H]epibatidine from alpha4beta2 nAChR expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Human)
University of Bath

Curated by PDSP Ki Database
LigandPNGBDBM50397935(CHEMBL2179541)
Affinity DataKi:  14nM ΔG°:  -10.6kcal/moleT: 2°CAssay Description:The binding of [3H]MLA was measured using a modification of the methods of Davies et al., Neuropharmacol. 38: 679 (1999). [3H]MLA (Specific Activity=...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2015
Entry Details
US Patent

TargetNeuronal acetylcholine receptor subunit alpha-4(Human)
University of Bath

Curated by PDSP Ki Database
LigandPNGBDBM141872(US8921410, Table 1 Compound 41)
Affinity DataKi:  14nM ΔG°:  -10.6kcal/moleT: 2°CAssay Description:The binding of [3H]MLA was measured using a modification of the methods of Davies et al., Neuropharmacol. 38: 679 (1999). [3H]MLA (Specific Activity=...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2015
Entry Details
US Patent

TargetNeuronal acetylcholine receptor subunit alpha-4(Human)
University of Bath

Curated by PDSP Ki Database
LigandPNGBDBM141868(US8921410, Table 1 Compound 35)
Affinity DataKi:  14nM ΔG°:  -10.6kcal/moleT: 2°CAssay Description:The binding of [3H]MLA was measured using a modification of the methods of Davies et al., Neuropharmacol. 38: 679 (1999). [3H]MLA (Specific Activity=...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2015
Entry Details
US Patent

TargetNeuronal acetylcholine receptor subunit alpha-4(Human)
University of Bath

Curated by PDSP Ki Database
LigandPNGBDBM141856(US8921410, Table 1 Compound 20)
Affinity DataKi:  14nM ΔG°:  -10.6kcal/moleT: 2°CAssay Description:The binding of [3H]MLA was measured using a modification of the methods of Davies et al., Neuropharmacol. 38: 679 (1999). [3H]MLA (Specific Activity=...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2015
Entry Details
US Patent

TargetNeuronal acetylcholine receptor subunit alpha-4(Human)
University of Bath

Curated by PDSP Ki Database
LigandPNGBDBM50397893(CHEMBL2179526)
Affinity DataKi:  16nM ΔG°:  -10.5kcal/moleT: 2°CAssay Description:The binding of [3H]MLA was measured using a modification of the methods of Davies et al., Neuropharmacol. 38: 679 (1999). [3H]MLA (Specific Activity=...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2015
Entry Details
US Patent

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