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Found 22 of ic50 for UniProtKB: P04049
TargetRAF proto-oncogene serine/threonine-protein kinase [1-324](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM202665(US10245267, Example 10 | US10709712, Example 10 | ...)
Affinity DataIC50:  0.118nMAssay Description:Raf and biotinylated Mek, kinase dead, were combined at 2 final concentrations in assay buffer (50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% BSA and 1 mM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRAF proto-oncogene serine/threonine-protein kinase [1-324](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM202697(US10245267, Example 42 | US10709712, Example 43 | ...)
Affinity DataIC50:  0.137nMAssay Description:Raf and biotinylated Mek, kinase dead, were combined at 2 final concentrations in assay buffer (50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% BSA and 1 mM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRAF proto-oncogene serine/threonine-protein kinase [1-324](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM202656(US10245267, Example 1 | US10709712, Example 1 | US...)
Affinity DataIC50:  0.144nMAssay Description:Raf and biotinylated Mek, kinase dead, were combined at 2 final concentrations in assay buffer (50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% BSA and 1 mM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRAF proto-oncogene serine/threonine-protein kinase [1-324](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM202772(US10245267, Example 119 | US10709712, Example 119 ...)
Affinity DataIC50:  0.270nMAssay Description:Raf and biotinylated Mek, kinase dead, were combined at 2 final concentrations in assay buffer (50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% BSA and 1 mM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRAF proto-oncogene serine/threonine-protein kinase [1-324](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM202771(US10245267, Example 118 | US10709712, Example 118 ...)
Affinity DataIC50:  0.308nMAssay Description:Raf and biotinylated Mek, kinase dead, were combined at 2 final concentrations in assay buffer (50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% BSA and 1 mM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRAF proto-oncogene serine/threonine-protein kinase [1-324](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM202696(US10245267, Example 43 | US10709712, Example 42 | ...)
Affinity DataIC50:  0.376nMAssay Description:Raf and biotinylated Mek, kinase dead, were combined at 2 final concentrations in assay buffer (50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% BSA and 1 mM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRAF proto-oncogene serine/threonine-protein kinase [1-324](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM202718(US10245267, Example 111 | US10709712, Example 111 ...)
Affinity DataIC50:  0.403nMAssay Description:Raf and biotinylated Mek, kinase dead, were combined at 2 final concentrations in assay buffer (50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% BSA and 1 mM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRAF proto-oncogene serine/threonine-protein kinase [1-324](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM202661(US10245267, Example 6 | US10709712, Example 6 | US...)
Affinity DataIC50:  0.408nMAssay Description:Raf and biotinylated Mek, kinase dead, were combined at 2 final concentrations in assay buffer (50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% BSA and 1 mM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRAF proto-oncogene serine/threonine-protein kinase [1-324](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM202845(US10245267, Example 198 | US10709712, Example 198 ...)
Affinity DataIC50:  0.455nMAssay Description:Raf and biotinylated Mek, kinase dead, were combined at 2 final concentrations in assay buffer (50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% BSA and 1 mM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRAF proto-oncogene serine/threonine-protein kinase [1-324](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM202717(US10245267, Example 63 | US10709712, Example 63 | ...)
Affinity DataIC50:  0.508nMAssay Description:Raf and biotinylated Mek, kinase dead, were combined at 2 final concentrations in assay buffer (50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% BSA and 1 mM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRAF proto-oncogene serine/threonine-protein kinase [1-324](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM77059(US10245267, Example 9 | US10709712, Example 9 | US...)
Affinity DataIC50:  0.514nMAssay Description:Raf and biotinylated Mek, kinase dead, were combined at 2 final concentrations in assay buffer (50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% BSA and 1 mM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRAF proto-oncogene serine/threonine-protein kinase [1-324](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM202668(US10245267, Example 13 | US10709712, Example 13 | ...)
Affinity DataIC50:  0.533nMAssay Description:Raf and biotinylated Mek, kinase dead, were combined at 2 final concentrations in assay buffer (50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% BSA and 1 mM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRAF proto-oncogene serine/threonine-protein kinase [1-324](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM202666(US10245267, Example 11 | US10709712, Example 11 | ...)
Affinity DataIC50:  0.580nMAssay Description:Raf and biotinylated Mek, kinase dead, were combined at 2 final concentrations in assay buffer (50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% BSA and 1 mM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRAF proto-oncogene serine/threonine-protein kinase [1-324](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM202843(US10245267, Example 196 | US10709712, Example 196 ...)
Affinity DataIC50:  0.621nMAssay Description:Raf and biotinylated Mek, kinase dead, were combined at 2 final concentrations in assay buffer (50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% BSA and 1 mM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRAF proto-oncogene serine/threonine-protein kinase [1-324](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM202698(US10245267, Example 44 | US10709712, Example 44 | ...)
Affinity DataIC50:  0.714nMAssay Description:Raf and biotinylated Mek, kinase dead, were combined at 2 final concentrations in assay buffer (50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% BSA and 1 mM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRAF proto-oncogene serine/threonine-protein kinase [1-324](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM202669(US10245267, Example 14 | US10709712, Example 14 | ...)
Affinity DataIC50:  0.803nMAssay Description:Raf and biotinylated Mek, kinase dead, were combined at 2 final concentrations in assay buffer (50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% BSA and 1 mM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRAF proto-oncogene serine/threonine-protein kinase [1-324](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM202764(US10245267, Example 64 | US10709712, Example 64 | ...)
Affinity DataIC50:  0.847nMAssay Description:Raf and biotinylated Mek, kinase dead, were combined at 2 final concentrations in assay buffer (50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% BSA and 1 mM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRAF proto-oncogene serine/threonine-protein kinase [1-324](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM77059(US10245267, Example 9 | US10709712, Example 9 | US...)
Affinity DataIC50:  0.899nMAssay Description:Raf and biotinylated Mek, kinase dead, were combined at 2 final concentrations in assay buffer (50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% BSA and 1 mM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRAF proto-oncogene serine/threonine-protein kinase [1-324](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM202699(US10245267, Example 45 | US10709712, Example 45 | ...)
Affinity DataIC50:  1.02nMAssay Description:Raf and biotinylated Mek, kinase dead, were combined at 2 final concentrations in assay buffer (50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% BSA and 1 mM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRAF proto-oncogene serine/threonine-protein kinase [1-324](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM202662(US10245267, Example 7 | US10709712, Example 7 | US...)
Affinity DataIC50:  1.11nMAssay Description:Raf and biotinylated Mek, kinase dead, were combined at 2 final concentrations in assay buffer (50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% BSA and 1 mM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRAF proto-oncogene serine/threonine-protein kinase [1-324](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM202846(US10245267, Example 199 | US10709712, Example 199 ...)
Affinity DataIC50:  1.29nMAssay Description:Raf and biotinylated Mek, kinase dead, were combined at 2 final concentrations in assay buffer (50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% BSA and 1 mM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRAF proto-oncogene serine/threonine-protein kinase [1-324](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM372340(US10245267, Example 2)
Affinity DataIC50:  2.95nMAssay Description:Raf and biotinylated Mek, kinase dead, were combined at 2 final concentrations in assay buffer (50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% BSA and 1 mM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent