Compile Data Set for Download or QSAR
maximum 50k data
Found 273 of ic50 for UniProtKB: P29476
TargetNitric oxide synthase, brain(Rattus norvegicus (rat))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50098959(5-Ethynyl-4,5-dihydro-thieno[2,3-c]pyridin-7-ylami...)
Affinity DataIC50:  6nMAssay Description:Ability to inhibit the conversion of [3H]-L-Arg to [3H]-L-citrulline catalyzed by n-NOS from rat cerebellumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Rattus norvegicus (rat))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50138977(CHEMBL419740 | N-(3-Aminomethyl-phenyl)-acetamidin...)
Affinity DataIC50:  11nMAssay Description:Inhibitory activity against neuronal nitric oxide synthase (nNOS)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Rattus norvegicus (rat))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50098962(5-Cyclopropyl-4,5-dihydro-thieno[2,3-c]pyridin-7-y...)
Affinity DataIC50:  11nMAssay Description:Ability to inhibit the conversion of [3H]-L-Arg to [3H]-L-citrulline catalyzed by n-NOS from rat cerebellumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Rattus norvegicus (rat))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50098961(6-Cyclopropyl-6,7-dihydro-thieno[3,2-c]pyridin-4-y...)
Affinity DataIC50:  18nMAssay Description:Ability to inhibit the conversion of [3H]-L-Arg to [3H]-L-citrulline catalyzed by n-NOS from rat cerebellumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Rattus norvegicus (rat))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50141086(6-[7-(2-Dimethylamino-ethoxy)-indan-4-yl]-pyridin-...)
Affinity DataIC50:  21.8nMAssay Description:In vitro inhibition of rat neuronal nitric oxide synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Rattus norvegicus (rat))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50098951(6-Ethynyl-6,7-dihydro-thieno[3,2-c]pyridin-4-ylami...)
Affinity DataIC50:  25nMAssay Description:Ability to inhibit the conversion of [3H]-L-Arg to [3H]-L-citrulline catalyzed by n-NOS from rat cerebellumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Rattus norvegicus (rat))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50141082(6-[4-(2-Dimethylamino-ethoxy)-5,6,7,8-tetrahydro-n...)
Affinity DataIC50:  34nMAssay Description:In vitro inhibition of rat neuronal nitric oxide synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Rattus norvegicus (rat))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50122307(CHEMBL293212 | N-{4-[2-(3-Chloro-benzylamino)-ethy...)
Affinity DataIC50:  35nMAssay Description:Inhibition of rat recombinant nNOS expressed in Escherichia coli using L-arginine as substrate assessed as NO production by hemoglobin capture assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Rattus norvegicus (rat))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM196649(US9212144, 4)
Affinity DataIC50:  35nMpH: 7.4Assay Description:To test for enzyme inhibition, the hemoglobin capture assay was used to measure nitric oxide production. The assay was performed at 37° C. in HEPES b...More data for this Ligand-Target Pair
TargetNitric oxide synthase, brain(Rattus norvegicus (rat))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50098950(5-Furan-2-yl-4,5-dihydro-thieno[2,3-c]pyridin-7-yl...)
Affinity DataIC50:  40nMAssay Description:Ability to inhibit the conversion of [3H]-L-Arg to [3H]-L-citrulline catalyzed by n-NOS from rat cerebellumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Rattus norvegicus (rat))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50091800(2-amino-4-methylpyridine | 4-METHYLPYRIDIN-2-AMINE...)
Affinity DataIC50:  40nMAssay Description:In vitro inhibition of rat neuronal nitric oxide synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Rattus norvegicus (rat))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50141081(6-[4-(1-Methyl-pyrrolidin-3-yloxy)-naphthalen-1-yl...)
Affinity DataIC50:  48nMAssay Description:In vitro inhibition of rat neuronal nitric oxide synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Rattus norvegicus (rat))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50098953(5-Thiophen-2-yl-4,5-dihydro-thieno[2,3-c]pyridin-7...)
Affinity DataIC50:  50nMAssay Description:Ability to inhibit the conversion of [3H]-L-Arg to [3H]-L-citrulline catalyzed by n-NOS from rat cerebellumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Rattus norvegicus (rat))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM142057(US8927730, Aminopyridinea)
Affinity DataIC50:  50nMpH: 7.4 T: 2°CAssay Description:The three NOS isoforms, rat nNOS, murine iNOS and bovine eNOS were recombinant enzymes overexpressed in E. coli and purified as reported in the liter...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNitric oxide synthase, brain(Rattus norvegicus (rat))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50206073(CHEMBL233652 | N-[2-(2-pyridin-2-yl-ethylamino)-be...)
Affinity DataIC50:  50nMAssay Description:Inhibition of rat neuronal NOS activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Rattus norvegicus (rat))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50065843(CHEMBL553081 | CHEMBL555715 | N-(3-Aminomethyl-phe...)
Affinity DataIC50:  50nMAssay Description:Inhibitory concentration tested against neuronal nitric oxide synthase (nNOS ) from rat cerebellumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Rattus norvegicus (rat))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50091805(2-amino-4,6-dimethylpyridine | 4,6-Dimethyl-pyridi...)
Affinity DataIC50:  50nMAssay Description:Inhibition of recombinant rat nNOS expressed in Escherichia coli by hemoglobin capture assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Rattus norvegicus (rat))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50141089(6-[7-(2-Pyrrolidin-1-yl-ethoxy)-indan-4-yl]-pyridi...)
Affinity DataIC50:  59nMAssay Description:In vitro inhibition of rat neuronal nitric oxide synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Rattus norvegicus (rat))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50138983((S)-2-Amino-5-(2-methyl-isothioureido)-pentanoic a...)
Affinity DataIC50:  60nMAssay Description:Inhibitory activity against neuronal nitric oxide synthase (nNOS)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Rattus norvegicus (rat))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50141085(6-[4-(2-Pyrrolidin-1-yl-ethoxy)-5,6,7,8-tetrahydro...)
Affinity DataIC50:  80nMAssay Description:In vitro inhibition of rat neuronal nitric oxide synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Rattus norvegicus (rat))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50122299(CHEMBL538500 | N-[4-(2-Amino-ethyl)-phenyl]-thioph...)
Affinity DataIC50:  80nMAssay Description:Inhibitory concentration tested against neuronal nitric oxide synthase (nNOS ) from rat cerebellumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Rattus norvegicus (rat))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50098954(5-Prop-1-ynyl-4,5-dihydro-thieno[2,3-c]pyridin-7-y...)
Affinity DataIC50:  80nMAssay Description:Ability to inhibit the conversion of [3H]-L-Arg to [3H]-L-citrulline catalyzed by n-NOS from rat cerebellumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Rattus norvegicus (rat))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50141077(6-[4-(1-Methyl-pyrrolidin-2-ylmethoxy)-naphthalen-...)
Affinity DataIC50:  80.5nMAssay Description:In vitro inhibition of rat neuronal nitric oxide synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Rattus norvegicus (rat))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50141074(6-{7-[2-(4-Methyl-piperazin-1-yl)-ethoxy]-indan-4-...)
Affinity DataIC50:  82nMAssay Description:In vitro inhibition of rat neuronal nitric oxide synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Rattus norvegicus (rat))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50141079(6-[4-(1-Aza-bicyclo[2.2.2]oct-2-ylmethoxy)-naphtha...)
Affinity DataIC50:  88nMAssay Description:In vitro inhibition of rat neuronal nitric oxide synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Rattus norvegicus (rat))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50206064(CHEMBL233857 | N-[2-(1-benzyl-piperidin-4-ylamino)...)
Affinity DataIC50:  90nMAssay Description:Inhibition of rat neuronal NOS activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Rattus norvegicus (rat))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50141088(6-[4-(2-Dimethylamino-ethoxy)-6,7,8,9-tetrahydro-5...)
Affinity DataIC50:  93nMAssay Description:In vitro inhibition of rat neuronal nitric oxide synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Rattus norvegicus (rat))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50141083(6-{4-[2-(4-Methyl-piperazin-1-yl)-ethoxy]-5,6,7,8-...)
Affinity DataIC50:  99.2nMAssay Description:In vitro inhibition of rat neuronal nitric oxide synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Rattus norvegicus (rat))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50230993((2S)-2-amino-5-[(N-methylcarbamimidoyl)amino]penta...)
Affinity DataIC50:  100nMAssay Description:Inhibition of conversion of [3H]-L-Arg to [3H]-L-citrulline catalyzed by neuronal NOS (n NOS) from rat cerebellumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Rattus norvegicus (rat))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50098952(6,7-Dihydro-thieno[3,2-c]pyridin-4-ylamine | CHEMB...)
Affinity DataIC50:  100nMAssay Description:Ability to inhibit the conversion of [3H]-L-Arg to [3H]-L-citrulline catalyzed by n-NOS from rat cerebellumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Rattus norvegicus (rat))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50279392((+/-)-6-((4-(2-(3-fluorophenethylamino)ethoxy)pyrr...)
Affinity DataIC50:  100nMAssay Description:Inhibition of wild type rat nNOS by hemoglobin capture assayMore data for this Ligand-Target Pair
TargetNitric oxide synthase, brain(Rattus norvegicus (rat))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50091805(2-amino-4,6-dimethylpyridine | 4,6-Dimethyl-pyridi...)
Affinity DataIC50:  100nMAssay Description:Inhibition of wild type rat nNOS by hemoglobin capture assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Rattus norvegicus (rat))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50279392((+/-)-6-((4-(2-(3-fluorophenethylamino)ethoxy)pyrr...)
Affinity DataIC50:  100nMAssay Description:Inhibition of wild type rat nNOS by radioactivity assayMore data for this Ligand-Target Pair
TargetNitric oxide synthase, brain(Rattus norvegicus (rat))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50279361((+/-)-N1-(4-((6-amino-4-methylpyridin-2-yl)methyl)...)
Affinity DataIC50:  100nMAssay Description:Inhibition of wild type rat nNOS by hemoglobin capture assayMore data for this Ligand-Target Pair
TargetNitric oxide synthase, brain(Rattus norvegicus (rat))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50230993((2S)-2-amino-5-[(N-methylcarbamimidoyl)amino]penta...)
Affinity DataIC50:  100nMAssay Description:Ability to inhibit the conversion of [3H]-L-Arg to [3H]-L-citrulline catalyzed by n-NOS from rat cerebellumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Rattus norvegicus (rat))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50081085(1-(4-{2-[4-(6-Amino-pyridin-2-yl)-phenyl]-ethyl}-p...)
Affinity DataIC50:  108nMAssay Description:Inhibitory activity against rat neuronal nitric oxide synthase (nNOS)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Rattus norvegicus (rat))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50209245(CHEMBL247378)
Affinity DataIC50:  110nMAssay Description:Inhibition of nNOS in Sprague-Dawley rat brain homogenates assessed as conversion of oxyhemoglobin to methemoglobin measured for 10 mins by UV-visibl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Rattus norvegicus (rat))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50379737(CHEMBL2011128)
Affinity DataIC50:  120nMAssay Description:Inhibition of rat nNOSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Rattus norvegicus (rat))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50122300(CHEMBL541300 | N-(3-{[3-(4-Hydroxy-3,5-diisopropyl...)
Affinity DataIC50:  120nMAssay Description:Inhibitory concentration tested against neuronal nitric oxide synthase (nNOS ) from rat cerebellumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Rattus norvegicus (rat))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM196649(US9212144, 4)
Affinity DataIC50:  120nMAssay Description:Inhibitory concentration tested against neuronal nitric oxide synthase (nNOS ) from rat cerebellumMore data for this Ligand-Target Pair
TargetNitric oxide synthase, brain(Rattus norvegicus (rat))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50081082(2-(4-{2-[4-(6-Amino-pyridin-2-yl)-phenyl]-ethyl}-p...)
Affinity DataIC50:  127nMAssay Description:In vitro inhibition of rat neuronal nitric oxide synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Rattus norvegicus (rat))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50081082(2-(4-{2-[4-(6-Amino-pyridin-2-yl)-phenyl]-ethyl}-p...)
Affinity DataIC50:  127nMAssay Description:Inhibitory activity against rat neuronal nitric oxide synthase (nNOS)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Rattus norvegicus (rat))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50081081(6-{4-[2-(4-Quinolin-8-yl-piperazin-1-yl)-ethyl]-ph...)
Affinity DataIC50:  130nMAssay Description:Inhibitory activity against rat neuronal nitric oxide synthase (nNOS)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Rattus norvegicus (rat))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50279392((+/-)-6-((4-(2-(3-fluorophenethylamino)ethoxy)pyrr...)
Affinity DataIC50:  130nMAssay Description:Inhibition of rat recombinant nNOS expressed in Escherichia coli assessed as formation of nitric oxide by hemoglobin capture assayMore data for this Ligand-Target Pair
TargetNitric oxide synthase, brain(Rattus norvegicus (rat))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50098956(5-Phenyl-4,5-dihydro-thieno[2,3-c]pyridin-7-ylamin...)
Affinity DataIC50:  140nMAssay Description:Ability to inhibit the conversion of [3H]-L-Arg to [3H]-L-citrulline catalyzed by n-NOS from rat cerebellumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Rattus norvegicus (rat))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50141080(6-[4-(2-Dimethylamino-cyclohexyloxy)-naphthalen-1-...)
Affinity DataIC50:  140nMAssay Description:In vitro inhibition of rat neuronal nitric oxide synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Rattus norvegicus (rat))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM190667(US10759791, Compound 14j | nNOS inhibitor, 5)
Affinity DataIC50:  142nMAssay Description:Inhibition of rat recombinant nNOS expressed in Escherichia coli using L-arginine as substrate assessed as reduction in NO production measured for 6 ...More data for this Ligand-Target Pair
TargetNitric oxide synthase, brain(Rattus norvegicus (rat))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50098937((S)-methyl 2-amino-5-(amino(nitroamino)methyleneam...)
Affinity DataIC50:  150nMAssay Description:Inhibition of conversion of [3H]-L-Arg to [3H]-L-citrulline catalyzed by neuronal NOS (n NOS) from rat cerebellumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Rattus norvegicus (rat))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50141084(6-[4-(2-Dimethylamino-ethoxy)-naphthalen-1-yl]-pyr...)
Affinity DataIC50:  167nMAssay Description:In vitro inhibition of rat neuronal nitric oxide synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Rattus norvegicus (rat))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50141076(6-[4-(2-Pyrrolidin-1-yl-ethoxy)-naphthalen-1-yl]-p...)
Affinity DataIC50:  175nMAssay Description:In vitro inhibition of rat neuronal nitric oxide synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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