Compile Data Set for Download or QSAR
maximum 50k data
Found 220 of ec50 for UniProtKB: Q7Z2W7
LigandPNGBDBM50268750(CHEMBL4064391)
Affinity DataEC50:  0.00100nMAssay Description:Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50268748(CHEMBL4069241)
Affinity DataEC50:  0.00200nMAssay Description:Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50268747(CHEMBL4070838)
Affinity DataEC50:  0.00400nMAssay Description:Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50268769(CHEMBL4087522)
Affinity DataEC50:  0.200nMAssay Description:Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50268764(CHEMBL4099556)
Affinity DataEC50:  0.300nMAssay Description:Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50268773(CHEMBL4075397)
Affinity DataEC50:  0.300nMAssay Description:Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50268837(CHEMBL4072494)
Affinity DataEC50:  0.400nMAssay Description:Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50268749(CHEMBL4097005)
Affinity DataEC50:  0.600nMAssay Description:Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50268746(CHEMBL4097943)
Affinity DataEC50:  0.700nMAssay Description:Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50268828(CHEMBL4079591)
Affinity DataEC50:  0.800nMAssay Description:Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50268729(CHEMBL4060261)
Affinity DataEC50:  1.10nMAssay Description:Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50268770(CHEMBL4105385)
Affinity DataEC50:  1.40nMAssay Description:Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50268835(CHEMBL4063252)
Affinity DataEC50:  2nMAssay Description:Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50268763(CHEMBL4064052)
Affinity DataEC50:  2nMAssay Description:Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50268724(CHEMBL4091381)
Affinity DataEC50:  3.70nMAssay Description:Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50268832(CHEMBL4096839)
Affinity DataEC50:  8nMAssay Description:Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50268841(CHEMBL4071703)
Affinity DataEC50:  8nMAssay Description:Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50268745(CHEMBL4087060)
Affinity DataEC50:  8nMAssay Description:Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50268810(CHEMBL4095201)
Affinity DataEC50:  10nMAssay Description:Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50269660(CHEMBL4067554)
Affinity DataEC50:  11nMAssay Description:Agonist activity at full length recombinant human TRPM8 expressed in HEK293 cells assessed as increase in intracellular Ca2+ level pre-incubated for ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50268756(CHEMBL4092493)
Affinity DataEC50:  20nMAssay Description:Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50268762(CHEMBL4091813)
Affinity DataEC50:  23nMAssay Description:Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50268735(CHEMBL4059464)
Affinity DataEC50:  24nMAssay Description:Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50269663(CHEMBL4076583)
Affinity DataEC50:  28nMAssay Description:Agonist activity at full length recombinant human TRPM8 expressed in HEK293 cells assessed as increase in intracellular Ca2+ level pre-incubated for ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50268827(CHEMBL4103845)
Affinity DataEC50:  39nMAssay Description:Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50442649(CHEMBL2441929)
Affinity DataEC50:  40nMAssay Description:Inhibition of human TRPM8 (unknown origin) expressed in HEK293 cells assessed as inhibition of WS12-induced Ca2+ elevation by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50268831(CHEMBL4078818)
Affinity DataEC50:  40nMAssay Description:Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50268730(CHEMBL4091183)
Affinity DataEC50:  40nMAssay Description:Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50268813(CHEMBL4094300)
Affinity DataEC50:  52nMAssay Description:Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50269664(CHEMBL4076657)
Affinity DataEC50:  54nMAssay Description:Agonist activity at full length recombinant human TRPM8 expressed in HEK293 cells assessed as increase in intracellular Ca2+ level pre-incubated for ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50241426(3-(2-hydroxyphenyl)-6-(3-nitrophenyl)-3,4-dihydrop...)
Affinity DataEC50:  60nMAssay Description:Activation of TRPM8 channelMore data for this Ligand-Target Pair
LigandPNGBDBM50268830(CHEMBL4060474)
Affinity DataEC50:  61nMAssay Description:Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50269681(CHEMBL4077565)
Affinity DataEC50:  66nMAssay Description:Agonist activity at full length recombinant human TRPM8 expressed in HEK293 cells assessed as increase in intracellular Ca2+ level pre-incubated for ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50268823(CHEMBL4079334)
Affinity DataEC50:  67nMAssay Description:Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50268840(CHEMBL4089135)
Affinity DataEC50:  70nMAssay Description:Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50268728(CHEMBL4087469)
Affinity DataEC50:  80nMAssay Description:Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50269669(CHEMBL4065256)
Affinity DataEC50:  82nMAssay Description:Agonist activity at full length recombinant human TRPM8 expressed in HEK293 cells assessed as increase in intracellular Ca2+ level pre-incubated for ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50269682(CHEMBL4076994)
Affinity DataEC50:  86nMAssay Description:Agonist activity at full length recombinant human TRPM8 expressed in HEK293 cells assessed as increase in intracellular Ca2+ level pre-incubated for ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50269676(CHEMBL4074380)
Affinity DataEC50:  87nMAssay Description:Agonist activity at full length recombinant human TRPM8 expressed in HEK293 cells assessed as increase in intracellular Ca2+ level pre-incubated for ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50268808(CHEMBL4105242)
Affinity DataEC50:  88nMAssay Description:Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50268717(CHEMBL4091126)
Affinity DataEC50:  93nMAssay Description:Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50268822(CHEMBL4077232)
Affinity DataEC50:  97nMAssay Description:Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM435142(US10584134, Example 1-1)
Affinity DataEC50:  100nMAssay Description:A test comparable with that previously described in the literature by Behrendt H. J. et al., Br. J. Pharmacol. 141, 2004, 737-745, is carried out. Th...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM50613652(CHEMBL2436830)
Affinity DataEC50:  100nMAssay Description:Agonist activity at TRPM8 (unknown origin)More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
LigandPNGBDBM435195(US10584134, Example 3-18)
Affinity DataEC50:  100nMAssay Description:Agonist activity at human TRMP8 expressed in HEK293 cells by fluorometric imaging plate reader analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM435195(US10584134, Example 3-18)
Affinity DataEC50:  100nMAssay Description:A test comparable with that previously described in the literature by Behrendt H. J. et al., Br. J. Pharmacol. 141, 2004, 737-745, is carried out. Th...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM50613650(CHEMBL5272743)
Affinity DataEC50:  100nMAssay Description:Agonist activity at human recombinant TRPM8More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
LigandPNGBDBM435160(US10584134, Example 2-7 | US10584134, Example 2-8)
Affinity DataEC50:  100nMAssay Description:A test comparable with that previously described in the literature by Behrendt H. J. et al., Br. J. Pharmacol. 141, 2004, 737-745, is carried out. Th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM435159(US10584134, Example 2-5)
Affinity DataEC50:  100nMAssay Description:A test comparable with that previously described in the literature by Behrendt H. J. et al., Br. J. Pharmacol. 141, 2004, 737-745, is carried out. Th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM435154(US10584134, Example 2-1 | US10584134, Example 2-15...)
Affinity DataEC50:  100nMAssay Description:A test comparable with that previously described in the literature by Behrendt H. J. et al., Br. J. Pharmacol. 141, 2004, 737-745, is carried out. Th...More data for this Ligand-Target Pair
In DepthDetails US Patent
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