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Tyrosine-protein kinase SYK(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

BDBM100350(US10533001, Example 99 | US11414410, Example 99 | ...)

IC50: 15nM Kd: 4.5nMAssay Description:ATP-site dependent competition binding assay using Ambit KinomeScan Screening kit.More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid Similars

Details US Patent

Filter my 157 hits

Targets 1▿
- Tyrosine-protein kinase SYK 157
Publications 19▿
- Nat Biotechnol 29: 1046-51 (2011) 72
- Nat Biotechnol 26: 127-32 (2008) 38
- Blood 114: 2984-92 (2009) 7
- PubChem Bioassay (2008) 7
- Bioorg Med Chem Lett 13: 1241-4 (2003) 5
- US Patent US10941115 (2021) 3
- US Patent US8501944 (2013) 3
- US Patent US8937070 (2015) 3
- US Patent US10533001 (2020) 3
- US Patent US10238658 (2019) 2
- J Med Chem 57: 3856-73 (2014) 2
- Nat Biotechnol 23: 329-36 (2005) 2
- Bioorg Med Chem Lett 29: (2019) 2
- US Patent US10813932 (2020) 2
- US Patent US9724347 (2017) 2
- Bioorg Med Chem 16: 1393-9 (2008) 1
- US Patent US9499486 (2016) 1
- J Med Chem 58: 1950-63 (2015) 1
- US Patent US9108950 (2015) 1
Institutions 8▿
- Ambit Biosciences 126
- Portola Pharmaceuticals 9
- Respivert 8
- Utrecht University 6
- Oxular Acquisitions 3
- Takeda Pharmaceutical 2
- Gilead Sciences 2
- Novartis Institutes For Biomedical Research 1
Affinity: 0.64 to 1.7E+5 nM▿
- IC50 1
- Kd 157
- Affinity ≤ nM
Xtal structures: 4
Docked structures: 6
Catalog Cmpds: 81