TargetVoltage-dependent L-type calcium channel subunit alpha-1C/alpha-1D/alpha-1S(Rattus norvegicus)
Prestwick Chemical
Curated by ChEMBL
Prestwick Chemical
Curated by ChEMBL
Affinity DataKi: 4.60nMAssay Description:Invitro evaluation against RXR-alpha in CV-1 cells by cotransfection assay was determinedMore data for this Ligand-Target Pair
TargetVoltage-dependent L-type calcium channel subunit alpha-1C/alpha-1D/alpha-1S(Rattus norvegicus)
Prestwick Chemical
Curated by ChEMBL
Prestwick Chemical
Curated by ChEMBL
Affinity DataKi: 480nMAssay Description:Inhibition of rat brain cortex L-type Ca2+-channel phenylalkylamine siteMore data for this Ligand-Target Pair
TargetVoltage-dependent L-type calcium channel subunit alpha-1C/alpha-1D/alpha-1S(Rattus norvegicus)
Prestwick Chemical
Curated by ChEMBL
Prestwick Chemical
Curated by ChEMBL
Affinity DataKi: 800nMAssay Description:Inhibition of rat brain cortex L-type Ca2+-channel benzothiazepine siteMore data for this Ligand-Target Pair
TargetVoltage-dependent L-type calcium channel subunit alpha-1C/alpha-1D/alpha-1S(Rattus norvegicus)
Prestwick Chemical
Curated by ChEMBL
Prestwick Chemical
Curated by ChEMBL
Affinity DataKi: >1.00E+3nMAssay Description:Inhibition of [3H]nitrendipine binding to rat L-type Ca-channel receptorMore data for this Ligand-Target Pair
TargetVoltage-dependent L-type calcium channel subunit alpha-1C/alpha-1D/alpha-1S(Rattus norvegicus)
Prestwick Chemical
Curated by ChEMBL
Prestwick Chemical
Curated by ChEMBL
Affinity DataKi: 5.40E+3nMAssay Description:The binding affinity of the compound was measured on dopamine receptor D2 using [3H]- spiperone as radioligand.More data for this Ligand-Target Pair
TargetVoltage-dependent L-type calcium channel subunit alpha-1C/alpha-1D/alpha-1S(Rattus norvegicus)
Prestwick Chemical
Curated by ChEMBL
Prestwick Chemical
Curated by ChEMBL
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of [3H]nitrendipine binding to L-type calcium channel dihydropyridine site of rat brainMore data for this Ligand-Target Pair
TargetVoltage-dependent L-type calcium channel subunit alpha-1C/alpha-1D/alpha-1S(Rattus norvegicus)
Prestwick Chemical
Curated by ChEMBL
Prestwick Chemical
Curated by ChEMBL
Affinity DataKi: >1.00E+4nMAssay Description:The binding affinity of the compound was measured on cholecystokinin type A receptor using [3H]- CCK-8 as radioligand.More data for this Ligand-Target Pair
TargetVoltage-dependent L-type calcium channel subunit alpha-1C/alpha-1D/alpha-1S(Rattus norvegicus)
Prestwick Chemical
Curated by ChEMBL
Prestwick Chemical
Curated by ChEMBL
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of [3H]nitrendipine binding to L-type calcium channel dihydropyridine site of rat brainMore data for this Ligand-Target Pair
TargetVoltage-dependent L-type calcium channel subunit alpha-1C/alpha-1D/alpha-1S(Rattus norvegicus)
Prestwick Chemical
Curated by ChEMBL
Prestwick Chemical
Curated by ChEMBL
Affinity DataKi: >1.00E+5nMAssay Description:Inhibition of rat whole brain L-type Ca2+-channel dihydropyridine siteMore data for this Ligand-Target Pair
TargetVoltage-dependent L-type calcium channel subunit alpha-1C/alpha-1D/alpha-1S(Rattus norvegicus)
Prestwick Chemical
Curated by ChEMBL
Prestwick Chemical
Curated by ChEMBL
Affinity DataIC50: 79nMAssay Description:Inhibition of L-type calcium channel in endothelium-denuded Wistar rat aorta rings assessed as relaxation of 60 mM K+-induced contractionMore data for this Ligand-Target Pair
TargetVoltage-dependent L-type calcium channel subunit alpha-1C/alpha-1D/alpha-1S(Rattus norvegicus)
Prestwick Chemical
Curated by ChEMBL
Prestwick Chemical
Curated by ChEMBL
Affinity DataIC50: 398nMAssay Description:Inhibition of L-type calcium channel in endothelium-denuded Wistar rat aorta rings assessed as relaxation of phenylephrine-induced contractionMore data for this Ligand-Target Pair
TargetVoltage-dependent L-type calcium channel subunit alpha-1C/alpha-1D/alpha-1S(Rattus norvegicus)
Prestwick Chemical
Curated by ChEMBL
Prestwick Chemical
Curated by ChEMBL
Affinity DataIC50: 481nMAssay Description:Inhibition of L-type calcium channel in Wistar rat aorta rings assessed as reduction in L-type Ba(2+) current at Vh of -50 mVMore data for this Ligand-Target Pair
TargetVoltage-dependent L-type calcium channel subunit alpha-1C/alpha-1D/alpha-1S(Rattus norvegicus)
Prestwick Chemical
Curated by ChEMBL
Prestwick Chemical
Curated by ChEMBL
Affinity DataIC50: 592nMAssay Description:Inhibition of [3H]PN-200-110 binding to L-type calcium channels in rat cortex membranes.More data for this Ligand-Target Pair
TargetVoltage-dependent L-type calcium channel subunit alpha-1C/alpha-1D/alpha-1S(Rattus norvegicus)
Prestwick Chemical
Curated by ChEMBL
Prestwick Chemical
Curated by ChEMBL
Affinity DataIC50: 900nMAssay Description:Inhibition of L-type calcium channels in GH-3 rat pituitary cellsMore data for this Ligand-Target Pair
TargetVoltage-dependent L-type calcium channel subunit alpha-1C/alpha-1D/alpha-1S(Rattus norvegicus)
Prestwick Chemical
Curated by ChEMBL
Prestwick Chemical
Curated by ChEMBL
Affinity DataIC50: 1.59E+3nMAssay Description:Inhibition of L-type calcium channel in endothelium-intact Wistar rat aorta rings assessed as relaxation of 30 mM K+-induced contractionMore data for this Ligand-Target Pair
TargetVoltage-dependent L-type calcium channel subunit alpha-1C/alpha-1D/alpha-1S(Rattus norvegicus)
Prestwick Chemical
Curated by ChEMBL
Prestwick Chemical
Curated by ChEMBL
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of L-type calcium channels in GH-3 rat pituitary cellsMore data for this Ligand-Target Pair
TargetVoltage-dependent L-type calcium channel subunit alpha-1C/alpha-1D/alpha-1S(Rattus norvegicus)
Prestwick Chemical
Curated by ChEMBL
Prestwick Chemical
Curated by ChEMBL
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of L-type [Ca2+] channel (VSCC) in rat A7r5 vascular smooth muscle cellsMore data for this Ligand-Target Pair
TargetVoltage-dependent L-type calcium channel subunit alpha-1C/alpha-1D/alpha-1S(Rattus norvegicus)
Prestwick Chemical
Curated by ChEMBL
Prestwick Chemical
Curated by ChEMBL
Affinity DataIC50: 4.10E+3nMAssay Description:Inhibition of L-type calcium channels in GH-3 rat pituitary cellsMore data for this Ligand-Target Pair
TargetVoltage-dependent L-type calcium channel subunit alpha-1C/alpha-1D/alpha-1S(Rattus norvegicus)
Prestwick Chemical
Curated by ChEMBL
Prestwick Chemical
Curated by ChEMBL
Affinity DataIC50: 4.20E+3nMAssay Description:Inhibition of L-type [Ca2+] channel (VSCC) in rat A7r5 vascular smooth muscle cellsMore data for this Ligand-Target Pair
TargetVoltage-dependent L-type calcium channel subunit alpha-1C/alpha-1D/alpha-1S(Rattus norvegicus)
Prestwick Chemical
Curated by ChEMBL
Prestwick Chemical
Curated by ChEMBL
Affinity DataIC50: 5.87E+3nMAssay Description:Displacement of [3H]nitrendipine from calcium channel receptorMore data for this Ligand-Target Pair
TargetVoltage-dependent L-type calcium channel subunit alpha-1C/alpha-1D/alpha-1S(Rattus norvegicus)
Prestwick Chemical
Curated by ChEMBL
Prestwick Chemical
Curated by ChEMBL
Affinity DataIC50: 9.10E+3nMAssay Description:Inhibition of L-type calcium channels in GH-3 rat pituitary cellsMore data for this Ligand-Target Pair
TargetVoltage-dependent L-type calcium channel subunit alpha-1C/alpha-1D/alpha-1S(Rattus norvegicus)
Prestwick Chemical
Curated by ChEMBL
Prestwick Chemical
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of [3H]nitrendipine from L-type [Ca2+] channel of rat brainMore data for this Ligand-Target Pair
TargetVoltage-dependent L-type calcium channel subunit alpha-1C/alpha-1D/alpha-1S(Rattus norvegicus)
Prestwick Chemical
Curated by ChEMBL
Prestwick Chemical
Curated by ChEMBL
Affinity DataIC50: 1.58E+4nMAssay Description:Inhibition of L-type calcium channel in endothelium-denuded Wistar rat aorta rings assessed as relaxation of 60 mM K+-induced contractionMore data for this Ligand-Target Pair
TargetVoltage-dependent L-type calcium channel subunit alpha-1C/alpha-1D/alpha-1S(Rattus norvegicus)
Prestwick Chemical
Curated by ChEMBL
Prestwick Chemical
Curated by ChEMBL
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of L-type calcium channel in endothelium-denuded Wistar rat aorta rings assessed as relaxation of phenylephrine-induced contractionMore data for this Ligand-Target Pair
TargetVoltage-dependent L-type calcium channel subunit alpha-1C/alpha-1D/alpha-1S(Rattus norvegicus)
Prestwick Chemical
Curated by ChEMBL
Prestwick Chemical
Curated by ChEMBL
Affinity DataIC50: 3.16E+4nMAssay Description:Inhibition of L-type calcium channel in endothelium-denuded Wistar rat aorta rings assessed as relaxation of 30 mM K+-induced contractionMore data for this Ligand-Target Pair
TargetVoltage-dependent L-type calcium channel subunit alpha-1C/alpha-1D/alpha-1S(Rattus norvegicus)
Prestwick Chemical
Curated by ChEMBL
Prestwick Chemical
Curated by ChEMBL
Affinity DataIC50: 3.98E+4nMAssay Description:Inhibition of L-type calcium channel in endothelium-intact Wistar rat aorta rings assessed as relaxation of 30 mM K+-induced contractionMore data for this Ligand-Target Pair
TargetVoltage-dependent L-type calcium channel subunit alpha-1C/alpha-1D/alpha-1S(Rattus norvegicus)
Prestwick Chemical
Curated by ChEMBL
Prestwick Chemical
Curated by ChEMBL
Affinity DataIC50: 5.01E+4nMAssay Description:Inhibition of L-type calcium channel in endothelium-denuded Wistar rat aorta rings assessed as relaxation of phenylephrine-induced contractionMore data for this Ligand-Target Pair
TargetVoltage-dependent L-type calcium channel subunit alpha-1C/alpha-1D/alpha-1S(Rattus norvegicus)
Prestwick Chemical
Curated by ChEMBL
Prestwick Chemical
Curated by ChEMBL
Affinity DataIC50: 6.31E+4nMAssay Description:Inhibition of L-type calcium channel in endothelium-intact Wistar rat aorta rings assessed as relaxation of 30 mM K+-induced contractionMore data for this Ligand-Target Pair
TargetVoltage-dependent L-type calcium channel subunit alpha-1C/alpha-1D/alpha-1S(Rattus norvegicus)
Prestwick Chemical
Curated by ChEMBL
Prestwick Chemical
Curated by ChEMBL
Affinity DataIC50: 7.94E+4nMAssay Description:Inhibition of L-type calcium channel in endothelium-denuded Wistar rat aorta rings assessed as relaxation of 60 mM K+-induced contractionMore data for this Ligand-Target Pair
TargetVoltage-dependent L-type calcium channel subunit alpha-1C/alpha-1D/alpha-1S(Rattus norvegicus)
Prestwick Chemical
Curated by ChEMBL
Prestwick Chemical
Curated by ChEMBL
Affinity DataIC50: 1.26E+5nMAssay Description:Inhibition of L-type calcium channel in endothelium-denuded Wistar rat aorta rings assessed as relaxation of 30 mM K+-induced contractionMore data for this Ligand-Target Pair
TargetVoltage-dependent L-type calcium channel subunit alpha-1C/alpha-1D/alpha-1S(Rattus norvegicus)
Prestwick Chemical
Curated by ChEMBL
Prestwick Chemical
Curated by ChEMBL
Affinity DataIC50: 2.51E+5nMAssay Description:Inhibition of L-type calcium channel in Wistar rat aorta rings assessed as reduction in L-type Ba(2+) current at Vh of -50 mVMore data for this Ligand-Target Pair
TargetVoltage-dependent L-type calcium channel subunit alpha-1C/alpha-1D/alpha-1S(Rattus norvegicus)
Prestwick Chemical
Curated by ChEMBL
Prestwick Chemical
Curated by ChEMBL
Affinity DataIC50: >5.00E+6nMAssay Description:Calcium channel binding activity against dihydropyridine receptor in rat brain cortical membranesMore data for this Ligand-Target Pair
TargetVoltage-dependent L-type calcium channel subunit alpha-1C/alpha-1D/alpha-1S(Rattus norvegicus)
Prestwick Chemical
Curated by ChEMBL
Prestwick Chemical
Curated by ChEMBL
Affinity DataIC50: >5.00E+6nMAssay Description:Calcium channel binding activity against dihydropyridine receptor in rat brain cortical membranesMore data for this Ligand-Target Pair
TargetVoltage-dependent L-type calcium channel subunit alpha-1C/alpha-1D/alpha-1S(Rattus norvegicus)
Prestwick Chemical
Curated by ChEMBL
Prestwick Chemical
Curated by ChEMBL
Affinity DataIC50: 5.00E+6nMAssay Description:Calcium channel binding activity against dihydropyridine receptor in rat brain cortical membranesMore data for this Ligand-Target Pair
TargetVoltage-dependent L-type calcium channel subunit alpha-1C/alpha-1D/alpha-1S(Rattus norvegicus)
Prestwick Chemical
Curated by ChEMBL
Prestwick Chemical
Curated by ChEMBL
Affinity DataEC50: 61nMAssay Description:Binding of [3H]-nitrendipine to calcium channel in rat heart membranesMore data for this Ligand-Target Pair