Compile Data Set for Download or QSAR
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Found 6 Enz. Inhib. hit(s) with all data for entry = 10799
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Sirgartan Holdings

US Patent
LigandPNGBDBM50194618(CHEMBL3937907 | US20240050427, Compound 1)
Affinity DataEC50:  231nMAssay Description:The compounds described herein have been shown to be positive allosteric modulators of the mGluR2 receptor using a [35S]-GTPγS binding assay as ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Sirgartan Holdings

US Patent
LigandPNGBDBM612290(2-(4-chloro-benzyl)-5-[3-(2,5-diaza-bicyclo[2.2.1]...)
Affinity DataEC50:  206nMAssay Description:The compounds described herein have been shown to be positive allosteric modulators of the mGluR2 receptor using a [35S]-GTPγS binding assay as ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Sirgartan Holdings

US Patent
LigandPNGBDBM612390(2-(4-chloro-benzyl)-7-methyl-5-[3-(2-methyl-pipera...)
Affinity DataEC50:  317nMAssay Description:The compounds described herein have been shown to be positive allosteric modulators of the mGluR2 receptor using a [35S]-GTPγS binding assay as ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Sirgartan Holdings

US Patent
LigandPNGBDBM612379(2-(4-chloro-benzyl)-7-mehtyl-5-(3-piperazin-1-ylme...)
Affinity DataEC50:  378nMAssay Description:The compounds described herein have been shown to be positive allosteric modulators of the mGluR2 receptor using a [35S]-GTPγS binding assay as ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Sirgartan Holdings

US Patent
LigandPNGBDBM612383(2-(4-chloro-benzyl)-7-methyl-5-[3-(2-methyl-pipera...)
Affinity DataEC50:  352nMAssay Description:The compounds described herein have been shown to be positive allosteric modulators of the mGluR2 receptor using a [35S]-GTPγS binding assay as ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Sirgartan Holdings

US Patent
LigandPNGBDBM612360(2-(4-chlorobenzyl)-7-methyl-5-[3-(3-methyl-piperaz...)
Affinity DataEC50:  154nMAssay Description:The compounds described herein have been shown to be positive allosteric modulators of the mGluR2 receptor using a [35S]-GTPγS binding assay as ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent