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Found 8 Enz. Inhib. hit(s) with all data for entry = 2207
TargetDihydrofolate reductase(Staphylococcus aureus)
Arpida

LigandPNGBDBM18071(5-chloro-3-({4-[(2,4-diaminopyrimidin-5-yl)methyl]...)
Affinity DataKi:  8nM ΔG°:  -47.0kJ/mole IC50:  50nMpH: 7.0 T: 2°CAssay Description:Activity was measured as a change in absorbance over time at a wavelength of 340 nm (A340), so as to monitor the disappearance of NADPH. After incuba...More data for this Ligand-Target Pair
In DepthDetails
TargetDihydrofolate reductase(Streptococcus pneumoniae (ATCC49619))
Arpida

LigandPNGBDBM18071(5-chloro-3-({4-[(2,4-diaminopyrimidin-5-yl)methyl]...)
Affinity DataKi:  9nM ΔG°:  -46.7kJ/mole IC50:  90nMpH: 7.0 T: 2°CAssay Description:Activity was measured as a change in absorbance over time at a wavelength of 340 nm (A340), so as to monitor the disappearance of NADPH. After incuba...More data for this Ligand-Target Pair
In DepthDetails
TargetDihydrofolate reductase(Streptococcus pneumoniae)
Arpida

LigandPNGBDBM18071(5-chloro-3-({4-[(2,4-diaminopyrimidin-5-yl)methyl]...)
Affinity DataKi:  27nM ΔG°:  -43.9kJ/mole IC50:  50nMpH: 7.0 T: 2°CAssay Description:Activity was measured as a change in absorbance over time at a wavelength of 340 nm (A340), so as to monitor the disappearance of NADPH. After incuba...More data for this Ligand-Target Pair
In DepthDetails
TargetDihydrofolate reductase(Staphylococcus aureus)
Arpida

LigandPNGBDBM18069(5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-d...)
Affinity DataKi:  40nM ΔG°:  -42.9kJ/mole IC50:  600nMpH: 7.0 T: 2°CAssay Description:Activity was measured as a change in absorbance over time at a wavelength of 340 nm (A340), so as to monitor the disappearance of NADPH. After incuba...More data for this Ligand-Target Pair
In DepthDetails PDB3D3D Structure (crystal)
TargetDihydrofolate reductase [F98Y](Staphylococcus aureus (subsp. aureus NCTC 8325))
Arpida

LigandPNGBDBM18071(5-chloro-3-({4-[(2,4-diaminopyrimidin-5-yl)methyl]...)
Affinity DataKi:  90nM ΔG°:  -40.9kJ/mole IC50:  900nMpH: 7.0 T: 2°CAssay Description:Activity was measured as a change in absorbance over time at a wavelength of 340 nm (A340), so as to monitor the disappearance of NADPH. After incuba...More data for this Ligand-Target Pair
In DepthDetails
TargetDihydrofolate reductase(Streptococcus pneumoniae)
Arpida

LigandPNGBDBM18069(5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-d...)
Affinity DataKi:  240nM ΔG°:  -38.4kJ/mole IC50:  3.00E+3nMpH: 7.0 T: 2°CAssay Description:Activity was measured as a change in absorbance over time at a wavelength of 340 nm (A340), so as to monitor the disappearance of NADPH. After incuba...More data for this Ligand-Target Pair
In DepthDetails
TargetDihydrofolate reductase [F98Y](Staphylococcus aureus (subsp. aureus NCTC 8325))
Arpida

LigandPNGBDBM18069(5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-d...)
Affinity DataKi:  5.50E+3nM ΔG°:  -30.5kJ/mole IC50:  4.50E+4nMpH: 7.0 T: 2°CAssay Description:Activity was measured as a change in absorbance over time at a wavelength of 340 nm (A340), so as to monitor the disappearance of NADPH. After incuba...More data for this Ligand-Target Pair
In DepthDetails PDB3D3D Structure (crystal)
TargetDihydrofolate reductase(Streptococcus pneumoniae (ATCC49619))
Arpida

LigandPNGBDBM18069(5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-d...)
Affinity DataKi:  5.60E+3nM ΔG°:  -30.5kJ/mole IC50:  4.20E+4nMpH: 7.0 T: 2°CAssay Description:Activity was measured as a change in absorbance over time at a wavelength of 340 nm (A340), so as to monitor the disappearance of NADPH. After incuba...More data for this Ligand-Target Pair
In DepthDetails