Compile Data Set for Download or QSAR
maximum 50k data
Found 47 Enz. Inhib. hit(s) with all data for entry = 50017906
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50188272(7-((1H-imidazol-1-yl)methyl)-3-(thiophen-3-yl)-1,4...)
Affinity DataIC50:  103nMAssay Description:Inhibition of cKit by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50188266(7-((4-methylpiperazin-1-yl)methyl)-3-(thiophen-3-y...)
Affinity DataIC50:  145nMAssay Description:Inhibition of cKit by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 3(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50188272(7-((1H-imidazol-1-yl)methyl)-3-(thiophen-3-yl)-1,4...)
Affinity DataIC50:  169nMAssay Description:Inhibition of FLT4 by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50188266(7-((4-methylpiperazin-1-yl)methyl)-3-(thiophen-3-y...)
Affinity DataIC50:  180nMAssay Description:Inhibition of VEGF-induced human KDR phosphorylation transfected in NIH3T3 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50188272(7-((1H-imidazol-1-yl)methyl)-3-(thiophen-3-yl)-1,4...)
Affinity DataIC50:  293nMAssay Description:Inhibition of VEGF-induced human KDR phosphorylation transfected in NIH3T3 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50188283(6-((4-methylpiperazin-1-yl)methyl)-3-(thiophen-3-y...)
Affinity DataIC50:  400nMAssay Description:Inhibition of VEGF-induced human KDR phosphorylation transfected in NIH3T3 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50188281(4-(6-((4-methylpiperazin-1-yl)methyl)-1,4-dihydroi...)
Affinity DataIC50:  500nMAssay Description:Inhibition of VEGF-induced human KDR phosphorylation transfected in NIH3T3 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50188290(7-((4-methylpiperazin-1-yl)methyl)-3-phenyl-1,4-di...)
Affinity DataIC50:  600nMAssay Description:Inhibition of VEGF-induced human KDR phosphorylation transfected in NIH3T3 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50188272(7-((1H-imidazol-1-yl)methyl)-3-(thiophen-3-yl)-1,4...)
Affinity DataIC50:  601nMAssay Description:Inhibition of FLT1 by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50188275(6-((4-methylpiperazin-1-yl)methyl)-3-phenyl-1,4-di...)
Affinity DataIC50:  700nMAssay Description:Inhibition of VEGF-induced human KDR phosphorylation transfected in NIH3T3 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50188292(3-(thiophen-2-yl)-1,4-dihydroindeno[1,2-c]pyrazole...)
Affinity DataIC50:  930nMAssay Description:Inhibition of VEGF-induced human KDR phosphorylation transfected in NIH3T3 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50188266(7-((4-methylpiperazin-1-yl)methyl)-3-(thiophen-3-y...)
Affinity DataIC50:  970nMAssay Description:Inhibition of FLT1 by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50188271(6-((4-methylpiperazin-1-yl)methyl)-3-(thiophen-2-y...)
Affinity DataIC50:  1.05E+3nMAssay Description:Inhibition of VEGF-induced human KDR phosphorylation transfected in NIH3T3 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50188284(3-phenyl-1,4-dihydroindeno[1,2-c]pyrazole | CHEMBL...)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of VEGF-induced human KDR phosphorylation transfected in NIH3T3 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50188269(3-(4-((4-methylpiperazin-1-yl)methyl)phenyl)-1,4-d...)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of VEGF-induced human KDR phosphorylation transfected in NIH3T3 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 3(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50188266(7-((4-methylpiperazin-1-yl)methyl)-3-(thiophen-3-y...)
Affinity DataIC50:  1.57E+3nMAssay Description:Inhibition of FLT4 by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50188277(6-((4-methylpiperazin-1-yl)methyl)-3-(thiazol-5-yl...)
Affinity DataIC50:  2.84E+3nMAssay Description:Inhibition of VEGF-induced human KDR phosphorylation transfected in NIH3T3 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50188289(3-(3-((4-methylpiperazin-1-yl)methyl)phenyl)-1,4-d...)
Affinity DataIC50:  3.40E+3nMAssay Description:Inhibition of VEGF-induced human KDR phosphorylation transfected in NIH3T3 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50188273(6-((4-methylpiperazin-1-yl)methyl)-3-(5-methylthio...)
Affinity DataIC50:  5.47E+3nMAssay Description:Inhibition of VEGF-induced human KDR phosphorylation transfected in NIH3T3 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50188274(6-((4-methylpiperazin-1-yl)methyl)-3-(thiazol-4-yl...)
Affinity DataIC50:  7.48E+3nMAssay Description:Inhibition of VEGF-induced human KDR phosphorylation transfected in NIH3T3 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50188279(6-((4-methylpiperazin-1-yl)methyl)-3-(pyridin-3-yl...)
Affinity DataIC50:  9.20E+3nMAssay Description:Inhibition of VEGF-induced human KDR phosphorylation transfected in NIH3T3 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50188265(6-((4-methylpiperazin-1-yl)methyl)-3-(4-methylthio...)
Affinity DataIC50:  1.25E+4nMAssay Description:Inhibition of VEGF-induced human KDR phosphorylation transfected in NIH3T3 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50188268(5-((4-methylpiperazin-1-yl)methyl)-3-phenyl-1,4-di...)
Affinity DataIC50:  1.41E+4nMAssay Description:Inhibition of VEGF-induced human KDR phosphorylation transfected in NIH3T3 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50188287(6-((4-methylpiperazin-1-yl)methyl)-3-(thiazol-2-yl...)
Affinity DataIC50:  1.66E+4nMAssay Description:Inhibition of VEGF-induced human KDR phosphorylation transfected in NIH3T3 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50188272(7-((1H-imidazol-1-yl)methyl)-3-(thiophen-3-yl)-1,4...)
Affinity DataIC50:  1.76E+4nMAssay Description:Inhibition of Tie2 by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50188272(7-((1H-imidazol-1-yl)methyl)-3-(thiophen-3-yl)-1,4...)
Affinity DataIC50:  2.11E+4nMAssay Description:Inhibition of Lck by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1/2/3/4(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50188272(7-((1H-imidazol-1-yl)methyl)-3-(thiophen-3-yl)-1,4...)
Affinity DataIC50:  3.44E+4nMAssay Description:Inhibition of FGFR by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50188266(7-((4-methylpiperazin-1-yl)methyl)-3-(thiophen-3-y...)
Affinity DataIC50:  4.78E+4nMAssay Description:Inhibition of Tie2 by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50188272(7-((1H-imidazol-1-yl)methyl)-3-(thiophen-3-yl)-1,4...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of EGFR by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50188278(3-(benzo[b]thiophen-2-yl)-6-((4-methylpiperazin-1-...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of VEGF-induced human KDR phosphorylation transfected in NIH3T3 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50188266(7-((4-methylpiperazin-1-yl)methyl)-3-(thiophen-3-y...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of cMet by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50188272(7-((1H-imidazol-1-yl)methyl)-3-(thiophen-3-yl)-1,4...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of cMet by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50188266(7-((4-methylpiperazin-1-yl)methyl)-3-(thiophen-3-y...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of Lck by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50188291(6-((4-methylpiperazin-1-yl)methyl)-3-(3-methylthio...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of VEGF-induced human KDR phosphorylation transfected in NIH3T3 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50188272(7-((1H-imidazol-1-yl)methyl)-3-(thiophen-3-yl)-1,4...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of PDGFR by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50188266(7-((4-methylpiperazin-1-yl)methyl)-3-(thiophen-3-y...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of PDGFR by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1/2/3/4(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50188266(7-((4-methylpiperazin-1-yl)methyl)-3-(thiophen-3-y...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of FGFR by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50188266(7-((4-methylpiperazin-1-yl)methyl)-3-(thiophen-3-y...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of EGFR by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50188286(7-((1H-1,2,4-triazol-1-yl)methyl)-3-(thiophen-3-yl...)
Affinity DataIC50:  1.08E+5nMAssay Description:Inhibition of VEGF-induced human KDR phosphorylation transfected in NIH3T3 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50188276(7-(2-(4-methylpiperazin-1-yl)ethyl)-3-(thiophen-3-...)
Affinity DataIC50:  1.43E+5nMAssay Description:Inhibition of VEGF-induced human KDR phosphorylation transfected in NIH3T3 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50188272(7-((1H-imidazol-1-yl)methyl)-3-(thiophen-3-yl)-1,4...)
Affinity DataIC50:  1.47E+5nMAssay Description:Inhibition of KDR-mediated biotin-Ahx-AEEEYFFLFA-amide substrate phosphorylation in presence of 1 mM ATP by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50188285(7-((4-isopropylpiperazin-1-yl)methyl)-3-(thiophen-...)
Affinity DataIC50:  1.90E+5nMAssay Description:Inhibition of VEGF-induced human KDR phosphorylation transfected in NIH3T3 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50188282(7-((1H-1,2,3-triazol-1-yl)methyl)-3-(thiophen-3-yl...)
Affinity DataIC50:  1.90E+5nMAssay Description:Inhibition of VEGF-induced human KDR phosphorylation transfected in NIH3T3 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50188280(4-((3-(thiophen-3-yl)-1,4-dihydroindeno[1,2-c]pyra...)
Affinity DataIC50:  6.65E+5nMAssay Description:Inhibition of VEGF-induced human KDR phosphorylation transfected in NIH3T3 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50188270(CHEMBL213531 | N-ethyl-N-((3-(thiophen-3-yl)-1,4-d...)
Affinity DataIC50:  8.24E+5nMAssay Description:Inhibition of VEGF-induced human KDR phosphorylation transfected in NIH3T3 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50188288(6-(4-methylpiperazin-1-yl)-3-(thiophen-2-yl)-1,4-d...)
Affinity DataIC50:  1.01E+6nMAssay Description:Inhibition of VEGF-induced human KDR phosphorylation transfected in NIH3T3 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50188267((4-methylpiperazin-1-yl)(3-(thiophen-3-yl)-1,4-dih...)
Affinity DataIC50:  4.08E+6nMAssay Description:Inhibition of VEGF-induced human KDR phosphorylation transfected in NIH3T3 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed