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Found 33 Enz. Inhib. hit(s) with all data for entry = 50000157
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
National Institute Of Biological Sciences, Beijing

Curated by ChEMBL
LigandPNGBDBM50357312(IBRUTINIB | PCI-32765 | US10124003, Ref. Ex. Compo...)
Affinity DataIC50:  0.110nMAssay Description:The compound was tested for the inhibition of fibrinogen receptorMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
National Institute Of Biological Sciences, Beijing

Curated by ChEMBL
LigandPNGBDBM50357312(IBRUTINIB | PCI-32765 | US10124003, Ref. Ex. Compo...)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of ADP-induced platelet aggregation in human platelet-rich plasmaMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
National Institute Of Biological Sciences, Beijing

Curated by ChEMBL
LigandPNGBDBM50241719(CHEMBL4101977)
Affinity DataIC50:  1.90nMAssay Description:Inhibition of ADP-induced platelet aggregation in human platelet-rich plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Tec(Homo sapiens (Human))
National Institute Of Biological Sciences, Beijing

Curated by ChEMBL
LigandPNGBDBM50357312(IBRUTINIB | PCI-32765 | US10124003, Ref. Ex. Compo...)
Affinity DataIC50:  1.90nMAssay Description:Inhibition of human TEC using poly[Glu:Tyr] as substrate preincubated for 20 mins followed by [gamma-33P]-ATP addition by filter binding methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Tec(Homo sapiens (Human))
National Institute Of Biological Sciences, Beijing

Curated by ChEMBL
LigandPNGBDBM50357312(IBRUTINIB | PCI-32765 | US10124003, Ref. Ex. Compo...)
Affinity DataIC50:  7nMAssay Description:The compound was tested for the inhibition of fibrinogen receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
National Institute Of Biological Sciences, Beijing

Curated by ChEMBL
LigandPNGBDBM50241719(CHEMBL4101977)
Affinity DataIC50:  8nMAssay Description:Inhibition of ADP-induced platelet aggregation in human platelet-rich plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
National Institute Of Biological Sciences, Beijing

Curated by ChEMBL
LigandPNGBDBM50241732(CHEMBL4091764)
Affinity DataIC50:  18nMAssay Description:Inhibition of ADP-induced platelet aggregation in human platelet-rich plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
National Institute Of Biological Sciences, Beijing

Curated by ChEMBL
LigandPNGBDBM50241719(CHEMBL4101977)
Affinity DataIC50:  44nMAssay Description:Inhibition of ADP-induced platelet aggregation in human platelet-rich plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
National Institute Of Biological Sciences, Beijing

Curated by ChEMBL
LigandPNGBDBM50241731(CHEMBL4064000)
Affinity DataIC50:  77nMAssay Description:Inhibition of His-tagged full length recombinant human LCK expressed in baculovirus expression system using TK-substrate-biotin after 40 mins by HTRF...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
National Institute Of Biological Sciences, Beijing

Curated by ChEMBL
LigandPNGBDBM50241733(CHEMBL4073371)
Affinity DataIC50:  106nMAssay Description:Inhibition of His-tagged full length recombinant human LCK expressed in baculovirus expression system using TK-substrate-biotin after 40 mins by HTRF...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
National Institute Of Biological Sciences, Beijing

Curated by ChEMBL
LigandPNGBDBM50241730(CHEMBL4100228)
Affinity DataIC50:  137nMAssay Description:Inhibition of ADP-induced platelet aggregation in human platelet-rich plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
National Institute Of Biological Sciences, Beijing

Curated by ChEMBL
LigandPNGBDBM50241732(CHEMBL4091764)
Affinity DataIC50:  153nMAssay Description:The compound was tested for the inhibition of fibrinogen receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
National Institute Of Biological Sciences, Beijing

Curated by ChEMBL
LigandPNGBDBM50241733(CHEMBL4073371)
Affinity DataIC50:  271nMAssay Description:Inhibition of ADP-induced platelet aggregation in human platelet-rich plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Tec(Homo sapiens (Human))
National Institute Of Biological Sciences, Beijing

Curated by ChEMBL
LigandPNGBDBM50241719(CHEMBL4101977)
Affinity DataIC50:  306nMAssay Description:Inhibition of human TEC using poly[Glu:Tyr] as substrate preincubated for 20 mins followed by [gamma-33P]-ATP addition by filter binding methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
National Institute Of Biological Sciences, Beijing

Curated by ChEMBL
LigandPNGBDBM50241731(CHEMBL4064000)
Affinity DataIC50:  334nMAssay Description:The compound was tested for the inhibition of fibrinogen receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
National Institute Of Biological Sciences, Beijing

Curated by ChEMBL
LigandPNGBDBM50241729(CHEMBL4079354)
Affinity DataIC50:  337nMAssay Description:Inhibition of ADP-induced platelet aggregation in human platelet-rich plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
National Institute Of Biological Sciences, Beijing

Curated by ChEMBL
LigandPNGBDBM50241728(CHEMBL4103618)
Affinity DataIC50:  468nMAssay Description:Inhibition of His-tagged full length recombinant human LCK expressed in baculovirus expression system using TK-substrate-biotin after 40 mins by HTRF...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lyn(Homo sapiens (Human))
National Institute Of Biological Sciences, Beijing

Curated by ChEMBL
LigandPNGBDBM50241718(CHEMBL1354522)
Affinity DataIC50:  500nMAssay Description:Inhibition of recombinant human LYN using TK-substrate-biotin after 40 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
National Institute Of Biological Sciences, Beijing

Curated by ChEMBL
LigandPNGBDBM50241730(CHEMBL4100228)
Affinity DataIC50:  526nMAssay Description:Inhibition of Fibrinogen binding to Fibrinogen receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
National Institute Of Biological Sciences, Beijing

Curated by ChEMBL
LigandPNGBDBM50241718(CHEMBL1354522)
Affinity DataIC50:  531nMAssay Description:The compound was tested for the inhibition of fibrinogen receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Fyn(Homo sapiens (Human))
National Institute Of Biological Sciences, Beijing

Curated by ChEMBL
LigandPNGBDBM50241718(CHEMBL1354522)
Affinity DataIC50:  600nMAssay Description:The compound was tested for the inhibition of fibrinogen receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
National Institute Of Biological Sciences, Beijing

Curated by ChEMBL
LigandPNGBDBM50241718(CHEMBL1354522)
Affinity DataIC50:  1.09E+3nMAssay Description:Inhibition of ADP-induced platelet aggregation in human platelet-rich plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
National Institute Of Biological Sciences, Beijing

Curated by ChEMBL
LigandPNGBDBM50241729(CHEMBL4079354)
Affinity DataIC50:  1.21E+3nMAssay Description:The compound was tested for the inhibition of fibrinogen receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
National Institute Of Biological Sciences, Beijing

Curated by ChEMBL
LigandPNGBDBM50241728(CHEMBL4103618)
Affinity DataIC50:  1.38E+3nMAssay Description:The compound was tested for the inhibition of fibrinogen receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
National Institute Of Biological Sciences, Beijing

Curated by ChEMBL
LigandPNGBDBM50241730(CHEMBL4100228)
Affinity DataIC50:  8.82E+3nMAssay Description:Inhibition of ADP-induced platelet aggregation in human platelet-rich plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
National Institute Of Biological Sciences, Beijing

Curated by ChEMBL
LigandPNGBDBM50241729(CHEMBL4079354)
Affinity DataIC50:  9.22E+3nMAssay Description:The compound was tested for the inhibition of fibrinogen receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
National Institute Of Biological Sciences, Beijing

Curated by ChEMBL
LigandPNGBDBM50241718(CHEMBL1354522)
Affinity DataIC50:  1.44E+4nMAssay Description:The compound was tested for the inhibition of fibrinogen receptorMore data for this Ligand-Target Pair
TargetCytoplasmic tyrosine-protein kinase BMX(Homo sapiens (Human))
National Institute Of Biological Sciences, Beijing

Curated by ChEMBL
LigandPNGBDBM50241718(CHEMBL1354522)
Affinity DataIC50:  1.83E+4nMAssay Description:Inhibition of His-tagged full length recombinant human BMX expressed in baculovirus expression system using TK-substrate-biotin after 40 mins by HTRF...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
National Institute Of Biological Sciences, Beijing

Curated by ChEMBL
LigandPNGBDBM50241719(CHEMBL4101977)
Affinity DataIC50:  2.05E+4nMAssay Description:The compound was tested for the inhibition of fibrinogen receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
National Institute Of Biological Sciences, Beijing

Curated by ChEMBL
LigandPNGBDBM50241728(CHEMBL4103618)
Affinity DataIC50:  2.71E+4nMAssay Description:Inhibition of ADP-induced platelet aggregation in human platelet-rich plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
National Institute Of Biological Sciences, Beijing

Curated by ChEMBL
LigandPNGBDBM50241731(CHEMBL4064000)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of ADP-induced platelet aggregation in human platelet-rich plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
National Institute Of Biological Sciences, Beijing

Curated by ChEMBL
LigandPNGBDBM50241733(CHEMBL4073371)
Affinity DataIC50: >5.00E+4nMAssay Description:The compound was tested for the inhibition of fibrinogen receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
National Institute Of Biological Sciences, Beijing

Curated by ChEMBL
LigandPNGBDBM50241732(CHEMBL4091764)
Affinity DataIC50: >1.00E+5nMAssay Description:The compound was tested for the inhibition of fibrinogen receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed