Compile Data Set for Download or QSAR
maximum 50k data
Found 28 Enz. Inhib. hit(s) with all data for entry = 50036699
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50454822(CHEMBL2062141 | L-370518)
Affinity DataKi:  0.0900nMAssay Description:Binding affinity towards thrombin was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50057828((S)-1-((R)-2-Amino-3,3-diphenyl-propionyl)-pyrroli...)
Affinity DataKi:  0.100nMAssay Description:Binding affinity towards thrombin was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50164268((S)-1-(9-Hydroxy-9H-fluorene-9-carbonyl)-pyrrolidi...)
Affinity DataKi:  1.5nMAssay Description:Binding affinity towards thrombin was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50062634((S)-1-[3-(4-Hydroxy-phenyl)-2-phenyl-propionyl]-py...)
Affinity DataKi:  2.5nMAssay Description:Binding affinity towards thrombin was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50062623((S)-1-[2-Hydroxy-2-(4-hydroxy-3-methoxy-phenyl)-ac...)
Affinity DataKi:  2.5nMAssay Description:Binding affinity towards thrombin was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50062628((S)-1-((S)-2-Amino-2-cyclohexyl-acetyl)-pyrrolidin...)
Affinity DataKi:  3nMAssay Description:Binding affinity towards thrombin was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50366827(CHEMBL125181 | L-371912)
Affinity DataKi:  4.90nMAssay Description:Binding affinity towards thrombin was determinedMore data for this Ligand-Target Pair
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50062624((S)-1-(2,3-Dihydro-benzo[1,4]dioxine-2-carbonyl)-p...)
Affinity DataKi:  75nMAssay Description:Binding affinity towards thrombin was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50164268((S)-1-(9-Hydroxy-9H-fluorene-9-carbonyl)-pyrrolidi...)
Affinity DataKi:  860nMAssay Description:Binding affinity towards trypsin was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50062628((S)-1-((S)-2-Amino-2-cyclohexyl-acetyl)-pyrrolidin...)
Affinity DataIC50:  3nMAssay Description:Inhibition of thrombin-catalyzed hydrolysis of a standard substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50164268((S)-1-(9-Hydroxy-9H-fluorene-9-carbonyl)-pyrrolidi...)
Affinity DataIC50:  4nMAssay Description:Inhibition of thrombin-catalyzed hydrolysis of a standard substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50062631((S)-1-(3-Phenyl-heptanoyl)-pyrrolidine-2-carboxyli...)
Affinity DataIC50:  5nMAssay Description:Inhibition of thrombin-catalyzed hydrolysis of a standard substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50366827(CHEMBL125181 | L-371912)
Affinity DataIC50:  6nMAssay Description:Inhibition of thrombin-catalyzed hydrolysis of a standard substrateMore data for this Ligand-Target Pair
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50062634((S)-1-[3-(4-Hydroxy-phenyl)-2-phenyl-propionyl]-py...)
Affinity DataIC50:  10nMAssay Description:Inhibition of thrombin-catalyzed hydrolysis of a standard substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50062623((S)-1-[2-Hydroxy-2-(4-hydroxy-3-methoxy-phenyl)-ac...)
Affinity DataIC50:  11nMAssay Description:Inhibition of thrombin-catalyzed hydrolysis of a standard substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50062637((S)-1-[2-(3,4,5-Trimethoxy-phenyl)-acetyl]-pyrroli...)
Affinity DataIC50:  50nMAssay Description:Inhibition of thrombin-catalyzed hydrolysis of a standard substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50062620((S)-1-(2,3-Diphenyl-propionyl)-pyrrolidine-2-carbo...)
Affinity DataIC50:  57nMAssay Description:Inhibition of thrombin-catalyzed hydrolysis of a standard substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50062636((S)-1-((2R,3S)-1-Methyl-5-oxo-3-pyridin-3-yl-pyrro...)
Affinity DataIC50:  60nMAssay Description:Inhibition of thrombin-catalyzed hydrolysis of a standard substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50062625((S)-1-(3-Oxo-1,2,3,5,6,10b-hexahydro-pyrrolo[2,1-a...)
Affinity DataIC50:  90nMAssay Description:Inhibition of thrombin-catalyzed hydrolysis of a standard substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50062624((S)-1-(2,3-Dihydro-benzo[1,4]dioxine-2-carbonyl)-p...)
Affinity DataIC50:  100nMAssay Description:Inhibition of thrombin-catalyzed hydrolysis of a standard substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50062629((S)-1-(2-9H-Fluoren-9-yl-acetyl)-pyrrolidine-2-car...)
Affinity DataIC50:  106nMAssay Description:Inhibition of thrombin-catalyzed hydrolysis of a standard substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50062635((S)-1-(Adamantane-1-carbonyl)-pyrrolidine-2-carbox...)
Affinity DataIC50:  120nMAssay Description:Inhibition of thrombin-catalyzed hydrolysis of a standard substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50062630((S)-1-((E)-2-Cyano-3-phenyl-acryloyl)-pyrrolidine-...)
Affinity DataIC50:  140nMAssay Description:Inhibition of thrombin-catalyzed hydrolysis of a standard substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50062622((S)-1-(2,2-Diphenyl-cyclopropanecarbonyl)-pyrrolid...)
Affinity DataIC50:  190nMAssay Description:Inhibition of thrombin-catalyzed hydrolysis of a standard substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50062627((S)-1-[3-(2-Methoxy-phenyl)-propionyl]-pyrrolidine...)
Affinity DataIC50:  230nMAssay Description:Inhibition of thrombin-catalyzed hydrolysis of a standard substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50062638((S)-1-(Bicyclo[4.2.0]octa-1,3,5-triene-7-carbonyl)...)
Affinity DataIC50:  230nMAssay Description:Inhibition of thrombin-catalyzed hydrolysis of a standard substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50062626((S)-1-(9H-Fluorene-9-carbonyl)-pyrrolidine-2-carbo...)
Affinity DataIC50:  380nMAssay Description:Inhibition of thrombin-catalyzed hydrolysis of a standard substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50062633((S)-1-(1,2,3,4-Tetrahydro-naphthalene-2-carbonyl)-...)
Affinity DataIC50:  910nMAssay Description:Inhibition of thrombin-catalyzed hydrolysis of a standard substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed