Compile Data Set for Download or QSAR
maximum 50k data
Found 26 Enz. Inhib. hit(s) with all data for entry = 50002551
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Albany College of Pharmacy and Health Sciences

Curated by ChEMBL
LigandPNGBDBM50149871((R)-2-((3-(biphenyl-4-yloxy)-3-(4-fluorophenyl)pro...)
Affinity DataIC50:  3nMAssay Description:Inhibition of human GlyT-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 2(Homo sapiens (Human))
Albany College of Pharmacy and Health Sciences

Curated by ChEMBL
LigandPNGBDBM50102692(4-Benzyloxy-N-(1-dimethylamino-cyclopentylmethyl)-...)
Affinity DataIC50:  16nMAssay Description:Inhibition of human GlyT-2 expressed in CHO cells assessed as reduction in [3H]-glycine uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 2(Homo sapiens (Human))
Albany College of Pharmacy and Health Sciences

Curated by ChEMBL
LigandPNGBDBM50256745((2S)-2-amino-3-((2-(benzyloxy)phenyl)(3-fluorophen...)
Affinity DataIC50:  100nMAssay Description:Inhibition of human GlyT-2 expressed in HEK293 cells assessed as reduction in [3H]-glycine uptake preincubated for 30 mins followed by 3H]-glycine ad...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Albany College of Pharmacy and Health Sciences

Curated by ChEMBL
LigandPNGBDBM50459962(Org 25935 | Org-25935 | SCH-900435 | Sch 900435)
Affinity DataIC50:  100nMAssay Description:Inhibition of human GlyT-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 2(Homo sapiens (Human))
Albany College of Pharmacy and Health Sciences

Curated by ChEMBL
LigandPNGBDBM50023924(CHEMBL3325507)
Affinity DataIC50:  105nMAssay Description:Inhibition of human GlyT-2 expressed in HEK293 cells assessed as reduction in [3H]-glycine uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 2(Homo sapiens (Human))
Albany College of Pharmacy and Health Sciences

Curated by ChEMBL
LigandPNGBDBM50459963(CHEMBL4228903)
Affinity DataIC50:  860nMAssay Description:Inhibition of human GlyT-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Albany College of Pharmacy and Health Sciences

Curated by ChEMBL
LigandPNGBDBM50459963(CHEMBL4228903)
Affinity DataIC50:  1.30E+3nMAssay Description:Antagonist activity at human 5-HT2AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 2(Homo sapiens (Human))
Albany College of Pharmacy and Health Sciences

Curated by ChEMBL
LigandPNGBDBM50056486(((5Z,8Z)-Icosa-5,8,11,14-tetraenoylamino)-acetic a...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of GlyT-2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Albany College of Pharmacy and Health Sciences

Curated by ChEMBL
LigandPNGBDBM50256745((2S)-2-amino-3-((2-(benzyloxy)phenyl)(3-fluorophen...)
Affinity DataIC50:  4.00E+3nMAssay Description:Inhibition of human GlyT-1 expressed in HEK293 cells assessed as reduction in [3H]-glycine uptake preincubated for 30 mins followed by 3H]-glycine ad...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Albany College of Pharmacy and Health Sciences

Curated by ChEMBL
LigandPNGBDBM50017225((methylamino)acetic acid | (methylamino)ethanoic a...)
Affinity DataIC50:  9.10E+4nMAssay Description:Inhibition of human GlyT-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Albany College of Pharmacy and Health Sciences

Curated by ChEMBL
LigandPNGBDBM50102692(4-Benzyloxy-N-(1-dimethylamino-cyclopentylmethyl)-...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human GlyT-1 expressed in CHO cells assessed as reduction in [3H]-glycine uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycine receptor subunit alpha-1(Homo sapiens (Human))
Albany College of Pharmacy and Health Sciences

Curated by ChEMBL
LigandPNGBDBM50459970(CHEMBL4227297)
Affinity DataEC50:  0.430nMAssay Description:Positive allosteric modulation of GlyRalpha1 (unknown origin) assessed as potentiation of glycine-induced responseMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlycine receptor subunit alpha-1(Homo sapiens (Human))
Albany College of Pharmacy and Health Sciences

Curated by ChEMBL
LigandPNGBDBM50229711(CHEMBL4074873)
Affinity DataEC50:  327nMAssay Description:Positive allosteric modulation of human GlyRalpha1 expressed in HEK293 cells assessed as potentiation of glycine-induced calcium flux by calcium dye-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycine receptor subunit alpha-1(Homo sapiens (Human))
Albany College of Pharmacy and Health Sciences

Curated by ChEMBL
LigandPNGBDBM50459971(CHEMBL4227144)
Affinity DataEC50:  0.000160nMAssay Description:Positive allosteric modulation of GlyRalpha1 (unknown origin) assessed as potentiation of glycine-induced responseMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlycine receptor subunit beta(Homo sapiens (Human))
Albany College of Pharmacy and Health Sciences

Curated by ChEMBL
LigandPNGBDBM50459969(CHEMBL4228024)
Affinity DataEC50:  3.98E+3nMAssay Description:Positive allosteric modulation of human GlyRalpha3beta expressed in CHO cells assessed as potentiation of EC20 glycine-induced ion flux by HT assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycine receptor subunit alpha-3(Homo sapiens (Human))
Albany College of Pharmacy and Health Sciences

Curated by ChEMBL
LigandPNGBDBM50229711(CHEMBL4074873)
Affinity DataEC50:  454nMAssay Description:Positive allosteric modulation of human GlyRalpha3 expressed in HEK293 cells assessed as potentiation of glycine-induced calcium flux by calcium dye-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycine receptor subunit alpha-1(Homo sapiens (Human))
Albany College of Pharmacy and Health Sciences

Curated by ChEMBL
LigandPNGBDBM50459968(CHEMBL4228372)
Affinity DataEC50:  0.0600nMAssay Description:Positive allosteric modulation of GlyRalpha1 (unknown origin) assessed as potentiation of glycine-induced responseMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlycine receptor subunit beta(Homo sapiens (Human))
Albany College of Pharmacy and Health Sciences

Curated by ChEMBL
LigandPNGBDBM50459967(CHEMBL4225948)
Affinity DataEC50:  1.02E+4nMAssay Description:Positive allosteric modulation of human GlyRalpha3beta expressed in CHO cells assessed as potentiation of EC20 glycine-induced ion flux by HT assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlycine receptor subunit alpha-1(Homo sapiens (Human))
Albany College of Pharmacy and Health Sciences

Curated by ChEMBL
LigandPNGBDBM199088(US9676786, example 6)
Affinity DataEC50:  0.00120nMAssay Description:Positive allosteric modulation of GlyRalpha1 (unknown origin) assessed as potentiation of glycine-induced responseMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlycine receptor subunit alpha-3(Homo sapiens (Human))
Albany College of Pharmacy and Health Sciences

Curated by ChEMBL
LigandPNGBDBM50459966(CHEMBL4226572)
Affinity DataEC50:  8.50E+3nMAssay Description:Positive allosteric modulation of human GlyRalpha3 expressed in HEK293 cells assessed as potentiation of glycine-induced current flux by electrophysi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlycine receptor subunit beta(Homo sapiens (Human))
Albany College of Pharmacy and Health Sciences

Curated by ChEMBL
LigandPNGBDBM50459965(CHEMBL4227048)
Affinity DataEC50:  661nMAssay Description:Positive allosteric modulation of human GlyRalpha3beta expressed in CHO cells assessed as potentiation of EC20 glycine-induced ion flux by HT assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlycine receptor subunit alpha-3(Mus musculus)
Albany College of Pharmacy and Health Sciences

Curated by ChEMBL
LigandPNGBDBM50229711(CHEMBL4074873)
Affinity DataEC50:  490nMAssay Description:Positive allosteric modulation of mouse GlyRalpha3 expressed in HEK293 cells assessed as potentiation of glycine-induced calcium flux by calcium dye-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycine receptor subunit alpha-1(Mus musculus)
Albany College of Pharmacy and Health Sciences

Curated by ChEMBL
LigandPNGBDBM50229711(CHEMBL4074873)
Affinity DataEC50:  268nMAssay Description:Positive allosteric modulation of mouse GlyRalpha1 expressed in HEK293 cells assessed as potentiation of glycine-induced calcium flux by calcium dye-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycine receptor subunit beta(Homo sapiens (Human))
Albany College of Pharmacy and Health Sciences

Curated by ChEMBL
LigandPNGBDBM50229711(CHEMBL4074873)
Affinity DataEC50:  330nMAssay Description:Positive allosteric modulation of human GlyRalpha3beta expressed in HEK293 cells assessed as potentiation of glycine-induced calcium flux by calcium ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycine receptor subunit alpha-1/beta(Homo sapiens (Human))
Albany College of Pharmacy and Health Sciences

Curated by ChEMBL
LigandPNGBDBM50229711(CHEMBL4074873)
Affinity DataEC50:  171nMAssay Description:Positive allosteric modulation of human GlyRalpha1beta expressed in HEK293 cells assessed as potentiation of glycine-induced calcium flux by calcium ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycine receptor subunit beta(Homo sapiens (Human))
Albany College of Pharmacy and Health Sciences

Curated by ChEMBL
LigandPNGBDBM50459964(CHEMBL4227298)
Affinity DataEC50:  13nMAssay Description:Positive allosteric modulation of human GlyRalpha3beta expressed in CHO cells assessed as potentiation of EC20 glycine-induced ion flux by HT assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed