TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Albany College of Pharmacy and Health Sciences
Curated by ChEMBL
Albany College of Pharmacy and Health Sciences
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Inhibition of human GlyT-1More data for this Ligand-Target Pair
TargetSodium- and chloride-dependent glycine transporter 2(Homo sapiens (Human))
Albany College of Pharmacy and Health Sciences
Curated by ChEMBL
Albany College of Pharmacy and Health Sciences
Curated by ChEMBL
Affinity DataIC50: 16nMAssay Description:Inhibition of human GlyT-2 expressed in CHO cells assessed as reduction in [3H]-glycine uptakeMore data for this Ligand-Target Pair
TargetSodium- and chloride-dependent glycine transporter 2(Homo sapiens (Human))
Albany College of Pharmacy and Health Sciences
Curated by ChEMBL
Albany College of Pharmacy and Health Sciences
Curated by ChEMBL
Affinity DataIC50: 100nMAssay Description:Inhibition of human GlyT-2 expressed in HEK293 cells assessed as reduction in [3H]-glycine uptake preincubated for 30 mins followed by 3H]-glycine ad...More data for this Ligand-Target Pair
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Albany College of Pharmacy and Health Sciences
Curated by ChEMBL
Albany College of Pharmacy and Health Sciences
Curated by ChEMBL
Affinity DataIC50: 100nMAssay Description:Inhibition of human GlyT-1More data for this Ligand-Target Pair
TargetSodium- and chloride-dependent glycine transporter 2(Homo sapiens (Human))
Albany College of Pharmacy and Health Sciences
Curated by ChEMBL
Albany College of Pharmacy and Health Sciences
Curated by ChEMBL
Affinity DataIC50: 105nMAssay Description:Inhibition of human GlyT-2 expressed in HEK293 cells assessed as reduction in [3H]-glycine uptakeMore data for this Ligand-Target Pair
TargetSodium- and chloride-dependent glycine transporter 2(Homo sapiens (Human))
Albany College of Pharmacy and Health Sciences
Curated by ChEMBL
Albany College of Pharmacy and Health Sciences
Curated by ChEMBL
Affinity DataIC50: 860nMAssay Description:Inhibition of human GlyT-2More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Albany College of Pharmacy and Health Sciences
Curated by ChEMBL
Albany College of Pharmacy and Health Sciences
Curated by ChEMBL
Affinity DataIC50: 1.30E+3nMAssay Description:Antagonist activity at human 5-HT2AMore data for this Ligand-Target Pair
TargetSodium- and chloride-dependent glycine transporter 2(Homo sapiens (Human))
Albany College of Pharmacy and Health Sciences
Curated by ChEMBL
Albany College of Pharmacy and Health Sciences
Curated by ChEMBL
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of GlyT-2 (unknown origin)More data for this Ligand-Target Pair
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Albany College of Pharmacy and Health Sciences
Curated by ChEMBL
Albany College of Pharmacy and Health Sciences
Curated by ChEMBL
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of human GlyT-1 expressed in HEK293 cells assessed as reduction in [3H]-glycine uptake preincubated for 30 mins followed by 3H]-glycine ad...More data for this Ligand-Target Pair
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Albany College of Pharmacy and Health Sciences
Curated by ChEMBL
Albany College of Pharmacy and Health Sciences
Curated by ChEMBL
Affinity DataIC50: 9.10E+4nMAssay Description:Inhibition of human GlyT-1More data for this Ligand-Target Pair
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Albany College of Pharmacy and Health Sciences
Curated by ChEMBL
Albany College of Pharmacy and Health Sciences
Curated by ChEMBL
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human GlyT-1 expressed in CHO cells assessed as reduction in [3H]-glycine uptakeMore data for this Ligand-Target Pair
TargetGlycine receptor subunit alpha-1(Homo sapiens (Human))
Albany College of Pharmacy and Health Sciences
Curated by ChEMBL
Albany College of Pharmacy and Health Sciences
Curated by ChEMBL
Affinity DataEC50: 0.430nMAssay Description:Positive allosteric modulation of GlyRalpha1 (unknown origin) assessed as potentiation of glycine-induced responseMore data for this Ligand-Target Pair
TargetGlycine receptor subunit alpha-1(Homo sapiens (Human))
Albany College of Pharmacy and Health Sciences
Curated by ChEMBL
Albany College of Pharmacy and Health Sciences
Curated by ChEMBL
Affinity DataEC50: 327nMAssay Description:Positive allosteric modulation of human GlyRalpha1 expressed in HEK293 cells assessed as potentiation of glycine-induced calcium flux by calcium dye-...More data for this Ligand-Target Pair
TargetGlycine receptor subunit alpha-1(Homo sapiens (Human))
Albany College of Pharmacy and Health Sciences
Curated by ChEMBL
Albany College of Pharmacy and Health Sciences
Curated by ChEMBL
Affinity DataEC50: 0.000160nMAssay Description:Positive allosteric modulation of GlyRalpha1 (unknown origin) assessed as potentiation of glycine-induced responseMore data for this Ligand-Target Pair
TargetGlycine receptor subunit beta(Homo sapiens (Human))
Albany College of Pharmacy and Health Sciences
Curated by ChEMBL
Albany College of Pharmacy and Health Sciences
Curated by ChEMBL
Affinity DataEC50: 3.98E+3nMAssay Description:Positive allosteric modulation of human GlyRalpha3beta expressed in CHO cells assessed as potentiation of EC20 glycine-induced ion flux by HT assayMore data for this Ligand-Target Pair
TargetGlycine receptor subunit alpha-3(Homo sapiens (Human))
Albany College of Pharmacy and Health Sciences
Curated by ChEMBL
Albany College of Pharmacy and Health Sciences
Curated by ChEMBL
Affinity DataEC50: 454nMAssay Description:Positive allosteric modulation of human GlyRalpha3 expressed in HEK293 cells assessed as potentiation of glycine-induced calcium flux by calcium dye-...More data for this Ligand-Target Pair
TargetGlycine receptor subunit alpha-1(Homo sapiens (Human))
Albany College of Pharmacy and Health Sciences
Curated by ChEMBL
Albany College of Pharmacy and Health Sciences
Curated by ChEMBL
Affinity DataEC50: 0.0600nMAssay Description:Positive allosteric modulation of GlyRalpha1 (unknown origin) assessed as potentiation of glycine-induced responseMore data for this Ligand-Target Pair
TargetGlycine receptor subunit beta(Homo sapiens (Human))
Albany College of Pharmacy and Health Sciences
Curated by ChEMBL
Albany College of Pharmacy and Health Sciences
Curated by ChEMBL
Affinity DataEC50: 1.02E+4nMAssay Description:Positive allosteric modulation of human GlyRalpha3beta expressed in CHO cells assessed as potentiation of EC20 glycine-induced ion flux by HT assayMore data for this Ligand-Target Pair
TargetGlycine receptor subunit alpha-1(Homo sapiens (Human))
Albany College of Pharmacy and Health Sciences
Curated by ChEMBL
Albany College of Pharmacy and Health Sciences
Curated by ChEMBL
Affinity DataEC50: 0.00120nMAssay Description:Positive allosteric modulation of GlyRalpha1 (unknown origin) assessed as potentiation of glycine-induced responseMore data for this Ligand-Target Pair
TargetGlycine receptor subunit alpha-3(Homo sapiens (Human))
Albany College of Pharmacy and Health Sciences
Curated by ChEMBL
Albany College of Pharmacy and Health Sciences
Curated by ChEMBL
Affinity DataEC50: 8.50E+3nMAssay Description:Positive allosteric modulation of human GlyRalpha3 expressed in HEK293 cells assessed as potentiation of glycine-induced current flux by electrophysi...More data for this Ligand-Target Pair
TargetGlycine receptor subunit beta(Homo sapiens (Human))
Albany College of Pharmacy and Health Sciences
Curated by ChEMBL
Albany College of Pharmacy and Health Sciences
Curated by ChEMBL
Affinity DataEC50: 661nMAssay Description:Positive allosteric modulation of human GlyRalpha3beta expressed in CHO cells assessed as potentiation of EC20 glycine-induced ion flux by HT assayMore data for this Ligand-Target Pair
TargetGlycine receptor subunit alpha-3(Mus musculus)
Albany College of Pharmacy and Health Sciences
Curated by ChEMBL
Albany College of Pharmacy and Health Sciences
Curated by ChEMBL
Affinity DataEC50: 490nMAssay Description:Positive allosteric modulation of mouse GlyRalpha3 expressed in HEK293 cells assessed as potentiation of glycine-induced calcium flux by calcium dye-...More data for this Ligand-Target Pair
TargetGlycine receptor subunit alpha-1(Mus musculus)
Albany College of Pharmacy and Health Sciences
Curated by ChEMBL
Albany College of Pharmacy and Health Sciences
Curated by ChEMBL
Affinity DataEC50: 268nMAssay Description:Positive allosteric modulation of mouse GlyRalpha1 expressed in HEK293 cells assessed as potentiation of glycine-induced calcium flux by calcium dye-...More data for this Ligand-Target Pair
TargetGlycine receptor subunit beta(Homo sapiens (Human))
Albany College of Pharmacy and Health Sciences
Curated by ChEMBL
Albany College of Pharmacy and Health Sciences
Curated by ChEMBL
Affinity DataEC50: 330nMAssay Description:Positive allosteric modulation of human GlyRalpha3beta expressed in HEK293 cells assessed as potentiation of glycine-induced calcium flux by calcium ...More data for this Ligand-Target Pair
TargetGlycine receptor subunit alpha-1/beta(Homo sapiens (Human))
Albany College of Pharmacy and Health Sciences
Curated by ChEMBL
Albany College of Pharmacy and Health Sciences
Curated by ChEMBL
Affinity DataEC50: 171nMAssay Description:Positive allosteric modulation of human GlyRalpha1beta expressed in HEK293 cells assessed as potentiation of glycine-induced calcium flux by calcium ...More data for this Ligand-Target Pair
TargetGlycine receptor subunit beta(Homo sapiens (Human))
Albany College of Pharmacy and Health Sciences
Curated by ChEMBL
Albany College of Pharmacy and Health Sciences
Curated by ChEMBL
Affinity DataEC50: 13nMAssay Description:Positive allosteric modulation of human GlyRalpha3beta expressed in CHO cells assessed as potentiation of EC20 glycine-induced ion flux by HT assayMore data for this Ligand-Target Pair