Compile Data Set for Download or QSAR
maximum 50k data
Found 26 Enz. Inhib. hit(s) with all data for entry = 50011293
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Jinan University

Curated by ChEMBL
LigandPNGBDBM50322535(3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N...)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of wild type human ABL Y253F mutant using [EAIYAAPFAKKK] as substrate in presence of gamma33P-ATP by radiometric HotSpot assayMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Jinan University

Curated by ChEMBL
LigandPNGBDBM50322535(3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N...)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of wild type human ABL M351T mutant using [EAIYAAPFAKKK] as substrate in presence of gamma33P-ATP by radiometric HotSpot assayMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Jinan University

Curated by ChEMBL
LigandPNGBDBM50322535(3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N...)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of wild type human ABL Q252H mutant using [EAIYAAPFAKKK] as substrate in presence of gamma33P-ATP by radiometric HotSpot assayMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Jinan University

Curated by ChEMBL
LigandPNGBDBM50322535(3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N...)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of wild type human ABL H396P mutant using [EAIYAAPFAKKK] as substrate in presence of gamma33P-ATP by radiometric HotSpot assayMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Jinan University

Curated by ChEMBL
LigandPNGBDBM50322535(3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N...)
Affinity DataIC50:  0.370nMAssay Description:Inhibition of wild type human ABL using [EAIYAAPFAKKK] as substrate in presence of gamma33P-ATP by radiometric HotSpot assayMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Jinan University

Curated by ChEMBL
LigandPNGBDBM499811(US11020398, Compound I-123 | US20230364079, Exampl...)
Affinity DataIC50:  0.390nMAssay Description:Inhibition of wild type human BTK C481S mutant using poly[Glu:Tyr] (4:1) as substrate in presence of [gamma33P]ATP by radiometric assayMore data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Jinan University

Curated by ChEMBL
LigandPNGBDBM50546203(CHEMBL4761560)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of N-terminal His6-tagged TRKA (unknown origin) (486 to 786 residues) expressed in Escherichia coli using poly-EAY substrate incubated for...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Jinan University

Curated by ChEMBL
LigandPNGBDBM499811(US11020398, Compound I-123 | US20230364079, Exampl...)
Affinity DataIC50:  0.850nMAssay Description:Inhibition of wild type human BTK using poly[Glu:Tyr] (4:1) as substrate in presence of [gamma33P]ATP by radiometric assayMore data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Jinan University

Curated by ChEMBL
LigandPNGBDBM50546202(CHEMBL3892335)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of N-terminal His6-tagged TRKA (unknown origin) (486 to 786 residues) expressed in Escherichia coli using poly-EAY substrate incubated for...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Jinan University

Curated by ChEMBL
LigandPNGBDBM50185140(AP-26113 | Brigatinib | US11248003, Example Brigat...)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of human ALK L1196M mutant using poly[Glu:Tyr] (4:1) as substrate in presence of [gamma-33P]-ATP assay by radiometric HotSpot assayMore data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Jinan University

Curated by ChEMBL
LigandPNGBDBM50546203(CHEMBL4761560)
Affinity DataIC50:  2nMAssay Description:Inhibition of N-terminal His6-tagged TRKA G595R mutant (unknown origin) (486 to 786 residues) expressed in Escherichia coli using poly-EAY substrate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Jinan University

Curated by ChEMBL
LigandPNGBDBM50322535(3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N...)
Affinity DataIC50:  2nMAssay Description:Inhibition of wild type human ABL T315I mutant using [EAIYAAPFAKKK] as substrate in presence of gamma33P-ATP by radiometric HotSpot assayMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Jinan University

Curated by ChEMBL
LigandPNGBDBM50357312(IBRUTINIB | PCI-32765 | US10124003, Ref. Ex. Compo...)
Affinity DataIC50:  2.20nMAssay Description:Inhibition of wild type BTK (unknown origin)More data for this Ligand-Target Pair
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Jinan University

Curated by ChEMBL
LigandPNGBDBM50546200(BIIB-062 | BSK-4841 | FP-0182 | FP0182 | Sns-062 |...)
Affinity DataIC50:  2.90nMAssay Description:Inhibition of wild type BTK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Jinan University

Curated by ChEMBL
LigandPNGBDBM50546200(BIIB-062 | BSK-4841 | FP-0182 | FP0182 | Sns-062 |...)
Affinity DataIC50:  4.5nMAssay Description:Inhibition of BTK C481S (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Jinan University

Curated by ChEMBL
LigandPNGBDBM50185140(AP-26113 | Brigatinib | US11248003, Example Brigat...)
Affinity DataIC50:  4.90nMAssay Description:Inhibition of human ALK G1202R mutant using poly[Glu:Tyr] (4:1) as substrate in presence of [gamma-33P]-ATP assay by radiometric HotSpot assayMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Jinan University

Curated by ChEMBL
LigandPNGBDBM50546201(CHEMBL4754443)
Affinity DataIC50:  5.10nMAssay Description:Inhibition of BTK (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Jinan University

Curated by ChEMBL
LigandPNGBDBM50546203(CHEMBL4761560)
Affinity DataIC50:  9.80nMAssay Description:Inhibition of N-terminal His6-tagged TRKA G667C mutant (unknown origin) (486 to 786 residues) expressed in Escherichia coli using poly-EAY substrate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Jinan University

Curated by ChEMBL
LigandPNGBDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
Affinity DataIC50:  28nMAssay Description:Inhibition of EGFR L858R/T790M/C797S mutant (unknown origin)More data for this Ligand-Target Pair
LigandPNGBDBM50185140(AP-26113 | Brigatinib | US11248003, Example Brigat...)
Affinity DataIC50:  41nMAssay Description:Inhibition of EML4/ALK L1196M mutant (unknown origin) expressed in mouse Ba/F3 cells assessed as antiproliferative activity after 72 hrs by CellTiter...More data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Jinan University

Curated by ChEMBL
LigandPNGBDBM50546202(CHEMBL3892335)
Affinity DataIC50:  46nMAssay Description:Inhibition of N-terminal His6-tagged TRKA G667C mutant (unknown origin) (486 to 786 residues) expressed in Escherichia coli using poly-EAY substrate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM374727((7S,13R)-11-fluoro-7,13-dimethyl-6,7,13,14- tetrah...)
Affinity DataIC50:  64nMAssay Description:Inhibition of EML4/ALK G1202R mutant (unknown origin) expressed in mouse Ba/F3 cells assessed as antiproliferative activity after 72 hrs by Cell Tite...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Jinan University

Curated by ChEMBL
LigandPNGBDBM50546202(CHEMBL3892335)
Affinity DataIC50:  69nMAssay Description:Inhibition of N-terminal His6-tagged TRKA G595R mutant (unknown origin) (486 to 786 residues) expressed in Escherichia coli using poly-EAY substrate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50185140(AP-26113 | Brigatinib | US11248003, Example Brigat...)
Affinity DataIC50:  184nMAssay Description:Inhibition of EML4/ALK G1202R mutant (unknown origin) expressed in mouse Ba/F3 cells assessed as antiproliferative activity after 72 hrs by CellTiter...More data for this Ligand-Target Pair
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Jinan University

Curated by ChEMBL
LigandPNGBDBM13530(4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of BCR-ABL T315I mutant (unknown origin)More data for this Ligand-Target Pair
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Jinan University

Curated by ChEMBL
LigandPNGBDBM50357312(IBRUTINIB | PCI-32765 | US10124003, Ref. Ex. Compo...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of BTK C481S (unknown origin)More data for this Ligand-Target Pair