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Found 85 Enz. Inhib. hit(s) with all data for entry = 50019140
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))TBA
LigandPNGBDBM145281(US8952169, 60 | US9771376, Example 60)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of human Nav1.7 alpha subunit expressed in HEK293 cells co-expressing beta1 subunit at -60 mV holding potential by whole-cell patch voltag...More data for this Ligand-Target Pair
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TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))TBA
LigandPNGBDBM145591(US8952169, 389)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of human Nav1.7 alpha subunit expressed in HEK293 cells co-expressing beta1 subunit at -60 mV holding potential by whole-cell patch voltag...More data for this Ligand-Target Pair
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TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))TBA
LigandPNGBDBM47139(US8952169, 175 | US8952169, 295)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of human Nav1.7 alpha subunit expressed in HEK293 cells co-expressing beta1 subunit at -60 mV holding potential by whole-cell patch voltag...More data for this Ligand-Target Pair
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TargetSodium channel protein type 2 subunit alpha(Homo sapiens (Human))TBA
LigandPNGBDBM145591(US8952169, 389)
Affinity DataIC50:  2nMAssay Description:Inhibition of human Nav1.2 alpha subunit expressed in HEK293 cells co-expressing beta1 subunit at -35 mV holding potential by PatchXpress automated v...More data for this Ligand-Target Pair
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LigandPNGBDBM145591(US8952169, 389)
Affinity DataIC50:  2.20nMAssay Description:Inhibition of mouse Nav1.7 at -60 mV holding potential by PatchXpress automated voltage clamp electrophysiology techniqueMore data for this Ligand-Target Pair
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LigandPNGBDBM145466(US8952169, 245)
Affinity DataIC50:  2.5nMAssay Description:Inhibition of mouse Nav1.7 at -60 mV holding potential by PatchXpress automated voltage clamp electrophysiology techniqueMore data for this Ligand-Target Pair
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TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))TBA
LigandPNGBDBM145466(US8952169, 245)
Affinity DataIC50:  3nMAssay Description:Inhibition of human Nav1.7 alpha subunit expressed in HEK293 cells co-expressing beta1 subunit at -60 mV holding potential by whole-cell patch voltag...More data for this Ligand-Target Pair
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TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))TBA
LigandPNGBDBM145374(US8952169, 153)
Affinity DataIC50:  3.10nMAssay Description:Inhibition of human Nav1.7 alpha subunit expressed in HEK293 cells co-expressing beta1 subunit at -60 mV holding potential by whole-cell patch voltag...More data for this Ligand-Target Pair
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LigandPNGBDBM145591(US8952169, 389)
Affinity DataIC50:  3.70nMAssay Description:Inhibition of rat Nav1.7 at -60 mV holding potential by PatchXpress automated voltage clamp electrophysiology techniqueMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))TBA
LigandPNGBDBM50615672(CHEMBL5272143)
Affinity DataIC50:  5nMAssay Description:Inhibition of human Nav1.7 alpha subunit expressed in HEK293 cells co-expressing beta1 subunit at -60 mV holding potential by whole-cell patch voltag...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetSodium channel protein type 1 subunit alpha(Homo sapiens (Human))TBA
LigandPNGBDBM145591(US8952169, 389)
Affinity DataIC50:  6nMAssay Description:Inhibition of human Nav1.1 alpha subunit expressed in HEK293 cells co-expressing beta1 subunit at -40 mV holding potential by PatchXpress automated v...More data for this Ligand-Target Pair
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TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))TBA
LigandPNGBDBM145281(US8952169, 60 | US9771376, Example 60)
Affinity DataIC50:  6nMAssay Description:Displacement of [3H]GX-545 from human Nav1.7 alpha subunit expressed in HEK293 cells co-expressing beta1 subunit by liquid scintillation counting ana...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSodium channel protein type 2 subunit alpha(Homo sapiens (Human))TBA
LigandPNGBDBM145466(US8952169, 245)
Affinity DataIC50:  6nMAssay Description:Inhibition of human Nav1.2 alpha subunit expressed in HEK293 cells co-expressing beta1 subunit at -35 mV holding potential by PatchXpress automated v...More data for this Ligand-Target Pair
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TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))TBA
LigandPNGBDBM145227(US8952169, 6 | US9771376, Example 6)
Affinity DataIC50:  6nMAssay Description:Inhibition of human Nav1.7 alpha subunit expressed in HEK293 cells co-expressing beta1 subunit at -60 mV holding potential by whole-cell patch voltag...More data for this Ligand-Target Pair
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TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))TBA
LigandPNGBDBM145266(US8952169, 45)
Affinity DataIC50:  6nMAssay Description:Inhibition of human Nav1.7 alpha subunit expressed in HEK293 cells co-expressing beta1 subunit at -60 mV holding potential by whole-cell patch voltag...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))TBA
LigandPNGBDBM145382(US8952169, 161)
Affinity DataIC50:  6nMAssay Description:Inhibition of human Nav1.7 alpha subunit expressed in HEK293 cells co-expressing beta1 subunit at -60 mV holding potential by whole-cell patch voltag...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))TBA
LigandPNGBDBM145623(US8952169, 426)
Affinity DataIC50:  6nMAssay Description:Inhibition of human Nav1.7 alpha subunit expressed in HEK293 cells co-expressing beta1 subunit at -60 mV holding potential by whole-cell patch voltag...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))TBA
LigandPNGBDBM145374(US8952169, 153)
Affinity DataIC50:  8nMAssay Description:Displacement of [3H]GX-545 from human Nav1.7 alpha subunit expressed in HEK293 cells co-expressing beta1 subunit by liquid scintillation counting ana...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))TBA
LigandPNGBDBM145438(US8952169, 217)
Affinity DataIC50:  8nMAssay Description:Inhibition of human Nav1.7 alpha subunit expressed in HEK293 cells co-expressing beta1 subunit at -60 mV holding potential by whole-cell patch voltag...More data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM145466(US8952169, 245)
Affinity DataIC50:  9nMAssay Description:Inhibition of rat Nav1.7 at -60 mV holding potential by PatchXpress automated voltage clamp electrophysiology techniqueMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))TBA
LigandPNGBDBM145623(US8952169, 426)
Affinity DataIC50:  10nMAssay Description:Displacement of [3H]GX-545 from human Nav1.7 alpha subunit expressed in HEK293 cells co-expressing beta1 subunit by liquid scintillation counting ana...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))TBA
LigandPNGBDBM50615671(CHEMBL5279943)
Affinity DataIC50:  10nMAssay Description:Inhibition of human Nav1.7 alpha subunit expressed in HEK293 cells co-expressing beta1 subunit at -60 mV holding potential by whole-cell patch voltag...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))TBA
LigandPNGBDBM145373(US8952169, 152 | US9771376, Example 152)
Affinity DataIC50:  11nMAssay Description:Inhibition of human Nav1.7 alpha subunit expressed in HEK293 cells co-expressing beta1 subunit at -60 mV holding potential by whole-cell patch voltag...More data for this Ligand-Target Pair
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TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))TBA
LigandPNGBDBM145387(US8952169, 166 | US9771376, Example 166)
Affinity DataIC50:  15nMAssay Description:Inhibition of human Nav1.7 alpha subunit expressed in HEK293 cells co-expressing beta1 subunit at -60 mV holding potential by whole-cell patch voltag...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))TBA
LigandPNGBDBM145591(US8952169, 389)
Affinity DataIC50:  15nMAssay Description:Displacement of [3H]GX-545 from human Nav1.7 alpha subunit expressed in HEK293 cells co-expressing beta1 subunit by liquid scintillation counting ana...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))TBA
LigandPNGBDBM145466(US8952169, 245)
Affinity DataIC50:  15nMAssay Description:Displacement of [3H]GX-545 from human Nav1.7 alpha subunit expressed in HEK293 cells co-expressing beta1 subunit by liquid scintillation counting ana...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))TBA
LigandPNGBDBM145266(US8952169, 45)
Affinity DataIC50:  15nMAssay Description:Displacement of [3H]GX-545 from human Nav1.7 alpha subunit expressed in HEK293 cells co-expressing beta1 subunit by liquid scintillation counting ana...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))TBA
LigandPNGBDBM50615672(CHEMBL5272143)
Affinity DataIC50:  17nMAssay Description:Displacement of [3H]GX-545 from human Nav1.7 alpha subunit expressed in HEK293 cells co-expressing beta1 subunit by liquid scintillation counting ana...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))TBA
LigandPNGBDBM145257(US8952169, 36 | US9771376, Example 36)
Affinity DataIC50:  17nMAssay Description:Inhibition of human Nav1.7 alpha subunit expressed in HEK293 cells co-expressing beta1 subunit at -60 mV holding potential by whole-cell patch voltag...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))TBA
LigandPNGBDBM47139(US8952169, 175 | US8952169, 295)
Affinity DataIC50:  22nMAssay Description:Displacement of [3H]GX-545 from human Nav1.7 alpha subunit expressed in HEK293 cells co-expressing beta1 subunit by liquid scintillation counting ana...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))TBA
LigandPNGBDBM50615671(CHEMBL5279943)
Affinity DataIC50:  28nMAssay Description:Displacement of [3H]GX-545 from human Nav1.7 alpha subunit expressed in HEK293 cells co-expressing beta1 subunit by liquid scintillation counting ana...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))TBA
LigandPNGBDBM145237(US8952169, 16 | US9771376, Example 16)
Affinity DataIC50:  31nMAssay Description:Inhibition of human Nav1.7 alpha subunit expressed in HEK293 cells co-expressing beta1 subunit at -60 mV holding potential by whole-cell patch voltag...More data for this Ligand-Target Pair
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TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))TBA
LigandPNGBDBM145438(US8952169, 217)
Affinity DataIC50:  33nMAssay Description:Displacement of [3H]GX-545 from human Nav1.7 alpha subunit expressed in HEK293 cells co-expressing beta1 subunit by liquid scintillation counting ana...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))TBA
LigandPNGBDBM145382(US8952169, 161)
Affinity DataIC50:  37nMAssay Description:Displacement of [3H]GX-545 from human Nav1.7 alpha subunit expressed in HEK293 cells co-expressing beta1 subunit by liquid scintillation counting ana...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSodium channel protein type 8 subunit alpha(Homo sapiens (Human))TBA
LigandPNGBDBM145591(US8952169, 389)
Affinity DataIC50:  38nMAssay Description:Inhibition of human Nav1.6 alpha subunit expressed in HEK293 cells co-expressing beta1 subunit at -35 mV holding potential by PatchXpress automated v...More data for this Ligand-Target Pair
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TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))TBA
LigandPNGBDBM145226(US8952169, 5 | US9771376, Example 5)
Affinity DataIC50:  41nMAssay Description:Inhibition of human Nav1.7 alpha subunit expressed in HEK293 cells co-expressing beta1 subunit at -60 mV holding potential by whole-cell patch voltag...More data for this Ligand-Target Pair
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TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))TBA
LigandPNGBDBM47138(US8952169, 268 | US8952169, 30 | US9771376, Exampl...)
Affinity DataIC50:  43nMAssay Description:Inhibition of human Nav1.7 alpha subunit expressed in HEK293 cells co-expressing beta1 subunit at -60 mV holding potential by whole-cell patch voltag...More data for this Ligand-Target Pair
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TargetSodium channel protein type 1 subunit alpha(Homo sapiens (Human))TBA
LigandPNGBDBM145466(US8952169, 245)
Affinity DataIC50:  48nMAssay Description:Inhibition of human Nav1.1 alpha subunit expressed in HEK293 cells co-expressing beta1 subunit at -40 mV holding potential by PatchXpress automated v...More data for this Ligand-Target Pair
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TargetSodium channel protein type 8 subunit alpha(Homo sapiens (Human))TBA
LigandPNGBDBM145466(US8952169, 245)
Affinity DataIC50:  49nMAssay Description:Inhibition of human Nav1.6 alpha subunit expressed in HEK293 cells co-expressing beta1 subunit at -35 mV holding potential by PatchXpress automated v...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))TBA
LigandPNGBDBM145591(US8952169, 389)
Affinity DataIC50:  50nMAssay Description:Inhibition of human Nav1.5 alpha subunit expressed in HEK293 cells co-expressing beta1 subunit at -60 mV holding potential by PatchXpress automated v...More data for this Ligand-Target Pair
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TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))TBA
LigandPNGBDBM145240(US8952169, 19 | US9771376, Example 19)
Affinity DataIC50:  59nMAssay Description:Inhibition of human Nav1.7 alpha subunit expressed in HEK293 cells co-expressing beta1 subunit at -60 mV holding potential by whole-cell patch voltag...More data for this Ligand-Target Pair
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TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))TBA
LigandPNGBDBM145326(US8952169, 105)
Affinity DataIC50:  68nMAssay Description:Inhibition of human Nav1.7 alpha subunit expressed in HEK293 cells co-expressing beta1 subunit at -60 mV holding potential by whole-cell patch voltag...More data for this Ligand-Target Pair
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TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))TBA
LigandPNGBDBM145227(US8952169, 6 | US9771376, Example 6)
Affinity DataIC50:  70nMAssay Description:Displacement of [3H]GX-545 from human Nav1.7 alpha subunit expressed in HEK293 cells co-expressing beta1 subunit by liquid scintillation counting ana...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))TBA
LigandPNGBDBM145446(US8952169, 225)
Affinity DataIC50:  75nMAssay Description:Inhibition of human Nav1.7 alpha subunit expressed in HEK293 cells co-expressing beta1 subunit at -60 mV holding potential by whole-cell patch voltag...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))TBA
LigandPNGBDBM145387(US8952169, 166 | US9771376, Example 166)
Affinity DataIC50:  93nMAssay Description:Displacement of [3H]GX-545 from human Nav1.7 alpha subunit expressed in HEK293 cells co-expressing beta1 subunit by liquid scintillation counting ana...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))TBA
LigandPNGBDBM47138(US8952169, 268 | US8952169, 30 | US9771376, Exampl...)
Affinity DataIC50:  180nMAssay Description:Displacement of [3H]GX-545 from human Nav1.7 alpha subunit expressed in HEK293 cells co-expressing beta1 subunit by liquid scintillation counting ana...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))TBA
LigandPNGBDBM145345(US8952169, 124)
Affinity DataIC50:  260nMAssay Description:Inhibition of human Nav1.7 alpha subunit expressed in HEK293 cells co-expressing beta1 subunit at -60 mV holding potential by whole-cell patch voltag...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))TBA
LigandPNGBDBM145466(US8952169, 245)
Affinity DataIC50:  260nMAssay Description:Inhibition of human Nav1.5 alpha subunit expressed in HEK293 cells co-expressing beta1 subunit at -60 mV holding potential by PatchXpress automated v...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))TBA
LigandPNGBDBM145373(US8952169, 152 | US9771376, Example 152)
Affinity DataIC50:  290nMAssay Description:Displacement of [3H]GX-545 from human Nav1.7 alpha subunit expressed in HEK293 cells co-expressing beta1 subunit by liquid scintillation counting ana...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))TBA
LigandPNGBDBM145446(US8952169, 225)
Affinity DataIC50:  304nMAssay Description:Displacement of [3H]GX-545 from human Nav1.7 alpha subunit expressed in HEK293 cells co-expressing beta1 subunit by liquid scintillation counting ana...More data for this Ligand-Target Pair
In DepthDetails PubMed
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