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Found 67 of ph data with Target = 'Proteinase-activated receptor 1'
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM230675(US9340530, 13)
Affinity DataKi:  3nMpH: 7.5Assay Description:Thrombin receptor antagonists were screened using a modification of the thrombin receptor radioligand binding assay of Ahn et al. (Ahn et al., Mol. P...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM230664(US9340530, 2)
Affinity DataKi:  3nMpH: 7.5Assay Description:Thrombin receptor antagonists were screened using a modification of the thrombin receptor radioligand binding assay of Ahn et al. (Ahn et al., Mol. P...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM230672(US9340530, 10)
Affinity DataKi:  3nMpH: 7.5Assay Description:Thrombin receptor antagonists were screened using a modification of the thrombin receptor radioligand binding assay of Ahn et al. (Ahn et al., Mol. P...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM150313(US8987248, 106)
Affinity DataIC50:  7.05nMpH: 7.5 T: 2°CAssay Description:Platelet membranes are incubated with 12 nM [3H]haTRAP and test substance in different concentrations in a buffer (50 mM Tris pH 7.5, 10 mM magnesium...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM150322(US8987248, 156)
Affinity DataIC50:  11.1nMpH: 7.5 T: 2°CAssay Description:Platelet membranes are incubated with 12 nM [3H]haTRAP and test substance in different concentrations in a buffer (50 mM Tris pH 7.5, 10 mM magnesium...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM150314(US8987248, 115)
Affinity DataIC50:  11.1nMpH: 7.5 T: 2°CAssay Description:Platelet membranes are incubated with 12 nM [3H]haTRAP and test substance in different concentrations in a buffer (50 mM Tris pH 7.5, 10 mM magnesium...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM150319(US8987248, 133)
Affinity DataIC50:  14.6nMpH: 7.5 T: 2°CAssay Description:Platelet membranes are incubated with 12 nM [3H]haTRAP and test substance in different concentrations in a buffer (50 mM Tris pH 7.5, 10 mM magnesium...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM150320(US8987248, 134)
Affinity DataIC50:  15.4nMpH: 7.5 T: 2°CAssay Description:Platelet membranes are incubated with 12 nM [3H]haTRAP and test substance in different concentrations in a buffer (50 mM Tris pH 7.5, 10 mM magnesium...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM150315(US8987248, 119)
Affinity DataIC50:  15.7nMpH: 7.5 T: 2°CAssay Description:Platelet membranes are incubated with 12 nM [3H]haTRAP and test substance in different concentrations in a buffer (50 mM Tris pH 7.5, 10 mM magnesium...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM150317(US8987248, 128)
Affinity DataIC50:  17.0nMpH: 7.5 T: 2°CAssay Description:Platelet membranes are incubated with 12 nM [3H]haTRAP and test substance in different concentrations in a buffer (50 mM Tris pH 7.5, 10 mM magnesium...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM150307(US8987248, 91)
Affinity DataIC50:  17.4nMpH: 7.5 T: 2°CAssay Description:Platelet membranes are incubated with 12 nM [3H]haTRAP and test substance in different concentrations in a buffer (50 mM Tris pH 7.5, 10 mM magnesium...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM150312(US8987248, 105)
Affinity DataIC50:  18.4nMpH: 7.5 T: 2°CAssay Description:Platelet membranes are incubated with 12 nM [3H]haTRAP and test substance in different concentrations in a buffer (50 mM Tris pH 7.5, 10 mM magnesium...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM150305(US8987248, 83)
Affinity DataIC50:  19.7nMpH: 7.5 T: 2°CAssay Description:Platelet membranes are incubated with 12 nM [3H]haTRAP and test substance in different concentrations in a buffer (50 mM Tris pH 7.5, 10 mM magnesium...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM150324(BDBM150325 | US8987248, 170)
Affinity DataIC50:  21.3nMpH: 7.5 T: 2°CAssay Description:Platelet membranes are incubated with 12 nM [3H]haTRAP and test substance in different concentrations in a buffer (50 mM Tris pH 7.5, 10 mM magnesium...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM150323(US8987248, 162)
Affinity DataIC50:  25nMpH: 7.5 T: 2°CAssay Description:Platelet membranes are incubated with 12 nM [3H]haTRAP and test substance in different concentrations in a buffer (50 mM Tris pH 7.5, 10 mM magnesium...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM150301(US8987248, 7)
Affinity DataIC50:  29nMpH: 7.5 T: 2°CAssay Description:Platelet membranes are incubated with 12 nM [3H]haTRAP and test substance in different concentrations in a buffer (50 mM Tris pH 7.5, 10 mM magnesium...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM150318(US8987248, 129)
Affinity DataIC50:  33.6nMpH: 7.5 T: 2°CAssay Description:Platelet membranes are incubated with 12 nM [3H]haTRAP and test substance in different concentrations in a buffer (50 mM Tris pH 7.5, 10 mM magnesium...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM150321(US8987248, 141)
Affinity DataIC50:  53.7nMpH: 7.5 T: 2°CAssay Description:Platelet membranes are incubated with 12 nM [3H]haTRAP and test substance in different concentrations in a buffer (50 mM Tris pH 7.5, 10 mM magnesium...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM150326(US8987248, 178)
Affinity DataIC50:  63nMpH: 7.5 T: 2°CAssay Description:Platelet membranes are incubated with 12 nM [3H]haTRAP and test substance in different concentrations in a buffer (50 mM Tris pH 7.5, 10 mM magnesium...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM150316(US8987248, 121)
Affinity DataIC50:  79.9nMpH: 7.5 T: 2°CAssay Description:Platelet membranes are incubated with 12 nM [3H]haTRAP and test substance in different concentrations in a buffer (50 mM Tris pH 7.5, 10 mM magnesium...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM150324(BDBM150325 | US8987248, 170)
Affinity DataIC50:  81nMpH: 7.5 T: 2°CAssay Description:Platelet membranes are incubated with 12 nM [3H]haTRAP and test substance in different concentrations in a buffer (50 mM Tris pH 7.5, 10 mM magnesium...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM135848(US8853206, 54)
Affinity DataIC50:  85nMpH: 7.5Assay Description:The synthesized substances were examined in a PAR1 binding test. This tested whether the substances can inhibit the binding of a radioactively labele...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM169633(US9079906, 117)
Affinity DataIC50:  98nMpH: 7.5 T: 2°CAssay Description:The synthesized substances were examined in a PAR1 binding test. This tested whether the substances can inhibit the binding of a radioactively labele...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM150304(US8987248, 36)
Affinity DataIC50:  98.2nMpH: 7.5 T: 2°CAssay Description:Platelet membranes are incubated with 12 nM [3H]haTRAP and test substance in different concentrations in a buffer (50 mM Tris pH 7.5, 10 mM magnesium...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM169631(US9079906, 89)
Affinity DataIC50:  107nMpH: 7.5 T: 2°CAssay Description:The synthesized substances were examined in a PAR1 binding test. This tested whether the substances can inhibit the binding of a radioactively labele...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM150309(US8987248, 97)
Affinity DataIC50:  109nMpH: 7.5 T: 2°CAssay Description:Platelet membranes are incubated with 12 nM [3H]haTRAP and test substance in different concentrations in a buffer (50 mM Tris pH 7.5, 10 mM magnesium...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM150302(US8987248, 8)
Affinity DataIC50:  109nMpH: 7.5 T: 2°CAssay Description:Platelet membranes are incubated with 12 nM [3H]haTRAP and test substance in different concentrations in a buffer (50 mM Tris pH 7.5, 10 mM magnesium...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM169650(US9079906, 239)
Affinity DataIC50:  113nMpH: 7.5 T: 2°CAssay Description:The synthesized substances were examined in a PAR1 binding test. This tested whether the substances can inhibit the binding of a radioactively labele...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM135846(US8853206, 46)
Affinity DataIC50:  114nMpH: 7.5Assay Description:The synthesized substances were examined in a PAR1 binding test. This tested whether the substances can inhibit the binding of a radioactively labele...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM169641(US9079906, 186)
Affinity DataIC50:  119nMpH: 7.5 T: 2°CAssay Description:The synthesized substances were examined in a PAR1 binding test. This tested whether the substances can inhibit the binding of a radioactively labele...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM169640(US9079906, 178)
Affinity DataIC50:  126nMpH: 7.5 T: 2°CAssay Description:The synthesized substances were examined in a PAR1 binding test. This tested whether the substances can inhibit the binding of a radioactively labele...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM135844(US8853206, 35)
Affinity DataIC50:  132nMpH: 7.5Assay Description:The synthesized substances were examined in a PAR1 binding test. This tested whether the substances can inhibit the binding of a radioactively labele...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM135843(US8853206, 29)
Affinity DataIC50:  136nMpH: 7.5Assay Description:The synthesized substances were examined in a PAR1 binding test. This tested whether the substances can inhibit the binding of a radioactively labele...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM169642(US9079906, 197)
Affinity DataIC50:  149nMpH: 7.5 T: 2°CAssay Description:The synthesized substances were examined in a PAR1 binding test. This tested whether the substances can inhibit the binding of a radioactively labele...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM135842(US8853206, 27)
Affinity DataIC50:  152nMpH: 7.5Assay Description:The synthesized substances were examined in a PAR1 binding test. This tested whether the substances can inhibit the binding of a radioactively labele...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM169646(US9079906, 221)
Affinity DataIC50:  155nMpH: 7.5 T: 2°CAssay Description:The synthesized substances were examined in a PAR1 binding test. This tested whether the substances can inhibit the binding of a radioactively labele...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM150310(US8987248, 102)
Affinity DataIC50:  165nMpH: 7.5 T: 2°CAssay Description:Platelet membranes are incubated with 12 nM [3H]haTRAP and test substance in different concentrations in a buffer (50 mM Tris pH 7.5, 10 mM magnesium...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM169644(US9079906, 207)
Affinity DataIC50:  174nMpH: 7.5 T: 2°CAssay Description:The synthesized substances were examined in a PAR1 binding test. This tested whether the substances can inhibit the binding of a radioactively labele...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM169639(US9079906, 174)
Affinity DataIC50:  183nMpH: 7.5 T: 2°CAssay Description:The synthesized substances were examined in a PAR1 binding test. This tested whether the substances can inhibit the binding of a radioactively labele...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM169643(US9079906, 199)
Affinity DataIC50:  206nMpH: 7.5 T: 2°CAssay Description:The synthesized substances were examined in a PAR1 binding test. This tested whether the substances can inhibit the binding of a radioactively labele...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM169645(US9079906, 215)
Affinity DataIC50:  219nMpH: 7.5 T: 2°CAssay Description:The synthesized substances were examined in a PAR1 binding test. This tested whether the substances can inhibit the binding of a radioactively labele...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM169648(US9079906, 230)
Affinity DataIC50:  234nMpH: 7.5 T: 2°CAssay Description:The synthesized substances were examined in a PAR1 binding test. This tested whether the substances can inhibit the binding of a radioactively labele...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM150308(US8987248, 95)
Affinity DataIC50:  237nMpH: 7.5 T: 2°CAssay Description:Platelet membranes are incubated with 12 nM [3H]haTRAP and test substance in different concentrations in a buffer (50 mM Tris pH 7.5, 10 mM magnesium...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM150311(US8987248, 104)
Affinity DataIC50:  248nMpH: 7.5 T: 2°CAssay Description:Platelet membranes are incubated with 12 nM [3H]haTRAP and test substance in different concentrations in a buffer (50 mM Tris pH 7.5, 10 mM magnesium...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM169638(US9079906, 168)
Affinity DataIC50:  257nMpH: 7.5 T: 2°CAssay Description:The synthesized substances were examined in a PAR1 binding test. This tested whether the substances can inhibit the binding of a radioactively labele...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM169625(US9079906, 14)
Affinity DataIC50:  279nMpH: 7.5 T: 2°CAssay Description:The synthesized substances were examined in a PAR1 binding test. This tested whether the substances can inhibit the binding of a radioactively labele...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM150306(US8987248, 90)
Affinity DataIC50:  359nMpH: 7.5 T: 2°CAssay Description:Platelet membranes are incubated with 12 nM [3H]haTRAP and test substance in different concentrations in a buffer (50 mM Tris pH 7.5, 10 mM magnesium...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM169637(US9079906, 163)
Affinity DataIC50:  364nMpH: 7.5 T: 2°CAssay Description:The synthesized substances were examined in a PAR1 binding test. This tested whether the substances can inhibit the binding of a radioactively labele...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM169636(US9079906, 161)
Affinity DataIC50:  365nMpH: 7.5 T: 2°CAssay Description:The synthesized substances were examined in a PAR1 binding test. This tested whether the substances can inhibit the binding of a radioactively labele...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM169647(US9079906, 222)
Affinity DataIC50:  416nMpH: 7.5 T: 2°CAssay Description:The synthesized substances were examined in a PAR1 binding test. This tested whether the substances can inhibit the binding of a radioactively labele...More data for this Ligand-Target Pair
In DepthDetails US Patent
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