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Found 5 of affinity data with PDB=5I8G
TargetCREB-binding protein(Homo sapiens (Human))
Constellation Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50178219(CHEMBL3814752)
Affinity DataIC50:  30nMAssay Description:Displacement of biotinylated ligand from recombinant His-tagged CBP (unknown origin) incubated for 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
TargetCREB-binding protein(Homo sapiens (Human))
Constellation Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50178219(CHEMBL3814752)
Affinity DataIC50:  30nMAssay Description:Inhibition of His tagged recombinant CBP (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
TargetHistone acetyltransferase p300(Homo sapiens (Human))
Constellation Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50178219(CHEMBL3814752)
Affinity DataIC50:  51nMAssay Description:Displacement of biotinylated ligand from recombinant His-tagged EP300 (unknown origin) incubated for 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
TargetCREB-binding protein(Homo sapiens (Human))
Constellation Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50178219(CHEMBL3814752)
Affinity DataKd:  30nMAssay Description:Binding affinity to human CBP at 17 uM by isothermal titration calorimetryMore data for this Ligand-Target Pair
TargetCREB-binding protein(Homo sapiens (Human))
Constellation Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50178219(CHEMBL3814752)
Affinity DataEC50:  300nMAssay Description:Inhibition of Halo-tagged histone H3.3 binding to CBP (unknown origin) expressed in HEK293 cells after overnight incubation by luciferase reporter ge...More data for this Ligand-Target Pair