Compile Data Set for Download or QSAR
Found 2 Enz. Inhib. hit(s) for PDB: 5HO8
Target3-phosphoinositide-dependent protein kinase 1(Homo sapiens (Human))
Merck KGaA

Curated by ChEMBL
LigandPNGBDBM50178294(CHEMBL3814340)
Show SMILES CCCCc1cc(nc(N)n1)-c1c[nH]c2ncccc12
Show InChI InChI=1S/C15H17N5/c1-2-3-5-10-8-13(20-15(16)19-10)12-9-18-14-11(12)6-4-7-17-14/h4,6-9H,2-3,5H2,1H3,(H,17,18)(H2,16,19,20)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of human His6-tagged PDK1 using biotinylated PDKtide as substrate after 60 mins by topcount methodMore data for this Ligand-Target Pair
Target3-phosphoinositide-dependent protein kinase 1(Homo sapiens (Human))
Merck KGaA

Curated by ChEMBL
LigandPNGBDBM50178294(CHEMBL3814340)
Show SMILES CCCCc1cc(nc(N)n1)-c1c[nH]c2ncccc12
Show InChI InChI=1S/C15H17N5/c1-2-3-5-10-8-13(20-15(16)19-10)12-9-18-14-11(12)6-4-7-17-14/h4,6-9H,2-3,5H2,1H3,(H,17,18)(H2,16,19,20)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PDK1 in human PC3 cells assessed as reduction in AKT Thr308 phosphorylation after 45 minsMore data for this Ligand-Target Pair