Compile Data Set for Download or QSAR
Found 1 Enz. Inhib. hit(s) for PDB: 4R5Y
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Temple University

Curated by ChEMBL
LigandPNGBDBM50453816(BGB-283 | Bgb 283 | Lifirafenib)
Show SMILES FC(F)(F)c1ccc2[nH]c(nc2c1)[C@@H]1[C@H]2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3[C@@H]12
Show InChI InChI=1S/C25H17F3N4O3/c26-25(27,28)11-1-4-15-16(9-11)31-24(30-15)21-20-14-10-12(2-5-17(14)35-22(20)21)34-18-7-8-29-23-13(18)3-6-19(33)32-23/h1-2,4-5,7-10,20-22H,3,6H2,(H,30,31)(H,29,32,33)/t20-,21-,22-/m0/s1
Affinity DataIC50: 23nMAssay Description:Inhibition of BRAF (unknown origin) using MEK1 K97R mutant as substrate preincubated for 60 to 120 mins followed by substrate addition measured after...More data for this Ligand-Target Pair