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Found 2327 Enz. Inhib. hit(s) with Target = 'Angiotensin-converting enzyme'
TargetAngiotensin-converting enzyme(Oryctolagus cuniculus)
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50044868(7-(1-Carboxy-3-phenyl-propylamino)-6-oxo-1,2,3,4,6...)
Affinity DataKi:  0.00400nMAssay Description:Binding affinity of compound against rabbit lung angiotensin I-converting enzyme (ACE) was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Homo sapiens (Human))TBA
LigandPNGBDBM50614466(CHEMBL5272537)
Affinity DataKi:  0.00400nMAssay Description:Binding affinity to angiotensin-converting enzyme (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetAngiotensin-converting enzyme(Homo sapiens (Human))TBA
LigandPNGBDBM50073120((4S,6S,9aS)-6-((S)-2-Mercapto-3-phenyl-propionylam...)
Affinity DataKi:  0.0150nMAssay Description:Inhibition of human fully glycosylated ACE N-terminal domain expressed in CHO cells using Cbz-Phe-His-Leu as substrate preincubated for 15 mins follo...More data for this Ligand-Target Pair
TargetAngiotensin-converting enzyme(Homo sapiens (Human))TBA
LigandPNGBDBM50073120((4S,6S,9aS)-6-((S)-2-Mercapto-3-phenyl-propionylam...)
Affinity DataKi:  0.0160nMAssay Description:Inhibition of human fully glycosylated ACE C-terminal domain expressed in CHO cells using Cbz-Phe-His-Leu as substrate preincubated for 15 mins follo...More data for this Ligand-Target Pair
TargetAngiotensin-converting enzyme(Oryctolagus cuniculus)
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50614462(CHEMBL5277842)
Affinity DataKi:  0.110nMAssay Description:Binding affinity to angiotensin-converting enzyme in rabbit lung assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetAngiotensin-converting enzyme(Oryctolagus cuniculus)
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50044866(7-(2-Mercapto-3-phenyl-propionylamino)-6-oxo-1,2,3...)
Affinity DataKi:  0.110nMAssay Description:Binding affinity of compound against rabbit lung angiotensin I-converting enzyme (ACE) was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Oryctolagus cuniculus)
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50044866(7-(2-Mercapto-3-phenyl-propionylamino)-6-oxo-1,2,3...)
Affinity DataKi:  0.110nMAssay Description:Binding affinity of compound against rabbit lung angiotensin I-converting enzyme (ACE) was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme 2(Homo sapiens (Human))
University of Athens

LigandPNGBDBM21464(2-benzyl-3-{[1-(2-acetamido-4-methylpentanoyl)pyrr...)
Affinity DataKi:  0.130nM ΔG°:  -56.4kJ/molepH: 6.8 T: 2°CAssay Description:Continuous assays were performed by recording the fluorescence increase at 405 nm (excitation@ 320 nm) induced by the cleavage of fluorogenic substra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Homo sapiens (Human))TBA
LigandPNGBDBM50369460(CHEMBL1788109)
Affinity DataKi:  0.160nMAssay Description:Enzyme inhibitory activity towards Angiotensin I converting enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Oryctolagus cuniculus)
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50018850(1-(3-Mercapto-2-methyl-propionyl)-4-phenylsulfanyl...)
Affinity DataKi:  0.400nMAssay Description:Inhibitory constant against rabbit lung Angiotensin I converting enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme 2(Homo sapiens (Human))
University of Athens

LigandPNGBDBM21474(3-({1-[2-acetamido-3-(1H-imidazol-4-yl)propanoyl]p...)
Affinity DataKi:  0.400nM ΔG°:  -53.6kJ/molepH: 6.8 T: 2°CAssay Description:Continuous assays were performed by recording the fluorescence increase at 405 nm (excitation@ 320 nm) induced by the cleavage of fluorogenic substra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Homo sapiens (Human))TBA
LigandPNGBDBM50303321((2S)-2-({3-[Hydroxyl(2-phenyl-(1R)-1-{[(benzyloxy)...)
Affinity DataKi:  0.400nMAssay Description:Inhibition of human somatic ACE C-terminal domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Homo sapiens (Human))TBA
LigandPNGBDBM50303319((S)-2-[(S)-3-[((R)-1-Benzyloxycarbonylamino-2-phen...)
Affinity DataKi:  0.410nMAssay Description:Inhibition of human somatic ACE C-terminal domainMore data for this Ligand-Target Pair
TargetAngiotensin-converting enzyme 2(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50367254(ENALAPRILAT)
Affinity DataKi:  0.5nMAssay Description:Binding affinity towards Angiotensin I converting enzyme of rat brain IgG immobilized enzyme.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Oryctolagus cuniculus)
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50021119(CHEMBL34389 | disodium (2S)-1-((2S)-2-{[(2-phenyle...)
Affinity DataKi:  0.5nMpH: 7.5Assay Description:Inhibition of Angiotensin I converting enzyme from rabbit lungs at pH 7.5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Homo sapiens (Human))TBA
LigandPNGBDBM50367249(CHEMBL309601)
Affinity DataKi:  0.5nMAssay Description:Compound was evaluated for the inhibition of Angiotensin I converting enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Homo sapiens (Human))TBA
LigandPNGBDBM50303320((S)-2-[(R)-3-[((R)-1-Benzyloxycarbonylamino-2-phen...)
Affinity DataKi:  0.650nMAssay Description:Inhibition of human ACE C-terminal domain expressed in CHO cells after 90 mins by fluorescence assayMore data for this Ligand-Target Pair
TargetAngiotensin-converting enzyme(Homo sapiens (Human))TBA
LigandPNGBDBM50303320((S)-2-[(R)-3-[((R)-1-Benzyloxycarbonylamino-2-phen...)
Affinity DataKi:  0.650nMAssay Description:Inhibition of human somatic ACE C-terminal domainMore data for this Ligand-Target Pair
TargetAngiotensin-converting enzyme(Homo sapiens (Human))TBA
LigandPNGBDBM50303320((S)-2-[(R)-3-[((R)-1-Benzyloxycarbonylamino-2-phen...)
Affinity DataKi:  0.680nMAssay Description:Inhibition of human somatic ACE in presence of bufferMore data for this Ligand-Target Pair
TargetAngiotensin-converting enzyme 2(Homo sapiens (Human))
University of Athens

LigandPNGBDBM21470(2-benzyl-3-({1-[2-acetamido-3-(1H-imidazol-4-yl)pr...)
Affinity DataKi:  0.700nM ΔG°:  -52.3kJ/molepH: 6.8 T: 2°CAssay Description:Continuous assays were performed by recording the fluorescence increase at 405 nm (excitation@ 320 nm) induced by the cleavage of fluorogenic substra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM471712(US10829438, Example 4B | US11174219, Example 4B)
Affinity DataKi: <1nMAssay Description:The assays were performed in 384-well white opaque plates at 37 C. using the fluorogenic peptide substrates at a concentration of 10 μM in Assa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM471714(US10829438, Example 6A | US11174219, Example 6A)
Affinity DataKi: <1nMAssay Description:The assays were performed in 384-well white opaque plates at 37 C. using the fluorogenic peptide substrates at a concentration of 10 μM in Assa...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM471713(US10829438, Example 5B | US11174219, Example 5B)
Affinity DataKi: <1nMAssay Description:The assays were performed in 384-well white opaque plates at 37 C. using the fluorogenic peptide substrates at a concentration of 10 μM in Assa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM471712(US10829438, Example 4B | US11174219, Example 4B)
Affinity DataKi: <1nMAssay Description:The assays were performed in 384-well white opaque plates at 37 C. using the fluorogenic peptide substrates at a concentration of 10 μM in Assa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM471710(US10829438, Example 1L | US11174219, Example 1L)
Affinity DataKi: <1nMAssay Description:The assays were performed in 384-well white opaque plates at 37 C. using the fluorogenic peptide substrates at a concentration of 10 μM in Assa...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM471705(US10829438, Example 1G | US11174219, Example 1G)
Affinity DataKi: <1nMAssay Description:The assays were performed in 384-well white opaque plates at 37 C. using the fluorogenic peptide substrates at a concentration of 10 μM in Assa...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM471714(US10829438, Example 6A | US11174219, Example 6A)
Affinity DataKi: <1nMAssay Description:The assays were performed in 384-well white opaque plates at 37 C. using the fluorogenic peptide substrates at a concentration of 10 μM in Assa...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM471713(US10829438, Example 5B | US11174219, Example 5B)
Affinity DataKi: <1nMAssay Description:The assays were performed in 384-well white opaque plates at 37 C. using the fluorogenic peptide substrates at a concentration of 10 μM in Assa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM471710(US10829438, Example 1L | US11174219, Example 1L)
Affinity DataKi: <1nMAssay Description:The assays were performed in 384-well white opaque plates at 37 C. using the fluorogenic peptide substrates at a concentration of 10 μM in Assa...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM471705(US10829438, Example 1G | US11174219, Example 1G)
Affinity DataKi: <1nMAssay Description:The assays were performed in 384-well white opaque plates at 37 C. using the fluorogenic peptide substrates at a concentration of 10 μM in Assa...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetAngiotensin-converting enzyme(Oryctolagus cuniculus)
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50021123(CHEMBL30505 | dipotassium (2S)-1-{(2S)-2-[(ethoxyp...)
Affinity DataKi:  1.20nMpH: 7.5Assay Description:Inhibition of Angiotensin I converting enzyme from rabbit lungs at pH 7.5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Homo sapiens (Human))TBA
LigandPNGBDBM50011270(2-[2-(1-Carboxy-3-phenyl-propylamino)-propionyl]-1...)
Affinity DataKi:  1.20nMAssay Description:Compound was tested for its inhibitory potency against angiotensin I converting enzyme.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Homo sapiens (Human))TBA
LigandPNGBDBM50367879(LISINOPRIL)
Affinity DataKi:  1.20nMAssay Description:Inhibition of recombinant human ACE C-domain expressed in CHO cells using Cbz-Phe-His-Leu as substrate preincubated for 15 mins followed by substrate...More data for this Ligand-Target Pair
TargetAngiotensin-converting enzyme(Oryctolagus cuniculus)
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50021118(CHEMBL30836 | dipotassium (2S)-1-((2S)-2-{[(benzyl...)
Affinity DataKi:  1.20nMpH: 7.5Assay Description:Inhibition of Angiotensin I converting enzyme from rabbit lungs at pH 7.5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme 2(Homo sapiens (Human))
University of Athens

LigandPNGBDBM21473(3-{[1-(2-acetamido-4-methylpentanoyl)pyrrolidin-2-...)
Affinity DataKi:  1.25nM ΔG°:  -50.8kJ/molepH: 6.8 T: 2°CAssay Description:Continuous assays were performed by recording the fluorescence increase at 405 nm (excitation@ 320 nm) induced by the cleavage of fluorogenic substra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Homo sapiens (Human))TBA
LigandPNGBDBM50115848((S)-3-(1H-Indol-3-yl)-2-[(R)-3-mercapto-2-((S)-5-m...)
Affinity DataKi:  1.30nMAssay Description:Inhibition constant against angiotensin I converting enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Homo sapiens (Human))TBA
LigandPNGBDBM50303322((2S)-2-({3-[Hydroxyl(2-phenyl-(1R)-1-{[(benzyloxy)...)
Affinity DataKi:  1.40nMAssay Description:Inhibition of human somatic ACE C-terminal domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Oryctolagus cuniculus)
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50021121(CHEMBL286181 | dipotassium (2S)-1-{(2S)-2-[(isopro...)
Affinity DataKi:  1.40nMpH: 7.5Assay Description:Inhibition of Angiotensin I converting enzyme from rabbit lungs at pH 7.5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Oryctolagus cuniculus)
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50021114(CHEMBL282987 | tripotassium (2S)-1-[(2S)-2-(phosph...)
Affinity DataKi:  1.40nMpH: 7.5Assay Description:Inhibition of Angiotensin I converting enzyme from rabbit lungs at pH 7.5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme 2(Homo sapiens (Human))
University of Athens

LigandPNGBDBM50411731(CHEMBL257726)
Affinity DataKi:  1.40nMAssay Description:Inhibition of human recombinant ACE2 by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme 2(Homo sapiens (Human))
University of Athens

LigandPNGBDBM50411736(CHEMBL271225)
Affinity DataKi:  1.40nMAssay Description:Inhibition of human recombinant ACE2 by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Homo sapiens (Human))TBA
LigandPNGBDBM50020843(2-[(2S)-2-carboxypyrrolidin-1-yl]-1-methyl-2-oxoet...)
Affinity DataKi:  1.40nMAssay Description:Compound was evaluated for the inhibition of Angiotensin I converting enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Oryctolagus cuniculus)
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50367254(ENALAPRILAT)
Affinity DataKi:  1.40nMAssay Description:Inhibitory activity against rabbit lung angiotensin-1 converting enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Homo sapiens (Human))TBA
LigandPNGBDBM50018849(4-Cyclohexyl-1-{2-[hydroxy-(4-phenyl-butyl)-phosph...)
Affinity DataKi:  1.5nMAssay Description:Inhibition of ACEMore data for this Ligand-Target Pair
TargetAngiotensin-converting enzyme(Oryctolagus cuniculus)
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50018849(4-Cyclohexyl-1-{2-[hydroxy-(4-phenyl-butyl)-phosph...)
Affinity DataKi:  1.5nMAssay Description:Inhibitory activity against rabbit lung angiotensin-1 converting enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme 2(Homo sapiens (Human))
University of Athens

LigandPNGBDBM50411605(CHEMBL252391)
Affinity DataKi:  1.5nMAssay Description:Inhibition of human recombinant ACE2 by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme 2(Homo sapiens (Human))
University of Athens

LigandPNGBDBM50411733(CHEMBL269997)
Affinity DataKi:  1.5nMAssay Description:Inhibition of human recombinant ACE2 by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme 2(Homo sapiens (Human))
University of Athens

LigandPNGBDBM50411729(CHEMBL269996)
Affinity DataKi:  1.60nMAssay Description:Inhibition of human recombinant ACE2 by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Homo sapiens (Human))TBA
LigandPNGBDBM50281632((2S)-1-{(2S)-2-[(lambda~4~-sulfanylmethyl)amino]pr...)
Affinity DataKi:  1.70nMAssay Description:Inhibitory activity of the compound against Angiotensin I converting enzymeMore data for this Ligand-Target Pair
In DepthDetails Article
TargetAngiotensin-converting enzyme(Oryctolagus cuniculus)
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM21642((2S)-1-[(2S)-2-methyl-3-sulfanylpropanoyl]pyrrolid...)
Affinity DataKi:  1.70nMAssay Description:Inhibitory activity against rabbit lung angiotensin-1 converting enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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