Report error Found 4846 Enz. Inhib. hit(s) with Target = 'Aurora kinase A'
Affinity DatapH: 7.0 T: 2°CAssay Description:Assays for Aurora kinase was performed in a DELFIA format. Aurora enzyme was incubated with test compound and cross-tide substrate in the reaction bu...More data for this Ligand-Target Pair
Affinity DataKd: 1.60E+3nMpH: 7.4 T: 2°CAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
Affinity DataKd: 590nMpH: 7.4 T: 2°CAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
Affinity DataKd: 7.40E+3nMpH: 7.4 T: 2°CAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
Affinity DataKd: 2.20E+3nMpH: 7.4 T: 2°CAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
Affinity DataKd: 7.10E+3nMpH: 7.4 T: 2°CAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
Affinity DataKd: 250nMpH: 7.4 T: 2°CAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
3D Structure (crystal)
Affinity DataKd: 6.5nMpH: 7.4 T: 2°CAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
Affinity DataKd: 120nMpH: 7.4 T: 2°CAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
Affinity DataKd: 110nMpH: 7.4 T: 2°CAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
Affinity DataKd: 1.70E+3nMpH: 7.4 T: 2°CAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
Affinity DataKd: 4.10nMpH: 7.4 T: 2°CAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
Affinity DataKd: 0.273nMT: 2°CAssay Description:A stock solution was prepared containing complex of Aurora A and Compound I (final total concentrations of 6nM and 5nM, respectively). Separately, se...More data for this Ligand-Target Pair
Affinity DataKd: 5.20nMT: 2°CAssay Description:A stock solution was prepared containing complex of Aurora A and Compound I (final total concentrations of 6nM and 5nM, respectively). Separately, se...More data for this Ligand-Target Pair
Affinity DataKd: 0.200nMT: 2°CAssay Description:A stock solution was prepared containing complex of Aurora A and Compound I (final total concentrations of 6nM and 5nM, respectively). Separately, se...More data for this Ligand-Target Pair
Affinity DataKd: 0.527nMT: 2°CAssay Description:A stock solution was prepared containing complex of Aurora A and Compound I (final total concentrations of 6nM and 5nM, respectively). Separately, se...More data for this Ligand-Target Pair
Affinity DataKd: 4.34nMT: 2°CAssay Description:A stock solution was prepared containing complex of Aurora A and Compound I (final total concentrations of 6nM and 5nM, respectively). Separately, se...More data for this Ligand-Target Pair
Affinity DataKd: 0.544nMT: 2°CAssay Description:A stock solution was prepared containing complex of Aurora A and Compound I (final total concentrations of 6nM and 5nM, respectively). Separately, se...More data for this Ligand-Target Pair
Affinity DataKd: 7.5nMAssay Description:The kinase selectivity was assessed by profiling Example 1 in a 442-kinase panel (386 non-mutant kinases) at a concentration of 1 μM using the K...More data for this Ligand-Target Pair
Affinity DataKd: 16nMAssay Description:Average Binding Constant for Aurora2; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
Affinity DataKd: 980nMAssay Description:Average Binding Constant for Aurora2; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
Affinity DataKd: 120nMAssay Description:Binding affinity to AURKAMore data for this Ligand-Target Pair
Affinity DataKd: 16nMAssay Description:Binding affinity to AURKAMore data for this Ligand-Target Pair
Affinity DataKd: 17nMAssay Description:Binding constant for AURKA kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for AURKA kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 16nMAssay Description:Binding constant for AURKA kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 120nMAssay Description:Binding constant for AURKA kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 7.5nMAssay Description:Binding affinity to Aurora A kinaseMore data for this Ligand-Target Pair
Affinity DataKd: 5.80nMAssay Description:Binding affinity to Aurora kinase A catalytic domain by competition binding assayMore data for this Ligand-Target Pair
Affinity DataKd: 8.80nMAssay Description:Binding affinity to Aurora kinase A catalytic domain by competition binding assayMore data for this Ligand-Target Pair
Affinity DataKd: 120nMAssay Description:Binding constant for AURKA kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 110nMAssay Description:Binding constant for AURKA kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 1.30nMAssay Description:Binding affinity to AURKA (unknown origin)More data for this Ligand-Target Pair
Affinity DataKd: 3.80E+3nMAssay Description:Average Binding Constant for Aurora2; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
Affinity DataKd: 6.60E+3nMAssay Description:Average Binding Constant for Aurora2; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
Affinity DataEC50: 510nMAssay Description:Inhibition of AURKA (unknown origin) by cell-based assayMore data for this Ligand-Target Pair
Affinity DataEC50: 510nMAssay Description:Inhibition of AURKA (unknown origin)More data for this Ligand-Target Pair
Affinity DataEC50: >6.00E+3nMAssay Description:Inhibition of AURKA (unknown origin) transfected in human HCT116 cells after 4 hrs by near infrared imager analysisMore data for this Ligand-Target Pair
Affinity DataKd: 0.440nMAssay Description:Binding affinity to purified recombinant full-length Aurora A (unknown origin) by fluorescence polarisation/anisotropy based equilibrium binding assa...More data for this Ligand-Target Pair
Affinity DataKd: 0.730nMAssay Description:Binding affinity to purified recombinant full-length Aurora A (unknown origin) by fluorescence polarisation/anisotropy based equilibrium binding assa...More data for this Ligand-Target Pair
Affinity DataKd: 2.5nMAssay Description:Binding affinity to purified recombinant full-length Aurora A (unknown origin) by fluorescence polarisation/anisotropy based equilibrium binding assa...More data for this Ligand-Target Pair
Affinity DataKd: 6.10nMAssay Description:Binding affinity to purified recombinant full-length Aurora A (unknown origin) by fluorescence polarisation/anisotropy based equilibrium binding assa...More data for this Ligand-Target Pair
Affinity DataKd: 5.70nMAssay Description:Binding affinity to purified recombinant full-length Aurora A (unknown origin) by fluorescence polarisation/anisotropy based equilibrium binding assa...More data for this Ligand-Target Pair
Affinity DataKd: 6.5nMAssay Description:Binding affinity to purified recombinant full-length Aurora A (unknown origin) by fluorescence polarisation/anisotropy based equilibrium binding assa...More data for this Ligand-Target Pair
Affinity DataKd: 9.10nMAssay Description:Binding affinity to purified recombinant full-length Aurora A (unknown origin) by fluorescence polarisation/anisotropy based equilibrium binding assa...More data for this Ligand-Target Pair
Affinity DataKd: 2.20nMAssay Description:Binding affinity to purified recombinant full-length Aurora A (unknown origin) by fluorescence polarisation/anisotropy based equilibrium binding assa...More data for this Ligand-Target Pair
Affinity DataKd: 1.90nMAssay Description:Binding affinity to purified recombinant full-length Aurora A (unknown origin) by fluorescence polarisation/anisotropy based equilibrium binding assa...More data for this Ligand-Target Pair
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to AURKAMore data for this Ligand-Target Pair
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to AURKAMore data for this Ligand-Target Pair
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to AURKAMore data for this Ligand-Target Pair
