Compile Data Set for Download or QSAR
Report error Found 48 Enz. Inhib. hit(s) with all data for entry = 9167
TargetAmyloid-beta precursor protein [672-713](Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 446555BDBM446555(7-(2-Chloro-4-fluorophenyl)-N2-(3-fluoro-4-(4-meth...)
Affinity DataEC50:  4nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details
US Patent

TargetAmyloid-beta precursor protein [672-713](Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 446518BDBM446518(7-(3,4-Difluorophenyl)-N2-(3-methoxy-4-(3-methyl-1...)
Affinity DataEC50:  5nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details
US Patent

TargetAmyloid-beta precursor protein [672-713](Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 446501BDBM446501(7-(4-Fluorophenyl)-N2-(5-methoxy-6-(4-methyl-1H-im...)
Affinity DataEC50:  5nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details
US Patent

TargetAmyloid-beta precursor protein [672-713](Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 50465355BDBM50465355(CHEMBL4285214 | US10669276, Example 1)
Affinity DataEC50:  5nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details
US Patent

TargetAmyloid-beta precursor protein [672-713](Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 446554BDBM446554(7-(2,3-Difluorophenyl)-N2-(5-methoxy-6-(4-methyl-1...)
Affinity DataEC50:  5nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details
US Patent

TargetAmyloid-beta precursor protein [672-713](Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 446553BDBM446553(7-(2,3-Difluorophenyl)-N2-(3-fluoro-4-(4-methyl-1H...)
Affinity DataEC50:  5nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details
US Patent

TargetAmyloid-beta precursor protein [672-713](Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 446556BDBM446556((S)- or (R) N2-(3-Fluoro-4-(4-methyl-1H-imidazol-1...)
Affinity DataEC50:  5nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details
US Patent

TargetAmyloid-beta precursor protein [672-713](Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 446550BDBM446550(7-(4-Fluorophenyl)-N2-(5-methoxy-6-(4-methyl-1H-im...)
Affinity DataEC50:  6nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details
US Patent

TargetAmyloid-beta precursor protein [672-713](Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 446549BDBM446549(7-(4-Fluorophenyl)-N2-(3-methoxy-4-(3-methyl-1H-1,...)
Affinity DataEC50:  6nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details
US Patent

TargetAmyloid-beta precursor protein [672-713](Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 446536BDBM446536(7-(2,4-Difluorophenyl)-N2-(5-fluoro-6-(4-methyl-1H...)
Affinity DataEC50:  6nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details
US Patent

TargetAmyloid-beta precursor protein [672-713](Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 446548BDBM446548(N2-(3-Fluoro-4-(4-methyl-1H-imidazol-1-yl)phenyl)-...)
Affinity DataEC50:  6nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details
US Patent

TargetAmyloid-beta precursor protein [672-713](Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 446543BDBM446543(7-(4-Fluorophenyl)-N2-(5-methoxy-6-(4-methyl-1H-im...)
Affinity DataEC50:  6nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details
US Patent

TargetAmyloid-beta precursor protein [672-713](Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 446539BDBM446539(2-((7-(4-Fluorophenyl)-2-((5-methoxy-6-(4-methyl-1...)
Affinity DataEC50:  6nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details
US Patent

TargetAmyloid-beta precursor protein [672-713](Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 50465354BDBM50465354(CHEMBL4293045 | US10669276, Example 4)
Affinity DataEC50:  7nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details
US Patent

TargetAmyloid-beta precursor protein [672-713](Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 446557BDBM446557((R) or (S) N2-(3-Fluoro-4-(4-methyl-1H-imidazol-1-...)
Affinity DataEC50:  7nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details
US Patent

TargetAmyloid-beta precursor protein [672-713](Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 446533BDBM446533(N2-(6-(4-Chloro-1H-imidazol-1-yl)-5-methoxypyridin...)
Affinity DataEC50:  8nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details
US Patent

TargetAmyloid-beta precursor protein [672-713](Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 446552BDBM446552(7-(2,3-Difluorophenyl)-N2-(5-fluoro-6-(4-methyl-1H...)
Affinity DataEC50:  8nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details
US Patent

TargetAmyloid-beta precursor protein [672-713](Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 50465357BDBM50465357(CHEMBL4283902 | US10669276, Example 25)
Affinity DataEC50:  8nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details
US Patent

TargetAmyloid-beta precursor protein [672-713](Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 446530BDBM446530(7-(2,4-Difluorophenyl)-N2-(5-methoxy-6-(4-methyl-1...)
Affinity DataEC50:  8nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details
US Patent

TargetAmyloid-beta precursor protein [672-713](Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 446529BDBM446529(7-(2,4-Difluorophenyl)-N2-(3-methoxy-4-(3-methyl-1...)
Affinity DataEC50:  8nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details
US Patent

TargetAmyloid-beta precursor protein [672-713](Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 446547BDBM446547(N2-(3-Fluoro-4-(4-methyl-1H-imidazol-1-yl)phenyl)-...)
Affinity DataEC50:  8nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details
US Patent

TargetAmyloid-beta precursor protein [672-713](Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 446525BDBM446525(7-(3,4-Difluorophenyl)-N2-(5-methoxy-6-(4-methyl-1...)
Affinity DataEC50:  8nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details
US Patent

TargetAmyloid-beta precursor protein [672-713](Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 446485BDBM446485(N2-(3-(Difluoromethoxy)-4-(3-methyl-1H-1,2,4-triaz...)
Affinity DataEC50:  8nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details
US Patent

TargetAmyloid-beta precursor protein [672-713](Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 446544BDBM446544(N2-(3-Fluoro-4-(4-methyl-1H-imidazol-1-yl)phenyl)-...)
Affinity DataEC50:  8nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details
US Patent

TargetAmyloid-beta precursor protein [672-713](Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 50465360BDBM50465360(CHEMBL4294948 | US10669276, Example 28)
Affinity DataEC50:  8nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details
US Patent

TargetAmyloid-beta precursor protein [672-713](Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 446551BDBM446551(7-(2,3-Difluorophenyl)-N2-(3-methoxy-4-(3-methyl-1...)
Affinity DataEC50:  9nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details
US Patent

TargetAmyloid-beta precursor protein [672-713](Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 446491BDBM446491(N2-(6-(4-Chloro-1H-imidazol-1-yl)-5-methoxypyridin...)
Affinity DataEC50:  9nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details
US Patent

TargetAmyloid-beta precursor protein [672-713](Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 446542BDBM446542(7-(4-Fluorophenyl)-N2-(3-methoxy-4-(3-methyl-1H-1,...)
Affinity DataEC50:  10nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details
US Patent

TargetAmyloid-beta precursor protein [672-713](Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 446524BDBM446524(N2-(6-(4-Chloro-1H-imidazol-1-yl)-5-methoxypyridin...)
Affinity DataEC50:  10nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details
US Patent

TargetAmyloid-beta precursor protein [672-713](Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 446540BDBM446540(2-((2-((6-(4-Chloro-1H-imidazol-1-yl)-5-methoxypyr...)
Affinity DataEC50:  11nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details
US Patent

TargetAmyloid-beta precursor protein [672-713](Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 50465363BDBM50465363(CHEMBL4278310 | US10669276, Example 35)
Affinity DataEC50:  13nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details
US Patent

TargetAmyloid-beta precursor protein [672-713](Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 446522BDBM446522(7-(4-Fluorophenyl)-N4,5,5-trimethyl-N2-(4-(4-methy...)
Affinity DataEC50:  13nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details
US Patent

TargetAmyloid-beta precursor protein [672-713](Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 446546BDBM446546(N2-(5-Fluoro-6-(4-methyl-1H-imidazol-1-yl)pyridin-...)
Affinity DataEC50:  14nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details
US Patent

TargetAmyloid-beta precursor protein [672-713](Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 446528BDBM446528(7-(3,3-Difluorocyclobutyl)-N2-(5-methoxy-6-(4-meth...)
Affinity DataEC50:  14nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details
US Patent

TargetAmyloid-beta precursor protein [672-713](Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 50465358BDBM50465358(CHEMBL4284649 | US10669276, Example 31)
Affinity DataEC50:  15nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details
US Patent

TargetAmyloid-beta precursor protein [672-713](Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 446487BDBM446487(N2-(3-Fluoro-4-(3-methyl-1H-1,2,4-triazol-1-yl)phe...)
Affinity DataEC50:  16nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details
US Patent

TargetAmyloid-beta precursor protein [672-713](Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 446527BDBM446527(7-(3,3-Difluorocyclobutyl)-N2-(3-methoxy-4-(3-meth...)
Affinity DataEC50:  19nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details
US Patent

TargetAmyloid-beta precursor protein [672-713](Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 446534BDBM446534(7-(2,4-Difluorophenyl)-N2-(3-fluoro-4-(3-methyl-1H...)
Affinity DataEC50:  22nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details
US Patent

TargetAmyloid-beta precursor protein [672-713](Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 446490BDBM446490(N2-(3-Fluoro-4-(5-methyl-1H-1,2,4-triazol-1-yl)phe...)
Affinity DataEC50:  22nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details
US Patent

TargetAmyloid-beta precursor protein [672-713](Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 446523BDBM446523(7-(4-Fluorophenyl)-N4,5,5-trimethyl-N2-(6-(3-methy...)
Affinity DataEC50:  23nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details
US Patent

TargetAmyloid-beta precursor protein [672-713](Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 446519BDBM446519(7-(3,4-Difluorophenyl)-N2-(3-fluoro-4-(3-methyl-1H...)
Affinity DataEC50:  26nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details
US Patent

TargetAmyloid-beta precursor protein [672-713](Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 446532BDBM446532(N2-(5-Methoxy-6-(4-methyl-1H-imidazol-1-yl)pyridin...)
Affinity DataEC50:  30nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details
US Patent

TargetAmyloid-beta precursor protein [672-713](Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 50465356BDBM50465356(CHEMBL4289270 | US10669276, Example 16)
Affinity DataEC50:  30nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details
US Patent

TargetAmyloid-beta precursor protein [672-713](Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 446537BDBM446537(7-(4-Fluorophenyl)-N2-(3-methoxy-4-(5-methyl-1,3,4...)
Affinity DataEC50:  30nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details
US Patent

TargetAmyloid-beta precursor protein [672-713](Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 50465359BDBM50465359(CHEMBL4279052 | US10669276, Example 11)
Affinity DataEC50:  33nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details
US Patent

TargetAmyloid-beta precursor protein [672-713](Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 446520BDBM446520(7-(4-Fluorophenyl)-N4,5,5-trimethyl-N2-(4-(3-methy...)
Affinity DataEC50:  51nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details
US Patent

TargetAmyloid-beta precursor protein [672-713](Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 446558BDBM446558(7-(4-Fluorophenyl)-N4,5,5-trimethyl-N2-(4-(5-methy...)
Affinity DataEC50:  55nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details
US Patent

TargetAmyloid-beta precursor protein [672-713](Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 446531BDBM446531(N2-(3-Methoxy-4-(3-methyl-1H-1,2,4-triazol-1-yl)ph...)
Affinity DataEC50:  72nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details
US Patent