Compile Data Set for Download or QSAR
Report error Found 20 Enz. Inhib. hit(s) with all data for entry = 10262
TargetMitogen-activated protein kinase kinase kinase 5(Human)
Galapagos

US Patent
LigandPNGBDBM523902(US11136325, Compound 4 | 2-amino-N-[1-(5-chloro-7H...)
Affinity DataIC50: 0.398nMAssay Description:ASK1 and ASK2 biochemical activities were also quantified using AlphaScreen technology which measures the degree of phosphorylation of a protein subs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase 5(Human)
Galapagos

US Patent
LigandPNGBDBM523904(US11136325, Compound 6 | 2-amino-N-[1-(5-cyano-3-m...)
Affinity DataIC50: 1.05nMAssay Description:IMAP technology provides a homogeneous assay applicable to a wide variety of kinases, phosphatases, and phosphodiesterases without regard for substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase 5(Human)
Galapagos

US Patent
LigandPNGBDBM523904(US11136325, Compound 6 | 2-amino-N-[1-(5-cyano-3-m...)
Affinity DataIC50: 1.05nMAssay Description:ASK1 and ASK2 biochemical activities were also quantified using AlphaScreen technology which measures the degree of phosphorylation of a protein subs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase 5(Human)
Galapagos

US Patent
LigandPNGBDBM523865(US11136325, Compound 2 | 2-amino-5-methyl-N-[1-(5-...)
Affinity DataIC50: 1.26nMAssay Description:ASK1 and ASK2 biochemical activities were also quantified using AlphaScreen technology which measures the degree of phosphorylation of a protein subs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase 5(Human)
Galapagos

US Patent
LigandPNGBDBM523903(US11136325, Compound 5 | 2-amino-N-[1-(5-chloro-7H...)
Affinity DataIC50: 1.58nMAssay Description:ASK1 and ASK2 biochemical activities were also quantified using AlphaScreen technology which measures the degree of phosphorylation of a protein subs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase 5(Human)
Galapagos

US Patent
LigandPNGBDBM523862(US11136325, Compound 1 | 2-amino-5-fluoro-N-[1-(5-...)
Affinity DataIC50: 1.91nMAssay Description:ASK1 and ASK2 biochemical activities were also quantified using AlphaScreen technology which measures the degree of phosphorylation of a protein subs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase 5(Human)
Galapagos

US Patent
LigandPNGBDBM523901(US11136325, Compound 3 | 2-amino-5-chloro-N-[1-(5-...)
Affinity DataIC50: 2nMAssay Description:ASK1 and ASK2 biochemical activities were also quantified using AlphaScreen technology which measures the degree of phosphorylation of a protein subs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase 5(Human)
Galapagos

US Patent
LigandPNGBDBM523902(US11136325, Compound 4 | 2-amino-N-[1-(5-chloro-7H...)
Affinity DataIC50: 3.47nMAssay Description:IMAP technology provides a homogeneous assay applicable to a wide variety of kinases, phosphatases, and phosphodiesterases without regard for substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase 5(Human)
Galapagos

US Patent
LigandPNGBDBM523903(US11136325, Compound 5 | 2-amino-N-[1-(5-chloro-7H...)
Affinity DataIC50: 3.72nMAssay Description:IMAP technology provides a homogeneous assay applicable to a wide variety of kinases, phosphatases, and phosphodiesterases without regard for substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase 5(Human)
Galapagos

US Patent
LigandPNGBDBM523905(US11136325, Compound 7 | 2-amino-N-[1-(3-chloro-1H...)
Affinity DataIC50: 5.75nMAssay Description:IMAP technology provides a homogeneous assay applicable to a wide variety of kinases, phosphatases, and phosphodiesterases without regard for substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase 5(Human)
Galapagos

US Patent
LigandPNGBDBM523862(US11136325, Compound 1 | 2-amino-5-fluoro-N-[1-(5-...)
Affinity DataIC50: 5.75nMAssay Description:IMAP technology provides a homogeneous assay applicable to a wide variety of kinases, phosphatases, and phosphodiesterases without regard for substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase 5(Human)
Galapagos

US Patent
LigandPNGBDBM523905(US11136325, Compound 7 | 2-amino-N-[1-(3-chloro-1H...)
Affinity DataIC50: 5.75nMAssay Description:ASK1 and ASK2 biochemical activities were also quantified using AlphaScreen technology which measures the degree of phosphorylation of a protein subs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase 6(Human)
Galapagos

US Patent
LigandPNGBDBM523902(US11136325, Compound 4 | 2-amino-N-[1-(5-chloro-7H...)
Affinity DataIC50: 6.31nMAssay Description:ASK1 and ASK2 biochemical activities were also quantified using AlphaScreen technology which measures the degree of phosphorylation of a protein subs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase 6(Human)
Galapagos

US Patent
LigandPNGBDBM523902(US11136325, Compound 4 | 2-amino-N-[1-(5-chloro-7H...)
Affinity DataIC50: 6.46nMAssay Description:IMAP technology provides a homogeneous assay applicable to a wide variety of kinases, phosphatases, and phosphodiesterases without regard for substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase 5(Human)
Galapagos

US Patent
LigandPNGBDBM523865(US11136325, Compound 2 | 2-amino-5-methyl-N-[1-(5-...)
Affinity DataIC50: 6.76nMAssay Description:IMAP technology provides a homogeneous assay applicable to a wide variety of kinases, phosphatases, and phosphodiesterases without regard for substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase 6(Human)
Galapagos

US Patent
LigandPNGBDBM523865(US11136325, Compound 2 | 2-amino-5-methyl-N-[1-(5-...)
Affinity DataIC50: 8.32nMAssay Description:IMAP technology provides a homogeneous assay applicable to a wide variety of kinases, phosphatases, and phosphodiesterases without regard for substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase 5(Human)
Galapagos

US Patent
LigandPNGBDBM523901(US11136325, Compound 3 | 2-amino-5-chloro-N-[1-(5-...)
Affinity DataIC50: 8.91nMAssay Description:IMAP technology provides a homogeneous assay applicable to a wide variety of kinases, phosphatases, and phosphodiesterases without regard for substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase 6(Human)
Galapagos

US Patent
LigandPNGBDBM523862(US11136325, Compound 1 | 2-amino-5-fluoro-N-[1-(5-...)
Affinity DataIC50: 11nMAssay Description:IMAP technology provides a homogeneous assay applicable to a wide variety of kinases, phosphatases, and phosphodiesterases without regard for substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase 6(Human)
Galapagos

US Patent
LigandPNGBDBM523901(US11136325, Compound 3 | 2-amino-5-chloro-N-[1-(5-...)
Affinity DataIC50: 15.8nMAssay Description:ASK1 and ASK2 biochemical activities were also quantified using AlphaScreen technology which measures the degree of phosphorylation of a protein subs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase 6(Human)
Galapagos

US Patent
LigandPNGBDBM523862(US11136325, Compound 1 | 2-amino-5-fluoro-N-[1-(5-...)
Affinity DataIC50: 19.5nMAssay Description:ASK1 and ASK2 biochemical activities were also quantified using AlphaScreen technology which measures the degree of phosphorylation of a protein subs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
US Patent