Compile Data Set for Download or QSAR
Report error Found 6 Enz. Inhib. hit(s) with all data for entry = 10265
TargetCytochrome P450 2D6(Human)
Rugen Holdings (Cayman)

US Patent
LigandChemical structure of BindingDB Monomer ID 280739BDBM280739(US10030026, Compound LX-1 | US10221182, Compound L...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibitory activities of test compounds on 5 major isoforms of CYP P450 were evaluated by using pooled human liver microsome (HLM, purchased from BD ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Rugen Holdings (Cayman)

US Patent
LigandChemical structure of BindingDB Monomer ID 280739BDBM280739(US10030026, Compound LX-1 | US10221182, Compound L...)
Affinity DataIC50: 4.50E+3nMAssay Description:The assay was performed on hERG channel stably expressed in HEK293 cells. The cells were cultured at 37° C. in a humidified CO2 incubator in the grow...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
US Patent

TargetCytochrome P450 2D6(Human)
Rugen Holdings (Cayman)

US Patent
LigandChemical structure of BindingDB Monomer ID 435146BDBM435146(US10584127, Compound E1-8.2 | US11136328, Compound...)
Affinity DataIC50: 5.90E+3nMAssay Description:Inhibitory activities of test compounds on 5 major isoforms of CYP P450 were evaluated by using pooled human liver microsome (HLM, purchased from BD ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Rugen Holdings (Cayman)

US Patent
LigandChemical structure of BindingDB Monomer ID 435146BDBM435146(US10584127, Compound E1-8.2 | US11136328, Compound...)
Affinity DataIC50: 6.80E+3nMAssay Description:The assay was performed on hERG channel stably expressed in HEK293 cells. The cells were cultured at 37° C. in a humidified CO2 incubator in the grow...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Rugen Holdings (Cayman)

US Patent
LigandChemical structure of BindingDB Monomer ID 388301BDBM388301(US10294230, Compound E1-22.2 | US10584127, Compoun...)
Affinity DataIC50: 1.00E+4nMAssay Description:The assay was performed on hERG channel stably expressed in HEK293 cells. The cells were cultured at 37° C. in a humidified CO2 incubator in the grow...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Rugen Holdings (Cayman)

US Patent
LigandChemical structure of BindingDB Monomer ID 388294BDBM388294(US10294230, Compound E1-1.2 | US10584127, Compound...)
Affinity DataIC50: 4.00E+4nMAssay Description:The assay was performed on hERG channel stably expressed in HEK293 cells. The cells were cultured at 37° C. in a humidified CO2 incubator in the grow...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
US Patent