Compile Data Set for Download or QSAR
Report error Found 20 Enz. Inhib. hit(s) with all data for entry = 13324
TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Albert Einstein College of Medicine

US Patent
LigandPNGBDBM50396483(PLX-4032 | RG 7204 | Ro 5185426 | VEMURAFENIB | US...)
Affinity DataIC50: 1.90nMAssay Description:BRAF kinase assays were performed using the Z′-LYTE™ enzymatic assay (Invitrogen, USA). Briefly, kinase activity was monitored in a cascade system co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/3/2026
Entry Details
US Patent

TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Albert Einstein College of Medicine

US Patent
LigandPNGBDBM50430022(CHEMBL2144069 | US12440494, Compound AZ-628)
Affinity DataIC50: 5.30nMAssay Description:BRAF kinase assays were performed using the Z′-LYTE™ enzymatic assay (Invitrogen, USA). Briefly, kinase activity was monitored in a cascade system co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/3/2026
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Albert Einstein College of Medicine

US Patent
LigandPNGBDBM780152(3-(2-[imidazo[1,2-b]pyridazin-3- yl]ethynyl)-4-met...)
Affinity DataIC50: 5.5nMAssay Description:BRAF kinase assays were performed using the Z′-LYTE™ enzymatic assay (Invitrogen, USA). Briefly, kinase activity was monitored in a cascade system co...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/3/2026
Entry Details
US Patent

TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Albert Einstein College of Medicine

US Patent
LigandPNGBDBM317744(US9624213, Compound P-0240 | US11337976, Compound ...)
Affinity DataIC50: 6.70nMAssay Description:BRAF kinase assays were performed using the Z′-LYTE™ enzymatic assay (Invitrogen, USA). Briefly, kinase activity was monitored in a cascade system co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/3/2026
Entry Details
US Patent

TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Albert Einstein College of Medicine

US Patent
LigandPNGBDBM780141(3-(imidazo[1,2-b]pyridazin-3- ylethynyl)-4-methyl-...)
Affinity DataIC50: 10.4nMAssay Description:BRAF kinase assays were performed using the Z′-LYTE™ enzymatic assay (Invitrogen, USA). Briefly, kinase activity was monitored in a cascade system co...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/3/2026
Entry Details
US Patent

TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Albert Einstein College of Medicine

US Patent
LigandPNGBDBM50096279(CHEMBL3577124 | US12440494, Compound LY3009120)
Affinity DataIC50: 12nMAssay Description:BRAF kinase assays were performed using the Z′-LYTE™ enzymatic assay (Invitrogen, USA). Briefly, kinase activity was monitored in a cascade system co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/3/2026
Entry Details
US Patent

TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Albert Einstein College of Medicine

US Patent
LigandPNGBDBM50322535(3-[2-(Imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-meth...)
Affinity DataIC50: 14nMAssay Description:BRAF kinase assays were performed using the Z′-LYTE™ enzymatic assay (Invitrogen, USA). Briefly, kinase activity was monitored in a cascade system co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/3/2026
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Albert Einstein College of Medicine

US Patent
LigandPNGBDBM780142(4-[2-[([4-[3-(2-[imidazo[1,2- b]pyridazin-3-yl]eth...)
Affinity DataIC50: 17.8nMAssay Description:BRAF kinase assays were performed using the Z′-LYTE™ enzymatic assay (Invitrogen, USA). Briefly, kinase activity was monitored in a cascade system co...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/3/2026
Entry Details
US Patent

TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Albert Einstein College of Medicine

US Patent
LigandPNGBDBM50396483(PLX-4032 | RG 7204 | Ro 5185426 | VEMURAFENIB | US...)
Affinity DataIC50: 21.8nMAssay Description:BRAF kinase assays were performed using the Z′-LYTE™ enzymatic assay (Invitrogen, USA). Briefly, kinase activity was monitored in a cascade system co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/3/2026
Entry Details
US Patent

TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Albert Einstein College of Medicine

US Patent
LigandPNGBDBM780145(3-(imidazo[1,2-b]pyridazin-3- ylethynyl)-4-methyl-...)
Affinity DataIC50: 29.4nMAssay Description:BRAF kinase assays were performed using the Z′-LYTE™ enzymatic assay (Invitrogen, USA). Briefly, kinase activity was monitored in a cascade system co...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/3/2026
Entry Details
US Patent

TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Albert Einstein College of Medicine

US Patent
LigandPNGBDBM780144(3-(imidazo[1,2-b]pyridazin-3- ylethynyl)-4-methyl-...)
Affinity DataIC50: 30.7nMAssay Description:BRAF kinase assays were performed using the Z′-LYTE™ enzymatic assay (Invitrogen, USA). Briefly, kinase activity was monitored in a cascade system co...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/3/2026
Entry Details
US Patent

TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Albert Einstein College of Medicine

US Patent
LigandPNGBDBM99471(US8497274, 32 | US12440494, Compound TAK-632)
Affinity DataIC50: 36.2nMAssay Description:BRAF kinase assays were performed using the Z′-LYTE™ enzymatic assay (Invitrogen, USA). Briefly, kinase activity was monitored in a cascade system co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/3/2026
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Albert Einstein College of Medicine

US Patent
LigandPNGBDBM780146(3-(imidazo[1,2-b]pyridazin-3- ylethynyl)-4-methyl-...)
Affinity DataIC50: 44.3nMAssay Description:BRAF kinase assays were performed using the Z′-LYTE™ enzymatic assay (Invitrogen, USA). Briefly, kinase activity was monitored in a cascade system co...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/3/2026
Entry Details
US Patent

TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Albert Einstein College of Medicine

US Patent
LigandPNGBDBM780143(3-(imidazo[1,2-b]pyridazin-3- ylethynyl)-N-(4-(((2...)
Affinity DataIC50: 48nMAssay Description:BRAF kinase assays were performed using the Z′-LYTE™ enzymatic assay (Invitrogen, USA). Briefly, kinase activity was monitored in a cascade system co...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/3/2026
Entry Details
US Patent

TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Albert Einstein College of Medicine

US Patent
LigandPNGBDBM780149(3-ethynyl-4-methyl-N-(4-(((2- morpholinoethyl)amin...)
Affinity DataIC50: 1.36E+3nMAssay Description:BRAF kinase assays were performed using the Z′-LYTE™ enzymatic assay (Invitrogen, USA). Briefly, kinase activity was monitored in a cascade system co...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/3/2026
Entry Details
US Patent

TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Albert Einstein College of Medicine

US Patent
LigandPNGBDBM780147(Methyl 4-[2-([[4-(3-Ethynyl-4- Methylbenzamido)-2-...)
Affinity DataIC50: 1.79E+3nMAssay Description:BRAF kinase assays were performed using the Z′-LYTE™ enzymatic assay (Invitrogen, USA). Briefly, kinase activity was monitored in a cascade system co...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/3/2026
Entry Details
US Patent

TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Albert Einstein College of Medicine

US Patent
LigandPNGBDBM780153(3-Ethynyl-4-Methyl-N-(4-(((2-(4- (Pyridin-2-Yl)Pip...)
Affinity DataIC50: 1.83E+3nMAssay Description:BRAF kinase assays were performed using the Z′-LYTE™ enzymatic assay (Invitrogen, USA). Briefly, kinase activity was monitored in a cascade system co...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/3/2026
Entry Details
US Patent

TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Albert Einstein College of Medicine

US Patent
LigandPNGBDBM780150(3-Ethynyl-4-Methyl-N-[4-([[2-(4- Phenylpiperazin-1...)
Affinity DataIC50: 8.94E+3nMAssay Description:BRAF kinase assays were performed using the Z′-LYTE™ enzymatic assay (Invitrogen, USA). Briefly, kinase activity was monitored in a cascade system co...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/3/2026
Entry Details
US Patent

TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Albert Einstein College of Medicine

US Patent
LigandPNGBDBM780148(Tert-Butyl4-[2-([[4-(3-Ethynyl-4- Methylbenzamido)...)
Affinity DataIC50: 1.09E+4nMAssay Description:BRAF kinase assays were performed using the Z′-LYTE™ enzymatic assay (Invitrogen, USA). Briefly, kinase activity was monitored in a cascade system co...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/3/2026
Entry Details
US Patent

TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Albert Einstein College of Medicine

US Patent
LigandPNGBDBM780151(3-Ethynyl-4-Methyl-N-[4-([[2- (Piperazin-1- Yl)Eth...)
Affinity DataIC50: 1.19E+4nMAssay Description:BRAF kinase assays were performed using the Z′-LYTE™ enzymatic assay (Invitrogen, USA). Briefly, kinase activity was monitored in a cascade system co...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/3/2026
Entry Details
US Patent