Compile Data Set for Download or QSAR
Report error Found 15 Enz. Inhib. hit(s) with all data for entry = 13397
LigandChemical structure of BindingDB Monomer ID 786032BDBM786032(5-(5-(3-(3-aminoprop- oxy)naphthalen-2-yl)- 1H-pyr...)
Affinity DataIC50: 0.933nMAssay Description:Inhibition of CHK-1 kinase or percent inhibition at defined concentrations was determined by TR-FRET assay. Kinase reactions were performed in a 20 μ...More data for this Ligand-Target Pair
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Date in BDB:
3/4/2026
Entry Details

LigandChemical structure of BindingDB Monomer ID 786029BDBM786029(5-(5-(3-(pyrrolidin-3- ylmethoxy)naphthalen- 2-yl)...)
Affinity DataIC50: 2.34nMAssay Description:Inhibition of CHK-1 kinase or percent inhibition at defined concentrations was determined by TR-FRET assay. Kinase reactions were performed in a 20 μ...More data for this Ligand-Target Pair
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Date in BDB:
3/4/2026
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LigandChemical structure of BindingDB Monomer ID 786026BDBM786026(5-(5-(3-(piperidin-4-yl- methoxy)naphthalen-2- yl)...)
Affinity DataIC50: 2.46nMAssay Description:Inhibition of CHK-1 kinase or percent inhibition at defined concentrations was determined by TR-FRET assay. Kinase reactions were performed in a 20 μ...More data for this Ligand-Target Pair
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Date in BDB:
3/4/2026
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LigandChemical structure of BindingDB Monomer ID 786027BDBM786027(5-(5-(3-(azetidine-3-yl- methoxy)naphthalen-2- yl)...)
Affinity DataIC50: 4.14nMAssay Description:Inhibition of CHK-1 kinase or percent inhibition at defined concentrations was determined by TR-FRET assay. Kinase reactions were performed in a 20 μ...More data for this Ligand-Target Pair
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Date in BDB:
3/4/2026
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LigandChemical structure of BindingDB Monomer ID 786030BDBM786030(5-(5-(3-(piperidin-3-yl- methoxy)naphthalen-2- yl)...)
Affinity DataIC50: 4.36nMAssay Description:Inhibition of CHK-1 kinase or percent inhibition at defined concentrations was determined by TR-FRET assay. Kinase reactions were performed in a 20 μ...More data for this Ligand-Target Pair
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In Depth
Date in BDB:
3/4/2026
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LigandChemical structure of BindingDB Monomer ID 786020BDBM786020(5-(5-(2-(piperidin-3-yl- methoxy)phenyl)isox- azol...)
Affinity DataIC50: 7.77nMAssay Description:Inhibition of CHK-1 kinase or percent inhibition at defined concentrations was determined by TR-FRET assay. Kinase reactions were performed in a 20 μ...More data for this Ligand-Target Pair
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In Depth
Date in BDB:
3/4/2026
Entry Details

LigandChemical structure of BindingDB Monomer ID 786022BDBM786022(5-(5-(2-(3-aminoprop- oxy)phenyl)isoxazol-3- ylami...)
Affinity DataIC50: 7.82nMAssay Description:Inhibition of CHK-1 kinase or percent inhibition at defined concentrations was determined by TR-FRET assay. Kinase reactions were performed in a 20 μ...More data for this Ligand-Target Pair
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Date in BDB:
3/4/2026
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LigandChemical structure of BindingDB Monomer ID 786028BDBM786028(5-(5-(3-(morpholin-2- ylmethoxy)naphthalen- 2-yl)-...)
Affinity DataIC50: 8.15nMAssay Description:Inhibition of CHK-1 kinase or percent inhibition at defined concentrations was determined by TR-FRET assay. Kinase reactions were performed in a 20 μ...More data for this Ligand-Target Pair
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In Depth
Date in BDB:
3/4/2026
Entry Details

LigandChemical structure of BindingDB Monomer ID 786023BDBM786023(5-(5-(2-(4-aminobut- oxy)phenyl)isoxazol-3- ylamin...)
Affinity DataIC50: 12.3nMAssay Description:Inhibition of CHK-1 kinase or percent inhibition at defined concentrations was determined by TR-FRET assay. Kinase reactions were performed in a 20 μ...More data for this Ligand-Target Pair
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In Depth
Date in BDB:
3/4/2026
Entry Details

LigandChemical structure of BindingDB Monomer ID 786019BDBM786019(5-(5-(2-(piperidin-4-yl- methoxy)phenyl)isox- azol...)
Affinity DataIC50: 13.3nMAssay Description:Inhibition of CHK-1 kinase or percent inhibition at defined concentrations was determined by TR-FRET assay. Kinase reactions were performed in a 20 μ...More data for this Ligand-Target Pair
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In Depth
Date in BDB:
3/4/2026
Entry Details

LigandChemical structure of BindingDB Monomer ID 786031BDBM786031(5-((5-(3-(2-amino- ethoxy)naphthalen-2- yl)-1H-pyr...)
Affinity DataIC50: 15.7nMAssay Description:Inhibition of CHK-1 kinase or percent inhibition at defined concentrations was determined by TR-FRET assay. Kinase reactions were performed in a 20 μ...More data for this Ligand-Target Pair
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In Depth
Date in BDB:
3/4/2026
Entry Details

LigandChemical structure of BindingDB Monomer ID 786018BDBM786018(5-(5-(2-(morpholin-2- ylmethoxy)phenyl)- isoxazol-...)
Affinity DataIC50: 67.7nMAssay Description:Inhibition of CHK-1 kinase or percent inhibition at defined concentrations was determined by TR-FRET assay. Kinase reactions were performed in a 20 μ...More data for this Ligand-Target Pair
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In Depth
Date in BDB:
3/4/2026
Entry Details

LigandChemical structure of BindingDB Monomer ID 786024BDBM786024(5-(5-(2-((4-methyl- morpholin-2-yl)meth- oxy)pheny...)
Affinity DataIC50: 76.6nMAssay Description:Inhibition of CHK-1 kinase or percent inhibition at defined concentrations was determined by TR-FRET assay. Kinase reactions were performed in a 20 μ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/4/2026
Entry Details

LigandChemical structure of BindingDB Monomer ID 786021BDBM786021(5-(5-(2-(azetidin-3-yl- oxy)phenyl)isoxazol- 3-yla...)
Affinity DataIC50: 86.4nMAssay Description:Inhibition of CHK-1 kinase or percent inhibition at defined concentrations was determined by TR-FRET assay. Kinase reactions were performed in a 20 μ...More data for this Ligand-Target Pair
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In Depth
Date in BDB:
3/4/2026
Entry Details

LigandChemical structure of BindingDB Monomer ID 786025BDBM786025(5-(3-(2-methoxy-4- (1,2,3,6-tetrahydropyr- idin-4-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CHK-1 kinase or percent inhibition at defined concentrations was determined by TR-FRET assay. Kinase reactions were performed in a 20 μ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/4/2026
Entry Details