Affinity DataEC50: 0.631nMAssay Description:Agonist activity at human dopamine D2L receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins...More data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataEC50: 0.690nMAssay Description:Agonist activity at D2 receptor (unknown origin) expressed in CHOK1 cells co-expressing G-alpha 15 by fluo-4 dye based FLIPR assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.780nMAssay Description:Agonist activity at N-terminal flag-tagged D2S receptor (unknown origin) expressed in HEK293 cells coexpressing renilla luciferase 2-tagged GalphaoB ...More data for this Ligand-Target Pair
Affinity DataEC50: 0.780nMAssay Description:Agonist activity at N-terminal flag-tagged D2S receptor (unknown origin) expressed in HEK293 cells coexpressing renilla luciferase 2-tagged GalphaoB ...More data for this Ligand-Target Pair
Affinity DataEC50: 0.800nMAssay Description:Agonist activity at D2R (unknown origin) expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gi-cAMP Glosensor...More data for this Ligand-Target Pair
Affinity DataEC50: 0.990nMAssay Description:Agonist activity at D2 receptor (unknown origin) expressed in CHOK1 cells assessed as increase in calcium flux incubated for 60 mins at 37 degC follo...More data for this Ligand-Target Pair
Affinity DataEC50: 1.10nMAssay Description:In vitro effective concentration tested on HEK293 cells co-transfected with rat Dopamine receptor D2 using FLIPR assayMore data for this Ligand-Target Pair
Affinity DataEC50: 1.10nMAssay Description:Agonist activity at rat D2 receptor in HEK293 cells coexpressing G-alpha-qo5 by FLIPRMore data for this Ligand-Target Pair
Affinity DataKi: 1.80nMAssay Description:Binding Affinity on high Affinity Site of Bovine dopamine receptor D2. Tested for ability to displace the radioligand [3H]pramipexole was testedMore data for this Ligand-Target Pair
Affinity DataKi: 1.90nMAssay Description:Displacement of [3H]quinpirole from human dopamine D2A receptors expressed in LtK cellsMore data for this Ligand-Target Pair
Affinity DataKi: 1.90nMAssay Description:Displacement of [3H]quinpirole from Dopamine receptor D2More data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Inhibitory concentration half-maximal displacement of 1.0 nM [3H]NPA specific binding from rat striatal membranes using 10e-5 (+/-)ADTNMore data for this Ligand-Target Pair
Affinity DataKi: 2nMAssay Description:Displacement of [3H]-raclopride from high-affinity state of human dopamine D2L receptor (443 amino acids) expressed in LTK deficient mouse fibroblast...More data for this Ligand-Target Pair
Affinity DataIC50: 2.10nMAssay Description:Inhibitory concentration for half-maximal displacement of 1.0 nM [3H]ADTN specific binding from rat striatal membranes using 10E-5 sulpirideMore data for this Ligand-Target Pair
Affinity DataEC50: 2.80nMAssay Description:Agonist activity at N-terminal flag-tagged D2S receptor (unknown origin) expressed in HEK293 cells coexpressing renilla luciferase 2-tagged Galphai1 ...More data for this Ligand-Target Pair
Affinity DataKi: 2.90nMAssay Description:Displacement of [3H]spiperone from human dopamine D2 receptor at high affinity state expressed in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 3.70nMAssay Description:Tested for binding to dopamine receptor using [3H]- ADTN as radioligand in calf caudate nucleus homogenates.More data for this Ligand-Target Pair
Affinity DataEC50: 3.90nMAssay Description:Agonist activity at N-terminal flag-tagged D2S receptor (unknown origin) expressed in HEK293 cells coexpressing renilla luciferase 2-tagged Galphai2 ...More data for this Ligand-Target Pair
Affinity DataIC50: 4.5nMAssay Description:Tested for binding to dopamine receptor using [3H]apomorphine as radioligand in calf caudate nucleus homogenates.More data for this Ligand-Target Pair
Affinity DataEC50: 4.5nMAssay Description:Agonist activity at N-terminal flag-tagged D2S receptor (unknown origin) expressed in HEK293 cells coexpressing renilla luciferase 2-tagged Galphai3 ...More data for this Ligand-Target Pair
Affinity DataEC50: 5nMAssay Description:Activity at rat dopamine D2L receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP productionMore data for this Ligand-Target Pair
Affinity DataEC50: 5nMAssay Description:Agonist activity at human D2 receptor transfected in HEK293T cells by BRET based G0 activation assayMore data for this Ligand-Target Pair
Affinity DataEC50: 6.70nMAssay Description:Agonist activity at dopamine D2 receptor (unknown origin) expressed in CHOK1 cells coexpressing Galpha15 by FLIPR assayMore data for this Ligand-Target Pair
Affinity DataEC50: 7.70nMAssay Description:Agonist activity at recombinant human D2 receptor expressing in CHOp cells assessed as receptor mediated stimulation of mitogenesis measured as [3H]t...More data for this Ligand-Target Pair
Affinity DataEC50: 8nMAssay Description:In vitro effective concentration tested on HEK293 cells co-transfected with ferret Dopamine receptor D2 using FLIPR assayMore data for this Ligand-Target Pair
Affinity DataEC50: 8nMAssay Description:Agonist activity at ferret D2 receptor in HEK293 cells coexpressing Galphaqo5 by FLIPRMore data for this Ligand-Target Pair
Affinity DataKi: 8nMAssay Description:Displacement of [3H]-NPA from dopamine D2L receptor (unknown origin) expressed in CHO cell membranesMore data for this Ligand-Target Pair
Affinity DataKi: 8.70nMAssay Description:Displacement of [3H]7-OH-DPAT from human D2 receptor transfected in HEK293 cells measured after 60 mins by liquid scintillation counterMore data for this Ligand-Target Pair
Affinity DataKi: 11nMAssay Description:Binding Affinity was tested on high Affinity Site of Bovine Dopamine D2 Receptor. Tested for ability to displace the radioligand [3H]spiperone was te...More data for this Ligand-Target Pair
Affinity DataKi: 13nMAssay Description:Binding affinity to D2 receptor (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
Affinity DataKi: 15nMAssay Description:Inhibition of [3H]YM-09151-2 binding to bovine retina membrane Dopamine receptor D2, high affinity siteMore data for this Ligand-Target Pair
Affinity DataIC50: 15nMAssay Description:The IC50 value was reported as apparent, since [3H]NCA was purported to be irreversible. Result indicates the mean of two separate experiments, each ...More data for this Ligand-Target Pair
Affinity DataKi: 15nMAssay Description:In vitro affinity against dopamine receptor D2 using [3H]DP-5,6-ADTN radioligand in rat striatal homogenateMore data for this Ligand-Target Pair
Affinity DataKi: 16nMAssay Description:Displacement of [3H]-(R)-(+)-7-OH-DPAT from human dopamine D2 receptor expressed in HEK293 cell membranes after 90 mins by micro beta scintillation c...More data for this Ligand-Target Pair
Affinity DataKi: 17nMAssay Description:Binding Affinity on High Affinity Site of Dopamine receptor D2SMore data for this Ligand-Target Pair
Affinity DataEC50: 18nMAssay Description:Agonist activity at human D2 receptor expressed in CHO-K1 cells by calcium 4 dye based FLIPR assayMore data for this Ligand-Target Pair
Affinity DataEC50: 18nMAssay Description:In vitro effective concentration tested on HEK293 cells co-transfected with human Dopamine receptor D2 using FLIPR assayMore data for this Ligand-Target Pair
Affinity DataEC50: 18nMAssay Description:Agonist activity at human D2 receptor in HEK293 cells coexpressing G-alpha-qo5 by FLIPRMore data for this Ligand-Target Pair
Affinity DataEC50: 19nMAssay Description:Agonist activity at dopamine D2 receptor long isoform (unknown origin) expressed in HEK293 cells assessed as induction of calcium flux after 60 min b...More data for this Ligand-Target Pair
Affinity DataKi: 20nMAssay Description:Binding affinity on High Affinity Site of Dopamine receptor D2LMore data for this Ligand-Target Pair
Affinity DataKi: 22nMAssay Description:Displacement of [3H]-iodosulpiride from cloned human dopamine D2S receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 34nMAssay Description:Binding Affinity was tested on relative proportion of High Affinity Site of Dopamine receptor D2SMore data for this Ligand-Target Pair
Affinity DataKi: 34nMAssay Description:Low binding affinity for dopamine receptor D2 from bovine anterior pituitary membrane, using radioligand [3H]spiroperidol in bovine anterior pituitar...More data for this Ligand-Target Pair
Affinity DataEC50: 36nMAssay Description:Agonist activity at human dopamine D2 receptor expressed in CHO cells assessed as increase of forskolin-induced cAMP production after 20 minsMore data for this Ligand-Target Pair
Affinity DataEC50: 40nMAssay Description:Agonist activity at human D2S receptor expressed in CHOK1 cells assessed as inhibition of forskolin induced cAMP production incubated for 10 mins fol...More data for this Ligand-Target Pair
Affinity DataKi: 42nMAssay Description:Binding Affinity was tested on relative proportion of High Affinity Site of Dopamine receptor D2LMore data for this Ligand-Target Pair
Affinity DataEC50: 43nMAssay Description:Agonist activity at human dopamine D2 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP productionMore data for this Ligand-Target Pair
Affinity DataKi: 48nMAssay Description:Displacement of [3H]spiperone from human D2S receptor expressed in CHO cellsMore data for this Ligand-Target Pair
