Compile Data Set for Download or QSAR
maximum 50k data
Found 44 Enz. Inhib. hit(s) with all data for entry = 50008691
LigandPNGBDBM50076142((S)-2-{[5-((R)-2-Amino-3-mercapto-propylamino)-bip...)
Affinity DataIC50:  7.30nMAssay Description:In vitro inhibition of [3H]-GGPP incorporation into H-Ras-CVLL by Geranylgeranyl transferase type IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
Yale University

Curated by ChEMBL
LigandPNGBDBM50076142((S)-2-{[5-((R)-2-Amino-3-mercapto-propylamino)-bip...)
Affinity DataIC50:  17nMAssay Description:In vitro inhibition of [3H]-FPP incorporation into H-Ras-CVLS by Farnesyl transferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50076127((S)-2-{[5-(2-Imidazol-1-yl-ethoxy)-biphenyl-2-carb...)
Affinity DataIC50:  32nMAssay Description:In vitro inhibition of [3H]-GGPP incorporation into H-Ras-CVLL by Geranylgeranyl transferase type IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50076135((2S)-2-(4-((1H-imidazol-4-yl)methylamino)-2-(napht...)
Affinity DataIC50:  38nMAssay Description:In vitro inhibition of [3H]-GGPP incorporation into H-Ras-CVLL by Geranylgeranyl transferase type IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50076130((S)-2-(4-{[(1H-Imidazol-4-ylmethyl)-amino]-methyl}...)
Affinity DataIC50:  44nMAssay Description:In vitro inhibition of [3H]-GGPP incorporation into H-Ras-CVLL by Geranylgeranyl transferase type IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50076141((S)-2-[4-((R)-2-Amino-3-mercapto-propylamino)-2-na...)
Affinity DataIC50:  55nMAssay Description:In vitro inhibition of [3H]-GGPP incorporation into H-Ras-CVLL by Geranylgeranyl transferase type IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50076126((S)-2-({5-[(1H-Imidazol-4-ylmethyl)-amino]-bipheny...)
Affinity DataIC50:  90nMAssay Description:In vitro inhibition of [3H]-GGPP incorporation into H-Ras-CVLL by Geranylgeranyl transferase type IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50076133((S)-2-({5-[(1H-Imidazol-4-ylmethyl)-amino]-3',5'-d...)
Affinity DataIC50:  150nMAssay Description:In vitro inhibition of [3H]-GGPP incorporation into H-Ras-CVLL by Geranylgeranyl transferase type IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
Yale University

Curated by ChEMBL
LigandPNGBDBM50076128((S)-2-{[5-((R)-2-Amino-3-mercapto-propylamino)-bip...)
Affinity DataIC50:  183nMAssay Description:In vitro inhibition of [3H]-FPP incorporation into H-Ras-CVLS by Farnesyl transferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
Yale University

Curated by ChEMBL
LigandPNGBDBM50076141((S)-2-[4-((R)-2-Amino-3-mercapto-propylamino)-2-na...)
Affinity DataIC50:  203nMAssay Description:In vitro inhibition of [3H]-FPP incorporation into H-Ras-CVLS by Farnesyl transferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50076131((S)-2-{4-[(1H-Imidazol-2-ylmethyl)-amino]-2-naphth...)
Affinity DataIC50:  210nMAssay Description:In vitro inhibition of [3H]-GGPP incorporation into H-Ras-CVLL by Geranylgeranyl transferase type IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50076128((S)-2-{[5-((R)-2-Amino-3-mercapto-propylamino)-bip...)
Affinity DataIC50:  240nMAssay Description:In vitro inhibition of [3H]-GGPP incorporation into H-Ras-CVLL by Geranylgeranyl transferase type IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
Yale University

Curated by ChEMBL
LigandPNGBDBM50076127((S)-2-{[5-(2-Imidazol-1-yl-ethoxy)-biphenyl-2-carb...)
Affinity DataIC50:  303nMAssay Description:In vitro inhibition of [3H]-FPP incorporation into H-Ras-CVLS by Farnesyl transferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50076132((S)-4-Methyl-2-({4-[(pyridin-4-ylmethyl)-amino]-bi...)
Affinity DataIC50:  400nMAssay Description:In vitro inhibition of [3H]-GGPP incorporation into H-Ras-CVLL by Geranylgeranyl transferase type IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
Yale University

Curated by ChEMBL
LigandPNGBDBM50076133((S)-2-({5-[(1H-Imidazol-4-ylmethyl)-amino]-3',5'-d...)
Affinity DataIC50:  900nMAssay Description:In vitro inhibition of [3H]-FPP incorporation into H-Ras-CVLS by Farnesyl transferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
Yale University

Curated by ChEMBL
LigandPNGBDBM50076126((S)-2-({5-[(1H-Imidazol-4-ylmethyl)-amino]-bipheny...)
Affinity DataIC50:  1.30E+3nMAssay Description:In vitro inhibition of [3H]-FPP incorporation into H-Ras-CVLS by Farnesyl transferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50076145((S)-4-Methyl-2-{2-naphthalen-1-yl-4-[(pyridin-4-yl...)
Affinity DataIC50:  1.60E+3nMAssay Description:In vitro inhibition of [3H]-GGPP incorporation into H-Ras-CVLL by Geranylgeranyl transferase type IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50076136((S)-4-Methyl-2-{2-naphthalen-1-yl-4-[(pyridin-2-yl...)
Affinity DataIC50:  4.00E+3nMAssay Description:In vitro inhibition of [3H]-GGPP incorporation into H-Ras-CVLL by Geranylgeranyl transferase type IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
Yale University

Curated by ChEMBL
LigandPNGBDBM50076135((2S)-2-(4-((1H-imidazol-4-yl)methylamino)-2-(napht...)
Affinity DataIC50:  5.40E+3nMAssay Description:In vitro inhibition of [3H]-FPP incorporation into H-Ras-CVLS by Farnesyl transferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50076137((S)-2-({3-[(1H-Imidazol-4-ylmethyl)-amino]-bipheny...)
Affinity DataIC50:  6.10E+3nMAssay Description:In vitro inhibition of [3H]-GGPP incorporation into H-Ras-CVLL by Geranylgeranyl transferase type IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
Yale University

Curated by ChEMBL
LigandPNGBDBM50076131((S)-2-{4-[(1H-Imidazol-2-ylmethyl)-amino]-2-naphth...)
Affinity DataIC50:  8.00E+3nMAssay Description:In vitro inhibition of [3H]-FPP incorporation into H-Ras-CVLS by Farnesyl transferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50076127((S)-2-{[5-(2-Imidazol-1-yl-ethoxy)-biphenyl-2-carb...)
Affinity DataIC50: >1.00E+4nMAssay Description:In vivo for inhibition of farnesylation based on the inhibition of H-Ras processing.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
Yale University

Curated by ChEMBL
LigandPNGBDBM50076130((S)-2-(4-{[(1H-Imidazol-4-ylmethyl)-amino]-methyl}...)
Affinity DataIC50:  1.00E+4nMAssay Description:In vitro inhibition of [3H]-FPP incorporation into H-Ras-CVLS by Farnesyl transferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50076140((S)-2-{[5-(2-Imidazol-1-yl-ethoxy)-biphenyl-2-carb...)
Affinity DataIC50: >1.00E+4nMAssay Description:In vivo for inhibition of farnesylation based on the inhibition of H-Ras processing.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50076126((S)-2-({5-[(1H-Imidazol-4-ylmethyl)-amino]-bipheny...)
Affinity DataIC50: >1.00E+4nMAssay Description:In vivo for inhibition of farnesylation based on the inhibition of H-Ras processing.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50076144((S)-2-(4-{[(1H-Imidazol-4-ylmethyl)-amino]-methyl}...)
Affinity DataIC50: >1.00E+4nMAssay Description:In vivo for inhibition of farnesylation based on the inhibition of H-Ras processing.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50076138((2S)-methyl 2-(4-((R)-2-amino-3-mercaptopropylamin...)
Affinity DataIC50: >2.00E+4nMAssay Description:In vivo for inhibition of farnesylation based on the inhibition of H-Ras processing.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50076139((S)-2-{4-[(1H-Imidazol-4-ylmethyl)-amino]-2-naphth...)
Affinity DataIC50: >3.00E+4nMAssay Description:In vivo for inhibition of farnesylation based on the inhibition of H-Ras processing.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50076129((S)-4-Methyl-2-{2-naphthalen-1-yl-4-[(pyridin-4-yl...)
Affinity DataIC50: >3.00E+4nMAssay Description:In vivo for inhibition of farnesylation based on the inhibition of H-Ras processing.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50076135((2S)-2-(4-((1H-imidazol-4-yl)methylamino)-2-(napht...)
Affinity DataIC50: >3.00E+4nMAssay Description:In vivo for inhibition of farnesylation based on the inhibition of H-Ras processing.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50076134((S)-2-({5-[(1H-Imidazol-4-ylmethyl)-amino]-bipheny...)
Affinity DataIC50: >3.00E+4nMAssay Description:In vivo for inhibition of farnesylation based on the inhibition of H-Ras processing.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50076141((S)-2-[4-((R)-2-Amino-3-mercapto-propylamino)-2-na...)
Affinity DataIC50: >3.00E+4nMAssay Description:In vivo for inhibition of farnesylation based on the inhibition of H-Ras processing.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50076128((S)-2-{[5-((R)-2-Amino-3-mercapto-propylamino)-bip...)
Affinity DataIC50: >3.00E+4nMAssay Description:In vivo for inhibition of farnesylation based on the inhibition of H-Ras processing.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50076131((S)-2-{4-[(1H-Imidazol-2-ylmethyl)-amino]-2-naphth...)
Affinity DataIC50: >3.00E+4nMAssay Description:In vivo for inhibition of farnesylation based on the inhibition of H-Ras processing.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50076143((S)-2-{4-[(1H-Imidazol-2-ylmethyl)-amino]-2-naphth...)
Affinity DataIC50: >3.00E+4nMAssay Description:In vivo for inhibition of farnesylation based on the inhibition of H-Ras processing.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50076145((S)-4-Methyl-2-{2-naphthalen-1-yl-4-[(pyridin-4-yl...)
Affinity DataIC50: >3.00E+4nMAssay Description:In vivo for inhibition of farnesylation based on the inhibition of H-Ras processing.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
Yale University

Curated by ChEMBL
LigandPNGBDBM50076137((S)-2-({3-[(1H-Imidazol-4-ylmethyl)-amino]-bipheny...)
Affinity DataIC50:  4.60E+4nMAssay Description:In vitro inhibition of [3H]-FPP incorporation into H-Ras-CVLS by Farnesyl transferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
Yale University

Curated by ChEMBL
LigandPNGBDBM50076132((S)-4-Methyl-2-({4-[(pyridin-4-ylmethyl)-amino]-bi...)
Affinity DataIC50:  5.00E+4nMAssay Description:In vitro inhibition of [3H]-FPP incorporation into H-Ras-CVLS by Farnesyl transferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
Yale University

Curated by ChEMBL
LigandPNGBDBM50076145((S)-4-Methyl-2-{2-naphthalen-1-yl-4-[(pyridin-4-yl...)
Affinity DataIC50:  5.80E+4nMAssay Description:In vitro inhibition of [3H]-FPP incorporation into H-Ras-CVLS by Farnesyl transferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50076133((S)-2-({5-[(1H-Imidazol-4-ylmethyl)-amino]-3',5'-d...)
Affinity DataIC50: >1.00E+5nMAssay Description:In vivo for inhibition of farnesylation based on the inhibition of H-Ras processing.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
Yale University

Curated by ChEMBL
LigandPNGBDBM50076136((S)-4-Methyl-2-{2-naphthalen-1-yl-4-[(pyridin-2-yl...)
Affinity DataIC50:  1.00E+5nMAssay Description:In vitro inhibition of [3H]-FPP incorporation into H-Ras-CVLS by Farnesyl transferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50076130((S)-2-(4-{[(1H-Imidazol-4-ylmethyl)-amino]-methyl}...)
Affinity DataIC50: >1.00E+5nMAssay Description:In vivo for inhibition of farnesylation based on the inhibition of H-Ras processing.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50076137((S)-2-({3-[(1H-Imidazol-4-ylmethyl)-amino]-bipheny...)
Affinity DataIC50: >1.00E+5nMAssay Description:In vivo for inhibition of farnesylation based on the inhibition of H-Ras processing.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50076132((S)-4-Methyl-2-({4-[(pyridin-4-ylmethyl)-amino]-bi...)
Affinity DataIC50: >1.00E+5nMAssay Description:In vivo for inhibition of farnesylation based on the inhibition of H-Ras processing.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed