Compile Data Set for Download or QSAR
maximum 50k data
Found 151 Enz. Inhib. hit(s) with all data for entry = 316
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM50409174(CHEMBL169119)
Affinity DataKi:  0.0300nMAssay Description:Tested for binding affinity against HIV proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM472(5-tert-butyl-4-{[(6S)-4-hydroxy-6-[2-(4-hydroxyphe...)
Affinity DataKi:  0.0300nMAssay Description:Tested for binding affinity against HIV proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM430(3-[(2-tert-butyl-4-hydroxy-5-methylphenyl)sulfanyl...)
Affinity DataKi:  0.0300nMAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Protease products were analyzed o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM472(5-tert-butyl-4-{[(6S)-4-hydroxy-6-[2-(4-hydroxyphe...)
Affinity DataKi:  0.0300nMAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Protease products were analyzed o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM465((6S)-3-[(4-amino-2-tert-butyl-5-methylphenyl)sulfa...)
Affinity DataKi:  0.0700nMAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Protease products were analyzed o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM469(CHEMBL2110206 | Dihydropyran-2-one deriv. 74 | N-(...)
Affinity DataKi:  0.200nMAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Protease products were analyzed o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM469(CHEMBL2110206 | Dihydropyran-2-one deriv. 74 | N-(...)
Affinity DataKi:  0.200nMAssay Description:Tested for binding affinity against HIV proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM402(CHEMBL354027 | Dihydropyran-2-one deriv. 7 | N-[5-...)
Affinity DataKi:  0.210nM ΔG°:  -57.5kJ/molepH: 6.2 T: 2°CAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Protease products were analyzed o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM402(CHEMBL354027 | Dihydropyran-2-one deriv. 7 | N-[5-...)
Affinity DataKi:  0.210nMAssay Description:Tested for binding affinity against HIV proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM470(CHEMBL2110205 | Dihydropyran-2-one deriv. 75 | N-(...)
Affinity DataKi:  0.310nMAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Protease products were analyzed o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM467((S)-N-(5-tert-Butyl-4-{4-hydroxy-6-[2-(4-hydroxyph...)
Affinity DataKi:  0.390nMAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Protease products were analyzed o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM467((S)-N-(5-tert-Butyl-4-{4-hydroxy-6-[2-(4-hydroxyph...)
Affinity DataKi:  0.390nMAssay Description:Tested for binding affinity against HIV proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM403(CHEMBL169391 | Dihydropyran-2-one deriv. 8 | N-[5-...)
Affinity DataKi:  0.410nM ΔG°:  -55.7kJ/mole IC50:  2.20nMpH: 6.2 T: 2°CAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Protease products were analyzed o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM403(CHEMBL169391 | Dihydropyran-2-one deriv. 8 | N-[5-...)
Affinity DataKi:  0.410nMAssay Description:Tested for binding affinity against HIV proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM398(CHEMBL287361 | Dihydropyran-2-one deriv. 3 | N-[5-...)
Affinity DataKi:  0.530nM ΔG°:  -55.1kJ/mole IC50:  1.80nMpH: 6.2 T: 2°CAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Protease products were analyzed o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM398(CHEMBL287361 | Dihydropyran-2-one deriv. 3 | N-[5-...)
Affinity DataKi:  0.530nMAssay Description:Tested for binding affinity against HIV proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM396(3-[(4-amino-2-tert-butyl-5-methylphenyl)sulfanyl]-...)
Affinity DataKi:  0.670nM ΔG°:  -54.5kJ/mole IC50:  2.70nMpH: 6.2 T: 2°CAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Protease products were analyzed o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM396(3-[(4-amino-2-tert-butyl-5-methylphenyl)sulfanyl]-...)
Affinity DataKi:  0.670nMAssay Description:Tested for binding affinity against HIV proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM464(5-tert-butyl-4-{[(6R)-4-hydroxy-2-oxo-6-(2-phenyle...)
Affinity DataKi:  0.700nMAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Protease products were analyzed o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM464(5-tert-butyl-4-{[(6R)-4-hydroxy-2-oxo-6-(2-phenyle...)
Affinity DataKi:  0.700nMAssay Description:Tested for binding affinity against HIV proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM421(CHEMBL169849 | Dihydropyran-2-one deriv. 26 | N-(5...)
Affinity DataKi:  0.830nM ΔG°:  -53.9kJ/molepH: 6.2 T: 2°CAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Protease products were analyzed o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM421(CHEMBL169849 | Dihydropyran-2-one deriv. 26 | N-(5...)
Affinity DataKi:  0.830nMAssay Description:Tested for binding affinity against HIV proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM429(Dihydropyran-2-one deriv. 34 | N-(5-tert-butyl-4-{...)
Affinity DataKi:  1.04nMAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Protease products were analyzed o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM448(3-[(2-tert-butyl-4-hydroxy-5-methylphenyl)sulfanyl...)
Affinity DataKi:  1.10nMAssay Description:Tested for binding affinity against HIV proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM448(3-[(2-tert-butyl-4-hydroxy-5-methylphenyl)sulfanyl...)
Affinity DataKi:  1.10nMAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Protease products were analyzed o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM423(CHEMBL263028 | Dihydropyran-2-one deriv. 28 | N-(5...)
Affinity DataKi:  1.40nM ΔG°:  -52.6kJ/molepH: 6.2 T: 2°CAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Protease products were analyzed o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM423(CHEMBL263028 | Dihydropyran-2-one deriv. 28 | N-(5...)
Affinity DataKi:  1.40nMAssay Description:Tested for binding affinity against HIV proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM470(CHEMBL2110205 | Dihydropyran-2-one deriv. 75 | N-(...)
Affinity DataKi:  6.40nMAssay Description:Tested for binding affinity against HIV proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM471(Dihydropyran-2-one deriv. 76 | N-(5-tert-butyl-4-{...)
Affinity DataKi:  6.40nMAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Protease products were analyzed o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM468(Dihydropyran-2-one deriv. 73 | N-(5-tert-butyl-4-{...)
Affinity DataKi:  9.54nMAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Protease products were analyzed o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM465((6S)-3-[(4-amino-2-tert-butyl-5-methylphenyl)sulfa...)
Affinity DataKi:  13nMAssay Description:Tested for binding affinity against HIV proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM466((6R)-3-[(4-amino-2-tert-butyl-5-methylphenyl)sulfa...)
Affinity DataKi:  13nMAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Protease products were analyzed o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM422(CHEMBL263026 | Dihydropyran-2-one deriv. 27 | N-(5...)
Affinity DataKi:  27nM ΔG°:  -44.9kJ/molepH: 6.2 T: 2°CAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Protease products were analyzed o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM422(CHEMBL263026 | Dihydropyran-2-one deriv. 27 | N-(5...)
Affinity DataKi:  27nMAssay Description:Tested for binding affinity against proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM452(4-({6-[2-(4-aminophenyl)ethyl]-4-hydroxy-2-oxo-6-(...)
Affinity DataIC50:  1.30nMAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Protease products were analyzed o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM452(4-({6-[2-(4-aminophenyl)ethyl]-4-hydroxy-2-oxo-6-(...)
Affinity DataIC50:  1.30nMAssay Description:Activity of potent nonpeptidic inhibitor against proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM410(CHEMBL168270 | Dihydropyran-2-one deriv. 15 | N-[5...)
Affinity DataIC50:  1.5nMpH: 6.2 T: 2°CAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Protease products were analyzed o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM410(CHEMBL168270 | Dihydropyran-2-one deriv. 15 | N-[5...)
Affinity DataIC50:  1.5nMAssay Description:Activity of potent nonpeptidic inhibitor against proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM457(3-({2-tert-butyl-4-[(ethylsulfamoyl)amino]-5-methy...)
Affinity DataIC50:  1.70nMAssay Description:Activity of potent nonpeptidic inhibitor against proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM457(3-({2-tert-butyl-4-[(ethylsulfamoyl)amino]-5-methy...)
Affinity DataIC50:  1.70nMAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Protease products were analyzed o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM398(CHEMBL287361 | Dihydropyran-2-one deriv. 3 | N-[5-...)
Affinity DataIC50:  1.80nMAssay Description:Activity of potent nonpeptidic inhibitor against proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM50409134(CHEMBL171434)
Affinity DataIC50:  1.90nMAssay Description:Activity of potent nonpeptidic inhibitor against proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM417(Dihydropyran-2-one deriv. 22 | N-[5-tert-butyl-4-(...)
Affinity DataIC50:  1.90nMpH: 6.2 T: 2°CAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Protease products were analyzed o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM428(Dihydropyran-2-one deriv. 33 | N-(5-tert-butyl-4-{...)
Affinity DataIC50:  1.90nMAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Protease products were analyzed o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM50409145(CHEMBL169878)
Affinity DataIC50:  1.90nMAssay Description:Activity of potent nonpeptidic inhibitor against proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM50409125(CHEMBL169256)
Affinity DataIC50:  2nMAssay Description:Activity of potent nonpeptidic inhibitor against proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM441(5-tert-butyl-4-({4-hydroxy-6-[2-(4-hydroxyphenyl)e...)
Affinity DataIC50:  2nMAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Protease products were analyzed o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM414(CHEMBL168369 | Dihydropyran-2-one deriv. 19 | N-[5...)
Affinity DataIC50:  2.10nMAssay Description:Activity of potent nonpeptidic inhibitor against proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM414(CHEMBL168369 | Dihydropyran-2-one deriv. 19 | N-[5...)
Affinity DataIC50:  2.10nMpH: 6.2 T: 2°CAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Protease products were analyzed o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM472(5-tert-butyl-4-{[(6S)-4-hydroxy-6-[2-(4-hydroxyphe...)
Affinity DataIC50:  2.20nMAssay Description:Activity of potent nonpeptidic inhibitor against proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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