Compile Data Set for Download or QSAR
Report error Found 5 Enz. Inhib. hit(s) with all data for entry = 50009936
TargetAmyloid-beta precursor protein(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50089193(4-Fluoro-N-(1,3,3-trimethyl-bicyclo[2.2.1]hept-2-y...)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of A-beta-42 production by inhibiting Gamma-secretase proteolytic pathway in HEK293 cell stably transfected with a double mutant form of h...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAmyloid-beta precursor protein(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50089190(Thiophene-2-sulfonic acid (1,3,3-trimethyl-bicyclo...)
Affinity DataIC50: 2.70E+3nMAssay Description:Inhibition of A-beta-42 production by inhibiting Gamma-secretase proteolytic pathway in HEK293 cell stably transfected with a double mutant form of h...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAmyloid-beta precursor protein(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50089192(4-Fluoro-N-(1,3,3-trimethyl-bicyclo[2.2.1]hept-2-y...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of A-beta-42 production by inhibiting Gamma-secretase proteolytic pathway in HEK293 cell stably transfected with a double mutant form of h...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAmyloid-beta precursor protein(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50089189(4-Bromo-N-(1,3,3-trimethyl-bicyclo[2.2.1]hept-2-yl...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of A-beta-42 production by inhibiting Gamma-secretase proteolytic pathway in HEK293 cell stably transfected with a double mutant form of h...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAmyloid-beta precursor protein(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50089191(4-Chloro-N-(1,3,3-trimethyl-bicyclo[2.2.1]hept-2-y...)
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibition of A-beta-42 production by inhibiting Gamma-secretase proteolytic pathway in HEK293 cell stably transfected with a double mutant form of h...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed