Compile Data Set for Download or QSAR
Report error Found 20 Enz. Inhib. hit(s) with all data for entry = 895
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
Dupont Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 6961BDBM6961(13-(4-hydroxyphenyl)-11-azatetracyclo[8.7.0.0^{2,7...)
Affinity DataIC50: 1.90E+3nMpH: 7.6 T: 2°CAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 mM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
Dupont Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 6960BDBM6960(13-(3-aminophenyl)-11-azatetracyclo[8.7.0.0^{2,7}....)
Affinity DataIC50: 2.30E+3nMpH: 7.6 T: 2°CAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 mM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
Dupont Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 6943BDBM6943(13-phenyl-11-azatetracyclo[8.7.0.0^{2,7}.0^{12,17}...)
Affinity DataIC50: 3.60E+3nMpH: 7.6 T: 2°CAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 mM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
Dupont Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 6947BDBM6947(13-phenyl-11-azatetracyclo[8.7.0.0^{2,7}.0^{12,17}...)
Affinity DataIC50: 5.80E+3nMpH: 7.6 T: 2°CAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 mM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
Dupont Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 6962BDBM6962(13-(4-chlorophenyl)-11-azatetracyclo[8.7.0.0^{2,7}...)
Affinity DataIC50: 9.90E+3nMpH: 7.6 T: 2°CAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 mM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
Dupont Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 6953BDBM6953(11-azatetracyclo[8.7.0.0^{2,7}.0^{12,17}]heptadeca...)
Affinity DataIC50: 1.74E+4nMpH: 7.6 T: 2°CAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 mM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
Dupont Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 6945BDBM6945(13-phenyl-11-azatetracyclo[8.7.0.0^{2,7}.0^{12,17}...)
Affinity DataIC50: 1.95E+4nMpH: 7.6 T: 2°CAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 mM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
Dupont Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 6950BDBM6950(14-phenyl-11-azatetracyclo[8.7.0.0^{2,7}.0^{12,17}...)
Affinity DataIC50: 2.20E+4nMpH: 7.6 T: 2°CAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 mM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
Dupont Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 6948BDBM6948(13-phenyl-11-azatetracyclo[8.7.0.0^{2,7}.0^{12,17}...)
Affinity DataIC50: 2.73E+4nMpH: 7.6 T: 2°CAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 mM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
Dupont Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 6946BDBM6946(13-phenyl-11-azatetracyclo[8.7.0.0^{2,7}.0^{12,17}...)
Affinity DataIC50: 2.90E+4nMpH: 7.6 T: 2°CAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 mM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
Dupont Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 6956BDBM6956(5,11-diazatetracyclo[8.7.0.0^{2,7}.0^{12,17}]hepta...)
Affinity DataIC50: 3.00E+4nMpH: 7.6 T: 2°CAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 mM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
Dupont Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 6951BDBM6951(15-phenyl-11-azatetracyclo[8.7.0.0^{2,7}.0^{12,17}...)
Affinity DataIC50: 3.75E+4nMpH: 7.6 T: 2°CAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 mM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
Dupont Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 6959BDBM6959(5-oxido-5,11-diazatetracyclo[8.7.0.0^{2,7}.0^{12,1...)
Affinity DataIC50: 5.90E+4nMpH: 7.6 T: 2°CAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 mM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
Dupont Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 6952BDBM6952(16-phenyl-11-azatetracyclo[8.7.0.0^{2,7}.0^{12,17}...)
Affinity DataIC50: 8.30E+4nMpH: 7.6 T: 2°CAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 mM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
Dupont Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 6955BDBM6955(4,11-diazatetracyclo[8.7.0.0^{2,7}.0^{12,17}]hepta...)
Affinity DataIC50: 1.59E+5nMpH: 7.6 T: 2°CAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 mM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
Dupont Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 6957BDBM6957(6,11-diazatetracyclo[8.7.0.0^{2,7}.0^{12,17}]hepta...)
Affinity DataIC50: 1.97E+5nMpH: 7.6 T: 2°CAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 mM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
Dupont Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 6944BDBM6944(4-methoxy-13-phenyl-11-azatetracyclo[8.7.0.0^{2,7}...)
Affinity DataIC50: 3.09E+5nMpH: 7.6 T: 2°CAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 mM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
Dupont Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 6949BDBM6949(13-phenyl-11-azatetracyclo[8.7.0.0^{2,7}.0^{12,17}...)
Affinity DataIC50: 3.41E+5nMpH: 7.6 T: 2°CAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 mM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
Dupont Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 6954BDBM6954(3,11-diazatetracyclo[8.7.0.0^{2,7}.0^{12,17}]hepta...)
Affinity DataIC50: 4.42E+5nMpH: 7.6 T: 2°CAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 mM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
Dupont Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 6958BDBM6958(4-oxido-4,11-diazatetracyclo[8.7.0.0^{2,7}.0^{12,1...)
Affinity DataIC50: 6.05E+5nMpH: 7.6 T: 2°CAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 mM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2005
Entry Details Article
PubMed