Compile Data Set for Download or QSAR
maximum 50k data
Found 20 Enz. Inhib. hit(s) with all data for entry = 895
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Dupont Pharmaceuticals

LigandPNGBDBM6961(13-(4-hydroxyphenyl)-11-azatetracyclo[8.7.0.0^{2,7...)
Affinity DataIC50:  1.90E+3nMpH: 7.6 T: 2°CAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 mM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Dupont Pharmaceuticals

LigandPNGBDBM6960(13-(3-aminophenyl)-11-azatetracyclo[8.7.0.0^{2,7}....)
Affinity DataIC50:  2.30E+3nMpH: 7.6 T: 2°CAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 mM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Dupont Pharmaceuticals

LigandPNGBDBM6943(13-phenyl-11-azatetracyclo[8.7.0.0^{2,7}.0^{12,17}...)
Affinity DataIC50:  3.60E+3nMpH: 7.6 T: 2°CAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 mM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Dupont Pharmaceuticals

LigandPNGBDBM6947(13-phenyl-11-azatetracyclo[8.7.0.0^{2,7}.0^{12,17}...)
Affinity DataIC50:  5.80E+3nMpH: 7.6 T: 2°CAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 mM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Dupont Pharmaceuticals

LigandPNGBDBM6962(13-(4-chlorophenyl)-11-azatetracyclo[8.7.0.0^{2,7}...)
Affinity DataIC50:  9.90E+3nMpH: 7.6 T: 2°CAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 mM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Dupont Pharmaceuticals

LigandPNGBDBM6953(11-azatetracyclo[8.7.0.0^{2,7}.0^{12,17}]heptadeca...)
Affinity DataIC50:  1.74E+4nMpH: 7.6 T: 2°CAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 mM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Dupont Pharmaceuticals

LigandPNGBDBM6945(13-phenyl-11-azatetracyclo[8.7.0.0^{2,7}.0^{12,17}...)
Affinity DataIC50:  1.95E+4nMpH: 7.6 T: 2°CAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 mM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Dupont Pharmaceuticals

LigandPNGBDBM6950(14-phenyl-11-azatetracyclo[8.7.0.0^{2,7}.0^{12,17}...)
Affinity DataIC50:  2.20E+4nMpH: 7.6 T: 2°CAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 mM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Dupont Pharmaceuticals

LigandPNGBDBM6948(13-phenyl-11-azatetracyclo[8.7.0.0^{2,7}.0^{12,17}...)
Affinity DataIC50:  2.73E+4nMpH: 7.6 T: 2°CAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 mM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Dupont Pharmaceuticals

LigandPNGBDBM6946(13-phenyl-11-azatetracyclo[8.7.0.0^{2,7}.0^{12,17}...)
Affinity DataIC50:  2.90E+4nMpH: 7.6 T: 2°CAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 mM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Dupont Pharmaceuticals

LigandPNGBDBM6956(5,11-diazatetracyclo[8.7.0.0^{2,7}.0^{12,17}]hepta...)
Affinity DataIC50:  3.00E+4nMpH: 7.6 T: 2°CAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 mM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Dupont Pharmaceuticals

LigandPNGBDBM6951(15-phenyl-11-azatetracyclo[8.7.0.0^{2,7}.0^{12,17}...)
Affinity DataIC50:  3.75E+4nMpH: 7.6 T: 2°CAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 mM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Dupont Pharmaceuticals

LigandPNGBDBM6959(5-oxido-5,11-diazatetracyclo[8.7.0.0^{2,7}.0^{12,1...)
Affinity DataIC50:  5.90E+4nMpH: 7.6 T: 2°CAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 mM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Dupont Pharmaceuticals

LigandPNGBDBM6952(16-phenyl-11-azatetracyclo[8.7.0.0^{2,7}.0^{12,17}...)
Affinity DataIC50:  8.30E+4nMpH: 7.6 T: 2°CAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 mM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Dupont Pharmaceuticals

LigandPNGBDBM6955(4,11-diazatetracyclo[8.7.0.0^{2,7}.0^{12,17}]hepta...)
Affinity DataIC50:  1.59E+5nMpH: 7.6 T: 2°CAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 mM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Dupont Pharmaceuticals

LigandPNGBDBM6957(6,11-diazatetracyclo[8.7.0.0^{2,7}.0^{12,17}]hepta...)
Affinity DataIC50:  1.97E+5nMpH: 7.6 T: 2°CAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 mM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Dupont Pharmaceuticals

LigandPNGBDBM6944(4-methoxy-13-phenyl-11-azatetracyclo[8.7.0.0^{2,7}...)
Affinity DataIC50: >3.09E+5nMpH: 7.6 T: 2°CAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 mM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Dupont Pharmaceuticals

LigandPNGBDBM6949(13-phenyl-11-azatetracyclo[8.7.0.0^{2,7}.0^{12,17}...)
Affinity DataIC50: >3.41E+5nMpH: 7.6 T: 2°CAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 mM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Dupont Pharmaceuticals

LigandPNGBDBM6954(3,11-diazatetracyclo[8.7.0.0^{2,7}.0^{12,17}]hepta...)
Affinity DataIC50:  4.42E+5nMpH: 7.6 T: 2°CAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 mM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Dupont Pharmaceuticals

LigandPNGBDBM6958(4-oxido-4,11-diazatetracyclo[8.7.0.0^{2,7}.0^{12,1...)
Affinity DataIC50:  6.05E+5nMpH: 7.6 T: 2°CAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 mM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed