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Found 33 Enz. Inhib. hit(s) with all data for entry = 50012389
TargetProtein lifeguard 1(Rattus norvegicus)
The Royal Danish School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50118479(2-Amino-4-(4-hydroxy-[1,2,5]thiadiazol-3-yl)-butyr...)
Affinity DataIC50:  2.87E+5nMAssay Description:Binding affinity towards N-methyl-D-aspartate glutamate receptor (NMDA) determined electrophysically using the rat cortical wedge model.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
The Royal Danish School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM26431((2R)-2-aminopentanedioic acid | CHEMBL76232 | D-Gl...)
Affinity DataEC50:  4.40E+3nMAssay Description:Compound was evaluated for the inhibitory activity against cloned Metabotropic glutamate receptor 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Rattus norvegicus (Rat))
The Royal Danish School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50060719((S)-2-Amino-4-(3-hydroxy-5-methyl-isoxazol-4-yl)-b...)
Affinity DataEC50: >1.00E+6nMAssay Description:Compound was evaluated for the inhibitory activity against cloned Metabotropic glutamate receptor 4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
The Royal Danish School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50060718((R)-2-Amino-4-(3-hydroxy-5-methyl-isoxazol-4-yl)-b...)
Affinity DataEC50: >1.00E+6nMAssay Description:Compound was evaluated for the inhibitory activity against cloned Metabotropic glutamate receptor 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
The Royal Danish School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50060718((R)-2-Amino-4-(3-hydroxy-5-methyl-isoxazol-4-yl)-b...)
Affinity DataEC50: >1.00E+6nMAssay Description:Compound was evaluated for the inhibitory activity against cloned Metabotropic glutamate receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
The Royal Danish School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50118480(2-Amino-4-(4-hydroxy-[1,2,5]thiadiazol-3-yl)-butyr...)
Affinity DataEC50:  4.00E+4nMAssay Description:Compound was evaluated for the inhibitory activity against cloned Metabotropic glutamate receptor 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
The Royal Danish School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50089901(2-Amino-3-(3-hydroxy-isoxazol-5-yl)-propionic acid...)
Affinity DataEC50:  4.90E+5nMAssay Description:Compound was evaluated for the inhibitory activity against cloned Metabotropic glutamate receptor 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
The Royal Danish School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50118479(2-Amino-4-(4-hydroxy-[1,2,5]thiadiazol-3-yl)-butyr...)
Affinity DataEC50: >1.00E+6nMAssay Description:Compound was evaluated for the inhibitory activity against cloned Metabotropic glutamate receptor 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
The Royal Danish School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50118480(2-Amino-4-(4-hydroxy-[1,2,5]thiadiazol-3-yl)-butyr...)
Affinity DataEC50: >1.00E+6nMAssay Description:Compound was evaluated for the inhibitory activity against cloned Metabotropic glutamate receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
The Royal Danish School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50052553((2S)-2-aminohexanedioic acid | (S)-2-aminohexanedi...)
Affinity DataEC50: >1.00E+6nMAssay Description:Compound was evaluated for the inhibitory activity against cloned Metabotropic glutamate receptor 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
The Royal Danish School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50060718((R)-2-Amino-4-(3-hydroxy-5-methyl-isoxazol-4-yl)-b...)
Affinity DataEC50: >1.00E+6nMAssay Description:Compound was evaluated for the inhibitory activity against cloned Metabotropic glutamate receptor 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
The Royal Danish School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50052553((2S)-2-aminohexanedioic acid | (S)-2-aminohexanedi...)
Affinity DataEC50:  3.50E+4nMAssay Description:Compound was evaluated for the inhibitory activity against cloned Metabotropic glutamate receptor 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
The Royal Danish School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50060719((S)-2-Amino-4-(3-hydroxy-5-methyl-isoxazol-4-yl)-b...)
Affinity DataEC50: >1.00E+6nMAssay Description:Compound was evaluated for the inhibitory activity against cloned Metabotropic glutamate receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
The Royal Danish School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50089901(2-Amino-3-(3-hydroxy-isoxazol-5-yl)-propionic acid...)
Affinity DataEC50:  2.50E+5nMAssay Description:Compound was evaluated for the inhibitory activity against cloned Metabotropic glutamate receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Rattus norvegicus (Rat))
The Royal Danish School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50118479(2-Amino-4-(4-hydroxy-[1,2,5]thiadiazol-3-yl)-butyr...)
Affinity DataEC50: >1.00E+6nMAssay Description:Compound was evaluated for the inhibitory activity against cloned Metabotropic glutamate receptor 4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
The Royal Danish School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50118481(2-Amino-3-(3-hydroxy-isoxazol-5-yl)-propionic acid...)
Affinity DataEC50: >1.00E+6nMAssay Description:Compound was evaluated for the inhibitory activity against cloned Metabotropic glutamate receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
The Royal Danish School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50118479(2-Amino-4-(4-hydroxy-[1,2,5]thiadiazol-3-yl)-butyr...)
Affinity DataEC50:  3.70E+4nMAssay Description:Compound was evaluated for the inhibitory activity against cloned Metabotropic glutamate receptor 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Rattus norvegicus (Rat))
The Royal Danish School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50052553((2S)-2-aminohexanedioic acid | (S)-2-aminohexanedi...)
Affinity DataEC50: >3.00E+6nMAssay Description:Compound was evaluated for the inhibitory activity against cloned Metabotropic glutamate receptor 4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
The Royal Danish School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50052553((2S)-2-aminohexanedioic acid | (S)-2-aminohexanedi...)
Affinity DataEC50: >1.00E+6nMAssay Description:Compound was evaluated for the inhibitory activity against cloned Metabotropic glutamate receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
The Royal Danish School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50089901(2-Amino-3-(3-hydroxy-isoxazol-5-yl)-propionic acid...)
Affinity DataEC50: >1.00E+6nMAssay Description:Compound was evaluated for the inhibitory activity against cloned Metabotropic glutamate receptor 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
The Royal Danish School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50118481(2-Amino-3-(3-hydroxy-isoxazol-5-yl)-propionic acid...)
Affinity DataEC50: >1.00E+6nMAssay Description:Compound was evaluated for the inhibitory activity against cloned Metabotropic glutamate receptor 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
The Royal Danish School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50118481(2-Amino-3-(3-hydroxy-isoxazol-5-yl)-propionic acid...)
Affinity DataEC50: >1.00E+6nMAssay Description:Compound was evaluated for the inhibitory activity against cloned Metabotropic glutamate receptor 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
The Royal Danish School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50118480(2-Amino-4-(4-hydroxy-[1,2,5]thiadiazol-3-yl)-butyr...)
Affinity DataEC50:  1.90E+5nMAssay Description:Compound was evaluated for the inhibitory activity against cloned Metabotropic glutamate receptor 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Rattus norvegicus (Rat))
The Royal Danish School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50118480(2-Amino-4-(4-hydroxy-[1,2,5]thiadiazol-3-yl)-butyr...)
Affinity DataEC50: >1.00E+6nMAssay Description:Compound was evaluated for the inhibitory activity against cloned Metabotropic glutamate receptor 4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Rattus norvegicus (Rat))
The Royal Danish School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50118481(2-Amino-3-(3-hydroxy-isoxazol-5-yl)-propionic acid...)
Affinity DataEC50: >1.00E+6nMAssay Description:Compound was evaluated for the inhibitory activity against cloned Metabotropic glutamate receptor 4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Rattus norvegicus (Rat))
The Royal Danish School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50089901(2-Amino-3-(3-hydroxy-isoxazol-5-yl)-propionic acid...)
Affinity DataEC50: >1.00E+6nMAssay Description:Compound was evaluated for the inhibitory activity against cloned Metabotropic glutamate receptor 4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Rattus norvegicus (Rat))
The Royal Danish School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50060718((R)-2-Amino-4-(3-hydroxy-5-methyl-isoxazol-4-yl)-b...)
Affinity DataEC50: >1.00E+6nMAssay Description:Compound was evaluated for the inhibitory activity against cloned Metabotropic glutamate receptor 4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
The Royal Danish School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50060719((S)-2-Amino-4-(3-hydroxy-5-methyl-isoxazol-4-yl)-b...)
Affinity DataEC50: >1.00E+6nMAssay Description:Compound was evaluated for the inhibitory activity against cloned Metabotropic glutamate receptor 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
The Royal Danish School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM26431((2R)-2-aminopentanedioic acid | CHEMBL76232 | D-Gl...)
Affinity DataEC50:  1.00E+4nMAssay Description:Compound was evaluated for the inhibitory activity against cloned Metabotropic glutamate receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Rattus norvegicus (Rat))
The Royal Danish School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM26431((2R)-2-aminopentanedioic acid | CHEMBL76232 | D-Gl...)
Affinity DataEC50:  1.20E+4nMAssay Description:Compound was evaluated for the inhibitory activity against cloned Metabotropic glutamate receptor 4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
The Royal Danish School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM26431((2R)-2-aminopentanedioic acid | CHEMBL76232 | D-Gl...)
Affinity DataEC50:  4.00E+3nMAssay Description:Compound was evaluated for the inhibitory activity against cloned Metabotropic glutamate receptor 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
The Royal Danish School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50118479(2-Amino-4-(4-hydroxy-[1,2,5]thiadiazol-3-yl)-butyr...)
Affinity DataEC50: >1.00E+6nMAssay Description:Compound was evaluated for the inhibitory activity against cloned Metabotropic glutamate receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
The Royal Danish School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50060719((S)-2-Amino-4-(3-hydroxy-5-methyl-isoxazol-4-yl)-b...)
Affinity DataEC50: >1.00E+6nMAssay Description:Compound was evaluated for the inhibitory activity against cloned Metabotropic glutamate receptor 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed