Compile Data Set for Download or QSAR
Report error Found 18 Enz. Inhib. hit(s) with all data for entry = 50013160
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50127246BDBM50127246(8-[Amino-(4-chloro-phenyl)-(3-methyl-3H-imidazol-4...)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of [3H]FPP incorporation into biotinylated laminB peptide by farnesyl transferaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50127246BDBM50127246(8-[Amino-(4-chloro-phenyl)-(3-methyl-3H-imidazol-4...)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of [3H]FPP incorporation into biotinylated laminB peptide by farnesyl transferaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50126335BDBM50126335(R-115777 | 6-[(S)-AMINO(4-CHLOROPHENYL)(1-METHYL-1...)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of [3H]FPP incorporation into biotinylated laminB peptide by farnesyl transferaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50127248BDBM50127248(6-(3-Chloro-phenyl)-8-[(4-chloro-phenyl)-hydroxy-(...)
Affinity DataIC50: 1nMAssay Description:Inhibition of [3H]FPP incorporation into biotinylated laminB peptide by farnesyl transferaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50127252BDBM50127252(8-[Amino-(4-chloro-phenyl)-(3-methyl-3H-imidazol-4...)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of [3H]FPP incorporation into biotinylated laminB peptide by farnesyl transferaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50127254BDBM50127254(9-[Amino-(4-chloro-phenyl)-(3-methyl-3H-imidazol-4...)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of [3H]FPP incorporation into biotinylated laminB peptide by farnesyl transferaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50127255BDBM50127255(6-[Amino-(4-chloro-phenyl)-(3-methyl-3H-imidazol-4...)
Affinity DataIC50: 3.5nMAssay Description:Inhibition of [3H]FPP incorporation into biotinylated laminB peptide by farnesyl transferaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50127247BDBM50127247(1-(3-Chloro-phenyl)-9-[(4-chloro-phenyl)-hydroxy-(...)
Affinity DataIC50: 4nMAssay Description:Inhibition of [3H]FPP incorporation into biotinylated laminB peptide by farnesyl transferaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50127257BDBM50127257(6-(3-Chloro-phenyl)-8-[(4-chloro-phenyl)-hydroxy-(...)
Affinity DataIC50: 6nMAssay Description:Inhibition of [3H]FPP incorporation into biotinylated laminB peptide by farnesyl transferaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50127249BDBM50127249(6-(3-Chloro-phenyl)-8-[(4-chloro-phenyl)-hydroxy-(...)
Affinity DataIC50: 6nMAssay Description:Inhibition of [3H]FPP incorporation into biotinylated laminB peptide by farnesyl transferaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50127250BDBM50127250(6-[Amino-(4-chloro-phenyl)-(3-methyl-3H-imidazol-4...)
Affinity DataIC50: 6.5nMAssay Description:Inhibition of [3H]FPP incorporation into biotinylated laminB peptide by farnesyl transferaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50127256BDBM50127256(7-[Amino-(4-chloro-phenyl)-(3-methyl-3H-imidazol-4...)
Affinity DataIC50: 22nMAssay Description:Inhibition of farnesyl transferase at 0.1 uMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50127258BDBM50127258(2-[Amino-(4-chloro-phenyl)-(3-methyl-3H-imidazol-4...)
Affinity DataIC50: 29nMAssay Description:Inhibition of [3H]FPP incorporation into biotinylated laminB peptide by farnesyl transferaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50127251BDBM50127251(7-[Amino-(4-chloro-phenyl)-(3-methyl-3H-imidazol-4...)
Affinity DataIC50: 48nMAssay Description:Inhibition of farnesyl transferase at 0.1 uMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50127246BDBM50127246(8-[Amino-(4-chloro-phenyl)-(3-methyl-3H-imidazol-4...)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of Geranylgeranylprotein transferase-I -catalyzed incorporation of [3H]GGPP into biotin YRASNRSCAIL substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50127246BDBM50127246(8-[Amino-(4-chloro-phenyl)-(3-methyl-3H-imidazol-4...)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of Geranylgeranylprotein transferase-I -catalyzed incorporation of [3H]GGPP into biotin YRASNRSCAIL substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50126335BDBM50126335(R-115777 | 6-[(S)-AMINO(4-CHLOROPHENYL)(1-METHYL-1...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Geranylgeranylprotein transferase-I -catalyzed incorporation of [3H]GGPP into biotin YRASNRSCAIL substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50127256BDBM50127256(7-[Amino-(4-chloro-phenyl)-(3-methyl-3H-imidazol-4...)
Affinity DataIC50: 3.20E+4nMAssay Description:Inhibition of Geranylgeranylprotein transferase-I at 10 uMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed