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Report error Found 41 Enz. Inhib. hit(s) with all data for entry = 12720
TargetLon protease homolog, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 722825BDBM722825(US20250059213, Compound 48 | US20250320234, Compou...)
Affinity DataIC50: 50nMAssay Description:In this Example, LONP1 (NM_004793.4) activity was measured by a FRET-based assay for protease activity using a fluorogenic peptide DabcylYRGIT(2Abu)S...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/19/2025
Entry Details
US Patent

TargetLon protease homolog, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 722826BDBM722826(US20250059213, Compound 50 | US20250320234, Compou...)
Affinity DataIC50: 50nMAssay Description:In this Example, LONP1 (NM_004793.4) activity was measured by a FRET-based assay for protease activity using a fluorogenic peptide DabcylYRGIT(2Abu)S...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/19/2025
Entry Details
US Patent

TargetLon protease homolog, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 722823BDBM722823(US20250059213, Compound 46)
Affinity DataIC50: 50nMAssay Description:In this Example, LONP1 (NM_004793.4) activity was measured by a FRET-based assay for protease activity using a fluorogenic peptide DabcylYRGIT(2Abu)S...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/19/2025
Entry Details
US Patent

TargetLon protease homolog, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 722821BDBM722821(US20250059213, Compound 44)
Affinity DataIC50: 50nMAssay Description:In this Example, LONP1 (NM_004793.4) activity was measured by a FRET-based assay for protease activity using a fluorogenic peptide DabcylYRGIT(2Abu)S...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/19/2025
Entry Details
US Patent

TargetLon protease homolog, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 722822BDBM722822(US20250059213, Compound 45)
Affinity DataIC50: 50nMAssay Description:In this Example, LONP1 (NM_004793.4) activity was measured by a FRET-based assay for protease activity using a fluorogenic peptide DabcylYRGIT(2Abu)S...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/19/2025
Entry Details
US Patent

TargetLon protease homolog, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 722819BDBM722819(US20250059213, Compound 42)
Affinity DataIC50: 50nMAssay Description:In this Example, LONP1 (NM_004793.4) activity was measured by a FRET-based assay for protease activity using a fluorogenic peptide DabcylYRGIT(2Abu)S...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/19/2025
Entry Details
US Patent

TargetLon protease homolog, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 722820BDBM722820(US20250059213, Compound 43)
Affinity DataIC50: 50nMAssay Description:In this Example, LONP1 (NM_004793.4) activity was measured by a FRET-based assay for protease activity using a fluorogenic peptide DabcylYRGIT(2Abu)S...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/19/2025
Entry Details
US Patent

TargetLon protease homolog, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 722809BDBM722809(US20250059213, Compound 29 | US20250320234, Compou...)
Affinity DataIC50: 50nMAssay Description:In this Example, LONP1 (NM_004793.4) activity was measured by a FRET-based assay for protease activity using a fluorogenic peptide DabcylYRGIT(2Abu)S...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/19/2025
Entry Details
US Patent

TargetLon protease homolog, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 722810BDBM722810(US20250059213, Compound 31)
Affinity DataIC50: 50nMAssay Description:In this Example, LONP1 (NM_004793.4) activity was measured by a FRET-based assay for protease activity using a fluorogenic peptide DabcylYRGIT(2Abu)S...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/19/2025
Entry Details
US Patent

TargetLon protease homolog, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 722807BDBM722807(US20250059213, Compound 23)
Affinity DataIC50: 50nMAssay Description:In this Example, LONP1 (NM_004793.4) activity was measured by a FRET-based assay for protease activity using a fluorogenic peptide DabcylYRGIT(2Abu)S...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/19/2025
Entry Details
US Patent

TargetLon protease homolog, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 722808BDBM722808(US20250059213, Compound 27)
Affinity DataIC50: 50nMAssay Description:In this Example, LONP1 (NM_004793.4) activity was measured by a FRET-based assay for protease activity using a fluorogenic peptide DabcylYRGIT(2Abu)S...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/19/2025
Entry Details
US Patent

TargetLon protease homolog, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 722805BDBM722805(US20250059213, Compound 21)
Affinity DataIC50: 50nMAssay Description:In this Example, LONP1 (NM_004793.4) activity was measured by a FRET-based assay for protease activity using a fluorogenic peptide DabcylYRGIT(2Abu)S...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/19/2025
Entry Details
US Patent

TargetLon protease homolog, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 722803BDBM722803(US20250059213, Compound 19)
Affinity DataIC50: 50nMAssay Description:In this Example, LONP1 (NM_004793.4) activity was measured by a FRET-based assay for protease activity using a fluorogenic peptide DabcylYRGIT(2Abu)S...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/19/2025
Entry Details
US Patent

TargetLon protease homolog, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 722804BDBM722804(US20250059213, Compound 20)
Affinity DataIC50: 50nMAssay Description:In this Example, LONP1 (NM_004793.4) activity was measured by a FRET-based assay for protease activity using a fluorogenic peptide DabcylYRGIT(2Abu)S...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/19/2025
Entry Details
US Patent

TargetLon protease homolog, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 722818BDBM722818(US20250059213, Compound 41)
Affinity DataIC50: 50nMAssay Description:In this Example, LONP1 (NM_004793.4) activity was measured by a FRET-based assay for protease activity using a fluorogenic peptide DabcylYRGIT(2Abu)S...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/19/2025
Entry Details
US Patent

TargetLon protease homolog, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 722815BDBM722815(US20250059213, Compound 38 | US20250320234, Compou...)
Affinity DataIC50: 50nMAssay Description:In this Example, LONP1 (NM_004793.4) activity was measured by a FRET-based assay for protease activity using a fluorogenic peptide DabcylYRGIT(2Abu)S...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/19/2025
Entry Details
US Patent

TargetLon protease homolog, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 722816BDBM722816(US20250059213, Compound 39)
Affinity DataIC50: 50nMAssay Description:In this Example, LONP1 (NM_004793.4) activity was measured by a FRET-based assay for protease activity using a fluorogenic peptide DabcylYRGIT(2Abu)S...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/19/2025
Entry Details
US Patent

TargetLon protease homolog, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 722813BDBM722813(US20250059213, Compound 35 | US20250320234, Compou...)
Affinity DataIC50: 50nMAssay Description:In this Example, LONP1 (NM_004793.4) activity was measured by a FRET-based assay for protease activity using a fluorogenic peptide DabcylYRGIT(2Abu)S...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/19/2025
Entry Details
US Patent

TargetLon protease homolog, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 722814BDBM722814(US20250059213, Compound 37)
Affinity DataIC50: 50nMAssay Description:In this Example, LONP1 (NM_004793.4) activity was measured by a FRET-based assay for protease activity using a fluorogenic peptide DabcylYRGIT(2Abu)S...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/19/2025
Entry Details
US Patent

TargetLon protease homolog, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 722811BDBM722811(US20250059213, Compound 32)
Affinity DataIC50: 50nMAssay Description:In this Example, LONP1 (NM_004793.4) activity was measured by a FRET-based assay for protease activity using a fluorogenic peptide DabcylYRGIT(2Abu)S...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/19/2025
Entry Details
US Patent

TargetLon protease homolog, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 722812BDBM722812(US20250059213, Compound 33)
Affinity DataIC50: 50nMAssay Description:In this Example, LONP1 (NM_004793.4) activity was measured by a FRET-based assay for protease activity using a fluorogenic peptide DabcylYRGIT(2Abu)S...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/19/2025
Entry Details
US Patent

TargetLon protease homolog, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 722793BDBM722793(US20250059213, Compound 6)
Affinity DataIC50: 50nMAssay Description:In this Example, LONP1 (NM_004793.4) activity was measured by a FRET-based assay for protease activity using a fluorogenic peptide DabcylYRGIT(2Abu)S...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/19/2025
Entry Details
US Patent

TargetLon protease homolog, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 722794BDBM722794(US20250059213, Compound 7)
Affinity DataIC50: 50nMAssay Description:In this Example, LONP1 (NM_004793.4) activity was measured by a FRET-based assay for protease activity using a fluorogenic peptide DabcylYRGIT(2Abu)S...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/19/2025
Entry Details
US Patent

TargetLon protease homolog, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 722791BDBM722791(US20250059213, Compound 4)
Affinity DataIC50: 50nMAssay Description:In this Example, LONP1 (NM_004793.4) activity was measured by a FRET-based assay for protease activity using a fluorogenic peptide DabcylYRGIT(2Abu)S...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/19/2025
Entry Details
US Patent

TargetLon protease homolog, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 722792BDBM722792(US20250059213, Compound 5)
Affinity DataIC50: 50nMAssay Description:In this Example, LONP1 (NM_004793.4) activity was measured by a FRET-based assay for protease activity using a fluorogenic peptide DabcylYRGIT(2Abu)S...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/19/2025
Entry Details
US Patent

TargetLon protease homolog, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 722789BDBM722789(US20250059213, Compound 2)
Affinity DataIC50: 50nMAssay Description:In this Example, LONP1 (NM_004793.4) activity was measured by a FRET-based assay for protease activity using a fluorogenic peptide DabcylYRGIT(2Abu)S...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/19/2025
Entry Details
US Patent

TargetLon protease homolog, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 722790BDBM722790(US20250059213, Compound 3)
Affinity DataIC50: 50nMAssay Description:In this Example, LONP1 (NM_004793.4) activity was measured by a FRET-based assay for protease activity using a fluorogenic peptide DabcylYRGIT(2Abu)S...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/19/2025
Entry Details
US Patent

TargetLon protease homolog, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 722735BDBM722735(US20250059213, Compound 1)
Affinity DataIC50: 50nMAssay Description:In this Example, LONP1 (NM_004793.4) activity was measured by a FRET-based assay for protease activity using a fluorogenic peptide DabcylYRGIT(2Abu)S...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/19/2025
Entry Details
US Patent

TargetLon protease homolog, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 720787BDBM720787(US20250051367, Compound 10)
Affinity DataIC50: 50nMAssay Description:In this Example, LONP1 (NM_004793.4) activity was measured by a FRET-based assay for protease activity using a fluorogenic peptide DabcylYRGIT(2Abu)S...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/19/2025
Entry Details
US Patent

TargetLon protease homolog, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 722802BDBM722802(US20250059213, Compound 17)
Affinity DataIC50: 50nMAssay Description:In this Example, LONP1 (NM_004793.4) activity was measured by a FRET-based assay for protease activity using a fluorogenic peptide DabcylYRGIT(2Abu)S...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/19/2025
Entry Details
US Patent

TargetLon protease homolog, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 720782BDBM720782(US20250051367, Compound 5)
Affinity DataIC50: 50nMAssay Description:In this Example, LONP1 (NM_004793.4) activity was measured by a FRET-based assay for protease activity using a fluorogenic peptide DabcylYRGIT(2Abu)S...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/19/2025
Entry Details
US Patent

TargetLon protease homolog, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 722800BDBM722800(US20250059213, Compound 13 | US20250320234, Compou...)
Affinity DataIC50: 50nMAssay Description:In this Example, LONP1 (NM_004793.4) activity was measured by a FRET-based assay for protease activity using a fluorogenic peptide DabcylYRGIT(2Abu)S...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/19/2025
Entry Details
US Patent

TargetLon protease homolog, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 722797BDBM722797(US20250059213, Compound 10)
Affinity DataIC50: 50nMAssay Description:In this Example, LONP1 (NM_004793.4) activity was measured by a FRET-based assay for protease activity using a fluorogenic peptide DabcylYRGIT(2Abu)S...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/19/2025
Entry Details
US Patent

TargetLon protease homolog, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 722798BDBM722798(US20250059213, Compound 11)
Affinity DataIC50: 50nMAssay Description:In this Example, LONP1 (NM_004793.4) activity was measured by a FRET-based assay for protease activity using a fluorogenic peptide DabcylYRGIT(2Abu)S...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/19/2025
Entry Details
US Patent

TargetLon protease homolog, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 722795BDBM722795(US20250059213, Compound 8)
Affinity DataIC50: 50nMAssay Description:In this Example, LONP1 (NM_004793.4) activity was measured by a FRET-based assay for protease activity using a fluorogenic peptide DabcylYRGIT(2Abu)S...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/19/2025
Entry Details
US Patent

TargetLon protease homolog, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 722796BDBM722796(US20250059213, Compound 9)
Affinity DataIC50: 50nMAssay Description:In this Example, LONP1 (NM_004793.4) activity was measured by a FRET-based assay for protease activity using a fluorogenic peptide DabcylYRGIT(2Abu)S...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/19/2025
Entry Details
US Patent

TargetLon protease homolog, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 722806BDBM722806(US20250059213, Compound 22)
Affinity DataIC50: 275nMAssay Description:In this Example, LONP1 (NM_004793.4) activity was measured by a FRET-based assay for protease activity using a fluorogenic peptide DabcylYRGIT(2Abu)S...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/19/2025
Entry Details
US Patent

TargetLon protease homolog, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 722817BDBM722817(US20250059213, Compound 40)
Affinity DataIC50: 275nMAssay Description:In this Example, LONP1 (NM_004793.4) activity was measured by a FRET-based assay for protease activity using a fluorogenic peptide DabcylYRGIT(2Abu)S...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/19/2025
Entry Details
US Patent

TargetLon protease homolog, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 722827BDBM722827(US20250059213, Compound 51)
Affinity DataIC50: 275nMAssay Description:In this Example, LONP1 (NM_004793.4) activity was measured by a FRET-based assay for protease activity using a fluorogenic peptide DabcylYRGIT(2Abu)S...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/19/2025
Entry Details
US Patent

TargetLon protease homolog, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 722828BDBM722828(US20250059213, Compound 52)
Affinity DataIC50: 275nMAssay Description:In this Example, LONP1 (NM_004793.4) activity was measured by a FRET-based assay for protease activity using a fluorogenic peptide DabcylYRGIT(2Abu)S...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/19/2025
Entry Details
US Patent

TargetLon protease homolog, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 722824BDBM722824(US20250059213, Compound 47)
Affinity DataIC50: 5.00E+4nMAssay Description:In this Example, LONP1 (NM_004793.4) activity was measured by a FRET-based assay for protease activity using a fluorogenic peptide DabcylYRGIT(2Abu)S...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/19/2025
Entry Details
US Patent