Compile Data Set for Download or QSAR
Report error Found 24 Enz. Inhib. hit(s) with all data for entry = 50013958
TargetMelanocortin receptor 4(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50119368BDBM50119368((R)-1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic a...)
Affinity DataEC50:  3.60nMAssay Description:Stimulation of adenylate cyclase in HEK293 cells expressing the human MC4R receptor was determined by measuring cAMP accumulation using the RPA559 SP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMelanocortin receptor 4(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50119368BDBM50119368((R)-1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic a...)
Affinity DataIC50: 9nMAssay Description:Binding activity was measured using membranes of Hi5 cells expressing the human MC4R receptorsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMelanocortin receptor 4(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50136366BDBM50136366((S)-Piperidine-3-carboxylic acid [(R)-1-(4-chloro-...)
Affinity DataIC50: 9nMAssay Description:Binding activity was measured using membranes of Hi5 cells expressing the human MC4R receptorsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50136357BDBM50136357(N-[(R)-1-(4-Chloro-benzyl)-2-(4-cyclohexyl-4-[1,2,...)
Affinity DataIC50: 10nMAssay Description:Binding activity was measured using membranes of Hi5 cells expressing the human MC4R receptorsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50136365BDBM50136365(N-[(R)-1-(4-Chloro-benzyl)-2-(4-cyclohexyl-4-[1,2,...)
Affinity DataIC50: 10nMAssay Description:Binding activity was measured using membranes of Hi5 cells expressing the human MC4R receptorsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50136372BDBM50136372(N-{2-[(R)-1-(4-Chloro-benzyl)-2-(4-cyclohexyl-4-[1...)
Affinity DataIC50: 11nMAssay Description:Binding activity was measured using membranes of Hi5 cells expressing the human MC4R receptorsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50136367BDBM50136367(N-{2-[(R)-1-(4-Chloro-benzyl)-2-(4-cyclohexyl-4-[1...)
Affinity DataIC50: 12nMAssay Description:Binding activity was measured using membranes of Hi5 cells expressing the human MC4R receptorsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50136364BDBM50136364((R)-Piperidine-3-carboxylic acid [(R)-1-(4-chloro-...)
Affinity DataIC50: 12nMAssay Description:Binding activity was measured using membranes of Hi5 cells expressing the human MC4R receptorsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50136360BDBM50136360(3-Acetylamino-N-[(R)-1-(4-chloro-benzyl)-2-(4-cycl...)
Affinity DataIC50: 12nMAssay Description:Binding activity was measured using membranes of Hi5 cells expressing the human MC4R receptorsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50136370BDBM50136370(3-Benzylamino-N-[(R)-1-(4-chloro-benzyl)-2-(4-cycl...)
Affinity DataIC50: 14nMAssay Description:Binding activity was measured using membranes of Hi5 cells expressing the human MC4R receptorsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50136368BDBM50136368(Azetidine-3-carboxylic acid [(R)-1-(4-chloro-benzy...)
Affinity DataIC50: 16nMAssay Description:Binding activity was measured using membranes of Hi5 cells expressing the human MC4R receptorsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50136355BDBM50136355(3-Amino-N-[(R)-1-(4-chloro-benzyl)-2-(4-cyclohexyl...)
Affinity DataIC50: 16nMAssay Description:Binding activity was measured using membranes of Hi5 cells expressing the human MC4R receptorsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50136363BDBM50136363(3-Amino-N-[(R)-1-(4-chloro-benzyl)-2-(4-cyclohexyl...)
Affinity DataIC50: 18nMAssay Description:Binding activity was measured using membranes of Hi5 cells expressing the human MC4R receptorsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50136356BDBM50136356(N-[(R)-1-(4-Chloro-benzyl)-2-(4-cyclohexyl-4-[1,2,...)
Affinity DataIC50: 21nMAssay Description:Binding activity was measured using membranes of Hi5 cells expressing the human MC4R receptorsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50136371BDBM50136371(N-[(R)-1-(4-Chloro-benzyl)-2-(4-cyclohexyl-4-[1,2,...)
Affinity DataIC50: 22nMAssay Description:Binding activity was measured using membranes of Hi5 cells expressing the human MC4R receptorsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50136369BDBM50136369((S)-Piperidine-3-carboxylic acid {2-[(R)-1-(4-chlo...)
Affinity DataIC50: 22nMAssay Description:Binding activity was measured using membranes of Hi5 cells expressing the human MC4R receptorsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50136361BDBM50136361((R)-Piperidine-3-carboxylic acid {2-[(R)-1-(4-chlo...)
Affinity DataIC50: 25nMAssay Description:Binding activity was measured using membranes of Hi5 cells expressing the human MC4R receptorsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50136362BDBM50136362(3-Amino-N-[(R)-1-(4-chloro-benzyl)-2-(4-cyclohexyl...)
Affinity DataIC50: 30nMAssay Description:Binding activity was measured using membranes of Hi5 cells expressing the human MC4R receptorsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50136357BDBM50136357(N-[(R)-1-(4-Chloro-benzyl)-2-(4-cyclohexyl-4-[1,2,...)
Affinity DataEC50:  40nMAssay Description:Stimulation of adenylate cyclase in HEK293 cells expressing the human MC4R receptor was determined by measuring cAMP accumulation using the RPA559 SP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50136365BDBM50136365(N-[(R)-1-(4-Chloro-benzyl)-2-(4-cyclohexyl-4-[1,2,...)
Affinity DataEC50:  70nMAssay Description:Stimulation of adenylate cyclase in HEK293 cells expressing the human MC4R receptor was determined by measuring cAMP accumulation using the RPA559 SP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50136359BDBM50136359(N-{2-[(R)-1-(4-Chloro-benzyl)-2-(4-cyclohexyl-4-[1...)
Affinity DataIC50: 90nMAssay Description:Binding activity was measured using membranes of Hi5 cells expressing the human MC4R receptorsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50136373BDBM50136373(N-[(R)-1-(4-Chloro-benzyl)-2-(4-cyclohexyl-4-[1,2,...)
Affinity DataIC50: 110nMAssay Description:Binding activity was measured using membranes of Hi5 cells expressing the human MC4R receptorsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50136355BDBM50136355(3-Amino-N-[(R)-1-(4-chloro-benzyl)-2-(4-cyclohexyl...)
Affinity DataEC50:  170nMAssay Description:Stimulation of adenylate cyclase in HEK293 cells expressing the human MC4R receptor was determined by measuring cAMP accumulation using the RPA559 SP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50136358BDBM50136358(N-[(R)-1-(4-Chloro-benzyl)-2-(4-cyclohexyl-4-[1,2,...)
Affinity DataIC50: 180nMAssay Description:Binding activity was measured using membranes of Hi5 cells expressing the human MC4R receptorsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed