Compile Data Set for Download or QSAR
Report error Found 68 Enz. Inhib. hit(s) with all data for entry = 780
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
Bristol-Myers Squibb

LigandChemical structure of BindingDB Monomer ID 6066BDBM6066(3-{3-[5-(1,4-diazepan-1-ylcarbonyl)thiophen-2-yl]-...)
Affinity DataIC50: 3nMAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 uM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/27/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
Bristol-Myers Squibb

LigandChemical structure of BindingDB Monomer ID 6059BDBM6059(1-morpholin-4-yl-3-{4-oxo-3-[5-(piperazin-1-ylcarb...)
Affinity DataIC50: 4nMAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 uM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/27/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Bristol-Myers Squibb

LigandChemical structure of BindingDB Monomer ID 6043BDBM6043(1-[3-(2,4-dimethyl-1,3-thiazol-5-yl)-4-oxo-2H,4H-i...)
Affinity DataIC50: 4nMAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 uM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/27/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
Bristol-Myers Squibb

LigandChemical structure of BindingDB Monomer ID 6067BDBM6067(3-(3-{5-[(4-methyl-1,4-diazepan-1-yl)carbonyl]thio...)
Affinity DataIC50: 4nMAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 uM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/27/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
Bristol-Myers Squibb

LigandChemical structure of BindingDB Monomer ID 6061BDBM6061(3-(3-{5-[(4-ethylpiperazin-1-yl)carbonyl]thiophen-...)
Affinity DataIC50: 5nMAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 uM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/27/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
Bristol-Myers Squibb

LigandChemical structure of BindingDB Monomer ID 6063BDBM6063(3-[3-(5-{[3-(methylamino)pyrrolidin-1-yl]carbonyl}...)
Affinity DataIC50: 5nMAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 uM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/27/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Bristol-Myers Squibb

LigandChemical structure of BindingDB Monomer ID 6066BDBM6066(3-{3-[5-(1,4-diazepan-1-ylcarbonyl)thiophen-2-yl]-...)
Affinity DataIC50: 6nMAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 uM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/27/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Bristol-Myers Squibb

LigandChemical structure of BindingDB Monomer ID 6040BDBM6040(1-[3-(5-chlorothiophen-3-yl)-4-oxo-2H,4H-indeno[1,...)
Affinity DataIC50: 7nMAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 uM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/27/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
Bristol-Myers Squibb

LigandChemical structure of BindingDB Monomer ID 6046BDBM6046(3-[3-(5-chlorothiophen-3-yl)-4-oxo-2H,4H-indeno[1,...)
Affinity DataIC50: 7nMpH: 7.6 T: 2°CAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 uM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/27/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
Bristol-Myers Squibb

LigandChemical structure of BindingDB Monomer ID 6068BDBM6068(3-(3-{5-[(4-ethyl-1,4-diazepan-1-yl)carbonyl]thiop...)
Affinity DataIC50: 7nMAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 uM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/27/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
Bristol-Myers Squibb

LigandChemical structure of BindingDB Monomer ID 6058BDBM6058(3-[3-(5-{[4-(dimethylamino)piperidin-1-yl]carbonyl...)
Affinity DataIC50: 8nMAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 uM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/27/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Bristol-Myers Squibb

LigandChemical structure of BindingDB Monomer ID 6047BDBM6047(3-[3-(2,5-dimethylthiophen-3-yl)-4-oxo-2H,4H-inden...)
Affinity DataIC50: 8nMAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 uM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/27/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Bristol-Myers Squibb

LigandChemical structure of BindingDB Monomer ID 6051BDBM6051(3-[3-(2,4-dimethyl-1,3-thiazol-5-yl)-4-oxo-2H,4H-i...)
Affinity DataIC50: 8nMAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 uM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/27/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Bristol-Myers Squibb

LigandChemical structure of BindingDB Monomer ID 6048BDBM6048(3-[3-(2,4-dimethyl-1,3-thiazol-5-yl)-4-oxo-2H,4H-i...)
Affinity DataIC50: 9nMAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 uM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/27/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
Bristol-Myers Squibb

LigandChemical structure of BindingDB Monomer ID 6060BDBM6060(3-(3-{5-[(4-methylpiperazin-1-yl)carbonyl]thiophen...)
Affinity DataIC50: 10nMAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 uM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/27/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Bristol-Myers Squibb

LigandChemical structure of BindingDB Monomer ID 6044BDBM6044(3-[3-(5-methylthiophen-2-yl)-4-oxo-2H,4H-indeno[1,...)
Affinity DataIC50: 10nMAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 uM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/27/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Bristol-Myers Squibb

LigandChemical structure of BindingDB Monomer ID 6046BDBM6046(3-[3-(5-chlorothiophen-3-yl)-4-oxo-2H,4H-indeno[1,...)
Affinity DataIC50: 10nMAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 uM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/27/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Bristol-Myers Squibb

LigandChemical structure of BindingDB Monomer ID 6063BDBM6063(3-[3-(5-{[3-(methylamino)pyrrolidin-1-yl]carbonyl}...)
Affinity DataIC50: 11nMAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 uM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/27/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
Bristol-Myers Squibb

LigandChemical structure of BindingDB Monomer ID 6064BDBM6064(3-[3-(5-{[3-(dimethylamino)pyrrolidin-1-yl]carbony...)
Affinity DataIC50: 12nMAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 uM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/27/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Bristol-Myers Squibb

LigandChemical structure of BindingDB Monomer ID 6050BDBM6050(3-[3-(2,5-dimethylthiophen-3-yl)-4-oxo-2H,4H-inden...)
Affinity DataIC50: 12nMAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 uM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/27/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
Bristol-Myers Squibb

LigandChemical structure of BindingDB Monomer ID 6057BDBM6057(3-[3-(5-{[3-(dimethylamino)piperidin-1-yl]carbonyl...)
Affinity DataIC50: 13nMAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 uM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/27/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Bristol-Myers Squibb

LigandChemical structure of BindingDB Monomer ID 6068BDBM6068(3-(3-{5-[(4-ethyl-1,4-diazepan-1-yl)carbonyl]thiop...)
Affinity DataIC50: 14nMAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 uM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/27/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
Bristol-Myers Squibb

LigandChemical structure of BindingDB Monomer ID 6052BDBM6052(N-[2-(dimethylamino)ethyl]-5-{5-[(morpholin-4-ylca...)
Affinity DataIC50: 15nMAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 uM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/27/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Bristol-Myers Squibb

LigandChemical structure of BindingDB Monomer ID 6067BDBM6067(3-(3-{5-[(4-methyl-1,4-diazepan-1-yl)carbonyl]thio...)
Affinity DataIC50: 15nMAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 uM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/27/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
Bristol-Myers Squibb

LigandChemical structure of BindingDB Monomer ID 6065BDBM6065(3-{3-[5-(azepan-1-ylcarbonyl)thiophen-2-yl]-4-oxo-...)
Affinity DataIC50: 17nMAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 uM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/27/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Bristol-Myers Squibb

LigandChemical structure of BindingDB Monomer ID 6061BDBM6061(3-(3-{5-[(4-ethylpiperazin-1-yl)carbonyl]thiophen-...)
Affinity DataIC50: 19nMAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 uM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/27/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
Bristol-Myers Squibb

LigandChemical structure of BindingDB Monomer ID 6040BDBM6040(1-[3-(5-chlorothiophen-3-yl)-4-oxo-2H,4H-indeno[1,...)
Affinity DataIC50: 21nMpH: 7.6 T: 2°CAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 uM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/27/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Bristol-Myers Squibb

LigandChemical structure of BindingDB Monomer ID 6052BDBM6052(N-[2-(dimethylamino)ethyl]-5-{5-[(morpholin-4-ylca...)
Affinity DataIC50: 21nMAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 uM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/27/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
Bristol-Myers Squibb

LigandChemical structure of BindingDB Monomer ID 6056BDBM6056(1-morpholin-4-yl-3-{4-oxo-3-[5-(piperidin-1-ylcarb...)
Affinity DataIC50: 22nMAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 uM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/27/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
Bristol-Myers Squibb

LigandChemical structure of BindingDB Monomer ID 6054BDBM6054(5-{5-[(morpholin-4-ylcarbamoyl)amino]-4-oxo-2H,4H-...)
Affinity DataIC50: 22nMAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 uM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/27/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Bristol-Myers Squibb

LigandChemical structure of BindingDB Monomer ID 6058BDBM6058(3-[3-(5-{[4-(dimethylamino)piperidin-1-yl]carbonyl...)
Affinity DataIC50: 23nMAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 uM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/27/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
Bristol-Myers Squibb

LigandChemical structure of BindingDB Monomer ID 6044BDBM6044(3-[3-(5-methylthiophen-2-yl)-4-oxo-2H,4H-indeno[1,...)
Affinity DataIC50: 23nMpH: 7.6 T: 2°CAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 uM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/27/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Bristol-Myers Squibb

LigandChemical structure of BindingDB Monomer ID 6065BDBM6065(3-{3-[5-(azepan-1-ylcarbonyl)thiophen-2-yl]-4-oxo-...)
Affinity DataIC50: 23nMAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 uM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/27/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
Bristol-Myers Squibb

LigandChemical structure of BindingDB Monomer ID 6053BDBM6053(5-{5-[(morpholin-4-ylcarbamoyl)amino]-4-oxo-2H,4H-...)
Affinity DataIC50: 23nMAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 uM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/27/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Bristol-Myers Squibb

LigandChemical structure of BindingDB Monomer ID 6039BDBM6039(3-(dimethylamino)-1-[4-oxo-3-(thiophen-3-yl)-2H,4H...)
Affinity DataIC50: 24nMAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 uM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/27/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Bristol-Myers Squibb

LigandChemical structure of BindingDB Monomer ID 6057BDBM6057(3-[3-(5-{[3-(dimethylamino)piperidin-1-yl]carbonyl...)
Affinity DataIC50: 24nMAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 uM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/27/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Bristol-Myers Squibb

LigandChemical structure of BindingDB Monomer ID 6056BDBM6056(1-morpholin-4-yl-3-{4-oxo-3-[5-(piperidin-1-ylcarb...)
Affinity DataIC50: 25nMAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 uM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/27/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Bristol-Myers Squibb

LigandChemical structure of BindingDB Monomer ID 6053BDBM6053(5-{5-[(morpholin-4-ylcarbamoyl)amino]-4-oxo-2H,4H-...)
Affinity DataIC50: 25nMAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 uM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/27/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Bristol-Myers Squibb

LigandChemical structure of BindingDB Monomer ID 6037BDBM6037(3-(dimethylamino)-1-[3-(5-methylthiophen-2-yl)-4-o...)
Affinity DataIC50: 25nMAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 uM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/27/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Bristol-Myers Squibb

LigandChemical structure of BindingDB Monomer ID 6041BDBM6041(3-(dimethylamino)-1-[3-(2,5-dimethylthiophen-3-yl)...)
Affinity DataIC50: 26nMAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 uM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/27/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Bristol-Myers Squibb

LigandChemical structure of BindingDB Monomer ID 6042BDBM6042(3-(dimethylamino)-1-[3-(furan-2-yl)-4-oxo-2H,4H-in...)
Affinity DataIC50: 26nMAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 uM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/27/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Bristol-Myers Squibb

LigandChemical structure of BindingDB Monomer ID 6038BDBM6038(ethyl 5-{5-[(N',N'-dimethylhydrazinecarbonyl)amino...)
Affinity DataIC50: 28nMAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 uM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/27/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
Bristol-Myers Squibb

LigandChemical structure of BindingDB Monomer ID 6045BDBM6045(ethyl 5-{5-[(morpholin-4-ylcarbamoyl)amino]-4-oxo-...)
Affinity DataIC50: 30nMpH: 7.6 T: 2°CAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 uM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/27/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
Bristol-Myers Squibb

LigandChemical structure of BindingDB Monomer ID 6049BDBM6049(ethyl 5-(5-{[(4-methylpiperazin-1-yl)carbamoyl]ami...)
Affinity DataIC50: 30nMpH: 7.6 T: 2°CAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 uM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/27/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Bristol-Myers Squibb

LigandChemical structure of BindingDB Monomer ID 6054BDBM6054(5-{5-[(morpholin-4-ylcarbamoyl)amino]-4-oxo-2H,4H-...)
Affinity DataIC50: 31nMAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 uM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/27/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Bristol-Myers Squibb

LigandChemical structure of BindingDB Monomer ID 6045BDBM6045(ethyl 5-{5-[(morpholin-4-ylcarbamoyl)amino]-4-oxo-...)
Affinity DataIC50: 31nMAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 uM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/27/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Bristol-Myers Squibb

LigandChemical structure of BindingDB Monomer ID 6060BDBM6060(3-(3-{5-[(4-methylpiperazin-1-yl)carbonyl]thiophen...)
Affinity DataIC50: 32nMAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 uM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/27/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Bristol-Myers Squibb

LigandChemical structure of BindingDB Monomer ID 6036BDBM6036(3-(dimethylamino)-1-[3-(5-methoxythiophen-2-yl)-4-...)
Affinity DataIC50: 32nMAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 uM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/27/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
Bristol-Myers Squibb

LigandChemical structure of BindingDB Monomer ID 6062BDBM6062(3-(3-{5-[(3-aminopyrrolidin-1-yl)carbonyl]thiophen...)
Affinity DataIC50: 35nMAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 uM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/27/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Bristol-Myers Squibb

LigandChemical structure of BindingDB Monomer ID 6049BDBM6049(ethyl 5-(5-{[(4-methylpiperazin-1-yl)carbamoyl]ami...)
Affinity DataIC50: 36nMAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 uM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/27/2005
Entry Details Article
PubMed
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