Compile Data Set for Download or QSAR
Report error Found 34 Enz. Inhib. hit(s) with all data for entry = 1467
TargetDipeptidyl peptidase 4(Human)
Hoffmann-La Roche

LigandPNGBDBM11593(5-(aminomethyl)-6-(2,4-dichlorophenyl)-2-(3,5-dime...)
Affinity DataIC50: 0.100nMAssay Description:DPP-IV inhibitors were measured for their ability to inhibit DPP-IV mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2006
Entry Details Article
PubMed
TargetDipeptidyl peptidase 4(Human)
Hoffmann-La Roche

LigandPNGBDBM11589(1c-para-F | 5-(aminomethyl)-6-(2,4-dichlorophenyl)...)
Affinity DataIC50: 0.200nMAssay Description:DPP-IV inhibitors were measured for their ability to inhibit DPP-IV mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2006
Entry Details Article
PubMed
TargetDipeptidyl peptidase 4(Human)
Hoffmann-La Roche

LigandPNGBDBM11588(1c-meta-F | 5-(aminomethyl)-6-(2,4-dichlorophenyl)...)
Affinity DataIC50: 0.200nMAssay Description:DPP-IV inhibitors were measured for their ability to inhibit DPP-IV mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2006
Entry Details Article
PubMed
TargetDipeptidyl peptidase 4(Human)
Hoffmann-La Roche

LigandPNGBDBM11580(1c-meta-Me | 5-(aminomethyl)-6-(2,4-dichlorophenyl...)
Affinity DataIC50: 0.900nMAssay Description:DPP-IV inhibitors were measured for their ability to inhibit DPP-IV mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2006
Entry Details Article
PubMed
TargetDipeptidyl peptidase 4(Human)
Hoffmann-La Roche

LigandPNGBDBM11592(5-(aminomethyl)-6-(2,4-dichlorophenyl)-2-(3,4-difl...)
Affinity DataIC50: 3nMAssay Description:DPP-IV inhibitors were measured for their ability to inhibit DPP-IV mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2006
Entry Details Article
PubMed
TargetDipeptidyl peptidase 4(Human)
Hoffmann-La Roche

LigandPNGBDBM11578(5-(aminomethyl)-6-(2,4-dichlorophenyl)-2-phenylpyr...)
Affinity DataIC50: 10nMAssay Description:DPP-IV inhibitors were measured for their ability to inhibit DPP-IV mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2006
Entry Details Article
PubMed
TargetDipeptidyl peptidase 4(Human)
Hoffmann-La Roche

LigandPNGBDBM11113(NVP-DPP728 | cyanopyrrolidine derivative 2 | CHEMB...)
Affinity DataKi:  11nM IC50: 15nMAssay Description:DPP-IV inhibitors were measured for their ability to inhibit DPP-IV mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2006
Entry Details Article
PubMed
TargetDipeptidyl peptidase 4(Human)
Hoffmann-La Roche

LigandPNGBDBM11587(1c-ortho-F | 5-(aminomethyl)-6-(2,4-dichlorophenyl...)
Affinity DataIC50: 47nMAssay Description:DPP-IV inhibitors were measured for their ability to inhibit DPP-IV mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2006
Entry Details Article
PubMed
TargetDipeptidyl peptidase 4(Human)
Hoffmann-La Roche

LigandPNGBDBM11583(1c-para-Cl | 5-(aminomethyl)-2-(4-chlorophenyl)-6-...)
Affinity DataIC50: 53nMAssay Description:DPP-IV inhibitors were measured for their ability to inhibit DPP-IV mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2006
Entry Details Article
PubMed
TargetDipeptidyl peptidase 4(Human)
Hoffmann-La Roche

LigandPNGBDBM11581(5-(aminomethyl)-6-(2,4-dichlorophenyl)-2-(4-methyl...)
Affinity DataIC50: 90nMAssay Description:DPP-IV inhibitors were measured for their ability to inhibit DPP-IV mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2006
Entry Details Article
PubMed
TargetDipeptidyl peptidase 4(Human)
Hoffmann-La Roche

LigandPNGBDBM11586(1c-para-OMe | 5-(aminomethyl)-6-(2,4-dichloropheny...)
Affinity DataIC50: 100nMAssay Description:DPP-IV inhibitors were measured for their ability to inhibit DPP-IV mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2006
Entry Details Article
PubMed
TargetDipeptidyl peptidase 4(Human)
Hoffmann-La Roche

LigandPNGBDBM11590(1c-meta-CF3 | 5-(aminomethyl)-6-(2,4-dichloropheny...)
Affinity DataIC50: 130nMAssay Description:DPP-IV inhibitors were measured for their ability to inhibit DPP-IV mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2006
Entry Details Article
PubMed
TargetDipeptidyl peptidase 4(Human)
Hoffmann-La Roche

LigandPNGBDBM11591(1c-para-CF3 | 5-(aminomethyl)-6-(2,4-dichloropheny...)
Affinity DataIC50: 180nMAssay Description:DPP-IV inhibitors were measured for their ability to inhibit DPP-IV mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2006
Entry Details Article
PubMed
TargetDipeptidyl peptidase 4(Human)
Hoffmann-La Roche

LigandPNGBDBM11582(5-(aminomethyl)-2-(3-chlorophenyl)-6-(2,4-dichloro...)
Affinity DataIC50: 240nMAssay Description:DPP-IV inhibitors were measured for their ability to inhibit DPP-IV mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2006
Entry Details Article
PubMed
TargetDipeptidyl peptidase 4(Human)
Hoffmann-La Roche

LigandPNGBDBM11585(1c-meta-OMe | 5-(aminomethyl)-6-(2,4-dichloropheny...)
Affinity DataIC50: 340nMAssay Description:DPP-IV inhibitors were measured for their ability to inhibit DPP-IV mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2006
Entry Details Article
PubMed
TargetDipeptidyl peptidase 4(Human)
Hoffmann-La Roche

LigandPNGBDBM11584(5-(aminomethyl)-6-(2,4-dichlorophenyl)-2-(2-methox...)
Affinity DataIC50: 350nMAssay Description:DPP-IV inhibitors were measured for their ability to inhibit DPP-IV mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2006
Entry Details Article
PubMed
TargetDipeptidyl peptidase 4(Human)
Hoffmann-La Roche

LigandPNGBDBM11565(5-(aminomethyl)-6-(4-methylphenyl)-2-phenylpyrimid...)
Affinity DataIC50: 1.00E+3nMpH: 7.5 T: 2°CAssay Description:DPP-IV inhibitors were measured for their ability to inhibit DPP-IV mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2006
Entry Details Article
PubMed
TargetDipeptidyl peptidase 4(Human)
Hoffmann-La Roche

LigandPNGBDBM11577(1b-para-CF3 | 5-(aminomethyl)-2-phenyl-6-[4-(trifl...)
Affinity DataIC50: 1.10E+3nMAssay Description:DPP-IV inhibitors were measured for their ability to inhibit DPP-IV mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2006
Entry Details Article
PubMed
TargetDipeptidyl peptidase 4(Human)
Hoffmann-La Roche

LigandPNGBDBM11568(5-(aminomethyl)-6-(4-chlorophenyl)-2-phenylpyrimid...)
Affinity DataIC50: 1.40E+3nMpH: 7.5 T: 2°CAssay Description:DPP-IV inhibitors were measured for their ability to inhibit DPP-IV mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2006
Entry Details Article
PubMed
TargetDipeptidyl peptidase 4(Human)
Hoffmann-La Roche

LigandPNGBDBM11563(5-(aminomethyl)-6-(2-methylphenyl)-2-phenylpyrimid...)
Affinity DataIC50: 1.50E+3nMpH: 7.5 T: 2°CAssay Description:DPP-IV inhibitors were measured for their ability to inhibit DPP-IV mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2006
Entry Details Article
PubMed
TargetDipeptidyl peptidase 4(Human)
Hoffmann-La Roche

LigandPNGBDBM11569(1b-ortho-OMe | 5-(aminomethyl)-6-(2-methoxyphenyl)...)
Affinity DataIC50: 1.50E+3nMpH: 7.5 T: 2°CAssay Description:DPP-IV inhibitors were measured for their ability to inhibit DPP-IV mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2006
Entry Details Article
PubMed
TargetDipeptidyl peptidase 4(Human)
Hoffmann-La Roche

LigandPNGBDBM11579(1c-ortho-Me | 5-(aminomethyl)-6-(2,4-dichloropheny...)
Affinity DataIC50: 1.75E+3nMAssay Description:DPP-IV inhibitors were measured for their ability to inhibit DPP-IV mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2006
Entry Details Article
PubMed
TargetDipeptidyl peptidase 4(Human)
Hoffmann-La Roche

LigandPNGBDBM11566(5-(aminomethyl)-6-(2-chlorophenyl)-2-phenylpyrimid...)
Affinity DataIC50: 2.50E+3nMpH: 7.5 T: 2°CAssay Description:DPP-IV inhibitors were measured for their ability to inhibit DPP-IV mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2006
Entry Details Article
PubMed
TargetDipeptidyl peptidase 4(Human)
Hoffmann-La Roche

LigandPNGBDBM11560(CHEMBL37980 | 5-(aminomethyl)-6-(2H-1,3-benzodioxo...)
Affinity DataIC50: 1.00E+4nMpH: 7.5 T: 2°CAssay Description:DPP-IV inhibitors were measured for their ability to inhibit DPP-IV mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2006
Entry Details Article
PubMed
TargetDipeptidyl peptidase 4(Human)
Hoffmann-La Roche

LigandPNGBDBM11575(5-(aminomethyl)-2-phenyl-6-[2-(trifluoromethyl)phe...)
Affinity DataIC50: 1.40E+4nMpH: 7.5 T: 2°CAssay Description:DPP-IV inhibitors were measured for their ability to inhibit DPP-IV mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2006
Entry Details Article
PubMed
TargetDipeptidyl peptidase 4(Human)
Hoffmann-La Roche

LigandPNGBDBM11572(1b-ortho-F | 5-(aminomethyl)-6-(2-fluorophenyl)-2-...)
Affinity DataIC50: 1.40E+4nMpH: 7.5 T: 2°CAssay Description:DPP-IV inhibitors were measured for their ability to inhibit DPP-IV mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2006
Entry Details Article
PubMed
TargetDipeptidyl peptidase 4(Human)
Hoffmann-La Roche

LigandPNGBDBM11574(1b-para-F | 5-(aminomethyl)-6-(4-fluorophenyl)-2-p...)
Affinity DataIC50: 1.80E+4nMpH: 7.5 T: 2°CAssay Description:DPP-IV inhibitors were measured for their ability to inhibit DPP-IV mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2006
Entry Details Article
PubMed
TargetDipeptidyl peptidase 4(Human)
Hoffmann-La Roche

LigandPNGBDBM11564(1b-meta-Me | 5-(aminomethyl)-6-(3-methylphenyl)-2-...)
Affinity DataIC50: 2.00E+4nMpH: 7.5 T: 2°CAssay Description:DPP-IV inhibitors were measured for their ability to inhibit DPP-IV mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2006
Entry Details Article
PubMed
TargetDipeptidyl peptidase 4(Human)
Hoffmann-La Roche

LigandPNGBDBM11567(5-(aminomethyl)-6-(3-chlorophenyl)-2-phenylpyrimid...)
Affinity DataIC50: 3.10E+4nMpH: 7.5 T: 2°CAssay Description:DPP-IV inhibitors were measured for their ability to inhibit DPP-IV mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2006
Entry Details Article
PubMed
TargetDipeptidyl peptidase 4(Human)
Hoffmann-La Roche

LigandPNGBDBM11573(5-(aminomethyl)-6-(3-fluorophenyl)-2-phenylpyrimid...)
Affinity DataIC50: 4.00E+4nMpH: 7.5 T: 2°CAssay Description:DPP-IV inhibitors were measured for their ability to inhibit DPP-IV mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2006
Entry Details Article
PubMed
TargetDipeptidyl peptidase 4(Human)
Hoffmann-La Roche

LigandPNGBDBM11562(5-(aminomethyl)-2,6-diphenylpyrimidin-4-amine | Am...)
Affinity DataIC50: 4.20E+4nMpH: 7.5 T: 2°CAssay Description:DPP-IV inhibitors were measured for their ability to inhibit DPP-IV mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2006
Entry Details Article
PubMed
TargetDipeptidyl peptidase 4(Human)
Hoffmann-La Roche

LigandPNGBDBM11571(1b-para-OMe | 5-(aminomethyl)-6-(4-methoxyphenyl)-...)
Affinity DataIC50: 4.70E+4nMpH: 7.5 T: 2°CAssay Description:DPP-IV inhibitors were measured for their ability to inhibit DPP-IV mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2006
Entry Details Article
PubMed
TargetDipeptidyl peptidase 4(Human)
Hoffmann-La Roche

LigandPNGBDBM11570(1b-meta-OMe | 5-(aminomethyl)-6-(3-methoxyphenyl)-...)
Affinity DataIC50: 8.00E+4nMpH: 7.5 T: 2°CAssay Description:DPP-IV inhibitors were measured for their ability to inhibit DPP-IV mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2006
Entry Details Article
PubMed
TargetDipeptidyl peptidase 4(Human)
Hoffmann-La Roche

LigandPNGBDBM11576(1b-meta-CF3 | 5-(aminomethyl)-2-phenyl-6-[3-(trifl...)
Affinity DataIC50: 1.70E+5nMAssay Description:DPP-IV inhibitors were measured for their ability to inhibit DPP-IV mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2006
Entry Details Article
PubMed