Compile Data Set for Download or QSAR
maximum 50k data
Found 34 Enz. Inhib. hit(s) with all data for entry = 1467
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Hoffmann-La Roche

LigandPNGBDBM11113(6-{[2-({2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl...)
Affinity DataKi:  11nM IC50:  15nMAssay Description:DPP-IV inhibitors were measured for their ability to inhibit DPP-IV mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Hoffmann-La Roche

LigandPNGBDBM11593(5-(aminomethyl)-6-(2,4-dichlorophenyl)-2-(3,5-dime...)
Affinity DataIC50:  0.100nMAssay Description:DPP-IV inhibitors were measured for their ability to inhibit DPP-IV mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic a...More data for this Ligand-Target Pair
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Hoffmann-La Roche

LigandPNGBDBM11588(1c-meta-F | 5-(aminomethyl)-6-(2,4-dichlorophenyl)...)
Affinity DataIC50:  0.200nMAssay Description:DPP-IV inhibitors were measured for their ability to inhibit DPP-IV mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Hoffmann-La Roche

LigandPNGBDBM11589(1c-para-F | 5-(aminomethyl)-6-(2,4-dichlorophenyl)...)
Affinity DataIC50:  0.200nMAssay Description:DPP-IV inhibitors were measured for their ability to inhibit DPP-IV mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Hoffmann-La Roche

LigandPNGBDBM11580(1c-meta-Me | 5-(aminomethyl)-6-(2,4-dichlorophenyl...)
Affinity DataIC50:  0.900nMAssay Description:DPP-IV inhibitors were measured for their ability to inhibit DPP-IV mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Hoffmann-La Roche

LigandPNGBDBM11592(5-(aminomethyl)-6-(2,4-dichlorophenyl)-2-(3,4-difl...)
Affinity DataIC50:  3nMAssay Description:DPP-IV inhibitors were measured for their ability to inhibit DPP-IV mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Hoffmann-La Roche

LigandPNGBDBM11578(5-(aminomethyl)-6-(2,4-dichlorophenyl)-2-phenylpyr...)
Affinity DataIC50:  10nMAssay Description:DPP-IV inhibitors were measured for their ability to inhibit DPP-IV mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Hoffmann-La Roche

LigandPNGBDBM11587(1c-ortho-F | 5-(aminomethyl)-6-(2,4-dichlorophenyl...)
Affinity DataIC50:  47nMAssay Description:DPP-IV inhibitors were measured for their ability to inhibit DPP-IV mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Hoffmann-La Roche

LigandPNGBDBM11583(1c-para-Cl | 5-(aminomethyl)-2-(4-chlorophenyl)-6-...)
Affinity DataIC50:  53nMAssay Description:DPP-IV inhibitors were measured for their ability to inhibit DPP-IV mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Hoffmann-La Roche

LigandPNGBDBM11581(1c-para-Me | 5-(aminomethyl)-6-(2,4-dichlorophenyl...)
Affinity DataIC50:  90nMAssay Description:DPP-IV inhibitors were measured for their ability to inhibit DPP-IV mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Hoffmann-La Roche

LigandPNGBDBM11586(1c-para-OMe | 5-(aminomethyl)-6-(2,4-dichloropheny...)
Affinity DataIC50:  100nMAssay Description:DPP-IV inhibitors were measured for their ability to inhibit DPP-IV mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Hoffmann-La Roche

LigandPNGBDBM11590(1c-meta-CF3 | 5-(aminomethyl)-6-(2,4-dichloropheny...)
Affinity DataIC50:  130nMAssay Description:DPP-IV inhibitors were measured for their ability to inhibit DPP-IV mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Hoffmann-La Roche

LigandPNGBDBM11591(1c-para-CF3 | 5-(aminomethyl)-6-(2,4-dichloropheny...)
Affinity DataIC50:  180nMAssay Description:DPP-IV inhibitors were measured for their ability to inhibit DPP-IV mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Hoffmann-La Roche

LigandPNGBDBM11582(1c-meta-Cl | 5-(aminomethyl)-2-(3-chlorophenyl)-6-...)
Affinity DataIC50:  240nMAssay Description:DPP-IV inhibitors were measured for their ability to inhibit DPP-IV mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Hoffmann-La Roche

LigandPNGBDBM11585(1c-meta-OMe | 5-(aminomethyl)-6-(2,4-dichloropheny...)
Affinity DataIC50:  340nMAssay Description:DPP-IV inhibitors were measured for their ability to inhibit DPP-IV mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Hoffmann-La Roche

LigandPNGBDBM11584(1c-ortho-OMe | 5-(aminomethyl)-6-(2,4-dichlorophen...)
Affinity DataIC50:  350nMAssay Description:DPP-IV inhibitors were measured for their ability to inhibit DPP-IV mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Hoffmann-La Roche

LigandPNGBDBM11565(1b-para-Me | 5-(aminomethyl)-6-(4-methylphenyl)-2-...)
Affinity DataIC50:  1.00E+3nMpH: 7.5 T: 2°CAssay Description:DPP-IV inhibitors were measured for their ability to inhibit DPP-IV mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Hoffmann-La Roche

LigandPNGBDBM11577(1b-para-CF3 | 5-(aminomethyl)-2-phenyl-6-[4-(trifl...)
Affinity DataIC50:  1.10E+3nMAssay Description:DPP-IV inhibitors were measured for their ability to inhibit DPP-IV mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Hoffmann-La Roche

LigandPNGBDBM11568(1b-para-Cl | 5-(aminomethyl)-6-(4-chlorophenyl)-2-...)
Affinity DataIC50:  1.40E+3nMpH: 7.5 T: 2°CAssay Description:DPP-IV inhibitors were measured for their ability to inhibit DPP-IV mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Hoffmann-La Roche

LigandPNGBDBM11563(1b-ortho-Me | 5-(aminomethyl)-6-(2-methylphenyl)-2...)
Affinity DataIC50:  1.50E+3nMpH: 7.5 T: 2°CAssay Description:DPP-IV inhibitors were measured for their ability to inhibit DPP-IV mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Hoffmann-La Roche

LigandPNGBDBM11569(1b-ortho-OMe | 5-(aminomethyl)-6-(2-methoxyphenyl)...)
Affinity DataIC50:  1.50E+3nMpH: 7.5 T: 2°CAssay Description:DPP-IV inhibitors were measured for their ability to inhibit DPP-IV mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Hoffmann-La Roche

LigandPNGBDBM11579(1c-ortho-Me | 5-(aminomethyl)-6-(2,4-dichloropheny...)
Affinity DataIC50:  1.75E+3nMAssay Description:DPP-IV inhibitors were measured for their ability to inhibit DPP-IV mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Hoffmann-La Roche

LigandPNGBDBM11566(1b-ortho-Cl | 5-(aminomethyl)-6-(2-chlorophenyl)-2...)
Affinity DataIC50:  2.50E+3nMpH: 7.5 T: 2°CAssay Description:DPP-IV inhibitors were measured for their ability to inhibit DPP-IV mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Hoffmann-La Roche

LigandPNGBDBM11560(5-(aminomethyl)-6-(2H-1,3-benzodioxol-5-yl)-2-phen...)
Affinity DataIC50:  1.00E+4nMpH: 7.5 T: 2°CAssay Description:DPP-IV inhibitors were measured for their ability to inhibit DPP-IV mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Hoffmann-La Roche

LigandPNGBDBM11575(1b-ortho-CF3 | 5-(aminomethyl)-2-phenyl-6-[2-(trif...)
Affinity DataIC50:  1.40E+4nMpH: 7.5 T: 2°CAssay Description:DPP-IV inhibitors were measured for their ability to inhibit DPP-IV mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Hoffmann-La Roche

LigandPNGBDBM11572(1b-ortho-F | 5-(aminomethyl)-6-(2-fluorophenyl)-2-...)
Affinity DataIC50:  1.40E+4nMpH: 7.5 T: 2°CAssay Description:DPP-IV inhibitors were measured for their ability to inhibit DPP-IV mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Hoffmann-La Roche

LigandPNGBDBM11574(1b-para-F | 5-(aminomethyl)-6-(4-fluorophenyl)-2-p...)
Affinity DataIC50:  1.80E+4nMpH: 7.5 T: 2°CAssay Description:DPP-IV inhibitors were measured for their ability to inhibit DPP-IV mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Hoffmann-La Roche

LigandPNGBDBM11564(1b-meta-Me | 5-(aminomethyl)-6-(3-methylphenyl)-2-...)
Affinity DataIC50:  2.00E+4nMpH: 7.5 T: 2°CAssay Description:DPP-IV inhibitors were measured for their ability to inhibit DPP-IV mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Hoffmann-La Roche

LigandPNGBDBM11567(1b-meta-Cl | 5-(aminomethyl)-6-(3-chlorophenyl)-2-...)
Affinity DataIC50:  3.10E+4nMpH: 7.5 T: 2°CAssay Description:DPP-IV inhibitors were measured for their ability to inhibit DPP-IV mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Hoffmann-La Roche

LigandPNGBDBM11573(1b-meta-F | 5-(aminomethyl)-6-(3-fluorophenyl)-2-p...)
Affinity DataIC50:  4.00E+4nMpH: 7.5 T: 2°CAssay Description:DPP-IV inhibitors were measured for their ability to inhibit DPP-IV mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Hoffmann-La Roche

LigandPNGBDBM11562(5-(aminomethyl)-2,6-diphenylpyrimidin-4-amine | Am...)
Affinity DataIC50:  4.20E+4nMpH: 7.5 T: 2°CAssay Description:DPP-IV inhibitors were measured for their ability to inhibit DPP-IV mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Hoffmann-La Roche

LigandPNGBDBM11571(1b-para-OMe | 5-(aminomethyl)-6-(4-methoxyphenyl)-...)
Affinity DataIC50:  4.70E+4nMpH: 7.5 T: 2°CAssay Description:DPP-IV inhibitors were measured for their ability to inhibit DPP-IV mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Hoffmann-La Roche

LigandPNGBDBM11570(1b-meta-OMe | 5-(aminomethyl)-6-(3-methoxyphenyl)-...)
Affinity DataIC50:  8.00E+4nMpH: 7.5 T: 2°CAssay Description:DPP-IV inhibitors were measured for their ability to inhibit DPP-IV mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Hoffmann-La Roche

LigandPNGBDBM11576(1b-meta-CF3 | 5-(aminomethyl)-2-phenyl-6-[3-(trifl...)
Affinity DataIC50:  1.70E+5nMAssay Description:DPP-IV inhibitors were measured for their ability to inhibit DPP-IV mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed