Compile Data Set for Download or QSAR
Report error Found 36 Enz. Inhib. hit(s) with all data for entry = 50014974
TargetMetabotropic glutamate receptor 5(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50149801BDBM50149801(5-(2-Methyl-thiazol-4-ylethynyl)-2-phenyl-pyridine...)
Affinity DataIC50: 0.5nMAssay Description:In vitro potency against human recombinant mGlu5 receptor was determined by [Ca2+] flux assay using glutamate as agonistMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50149792BDBM50149792(5-(2-Methyl-thiazol-4-ylethynyl)-[3,3'']bipyridiny...)
Affinity DataKi:  1nMAssay Description:Displacement by compound of [3H]3-methoxy-5-(pyridin-2-ylethynyl)pyridine from rat cortical membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50149802BDBM50149802(2-Methyl-4-m-tolylethynyl-thiazole | 2-methyl-4-(m...)
Affinity DataIC50: 2nMAssay Description:In vitro potency against human recombinant mGlu5 receptor was determined by [Ca2+] flux assay using glutamate as agonistMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50149801BDBM50149801(5-(2-Methyl-thiazol-4-ylethynyl)-2-phenyl-pyridine...)
Affinity DataKi:  2nMAssay Description:Displacement by compound of [3H]3-methoxy-5-(pyridin-2-ylethynyl)pyridine from rat cortical membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50149805BDBM50149805(2-(Pyridin-3-yl)-5-(2-methylthiazol-4ylethynyl)pyr...)
Affinity DataKi:  2nMAssay Description:Displacement by compound of [3H]3-methoxy-5-(pyridin-2-ylethynyl)pyridine from rat cortical membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50149793BDBM50149793(3-(2-Methyl-thiazol-4-ylethynyl)-5-phenyl-pyridine...)
Affinity DataIC50: 2nMAssay Description:In vitro potency against human recombinant mGlu5 receptor was determined by [Ca2+] flux assay using glutamate as agonistMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50149805BDBM50149805(2-(Pyridin-3-yl)-5-(2-methylthiazol-4ylethynyl)pyr...)
Affinity DataIC50: 2nMAssay Description:In vitro potency against human recombinant mGlu5 receptor was determined by [Ca2+] flux assay using glutamate as agonistMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50149792BDBM50149792(5-(2-Methyl-thiazol-4-ylethynyl)-[3,3'']bipyridiny...)
Affinity DataIC50: 3nMAssay Description:In vitro potency against human recombinant mGlu5 receptor was determined by [Ca2+] flux assay using glutamate as agonistMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50122759BDBM50122759(2-Methyl-4-phenylethynyl-thiazole | CHEMBL63042)
Affinity DataIC50: 4nMAssay Description:In vitro potency against human recombinant mGlu5 receptor was determined by [Ca2+] flux assay using glutamate as agonistMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50149796BDBM50149796(5-(2-Methyl-thiazol-4-ylethynyl)-[2,2'']bipyridiny...)
Affinity DataIC50: 4nMAssay Description:In vitro potency against human recombinant mGlu5 receptor was determined by [Ca2+] flux assay using glutamate as agonistMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50122758BDBM50122758(3-(2-(2-methylthiazol-4-yl)ethynyl)pyridine | 3-[(...)
Affinity DataIC50: 5nMAssay Description:In vitro potency against human recombinant mGlu5 receptor was determined by [Ca2+] flux assay using glutamate as agonistMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50122759BDBM50122759(2-Methyl-4-phenylethynyl-thiazole | CHEMBL63042)
Affinity DataKi:  9nMAssay Description:Displacement by compound of [3H]3-methoxy-5-(pyridin-2-ylethynyl)pyridine from rat cortical membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50149802BDBM50149802(2-Methyl-4-m-tolylethynyl-thiazole | 2-methyl-4-(m...)
Affinity DataKi:  10nMAssay Description:Displacement by compound of [3H]3-methoxy-5-(pyridin-2-ylethynyl)pyridine from rat cortical membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50122758BDBM50122758(3-(2-(2-methylthiazol-4-yl)ethynyl)pyridine | 3-[(...)
Affinity DataKi:  12nMAssay Description:Displacement by compound of [3H]3-methoxy-5-(pyridin-2-ylethynyl)pyridine from rat cortical membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50149797BDBM50149797(2-Methyl-4-o-tolylethynyl-thiazole | CHEMBL181915)
Affinity DataIC50: 15nMAssay Description:In vitro potency against human recombinant mGlu5 receptor was determined by [Ca2+] flux assay using glutamate as agonistMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50149800BDBM50149800(5-(2-Methyl-thiazol-4-ylethynyl)-[3,4'']bipyridiny...)
Affinity DataKi:  15nMAssay Description:Displacement by compound of [3H]3-methoxy-5-(pyridin-2-ylethynyl)pyridine from rat cortical membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50149798BDBM50149798(3-Phenyl-1-(2-methylthiazol-4-ylethynyl)benzene | ...)
Affinity DataKi:  16nMAssay Description:Displacement by compound of [3H]3-methoxy-5-(pyridin-2-ylethynyl)pyridine from rat cortical membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50149796BDBM50149796(5-(2-Methyl-thiazol-4-ylethynyl)-[2,2'']bipyridiny...)
Affinity DataKi:  16nMAssay Description:Displacement by compound of [3H]3-methoxy-5-(pyridin-2-ylethynyl)pyridine from rat cortical membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50149800BDBM50149800(5-(2-Methyl-thiazol-4-ylethynyl)-[3,4'']bipyridiny...)
Affinity DataIC50: 18nMAssay Description:In vitro potency against human recombinant mGlu5 receptor was determined by [Ca2+] flux assay using glutamate as agonistMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50149795BDBM50149795(5-(2-Methyl-thiazol-4-ylethynyl)-[2,4'']bipyridiny...)
Affinity DataKi:  21nMAssay Description:Displacement by compound of [3H]3-methoxy-5-(pyridin-2-ylethynyl)pyridine from rat cortical membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50149799BDBM50149799(4-Biphenyl-4-ylethynyl-2-methyl-thiazole | CHEMBL1...)
Affinity DataIC50: 22nMAssay Description:In vitro potency against human recombinant mGlu5 receptor was determined by [Ca2+] flux assay using glutamate as agonistMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50149794BDBM50149794(5''-(2-Methyl-thiazol-4-ylethynyl)-[2,3'']bipyridi...)
Affinity DataIC50: 22nMAssay Description:In vitro potency against human recombinant mGlu5 receptor was determined by [Ca2+] flux assay using glutamate as agonistMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50149794BDBM50149794(5''-(2-Methyl-thiazol-4-ylethynyl)-[2,3'']bipyridi...)
Affinity DataKi:  28nMAssay Description:Displacement by compound of [3H]3-methoxy-5-(pyridin-2-ylethynyl)pyridine from rat cortical membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50149795BDBM50149795(5-(2-Methyl-thiazol-4-ylethynyl)-[2,4'']bipyridiny...)
Affinity DataIC50: 29nMAssay Description:In vitro potency against human recombinant mGlu5 receptor was determined by [Ca2+] flux assay using glutamate as agonistMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50149793BDBM50149793(3-(2-Methyl-thiazol-4-ylethynyl)-5-phenyl-pyridine...)
Affinity DataKi:  40nMAssay Description:Displacement by compound of [3H]3-methoxy-5-(pyridin-2-ylethynyl)pyridine from rat cortical membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50149798BDBM50149798(3-Phenyl-1-(2-methylthiazol-4-ylethynyl)benzene | ...)
Affinity DataIC50: 41nMAssay Description:In vitro potency against human recombinant mGlu5 receptor was determined by [Ca2+] flux assay using glutamate as agonistMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50149799BDBM50149799(4-Biphenyl-4-ylethynyl-2-methyl-thiazole | CHEMBL1...)
Affinity DataKi:  43nMAssay Description:Displacement by compound of [3H]3-methoxy-5-(pyridin-2-ylethynyl)pyridine from rat cortical membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50149797BDBM50149797(2-Methyl-4-o-tolylethynyl-thiazole | CHEMBL181915)
Affinity DataKi:  51nMAssay Description:Displacement by compound of [3H]3-methoxy-5-(pyridin-2-ylethynyl)pyridine from rat cortical membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50122757BDBM50122757(2-(2-Methyl-thiazol-4-ylethynyl)-pyridine | CHEMBL...)
Affinity DataIC50: 53nMAssay Description:In vitro potency against human recombinant mGlu5 receptor was determined by [Ca2+] flux assay using glutamate as agonistMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50122757BDBM50122757(2-(2-Methyl-thiazol-4-ylethynyl)-pyridine | CHEMBL...)
Affinity DataKi:  54nMAssay Description:Displacement by compound of [3H]3-methoxy-5-(pyridin-2-ylethynyl)pyridine from rat cortical membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50122763BDBM50122763(4-(2-Methyl-thiazol-4-ylethynyl)-pyridine | CHEMBL...)
Affinity DataIC50: 127nMAssay Description:In vitro potency against human recombinant mGlu5 receptor was determined by [Ca2+] flux assay using glutamate as agonistMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50149804BDBM50149804(4-Biphenyl-2-ylethynyl-2-methyl-thiazole | CHEMBL1...)
Affinity DataKi:  145nMAssay Description:Displacement by compound of [3H]3-methoxy-5-(pyridin-2-ylethynyl)pyridine from rat cortical membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50122763BDBM50122763(4-(2-Methyl-thiazol-4-ylethynyl)-pyridine | CHEMBL...)
Affinity DataKi:  218nMAssay Description:Displacement by compound of [3H]3-methoxy-5-(pyridin-2-ylethynyl)pyridine from rat cortical membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50149804BDBM50149804(4-Biphenyl-2-ylethynyl-2-methyl-thiazole | CHEMBL1...)
Affinity DataIC50: 423nMAssay Description:In vitro potency against human recombinant mGlu5 receptor was determined by [Ca2+] flux assay using glutamate as agonistMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50149803BDBM50149803(2-Methyl-4-p-tolylethynyl-thiazole | CHEMBL185813)
Affinity DataKi:  638nMAssay Description:Displacement by compound of [3H]3-methoxy-5-(pyridin-2-ylethynyl)pyridine from rat cortical membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50149803BDBM50149803(2-Methyl-4-p-tolylethynyl-thiazole | CHEMBL185813)
Affinity DataIC50: 845nMAssay Description:In vitro potency against human recombinant mGlu5 receptor was determined by [Ca2+] flux assay using glutamate as agonistMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed