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Found 4 Enz. Inhib. hit(s) with all data for entry = 50037566
TargetDNA topoisomerase 1(Homo sapiens (Human))
Decode Biostructures

Curated by ChEMBL
LigandPNGBDBM50073854(2,10-dihydroxy-12-(3,4,5-trihydroxy-6-hydroxymethy...)
Affinity DataIC50:  30nMAssay Description:Inhibition of topoisomerase I-DNA complex in trapping assayMore data for this Ligand-Target Pair
TargetDNA topoisomerase 1(Homo sapiens (Human))
Decode Biostructures

Curated by ChEMBL
LigandPNGBDBM50008935((20S)-10-Dimethylaminomethyl-4-ethyl-4,9-dihydroxy...)
Affinity DataIC50:  50nMAssay Description:Inhibition of topoisomerase I-DNA complex in trapping assayMore data for this Ligand-Target Pair
TargetDNA topoisomerase 1(Homo sapiens (Human))
Decode Biostructures

Curated by ChEMBL
LigandPNGBDBM50008923((S)-4-ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-...)
Affinity DataIC50:  300nMAssay Description:Inhibition of topoisomerase I-DNA complex in trapping assayMore data for this Ligand-Target Pair
TargetDNA topoisomerase 1(Homo sapiens (Human))
Decode Biostructures

Curated by ChEMBL
LigandPNGBDBM50164286(4-(5,11-Dioxo-5,6a,11,11a-tetrahydro-indeno[1,2-c]...)
Affinity DataIC50:  4.90E+3nMAssay Description:Inhibition of topoisomerase I-DNA complex in trapping assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed