Compile Data Set for Download or QSAR
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Found 55 Enz. Inhib. hit(s) with all data for entry = 50016666
TargetGlucagon receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50171818(4-[1-(4-tert-Butyl-cyclohexyl)-3-(4-trifluorometho...)
Affinity DataIC50:  3.20nMAssay Description:Antagonist activity against human glucagon receptor expressed in CHO cell membranes using [125I]glucagonMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50171817(3-(4-((1-(4-tert-butylcyclohexyl)-3-(4-(trifluorom...)
Affinity DataIC50:  21nMAssay Description:Antagonist activity against human glucagon receptor expressed in CHO cell membranes using [125I]glucagonMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50171839(4-{3-[1-(4-Bromo-phenyl)-ethyl]-8-tert-butyl-2-oxo...)
Affinity DataIC50:  30nMAssay Description:Antagonist activity against human glucagon receptor expressed in CHO cell membranes using [125I]glucagonMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50171814(4-[8-tert-Butyl-2-oxo-3-(3-trifluoromethoxy-phenyl...)
Affinity DataIC50:  33nMAssay Description:Inhibitory concentration against glucagon-induced cAMP accumulation in human glucagon receptor transfected CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50171819(4-[9-tert-Butyl-2-oxo-3-(4-trifluoromethoxy-phenyl...)
Affinity DataIC50:  34nMAssay Description:Antagonist activity against human glucagon receptor expressed in CHO cell membranes using [125I]glucagonMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50171829(4-[8-tert-Butyl-3-(3,5-dichloro-phenyl)-2-oxo-1,3-...)
Affinity DataIC50:  36nMAssay Description:Antagonist activity against human glucagon receptor expressed in CHO cell membranes using [125I]glucagonMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50171820(3-{4-[8-tert-Butyl-3-(3,5-dichloro-phenyl)-2-oxo-1...)
Affinity DataIC50:  43nMAssay Description:Antagonist activity against human glucagon receptor expressed in CHO cell membranes using [125I]glucagonMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50171818(4-[1-(4-tert-Butyl-cyclohexyl)-3-(4-trifluorometho...)
Affinity DataIC50:  46nMAssay Description:Inhibitory concentration against glucagon-induced cAMP accumulation in human glucagon receptor transfected CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50171834(3-{4-[8-tert-Butyl-2-oxo-3-(3-trifluoromethoxy-phe...)
Affinity DataIC50:  60nMAssay Description:Inhibitory concentration against glucagon-induced cAMP accumulation in human glucagon receptor transfected CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50171828(4-[8-tert-Butyl-3-(3,4-difluoro-phenyl)-2-oxo-1,3-...)
Affinity DataIC50:  65nMAssay Description:Inhibitory concentration against glucagon-induced cAMP accumulation in human glucagon receptor transfected CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50171835(4-[9-tert-Butyl-2-oxo-3-(4-trifluoromethoxy-phenyl...)
Affinity DataIC50:  92nMAssay Description:Antagonist activity against human glucagon receptor expressed in CHO cell membranes using [125I]glucagonMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50171819(4-[9-tert-Butyl-2-oxo-3-(4-trifluoromethoxy-phenyl...)
Affinity DataIC50:  92nMAssay Description:Inhibitory concentration against glucagon-induced cAMP accumulation in human glucagon receptor transfected CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50171825(4-[8-tert-Butyl-3-(3-chloro-phenyl)-2-oxo-1,3-diaz...)
Affinity DataIC50:  94nMAssay Description:Antagonist activity against human glucagon receptor expressed in CHO cell membranes using [125I]glucagonMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50171836(4-[8-tert-Butyl-2-oxo-3-(4-trifluoromethoxy-phenyl...)
Affinity DataIC50:  105nMAssay Description:Antagonist activity against human glucagon receptor expressed in CHO cell membranes using [125I]glucagonMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50171831(4-[8-tert-Butyl-2-oxo-3-(4-trifluoromethyl-phenyl)...)
Affinity DataIC50:  113nMAssay Description:Inhibitory concentration against glucagon-induced cAMP accumulation in human glucagon receptor transfected CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50171829(4-[8-tert-Butyl-3-(3,5-dichloro-phenyl)-2-oxo-1,3-...)
Affinity DataIC50:  116nMAssay Description:Inhibitory concentration against glucagon-induced cAMP accumulation in human glucagon receptor transfected CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50171815(4-[8-tert-Butyl-3-(4-chloro-phenyl)-2-oxo-1,3-diaz...)
Affinity DataIC50:  116nMAssay Description:Antagonist activity against human glucagon receptor expressed in CHO cell membranes using [125I]glucagonMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50171831(4-[8-tert-Butyl-2-oxo-3-(4-trifluoromethyl-phenyl)...)
Affinity DataIC50:  135nMAssay Description:Inhibitory concentration against glucagon-induced cAMP accumulation in human glucagon receptor transfected CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50171817(3-(4-((1-(4-tert-butylcyclohexyl)-3-(4-(trifluorom...)
Affinity DataIC50:  144nMAssay Description:Inhibitory concentration against glucagon-induced cAMP accumulation in human glucagon receptor transfected CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50171824(4-[3-(4-Bromo-phenyl)-8-tert-butyl-2-oxo-1,3-diaza...)
Affinity DataIC50:  156nMAssay Description:Antagonist activity against human glucagon receptor expressed in CHO cell membranes using [125I]glucagonMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50171839(4-{3-[1-(4-Bromo-phenyl)-ethyl]-8-tert-butyl-2-oxo...)
Affinity DataIC50:  164nMAssay Description:Inhibitory concentration against glucagon-induced cAMP accumulation in human glucagon receptor transfected CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50171823(4-[8-tert-Butyl-3-(4-fluoro-phenyl)-2-oxo-1,3-diaz...)
Affinity DataIC50:  178nMAssay Description:Antagonist activity against human glucagon receptor expressed in CHO cell membranes using [125I]glucagonMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50171830(3-{4-[9-tert-Butyl-2-oxo-3-(4-trifluoromethoxy-phe...)
Affinity DataIC50:  182nMAssay Description:Antagonist activity against human glucagon receptor expressed in CHO cell membranes using [125I]glucagonMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50171836(4-[8-tert-Butyl-2-oxo-3-(4-trifluoromethoxy-phenyl...)
Affinity DataIC50:  193nMAssay Description:Inhibitory concentration against glucagon-induced cAMP accumulation in human glucagon receptor transfected CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50171828(4-[8-tert-Butyl-3-(3,4-difluoro-phenyl)-2-oxo-1,3-...)
Affinity DataIC50:  227nMAssay Description:Inhibitory concentration against glucagon-induced cAMP accumulation in human glucagon receptor transfected CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50171814(4-[8-tert-Butyl-2-oxo-3-(3-trifluoromethoxy-phenyl...)
Affinity DataIC50:  234nMAssay Description:Inhibitory concentration against glucagon-induced cAMP accumulation in human glucagon receptor transfected CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50171830(3-{4-[9-tert-Butyl-2-oxo-3-(4-trifluoromethoxy-phe...)
Affinity DataIC50:  282nMAssay Description:Inhibitory concentration against glucagon-induced cAMP accumulation in human glucagon receptor transfected CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50171833(4-[8-tert-Butyl-3-(2,4-dichloro-phenyl)-2-oxo-1,3-...)
Affinity DataIC50:  286nMAssay Description:Antagonist activity against human glucagon receptor expressed in CHO cell membranes using [125I]glucagonMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50410443(CHEMBL2113103)
Affinity DataIC50:  303nMAssay Description:Inhibitory concentration against glucagon-induced cAMP accumulation in human glucagon receptor transfected CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50171821(3-{4-[8-tert-Butyl-2-oxo-3-(4-trifluoromethoxy-phe...)
Affinity DataIC50:  336nMAssay Description:Antagonist activity against human glucagon receptor expressed in CHO cell membranes using [125I]glucagonMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50171844(3-{4-[8-tert-Butyl-3-(3-chloro-phenyl)-2-oxo-1,3-d...)
Affinity DataIC50:  351nMAssay Description:Inhibitory concentration against glucagon-induced cAMP accumulation in human glucagon receptor transfected CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50171825(4-[8-tert-Butyl-3-(3-chloro-phenyl)-2-oxo-1,3-diaz...)
Affinity DataIC50:  353nMAssay Description:Inhibitory concentration against glucagon-induced cAMP accumulation in human glucagon receptor transfected CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50171827(4-[8-tert-Butyl-3-(4-methanesulfonyl-phenyl)-2-oxo...)
Affinity DataIC50:  407nMAssay Description:Inhibitory concentration against glucagon-induced cAMP accumulation in human glucagon receptor transfected CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50171820(3-{4-[8-tert-Butyl-3-(3,5-dichloro-phenyl)-2-oxo-1...)
Affinity DataIC50:  423nMAssay Description:Inhibitory concentration against glucagon-induced cAMP accumulation in human glucagon receptor transfected CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50171813(4-(8-tert-Butyl-2-oxo-3-p-tolyl-1,3-diaza-spiro[4....)
Affinity DataIC50:  427nMAssay Description:Inhibitory concentration against glucagon-induced cAMP accumulation in human glucagon receptor transfected CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGastric inhibitory polypeptide receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50171819(4-[9-tert-Butyl-2-oxo-3-(4-trifluoromethoxy-phenyl...)
Affinity DataIC50:  430nMAssay Description:Inhibitory concentration against human gastric inhibitory polypeptide receptor (hGIP) mediated cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50171815(4-[8-tert-Butyl-3-(4-chloro-phenyl)-2-oxo-1,3-diaz...)
Affinity DataIC50:  446nMAssay Description:Inhibitory concentration against glucagon-induced cAMP accumulation in human glucagon receptor transfected CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50171821(3-{4-[8-tert-Butyl-2-oxo-3-(4-trifluoromethoxy-phe...)
Affinity DataIC50:  459nMAssay Description:Inhibitory concentration against glucagon-induced cAMP accumulation in human glucagon receptor transfected CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50171834(3-{4-[8-tert-Butyl-2-oxo-3-(3-trifluoromethoxy-phe...)
Affinity DataIC50:  515nMAssay Description:Inhibitory concentration against glucagon-induced cAMP accumulation in human glucagon receptor transfected CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50171844(3-{4-[8-tert-Butyl-3-(3-chloro-phenyl)-2-oxo-1,3-d...)
Affinity DataIC50:  601nMAssay Description:Inhibitory concentration against glucagon-induced cAMP accumulation in human glucagon receptor transfected CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50171823(4-[8-tert-Butyl-3-(4-fluoro-phenyl)-2-oxo-1,3-diaz...)
Affinity DataIC50:  611nMAssay Description:Inhibitory concentration against glucagon-induced cAMP accumulation in human glucagon receptor transfected CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50171838(4-[8-tert-Butyl-2,4-dioxo-3-(4-trifluoromethoxy-ph...)
Affinity DataIC50:  631nMAssay Description:Inhibitory concentration against glucagon-induced cAMP accumulation in human glucagon receptor transfected CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50171824(4-[3-(4-Bromo-phenyl)-8-tert-butyl-2-oxo-1,3-diaza...)
Affinity DataIC50:  655nMAssay Description:Inhibitory concentration against glucagon-induced cAMP accumulation in human glucagon receptor transfected CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50171841(4-(8-tert-Butyl-3-cyclohexyl-2-oxo-1,3-diaza-spiro...)
Affinity DataIC50:  700nMAssay Description:Inhibitory concentration against glucagon-induced cAMP accumulation in human glucagon receptor transfected CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50171816(4-[8-tert-Butyl-3-(2-chloro-phenyl)-2-oxo-1,3-diaz...)
Affinity DataIC50:  739nMAssay Description:Inhibitory concentration against glucagon-induced cAMP accumulation in human glucagon receptor transfected CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50171822(3-{4-[8-tert-Butyl-2,4-dioxo-3-(4-trifluoromethoxy...)
Affinity DataIC50:  856nMAssay Description:Inhibitory concentration against glucagon-induced cAMP accumulation in human glucagon receptor transfected CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50171843(4-(8-tert-Butyl-2-oxo-3-phenyl-1,3-diaza-spiro[4.5...)
Affinity DataIC50:  894nMAssay Description:Inhibitory concentration against glucagon-induced cAMP accumulation in human glucagon receptor transfected CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50171833(4-[8-tert-Butyl-3-(2,4-dichloro-phenyl)-2-oxo-1,3-...)
Affinity DataIC50:  1.42E+3nMAssay Description:Inhibitory concentration against glucagon-induced cAMP accumulation in human glucagon receptor transfected CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50171826(4-(3,8-Di-tert-butyl-2-oxo-1,3-diaza-spiro[4.5]dec...)
Affinity DataIC50:  1.66E+3nMAssay Description:Inhibitory concentration against glucagon-induced cAMP accumulation in human glucagon receptor transfected CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50171842(3-{4-[9-tert-Butyl-2,4-dioxo-3-(4-trifluoromethoxy...)
Affinity DataIC50:  1.69E+3nMAssay Description:Inhibitory concentration against glucagon-induced cAMP accumulation in human glucagon receptor transfected CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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