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Found 26 Enz. Inhib. hit(s) with all data for entry = 50037593
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50173945(CHEMBL195190 | [2,2']Bithiophenyl-5-carboxylic aci...)
Affinity DataKi:  1.10nMAssay Description:Binding affinity towards human nicotinic acetylcholine receptor alpha 7 expressed in GH4C1 cell using [3H]methyllycaconitineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50173953(CHEMBL364069 | N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl...)
Affinity DataKi:  1.30nMAssay Description:Binding affinity towards human nicotinic acetylcholine receptor alpha 7 expressed in GH4C1 cell using [3H]methyllycaconitineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50173956(CHEMBL370535 | N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl...)
Affinity DataKi:  1.80nMAssay Description:Binding affinity towards human nicotinic acetylcholine receptor alpha 7 expressed in GH4C1 cell using [3H]methyllycaconitineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50173944(5'-phenyl-(2'R)-spiro[4-azabicyclo[2.2.2]octane-2,...)
Affinity DataKi:  3.10nMAssay Description:Binding affinity towards human nicotinic acetylcholine receptor alpha 7 expressed in GH4C1 cell using [3H]methyllycaconitineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50173943(5-Phenyl-thiophene-2-carboxylic acid (1-aza-bicycl...)
Affinity DataKi:  3.40nMAssay Description:Binding affinity towards human nicotinic acetylcholine receptor alpha 7 expressed in GH4C1 cell using [3H]methyllycaconitineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50173942(CHEMBL195329 | N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl...)
Affinity DataKi:  3.40nMAssay Description:Binding affinity towards human nicotinic acetylcholine receptor alpha 7 expressed in GH4C1 cell using [3H]methyllycaconitineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50173947(5-Phenyl-isothiazole-3-carboxylic acid (1-aza-bicy...)
Affinity DataKi:  4.10nMAssay Description:Binding affinity towards human nicotinic acetylcholine receptor alpha 7 expressed in GH4C1 cell using [3H]methyllycaconitineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50170587(5-Pyridin-2-yl-thiophene-2-carboxylic acid (1-aza-...)
Affinity DataKi:  6.90nMAssay Description:Binding affinity towards human nicotinic acetylcholine receptor alpha 7 expressed in GH4C1 cell using [3H]methyllycaconitineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50366779(METHYLLYCACONITINE)
Affinity DataKi:  7.30nMAssay Description:Binding affinity towards human nicotinic acetylcholine receptor alpha 7 expressed in GH4C1 cell using [3H]methyllycaconitineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50173941(5'N-(3-pyridylmethyl)-(2'R)-spiro[4-azabicyclo[2.2...)
Affinity DataKi:  8.30nMAssay Description:Binding affinity towards human nicotinic acetylcholine receptor alpha 7 expressed in GH4C1 cell using [3H]methyllycaconitineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50173952(Benzo[b]thiophene-2-carboxylic acid (1-aza-bicyclo...)
Affinity DataKi:  14.6nMAssay Description:Binding affinity towards human nicotinic acetylcholine receptor alpha 7 expressed in GH4C1 cell using [3H]methyllycaconitineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50173949(5-Phenyl-thiophene-3-carboxylic acid (1-aza-bicycl...)
Affinity DataKi:  16.7nMAssay Description:Binding affinity towards human nicotinic acetylcholine receptor alpha 7 expressed in GH4C1 cell using [3H]methyllycaconitineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50173951(CHEMBL194984 | N-[(3S)-1-azabicyclo[2.2.2]oct-3-yl...)
Affinity DataKi:  26.9nMAssay Description:Binding affinity towards human nicotinic acetylcholine receptor alpha 7 expressed in GH4C1 cell using [3H]methyllycaconitineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A/3B/3C/3D/3E(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50173952(Benzo[b]thiophene-2-carboxylic acid (1-aza-bicyclo...)
Affinity DataKi:  49.8nMAssay Description:Binding affinity for human 5-hydroxytryptamine 3 serotonin membrane receptor using [3H]GR-65630More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A/3B/3C/3D/3E(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50173944(5'-phenyl-(2'R)-spiro[4-azabicyclo[2.2.2]octane-2,...)
Affinity DataKi:  73nMAssay Description:Binding affinity for human 5-hydroxytryptamine 3 serotonin membrane receptor using [3H]GR-65630More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50173954(2-Phenyl-thiazole-4-carboxylic acid (1-aza-bicyclo...)
Affinity DataKi:  121nMAssay Description:Binding affinity towards human nicotinic acetylcholine receptor alpha 7 expressed in GH4C1 cell using [3H]methyllycaconitineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50173948(5-(2-Methoxy-phenyl)-thiophene-2-carboxylic acid (...)
Affinity DataKi:  268nMAssay Description:Binding affinity towards human nicotinic acetylcholine receptor alpha 7 expressed in GH4C1 cell using [3H]methyllycaconitineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A/3B/3C/3D/3E(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50173949(5-Phenyl-thiophene-3-carboxylic acid (1-aza-bicycl...)
Affinity DataKi:  409nMAssay Description:Binding affinity for human 5-hydroxytryptamine 3 serotonin membrane receptor using [3H]GR-65630More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50173955((2'R)-spiro[4-azabicyclo[2.2.2]octane-2,5'-(dihydr...)
Affinity DataKi:  420nMAssay Description:Binding affinity towards human nicotinic acetylcholine receptor alpha 7 expressed in GH4C1 cell using [3H]methyllycaconitineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50173950(5-(2-Chloro-phenyl)-thiophene-2-carboxylic acid (1...)
Affinity DataKi:  525nMAssay Description:Binding affinity towards human nicotinic acetylcholine receptor alpha 7 expressed in GH4C1 cell using [3H]methyllycaconitineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A/3B/3C/3D/3E(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50173954(2-Phenyl-thiazole-4-carboxylic acid (1-aza-bicyclo...)
Affinity DataKi:  665nMAssay Description:Binding affinity for human 5-hydroxytryptamine 3 serotonin membrane receptor using [3H]GR-65630More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A/3B/3C/3D/3E(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50173945(CHEMBL195190 | [2,2']Bithiophenyl-5-carboxylic aci...)
Affinity DataKi:  1.04E+3nMAssay Description:Binding affinity for human 5-hydroxytryptamine 3 serotonin membrane receptor using [3H]GR-65630More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A/3B/3C/3D/3E(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50173951(CHEMBL194984 | N-[(3S)-1-azabicyclo[2.2.2]oct-3-yl...)
Affinity DataKi:  1.55E+3nMAssay Description:Binding affinity for human 5-hydroxytryptamine 3 serotonin membrane receptor using [3H]GR-65630More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A/3B/3C/3D/3E(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50173943(5-Phenyl-thiophene-2-carboxylic acid (1-aza-bicycl...)
Affinity DataKi:  2.02E+3nMAssay Description:Binding affinity for human 5-hydroxytryptamine 3 serotonin membrane receptor using [3H]GR-65630More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A/3B/3C/3D/3E(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50173942(CHEMBL195329 | N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl...)
Affinity DataKi:  2.02E+3nMAssay Description:Binding affinity for human 5-hydroxytryptamine 3 serotonin membrane receptor using [3H]GR-65630More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A/3B/3C/3D/3E(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50173941(5'N-(3-pyridylmethyl)-(2'R)-spiro[4-azabicyclo[2.2...)
Affinity DataKi:  2.23E+3nMAssay Description:Binding affinity for human 5-hydroxytryptamine 3 serotonin membrane receptor using [3H]GR-65630More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed