Compile Data Set for Download or QSAR
Report error Found 61 Enz. Inhib. hit(s) with all data for entry = 50016956
TargetMitogen-activated protein kinase 14(Human)
Merck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50175747BDBM50175747(7-(1-tert-butylpiperidin-4-yl)-5-(2-chlorophenyl)-...)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of P38 alpha MAPKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Merck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50175745BDBM50175745(7-(1-tert-butylpiperidin-4-yl)-1-(2,6-dichlorophen...)
Affinity DataIC50: 0.140nMAssay Description:Inhibition of P38 alpha MAPKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Merck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50175762BDBM50175762(5-(2-chloro-4-fluorophenyl)-1-(2,6-dichlorophenyl)...)
Affinity DataIC50: 0.260nMAssay Description:Inhibition of P38 alpha MAPKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Merck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50175758BDBM50175758(7-(1-tert-butylpiperidin-4-yl)-5-(2-chloro-4-fluor...)
Affinity DataIC50: 0.270nMAssay Description:Inhibition of TNF alpha release in THP1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Merck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50175760BDBM50175760(7-(1-tert-butylpiperidin-4-yl)-5-(2-chloro-4-fluor...)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of P38 alpha MAPKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Merck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50175758BDBM50175758(7-(1-tert-butylpiperidin-4-yl)-5-(2-chloro-4-fluor...)
Affinity DataIC50: 0.310nMAssay Description:Inhibition of P38 alpha MAPKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Merck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50175761BDBM50175761(7-(1-tert-butylpiperidin-4-yl)-5-(2-chloro-4-fluor...)
Affinity DataIC50: 0.380nMAssay Description:Inhibition of P38 alpha MAPKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Merck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50175760BDBM50175760(7-(1-tert-butylpiperidin-4-yl)-5-(2-chloro-4-fluor...)
Affinity DataIC50: 0.420nMAssay Description:Inhibition of TNF alpha release in THP1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Merck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50175742BDBM50175742(7-(8-aza-bicyclo[3.2.1]octan-3-yl)-5-(2-chloro-4-f...)
Affinity DataIC50: 0.450nMAssay Description:Inhibition of P38 alpha MAPKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Merck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50175750BDBM50175750(5-(2-chloro-4-fluorophenyl)-1-(2,6-dichlorophenyl)...)
Affinity DataIC50: 0.510nMAssay Description:Inhibition of P38 alpha MAPKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Merck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50175751BDBM50175751(7-(1-tert-butylpiperidin-4-yl)-1-(2,6-dichlorophen...)
Affinity DataIC50: 0.510nMAssay Description:Inhibition of P38 alpha MAPKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Merck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50175748BDBM50175748(5-(2-chloro-4-fluorophenyl)-1-(2,6-dichlorophenyl)...)
Affinity DataIC50: 0.610nMAssay Description:Inhibition of P38 alpha MAPKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Merck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50175751BDBM50175751(7-(1-tert-butylpiperidin-4-yl)-1-(2,6-dichlorophen...)
Affinity DataIC50: 0.690nMAssay Description:Inhibition of TNF alpha release in THP1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Merck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50175744BDBM50175744(7-(1-tert-butyl-1,2,3,6-tetrahydropyridin-4-yl)-5-...)
Affinity DataIC50: 0.740nMAssay Description:Inhibition of TNF alpha release in THP1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Merck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50175749BDBM50175749(7-(1-tert-butylpiperidin-4-yloxy)-1-(2,6-dichlorop...)
Affinity DataIC50: 0.770nMAssay Description:Inhibition of TNF alpha release in THP1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Merck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50175748BDBM50175748(5-(2-chloro-4-fluorophenyl)-1-(2,6-dichlorophenyl)...)
Affinity DataIC50: 0.820nMAssay Description:Inhibition of TNF alpha release in THP1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Merck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50175755BDBM50175755(2-(4-(5-(2-chloro-4-fluorophenyl)-1-(2,6-dichlorop...)
Affinity DataIC50: 0.840nMAssay Description:Inhibition of P38 alpha MAPKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Merck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50175742BDBM50175742(7-(8-aza-bicyclo[3.2.1]octan-3-yl)-5-(2-chloro-4-f...)
Affinity DataIC50: 0.890nMAssay Description:Inhibition of TNF alpha release in THP1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Merck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50175750BDBM50175750(5-(2-chloro-4-fluorophenyl)-1-(2,6-dichlorophenyl)...)
Affinity DataIC50: 0.990nMAssay Description:Inhibition of TNF alpha release in THP1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Merck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50175747BDBM50175747(7-(1-tert-butylpiperidin-4-yl)-5-(2-chlorophenyl)-...)
Affinity DataIC50: 1nMAssay Description:Inhibition of TNF alpha release in THP1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Merck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50175760BDBM50175760(7-(1-tert-butylpiperidin-4-yl)-5-(2-chloro-4-fluor...)
Affinity DataIC50: 1nMAssay Description:Inhibition of LPS stimulated TNF alpha release in whole bloodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Merck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50175744BDBM50175744(7-(1-tert-butyl-1,2,3,6-tetrahydropyridin-4-yl)-5-...)
Affinity DataIC50: 1.15nMAssay Description:Inhibition of P38 alpha MAPKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Merck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50175757BDBM50175757((2S)-2-(4-(5-(2-chloro-4-fluorophenyl)-1-(2,6-dich...)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of P38 alpha MAPKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Merck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50175743BDBM50175743(methyl 2-(4-(5-(2-chloro-4-fluorophenyl)-1-(2,6-di...)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of TNF alpha release in THP1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Merck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50175759BDBM50175759(7-(1-tert-butylpiperidin-4-yl)-5-(2-chlorophenyl)-...)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of P38 alpha MAPKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Merck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50175752BDBM50175752(7-(1-tert-butylpiperidin-4-yloxy)-5-(2-chloropheny...)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of P38 alpha MAPKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Merck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50175761BDBM50175761(7-(1-tert-butylpiperidin-4-yl)-5-(2-chloro-4-fluor...)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of TNF alpha release in THP1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Merck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50175745BDBM50175745(7-(1-tert-butylpiperidin-4-yl)-1-(2,6-dichlorophen...)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of TNF alpha release in THP1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Merck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50175752BDBM50175752(7-(1-tert-butylpiperidin-4-yloxy)-5-(2-chloropheny...)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of TNF alpha release in THP1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Merck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50175749BDBM50175749(7-(1-tert-butylpiperidin-4-yloxy)-1-(2,6-dichlorop...)
Affinity DataIC50: 1.87nMAssay Description:Inhibition of P38 alpha MAPKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Merck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50175746BDBM50175746(7-(1-tert-butylpiperidin-4-yloxy)-5-(2,4-difluorop...)
Affinity DataIC50: 2.20nMAssay Description:Inhibition of TNF alpha release in THP1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Merck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50175745BDBM50175745(7-(1-tert-butylpiperidin-4-yl)-1-(2,6-dichlorophen...)
Affinity DataIC50: 2.40nMAssay Description:Inhibition of LPS stimulated TNF alpha release in whole bloodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Merck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50175754BDBM50175754(7-(1-tert-butylpiperidin-4-yloxy)-5-(2-chloro-4-fl...)
Affinity DataIC50: 2.40nMAssay Description:Inhibition of TNF alpha release in THP1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Merck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50175756BDBM50175756(methyl 2-(4-(5-(2-chloro-4-fluorophenyl)-1-(2,6-di...)
Affinity DataIC50: 2.59nMAssay Description:Inhibition of TNF alpha release in THP1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Merck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50175758BDBM50175758(7-(1-tert-butylpiperidin-4-yl)-5-(2-chloro-4-fluor...)
Affinity DataIC50: 2.60nMAssay Description:Inhibition of LPS stimulated TNF alpha release in whole bloodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Merck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50175753BDBM50175753((2R)-2-(4-(5-(2-chloro-4-fluorophenyl)-1-(2,6-dich...)
Affinity DataIC50: 3.20nMAssay Description:Inhibition of P38 alpha MAPKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Merck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50175757BDBM50175757((2S)-2-(4-(5-(2-chloro-4-fluorophenyl)-1-(2,6-dich...)
Affinity DataIC50: 3.20nMAssay Description:Inhibition of TNF alpha release in THP1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Merck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50175762BDBM50175762(5-(2-chloro-4-fluorophenyl)-1-(2,6-dichlorophenyl)...)
Affinity DataIC50: 3.32nMAssay Description:Inhibition of TNF alpha release in THP1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Merck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50175755BDBM50175755(2-(4-(5-(2-chloro-4-fluorophenyl)-1-(2,6-dichlorop...)
Affinity DataIC50: 3.75nMAssay Description:Inhibition of TNF alpha release in THP1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Merck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50175753BDBM50175753((2R)-2-(4-(5-(2-chloro-4-fluorophenyl)-1-(2,6-dich...)
Affinity DataIC50: 3.80nMAssay Description:Inhibition of TNF alpha release in THP1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Merck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50175751BDBM50175751(7-(1-tert-butylpiperidin-4-yl)-1-(2,6-dichlorophen...)
Affinity DataIC50: 5.20nMAssay Description:Inhibition of LPS stimulated TNF alpha release in whole bloodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Merck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50175761BDBM50175761(7-(1-tert-butylpiperidin-4-yl)-5-(2-chloro-4-fluor...)
Affinity DataIC50: 5.30nMAssay Description:Inhibition of LPS stimulated TNF alpha release in whole bloodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Merck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50175747BDBM50175747(7-(1-tert-butylpiperidin-4-yl)-5-(2-chlorophenyl)-...)
Affinity DataIC50: 6.40nMAssay Description:Inhibition of LPS stimulated TNF alpha release in whole bloodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Merck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50175756BDBM50175756(methyl 2-(4-(5-(2-chloro-4-fluorophenyl)-1-(2,6-di...)
Affinity DataIC50: 6.70nMAssay Description:Inhibition of P38 alpha MAPKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Merck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50175759BDBM50175759(7-(1-tert-butylpiperidin-4-yl)-5-(2-chlorophenyl)-...)
Affinity DataIC50: 6.80nMAssay Description:Inhibition of LPS stimulated TNF alpha release in whole bloodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Merck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50175754BDBM50175754(7-(1-tert-butylpiperidin-4-yloxy)-5-(2-chloro-4-fl...)
Affinity DataIC50: 7.10nMAssay Description:Inhibition of P38 alpha MAPKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Merck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50175748BDBM50175748(5-(2-chloro-4-fluorophenyl)-1-(2,6-dichlorophenyl)...)
Affinity DataIC50: 7.71nMAssay Description:Inhibition of LPS stimulated TNF alpha release in whole bloodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Merck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50175743BDBM50175743(methyl 2-(4-(5-(2-chloro-4-fluorophenyl)-1-(2,6-di...)
Affinity DataIC50: 8.10nMAssay Description:Inhibition of P38 alpha MAPKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Merck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50175750BDBM50175750(5-(2-chloro-4-fluorophenyl)-1-(2,6-dichlorophenyl)...)
Affinity DataIC50: 8.51nMAssay Description:Inhibition of LPS stimulated TNF alpha release in whole bloodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Merck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50175746BDBM50175746(7-(1-tert-butylpiperidin-4-yloxy)-5-(2,4-difluorop...)
Affinity DataIC50: 10.5nMAssay Description:Inhibition of P38 alpha MAPKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
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