Compile Data Set for Download or QSAR
Report error Found 46 Enz. Inhib. hit(s) with all data for entry = 50017009
TargetKappa-type opioid receptor(Human)
Adolor

Curated by ChEMBL
LigandPNGBDBM50176369(N-((S)-2-((S)-3-hydroxypyrrolidin-1-yl)-1-phenylet...)
Affinity DataEC50:  0.0500nMAssay Description:Agonist activity at kappa opioid receptor in a [35S]GTP-gamma-S functional assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Adolor

Curated by ChEMBL
LigandPNGBDBM50176375(2-(3,4-dichlorophenylamino)-N-((S)-2-((S)-3-hydrox...)
Affinity DataKi:  0.110nMAssay Description:Binding affinity to kappa opioid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Adolor

Curated by ChEMBL
LigandPNGBDBM50176369(N-((S)-2-((S)-3-hydroxypyrrolidin-1-yl)-1-phenylet...)
Affinity DataKi:  0.170nMAssay Description:Binding affinity to kappa opioid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Adolor

Curated by ChEMBL
LigandPNGBDBM50176370(N-((S)-2-((S)-3-hydroxypyrrolidin-1-yl)-1-phenylet...)
Affinity DataKi:  0.210nMAssay Description:Binding affinity to kappa opioid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Adolor

Curated by ChEMBL
LigandPNGBDBM50176374(N-((S)-2-((S)-3-hydroxypyrrolidin-1-yl)-1-phenylet...)
Affinity DataEC50:  0.230nMAssay Description:Agonist activity at kappa opioid receptor in a [35S]GTP-gamma-S functional assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Adolor

Curated by ChEMBL
LigandPNGBDBM50176370(N-((S)-2-((S)-3-hydroxypyrrolidin-1-yl)-1-phenylet...)
Affinity DataEC50:  0.230nMAssay Description:Agonist activity at kappa opioid receptor in a [35S]GTP-gamma-S functional assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Adolor

Curated by ChEMBL
LigandPNGBDBM50176375(2-(3,4-dichlorophenylamino)-N-((S)-2-((S)-3-hydrox...)
Affinity DataEC50:  0.270nMAssay Description:Agonist activity at kappa opioid receptor in a [35S]GTP-gamma-S functional assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Adolor

Curated by ChEMBL
LigandPNGBDBM50176374(N-((S)-2-((S)-3-hydroxypyrrolidin-1-yl)-1-phenylet...)
Affinity DataKi:  0.320nMAssay Description:Binding affinity to kappa opioid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Adolor

Curated by ChEMBL
LigandPNGBDBM50176373(2-(2-cyanophenylamino)-N-((S)-2-((S)-3-hydroxypyrr...)
Affinity DataKi:  0.390nMAssay Description:Binding affinity to kappa opioid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Adolor

Curated by ChEMBL
LigandPNGBDBM50176365(N-((S)-2-((S)-3-hydroxypyrrolidin-1-yl)-1-phenylet...)
Affinity DataKi:  0.390nMAssay Description:Binding affinity to kappa opioid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Adolor

Curated by ChEMBL
LigandPNGBDBM50176373(2-(2-cyanophenylamino)-N-((S)-2-((S)-3-hydroxypyrr...)
Affinity DataEC50:  0.420nMAssay Description:Agonist activity at kappa opioid receptor in a [35S]GTP-gamma-S functional assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Adolor

Curated by ChEMBL
LigandPNGBDBM50176376(2-(4-cyanophenylamino)-N-((S)-2-((S)-3-hydroxypyrr...)
Affinity DataEC50:  0.490nMAssay Description:Agonist activity at kappa opioid receptor in a [35S]GTP-gamma-S functional assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Adolor

Curated by ChEMBL
LigandPNGBDBM50176367(2-(3-cyanophenylamino)-N-((S)-2-((S)-3-hydroxypyrr...)
Affinity DataKi:  0.5nMAssay Description:Binding affinity to kappa opioid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Adolor

Curated by ChEMBL
LigandPNGBDBM50176372(N-((S)-2-((S)-3-hydroxypyrrolidin-1-yl)-1-phenylet...)
Affinity DataEC50:  0.520nMAssay Description:Agonist activity at kappa opioid receptor in a [35S]GTP-gamma-S functional assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Adolor

Curated by ChEMBL
LigandPNGBDBM50176367(2-(3-cyanophenylamino)-N-((S)-2-((S)-3-hydroxypyrr...)
Affinity DataEC50:  0.580nMAssay Description:Agonist activity at kappa opioid receptor in a [35S]GTP-gamma-S functional assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Adolor

Curated by ChEMBL
LigandPNGBDBM50176376(2-(4-cyanophenylamino)-N-((S)-2-((S)-3-hydroxypyrr...)
Affinity DataKi:  0.660nMAssay Description:Binding affinity to kappa opioid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Adolor

Curated by ChEMBL
LigandPNGBDBM50176372(N-((S)-2-((S)-3-hydroxypyrrolidin-1-yl)-1-phenylet...)
Affinity DataKi:  0.780nMAssay Description:Binding affinity to kappa opioid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Adolor

Curated by ChEMBL
LigandPNGBDBM50176365(N-((S)-2-((S)-3-hydroxypyrrolidin-1-yl)-1-phenylet...)
Affinity DataEC50:  0.800nMAssay Description:Agonist activity at kappa opioid receptor in a [35S]GTP-gamma-S functional assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Adolor

Curated by ChEMBL
LigandPNGBDBM50176362(2-((4-cyanophenyl)(methyl)amino)-N-((S)-2-((S)-3-h...)
Affinity DataKi:  1nMAssay Description:Binding affinity to kappa opioid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Adolor

Curated by ChEMBL
LigandPNGBDBM50176371(N-((S)-2-((S)-3-hydroxypyrrolidin-1-yl)-1-phenylet...)
Affinity DataKi:  1.5nMAssay Description:Binding affinity to kappa opioid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Adolor

Curated by ChEMBL
LigandPNGBDBM50176362(2-((4-cyanophenyl)(methyl)amino)-N-((S)-2-((S)-3-h...)
Affinity DataEC50:  2.30nMAssay Description:Agonist activity at kappa opioid receptor in a [35S]GTP-gamma-S functional assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Adolor

Curated by ChEMBL
LigandPNGBDBM50176364(2-(Acetyl-phenyl-amino)-N-[(S)-2-((S)-3-hydroxy-py...)
Affinity DataKi:  3.80nMAssay Description:Binding affinity to kappa opioid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Adolor

Curated by ChEMBL
LigandPNGBDBM50176366(N-((S)-2-((S)-3-hydroxypyrrolidin-1-yl)-1-phenylet...)
Affinity DataKi:  3.90nMAssay Description:Binding affinity to kappa opioid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Adolor

Curated by ChEMBL
LigandPNGBDBM50176366(N-((S)-2-((S)-3-hydroxypyrrolidin-1-yl)-1-phenylet...)
Affinity DataEC50:  4.80nMAssay Description:Agonist activity at kappa opioid receptor in a [35S]GTP-gamma-S functional assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Adolor

Curated by ChEMBL
LigandPNGBDBM50176363(N-((S)-2-((S)-3-hydroxypyrrolidin-1-yl)-1-phenylet...)
Affinity DataKi:  5.70nMAssay Description:Binding affinity to kappa opioid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Adolor

Curated by ChEMBL
LigandPNGBDBM50176364(2-(Acetyl-phenyl-amino)-N-[(S)-2-((S)-3-hydroxy-py...)
Affinity DataEC50:  7.40nMAssay Description:Agonist activity at kappa opioid receptor in a [35S]GTP-gamma-S functional assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Adolor

Curated by ChEMBL
LigandPNGBDBM50176371(N-((S)-2-((S)-3-hydroxypyrrolidin-1-yl)-1-phenylet...)
Affinity DataEC50:  8.30nMAssay Description:Agonist activity at kappa opioid receptor in a [35S]GTP-gamma-S functional assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Adolor

Curated by ChEMBL
LigandPNGBDBM50176363(N-((S)-2-((S)-3-hydroxypyrrolidin-1-yl)-1-phenylet...)
Affinity DataEC50:  14nMAssay Description:Agonist activity at kappa opioid receptor in a [35S]GTP-gamma-S functional assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Adolor

Curated by ChEMBL
LigandPNGBDBM50176368(N-((S)-2-((S)-3-hydroxypyrrolidin-1-yl)-1-phenylet...)
Affinity DataKi:  16nMAssay Description:Binding affinity to kappa opioid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Adolor

Curated by ChEMBL
LigandPNGBDBM50176368(N-((S)-2-((S)-3-hydroxypyrrolidin-1-yl)-1-phenylet...)
Affinity DataEC50:  24nMAssay Description:Agonist activity at kappa opioid receptor in a [35S]GTP-gamma-S functional assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Adolor

Curated by ChEMBL
LigandPNGBDBM50176365(N-((S)-2-((S)-3-hydroxypyrrolidin-1-yl)-1-phenylet...)
Affinity DataIC50: 190nMAssay Description:Inhibitory activity against CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Adolor

Curated by ChEMBL
LigandPNGBDBM50176364(2-(Acetyl-phenyl-amino)-N-[(S)-2-((S)-3-hydroxy-py...)
Affinity DataIC50: 300nMAssay Description:Inhibitory activity against CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Adolor

Curated by ChEMBL
LigandPNGBDBM50176373(2-(2-cyanophenylamino)-N-((S)-2-((S)-3-hydroxypyrr...)
Affinity DataIC50: 510nMAssay Description:Inhibitory activity against CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Adolor

Curated by ChEMBL
LigandPNGBDBM50176374(N-((S)-2-((S)-3-hydroxypyrrolidin-1-yl)-1-phenylet...)
Affinity DataIC50: 530nMAssay Description:Inhibitory activity against CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Adolor

Curated by ChEMBL
LigandPNGBDBM50176362(2-((4-cyanophenyl)(methyl)amino)-N-((S)-2-((S)-3-h...)
Affinity DataIC50: 670nMAssay Description:Inhibitory activity against CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Adolor

Curated by ChEMBL
LigandPNGBDBM50176375(2-(3,4-dichlorophenylamino)-N-((S)-2-((S)-3-hydrox...)
Affinity DataIC50: 760nMAssay Description:Inhibitory activity against CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Adolor

Curated by ChEMBL
LigandPNGBDBM50176372(N-((S)-2-((S)-3-hydroxypyrrolidin-1-yl)-1-phenylet...)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibitory activity against CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Adolor

Curated by ChEMBL
LigandPNGBDBM50176376(2-(4-cyanophenylamino)-N-((S)-2-((S)-3-hydroxypyrr...)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibitory activity against CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Adolor

Curated by ChEMBL
LigandPNGBDBM50176367(2-(3-cyanophenylamino)-N-((S)-2-((S)-3-hydroxypyrr...)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibitory activity against CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Adolor

Curated by ChEMBL
LigandPNGBDBM50176370(N-((S)-2-((S)-3-hydroxypyrrolidin-1-yl)-1-phenylet...)
Affinity DataIC50: 3.40E+3nMAssay Description:Inhibitory activity against CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Adolor

Curated by ChEMBL
LigandPNGBDBM50176369(N-((S)-2-((S)-3-hydroxypyrrolidin-1-yl)-1-phenylet...)
Affinity DataIC50: 4.10E+3nMAssay Description:Inhibitory activity against CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Adolor

Curated by ChEMBL
LigandPNGBDBM50176364(2-(Acetyl-phenyl-amino)-N-[(S)-2-((S)-3-hydroxy-py...)
Affinity DataKi: >5.00E+3nMAssay Description:Binding affinity to mu opioid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Adolor

Curated by ChEMBL
LigandPNGBDBM50176363(N-((S)-2-((S)-3-hydroxypyrrolidin-1-yl)-1-phenylet...)
Affinity DataKi: >5.00E+3nMAssay Description:Binding affinity to mu opioid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Adolor

Curated by ChEMBL
LigandPNGBDBM50176368(N-((S)-2-((S)-3-hydroxypyrrolidin-1-yl)-1-phenylet...)
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibitory activity against CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Adolor

Curated by ChEMBL
LigandPNGBDBM50176366(N-((S)-2-((S)-3-hydroxypyrrolidin-1-yl)-1-phenylet...)
Affinity DataIC50: 8.70E+3nMAssay Description:Inhibitory activity against CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Adolor

Curated by ChEMBL
LigandPNGBDBM50176371(N-((S)-2-((S)-3-hydroxypyrrolidin-1-yl)-1-phenylet...)
Affinity DataIC50: 9.00E+3nMAssay Description:Inhibitory activity against CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed